{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:25:37Z","timestamp":1792596337801,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004920","name":"Royan Institute","doi-asserted-by":"publisher","award":["97000243"],"award-info":[{"award-number":["97000243"]}],"id":[{"id":"10.13039\/501100004920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.repbio.2021.100543","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T17:56:33Z","timestamp":1630778193000},"page":"100543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Role of peroxisome proliferator-activated receptor gamma (PPAR\u03b3) in the regulation of fatty acid metabolism related gene expressions in testis of men with impaired spermatogenesis"],"prefix":"10.1016","volume":"21","author":[{"given":"Fateme","family":"Olia Bagheri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7273-9793","authenticated-orcid":false,"given":"AliReza","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ali","family":"Sadighi Gilani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9021-6408","authenticated-orcid":false,"given":"Maryam","family":"Shahhoseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.repbio.2021.100543_bib0005","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/humrep\/dep343","article-title":"The international committee for monitoring assisted reproductive technology (ICMART) and the world health organization (WHO) revised glossary on ART terminology, 2009","volume":"24","author":"Zegers-Hochschild","year":"2009","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.repbio.2021.100543_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.repbio.2021.100543_bib0015","article-title":"Male infertility problem: a contemporary review on present status and future perspective","volume":"3","author":"Dissanayake","year":"2019","journal-title":"Gend Genome"},{"issue":"3","key":"10.1016\/j.repbio.2021.100543_bib0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.29252\/ijrm.16.3.131","article-title":"Basic and clinical genetic studies on male infertility in Iran during 2000-2016: a review","volume":"16","author":"Moghbelinejad","year":"2018","journal-title":"Int J Reprod Biomed"},{"issue":"1","key":"10.1016\/j.repbio.2021.100543_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00013.2015","article-title":"Spermatogenesis: the commitment to meiosis","volume":"96","author":"Griswold","year":"2016","journal-title":"Physiol Rev"},{"key":"10.1016\/j.repbio.2021.100543_bib0030","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3640450","article-title":"Fatty acid profile and metabolism are related to human sperm parameters and are relevant in idiopathic infertility and varicocele","volume":"2020","author":"Collodel","year":"2020","journal-title":"Mediators Inflamm"},{"issue":"4","key":"10.1016\/j.repbio.2021.100543_bib0035","first-page":"336","article-title":"Genetics of human male infertility","volume":"50","author":"Poongothai","year":"2009","journal-title":"Singapore Med J"},{"issue":"1","key":"10.1016\/j.repbio.2021.100543_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12888-018-1868-7","article-title":"FADS1-FADS2 and ELOVL2 gene polymorphisms in susceptibility to autism spectrum disorders in Chinese children","volume":"18","author":"Sun","year":"2018","journal-title":"BMC Psychiatry"},{"issue":"2","key":"10.1016\/j.repbio.2021.100543_bib0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1194\/jlr.M011346","article-title":"ELOVL2 controls the level of n-6 28: 5 and 30: 5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice","volume":"52","author":"Zadravec","year":"2011","journal-title":"J Lipid Res"},{"issue":"9","key":"10.1016\/j.repbio.2021.100543_bib0050","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1194\/jlr.M900039-JLR200","article-title":"Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration","volume":"50","author":"Stroud","year":"2009","journal-title":"J Lipid Res"},{"key":"10.1016\/j.repbio.2021.100543_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-020-01282-y","article-title":"Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health","volume":"19","author":"Svendsen","year":"2020","journal-title":"Lipids Health Dis"},{"issue":"1","key":"10.1016\/j.repbio.2021.100543_bib0060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1095\/biolreprod.102.014035","article-title":"Expression and regulation of \u03945-desaturase, \u03946-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis","volume":"69","author":"S\u00e6ther","year":"2003","journal-title":"Biol