{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:44:24Z","timestamp":1777272264031,"version":"3.51.4"},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004101","name":"Lady Tata Memorial Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.repbio.2021.100532","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T20:11:01Z","timestamp":1625775061000},"page":"100532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["High fat diet-induced- and genetically inherited- obesity differential alters DNA demethylation pathways in the germline of adult male rats"],"prefix":"10.1016","volume":"21","author":[{"given":"Sharvari S.S.","family":"Deshpande","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harishankar","family":"Nemani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafisa H.","family":"Balasinor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.repbio.2021.100532_bib0005","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/humupd\/dmr017","article-title":"Functional relationship between obesity and male reproduction: from humans to animal models","volume":"17","author":"Teerds","year":"2011","journal-title":"Hum Reprod Update"},{"issue":"3","key":"10.1016\/j.repbio.2021.100532_bib0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1530\/REP-09-0568","article-title":"The adverse effects of obesity on conception and implantation","volume":"140","author":"Brewer","year":"2010","journal-title":"Reproduction"},{"issue":"9","key":"10.1016\/j.repbio.2021.100532_bib0015","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1093\/humrep\/dem139","article-title":"Men\u2019s body mass index and infertility","volume":"22","author":"Nguyen","year":"2007","journal-title":"Hum Reprod"},{"issue":"6","key":"10.1016\/j.repbio.2021.100532_bib0020","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1093\/humrep\/dem035","article-title":"Subfecundity in overweight and obese couples","volume":"22","author":"Ramlau-Hansen","year":"2007","journal-title":"Hum Reprod"},{"issue":"9","key":"10.1016\/j.repbio.2021.100532_bib0025","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10815-010-9439-y","article-title":"Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles","volume":"27","author":"Keltz","year":"2010","journal-title":"J Assist Reprod Genet"},{"issue":"4","key":"10.1016\/j.repbio.2021.100532_bib0030","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4161\/spmg.21362","article-title":"Impact of obesity on male fertility, sperm function and molecular composition","volume":"2","author":"Palmer","year":"2012","journal-title":"Spermatogenesis"},{"issue":"3","key":"10.1016\/j.repbio.2021.100532_bib0035","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.molmet.2015.12.002","article-title":"High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring","volume":"5","author":"de Castro Barbosa","year":"2015","journal-title":"Mol Metab"},{"issue":"2","key":"10.1016\/j.repbio.2021.100532_bib0040","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cmet.2015.11.004","article-title":"Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans","volume":"23","author":"Donkin","year":"2016","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.repbio.2021.100532_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2891-3-3","article-title":"Obesity: an overview on its current perspectives and treatment options","volume":"3","author":"Nammi","year":"2004","journal-title":"Nutr J"},{"issue":"1","key":"10.1016\/j.repbio.2021.100532_bib0050","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1210\/en.2018-00569","article-title":"Genetically inherited obesity and high-fat diet-induced obesity differentially alter spermatogenesis in adult male rats","volume":"160","author":"Deshpande","year":"2019","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.repbio.2021.100532_bib0055","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.repbio.2019.06.005","article-title":"Altered endocrine, cytokine signaling and oxidative stress: a plausible reason for differential changes in testicular cells in diet-induced and genetically-inherited - obesity in adult rats","volume":"19","author":"Deshpande","year":"2019","journal-title":"Reprod Biol"},{"issue":"1","key":"10.1016\/j.repbio.2021.100532_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-020-00974-7","article-title":"High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male rats","volume":"12","author":"Deshpande","year":"2020","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.repbio.2021.100532_bib0065","first-page":"131","article-title":"A new rat model for the study of obesity","volume":"23","author":"Giridharan","year":"1996","journal-title":"Scand J Lab Anim Sci"},{"key":"10.1016\/j.repbio.2021.100532_bib0070","article-title":"Infertility in WNIN obese mutant rats-causes?","volume":"2011","author":"Harishankar","year":"2011","journal-title":"ISRN Endocrinol"},{"key":"10.1016\/j.repbio.2021.100532_bib0075","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/617569","article-title":"Obesity, insulin resistance, and metabolic syndrome: a study in WNIN\/Ob rats from a pancreatic perspective","volume":"2013","author":"Venkatesan","year":"2013","journal-title":"Biomed Res Int"},{"issue":"10","key":"10.1016\/j.repbio.2021.100532_bib0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077679","article-title":"Obese locus in WNIN\/obese rat maps on chromosome 5 upstream of leptin receptor","volume":"8","author":"Kalashikam","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.repbio.2021.100532_bib0085","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.cell.2011.08.042","article-title":"DNA demethylation dynamics","volume":"146","author":"Bhutani","year":"2011","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.repbio.2021.100532_bib0090","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nrm2950","article-title":"Active DNA demethylation: many roads lead to