Reprod"},{"issue":"2","key":"10.1016\/j.repbio.2021.100543_bib0065","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.atherosclerosis.2014.10.016","article-title":"Lipoprotein lipase: from gene to atherosclerosis","volume":"237","author":"Li","year":"2014","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.repbio.2021.100543_bib0070","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.90920.2008","article-title":"Lipoprotein lipase: from gene to obesity","volume":"297","author":"Wang","year":"2009","journal-title":"Am J Physiol-Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.repbio.2021.100543_bib0075","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1194\/jlr.R200015-JLR200","article-title":"Lipoprotein lipase","volume":"43","author":"Merkel","year":"2002","journal-title":"J Lipid Res"},{"key":"10.1016\/j.repbio.2021.100543_bib0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cca.2019.12.029","article-title":"Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation","volume":"503","author":"Li","year":"2020","journal-title":"Clin Chim Acta"},{"issue":"12","key":"10.1016\/j.repbio.2021.100543_bib0085","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00109-002-0384-9","article-title":"Lipoprotein lipase: structure, function, regulation, and role in disease","volume":"80","author":"Mead","year":"2002","journal-title":"J Mol Med"},{"issue":"9","key":"10.1016\/j.repbio.2021.100543_bib0090","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1093\/humrep\/deaa153","article-title":"Peroxisome proliferator-activated receptor gamma expression along the male genital system and its role in male fertility","volume":"35","author":"Santoro","year":"2020","journal-title":"Hum Reprod"},{"issue":"6","key":"10.1016\/j.repbio.2021.100543_bib0095","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4103\/1008-682X.150253","article-title":"Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology","volume":"17","author":"Liu","year":"2015","journal-title":"Asian J Androl"},{"issue":"1","key":"10.1016\/j.repbio.2021.100543_bib0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.urology.2013.09.021","article-title":"Comparison of sperm retrieval and intracytoplasmic sperm injection outcome in patients with and without Klinefelter syndrome","volume":"83","author":"Sabbaghian","year":"2014","journal-title":"Urology"},{"issue":"1","key":"10.1016\/j.repbio.2021.100543_bib0105","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.rbmo.2016.09.005","article-title":"Deficient expression of JMJD1A histone demethylase in patients with round spermatid maturation arrest","volume":"34","author":"Eelaminejad","year":"2017","journal-title":"Reprod Biomed Online"},{"issue":"3","key":"10.1016\/j.repbio.2021.100543_bib0110","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/andr.12024","article-title":"Dietary fatty acids affect semen quality: a review","volume":"3","author":"Esmaeili","year":"2015","journal-title":"Andrology"},{"issue":"6","key":"10.1016\/j.repbio.2021.100543_bib0115","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.00235.2020","article-title":"Diet during early life defines testicular lipid content and sperm quality in adulthood","volume":"319","author":"Cris\u00f3stomo","year":"2020","journal-title":"Am J Physiol-Endocrinol Metab"},{"key":"10.1016\/j.repbio.2021.100543_bib0120","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/409168","article-title":"PPARG: gene expression regulation and next-generation sequencing for unsolved issues","volume":"2010","author":"Costa","year":"2010","journal-title":"PPAR Res"},{"issue":"6","key":"10.1016\/j.repbio.2021.100543_bib0125","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/19396368.2019.1677801","article-title":"Peroxisome Proliferator-Activated Receptors (PPARs) levels in spermatozoa of normozoospermic and asthenozoospermic men","volume":"65","author":"Mousavi","year":"2019","journal-title":"Syst Biol Reprod Med"},{"issue":"3","key":"10.1016\/j.repbio.2021.100543_bib0130","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1439-0272.1983.tb00365.x","article-title":"Endocrine profile of 45 patients with Sertoli cell only syndrome","volume":"15","author":"Mi\u0107i\u0107","year":"1983","journal-title":"Andrologia"},{"issue":"3","key":"10.1016\/j.repbio.2021.100543_bib0135","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/01485017908987321","article-title":"Endocrine studies of azoospermia. I. Serum steroid levels in Sertoli cell only syndrome","volume":"2","author":"Abdalla","year":"1979","journal-title":"Arch Androl"},{"issue":"2","key":"10.1016\/j.repbio.2021.100543_bib0140","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2164\/jandrol.109.007609","article-title":"Assessment