Rome","volume":"11","author":"Wu","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.repbio.2021.100532_bib0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/dmrr.1281","article-title":"Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat","volume":"28","author":"Williams","year":"2012","journal-title":"Diab Metab Res Rev"},{"issue":"1","key":"10.1016\/j.repbio.2021.100532_bib0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.repbio.2021.100532_bib0105","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.tcb.2012.01.002","article-title":"Active DNA demethylation by Gadd45 and DNA repair","volume":"22","author":"Niehrs","year":"2012","journal-title":"Trends Cell Biol"},{"issue":"16","key":"10.1016\/j.repbio.2021.100532_bib0110","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.4161\/cc.10.16.17093","article-title":"Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond","volume":"10","author":"Guo","year":"2011","journal-title":"Cell Cycle"},{"issue":"March (2)","key":"10.1016\/j.repbio.2021.100532_bib0115","article-title":"Pre-pubertal diet restriction reduces reactive oxygen species and restores fertility in male WNIN\/Obese rat","volume":"50","author":"Dinesh Yadav","year":"2018","journal-title":"Andrologia"},{"issue":"3","key":"10.1016\/j.repbio.2021.100532_bib0120","first-page":"271","article-title":"The effects of exercise and food restriction on obesity and diabetes in young ob\/ob mice","volume":"8","author":"Dubuc","year":"1984","journal-title":"Int J Obes"},{"issue":"4","key":"10.1016\/j.repbio.2021.100532_bib0125","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1073\/pnas.93.4.1726","article-title":"Decreased food intake does not completely account for adiposity reduction after ob protein infusion","volume":"93","author":"Levin","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"10.1016\/j.repbio.2021.100532_bib0130","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1080\/15592294.2017.1382786","article-title":"Estrogen, through estrogen receptor 1, regulates histone modifications and chromatin remodeling during spermatogenesis in adult rats","volume":"12","author":"Dumasia","year":"2017","journal-title":"Epigenetics"},{"issue":"4","key":"10.1016\/j.repbio.2021.100532_bib0135","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrg2045","article-title":"Environmental epigenomics and disease susceptibility","volume":"8","author":"Jirtle","year":"2007","journal-title":"Nat Rev Genet"},{"issue":"2","key":"10.1016\/j.repbio.2021.100532_bib0140","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrg3142","article-title":"Epigenetics and the environment: emerging patterns and implications","volume":"13","author":"Feil","year":"2012","journal-title":"Nat Rev Genet"},{"issue":"21","key":"10.1016\/j.repbio.2021.100532_bib0145","doi-asserted-by":"crossref","first-page":"18347","DOI":"10.1074\/jbc.R110.205286","article-title":"DNA methylation and demethylation in mammals","volume":"286","author":"Chen","year":"2011","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.repbio.2021.100532_bib0150","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12640-014-9497-5","article-title":"A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants","volume":"27","author":"Sadakierska-Chudy","year":"2015","journal-title":"Neurotox Res"},{"issue":"1","key":"10.1016\/j.repbio.2021.100532_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms2995","article-title":"Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis","volume":"4","author":"Gan","year":"2013","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.repbio.2021.100532_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/celldisc.2017.13","article-title":"Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation","volume":"3","author":"Landfors","year":"2017","journal-title":"Cell Discov"},{"issue":"7","key":"10.1016\/j.repbio.2021.100532_bib0165","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1093\/humrep\/dew096","article-title":"TET enzymes are successively expressed during human spermatogenesis and their expression level is pivotal for male fertility","volume":"31","author":"Ni","year":"2016","journal-title":"Hum Reprod"},{"issue":"51","key":"10.1016\/j.repbio.2021.100532_bib0170","doi-asserted-by":"crossref","first-page":"88294","DOI":"10.18632\/oncotarget.18331","article-title":"Genome-wide 5-hydroxymethylcytosine patterns in human spermatogenesis are associated with semen quality","volume":"8","author":"Efimova","year":"2017","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.repbio.2021.100532_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082881","article-title":"Analysis of TET expression\/activity and 5mC oxidation during normal and malignant germ cell development","volume":"8","author":"Nettersheim","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.repbio.2021.100532_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.100908","article-title":"Tet1 deficiency leads to premature reproductive aging by reducing spermatogonia stem cells and germ cell differentiation","volume":"23","author":"Huang","year":"2020","journal-title":"iScience"},{"issue":"7696","key":"10.1016\/j.repbio.2021.100532_bib0185","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature25964","article-title":"Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte","volume":"555","author":"Hill","year":"2018","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.repbio.2021.100532_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2014-15-6-r81","article-title":"Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells","volume":"15","author":"Putiri","year":"2014","journal-title":"Genome Biol"},{"issue":"5","key":"10.1016\/j.repbio.2021.100532_bib0195","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ygeno.2014.08.015","article-title":"5-Hydroxymethylcytosine: a stable or transient DNA modification?","volume":"104","author":"Hahn","year":"2014","journal-title":"Genomics"},{"issue":"6","key":"10.1016\/j.repbio.2021.100532_bib0200","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2217\/epi.15.39","article-title":"Methyl-CpG-binding domain proteins: readers of the epigenome","volume":"7","author":"Du","year":"2015","journal-title":"Epigenomics"},{"issue":"9","key":"10.1016\/j.repbio.2021.100532_bib0205","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.2337\/db13-1916","article-title":"Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation","volume":"63","author":"Dhliwayo","year":"2014","journal-title":"Diabetes"},{"issue":"17","key":"10.1016\/j.repbio.2021.100532_bib0210","doi-asserted-by":"crossref","first-page":"8276","DOI":"10.1093\/nar\/gks628","article-title":"Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation","volume":"40","author":"Hashimoto","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"10.1016\/j.repbio.2021.100532_bib0215","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.fertnstert.2015.08.019","article-title":"Aberrant sperm DNA methylation predicts male fertility status and embryo quality","volume":"104","author":"Aston","year":"2015","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1016\/j.repbio.2021.100532_bib0220","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/humrep\/dev283","article-title":"Promoter targeted bisulfite sequencing reveals DNA methylation profiles associated with low sperm motility in asthenozoospermia","volume":"31","author":"Du","year":"2016","journal-title":"Hum Reprod"},{"issue":"5","key":"10.1016\/j.repbio.2021.100532_bib0225","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/humrep\/dev053","article-title":"Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility","volume":"30","author":"Urdinguio","year":"2015","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.repbio.2021.100532_bib0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0211837","article-title":"Adverse effects of paternal obesity on the motile spermatozoa quality","volume":"14","author":"Raad","year":"2019","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.repbio.2021.100532_bib0235","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/mrd.22280","article-title":"DNA methylation and demethylation: a pathway to gametogenesis and development","volume":"81","author":"Dean","year":"2014","journal-title":"Mol Reprod Dev"},{"issue":"11","key":"10.1016\/j.repbio.2021.100532_bib0240","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1093\/nar\/gku334","article-title":"Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA","volume":"42","author":"Madugundu","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.repbio.2021.100532_bib0245","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.radphyschem.2016.04.018","article-title":"Radiation-induced damage to cellular DNA: chemical nature and mechanisms of lesion formation","volume":"128","author":"Cadet","year":"2016","journal-title":"Radiat Phys Chem"},{"issue":"9","key":"10.1016\/j.repbio.2021.100532_bib0250","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.cellsig.2016.05.021","article-title":"OGG1 is essential in oxidative stress induced DNA demethylation","volume":"28","author":"Zhou","year":"2016","journal-title":"Cell Signal"},{"issue":"2","key":"10.1016\/j.repbio.2021.100532_bib0255","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.acthis.2009.10.004","article-title":"Alterations in the spermatic function generated by obesity in rats","volume":"113","author":"Vigueras-Villase\u00f1or","year":"2011","journal-title":"Acta Histochem"},{"issue":"5","key":"10.1016\/j.repbio.2021.100532_bib0260","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/humrep\/des030","article-title":"Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice","volume":"27","author":"Fullston","year":"2012","journal-title":"Hum Reprod"},{"issue":"5 Pt 1","key":"10.1016\/j.repbio.2021.100532_bib0265","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1365-2605.2010.01092.x","article-title":"The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model","volume":"34","author":"Bakos","year":"2011","journal-title":"Int J Androl"},{"key":"10.1016\/j.repbio.2021.100532_bib0270","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/190945","article-title":"Leptin level and oxidative stress contribute to obesity-induced low testosterone in murine testicular tissue","volume":"2014","author":"Zhao","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.repbio.2021.100532_bib0275","doi-asserted-by":"crossref","first-page":"8219","DOI":"10.1038\/ncomms9219","article-title":"TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression","volume":"6","author":"Takayama","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.repbio.2021.100532_bib0280","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13148-019-0660-y","article-title":"Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs","volume":"11","author":"Yuan","year":"2019","journal-title":"Clin Epigenetics"},{"issue":"1","key":"10.1016\/j.repbio.2021.100532_bib0285","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/art.38200","article-title":"A global increase in 5-hydroxymethylcytosine levels marks osteoarthritic chondrocytes","volume":"66","author":"Taylor","year":"2014","journal-title":"Arthritis Rheumatol."},{"issue":"11","key":"10.1016\/j.repbio.2021.100532_bib0290","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019463","article-title":"Metabolic signaling to chromatin","volume":"8","author":"Berger","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X2100053X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X2100053X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:20:42Z","timestamp":1761646842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X2100053X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1642431X2100053X"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2021.100532","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High fat diet-induced- and genetically inherited- obesity differential alters DNA demethylation pathways in the germline of adult male rats","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2021.100532","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100532"}}