of seminal estradiol and testosterone levels as predictors of human spermatogenesis","volume":"31","author":"Zhang","year":"2010","journal-title":"J Androl"},{"key":"10.1016\/j.repbio.2021.100543_bib0145","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0074-7696(00)00002-4","article-title":"Gonadal development in mammals at the cellular and molecular levels","volume":"200","author":"Mackay","year":"2000","journal-title":"Int Rev Cytol"},{"issue":"6","key":"10.1016\/j.repbio.2021.100543_bib0150","first-page":"1085","article-title":"Sperm metabolism in pigs: a role for peroxisome proliferator-activated receptor gamma (PPAR\u03b3)","volume":"216","author":"Santoro","year":"2013","journal-title":"J Exp Biol"},{"key":"10.1016\/j.repbio.2021.100543_bib0155","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7508014","article-title":"Increased F2-isoprostane levels in semen and immunolocalization of the 8-iso prostaglandin F2\u03b1 in spermatozoa from infertile patients with varicocele","volume":"2018","author":"Collodel","year":"2018","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"10.1016\/j.repbio.2021.100543_bib0160","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.acthis.2009.10.004","article-title":"Alterations in the spermatic function generated by obesity in rats","volume":"113","author":"Vigueras-Villase\u00f1or","year":"2011","journal-title":"Acta Histochem"},{"key":"10.1016\/j.repbio.2021.100543_bib0165","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.2741\/e324","article-title":"Developmental patterns of PPAR and RXR gene expression during spermatogenesis","volume":"3","author":"Thomas","year":"2011","journal-title":"Front Biosci (Elite Ed)"},{"issue":"3","key":"10.1016\/j.repbio.2021.100543_bib0170","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/jcp.20807","article-title":"Peroxisome proliferator\u2010activated receptor (PPAR) \u03b3 is expressed by human spermatozoa: its potential role on the sperm physiology","volume":"209","author":"Aquila","year":"2006","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.repbio.2021.100543_bib0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.100974","article-title":"Dietary \u03c93-and \u03c96-Polyunsaturated fatty acids reconstitute fertility of Juvenile and adult Fads2-Deficient mice","volume":"36","author":"Stoffel","year":"2020","journal-title":"Mol Metab"},{"issue":"3","key":"10.1016\/j.repbio.2021.100543_bib0180","first-page":"289","article-title":"Dietary fish oil can change sperm parameters and fatty acid profiles of ram sperm during oil consumption period and after removal of oil source","volume":"16","author":"Alizadeh","year":"2014","journal-title":"Cell J (Yakhteh)"},{"issue":"5","key":"10.1016\/j.repbio.2021.100543_bib0185","doi-asserted-by":"crossref","first-page":"622","DOI":"10.5713\/ajas.15.1034","article-title":"Polyunsaturated fatty acids in male ruminant reproduction\u2014a review","volume":"30","author":"Van Tran","year":"2017","journal-title":"Asian-Australas J Anim Sci"},{"issue":"1","key":"10.1016\/j.repbio.2021.100543_bib0190","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2605.2009.00988.x","article-title":"Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms","volume":"33","author":"Nielsen","year":"2010","journal-title":"Int J Androl"},{"issue":"6","key":"10.1016\/j.repbio.2021.100543_bib0195","doi-asserted-by":"crossref","DOI":"10.1111\/and.13273","article-title":"Effect of aerobic exercise, low\u2010fat and high\u2010fat diet on the testis tissue and sperm parameters in obese and nonobese mice model","volume":"51","author":"Nematollahi","year":"2019","journal-title":"Andrologia"},{"issue":"2","key":"10.1016\/j.repbio.2021.100543_bib0200","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/humrep\/det428","article-title":"The relationship between male BMI and waist circumference on semen quality: data from the LIFE study","volume":"29","author":"Eisenberg","year":"2014","journal-title":"Hum Reprod"},{"issue":"5","key":"10.1016\/j.repbio.2021.100543_bib0205","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/andr.12227","article-title":"Fatty acid composition of spermatozoa is associated with BMI and with semen quality","volume":"4","author":"Andersen","year":"2016","journal-title":"Andrology"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X21000644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X21000644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:39:43Z","timestamp":1778621983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X21000644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1642431X21000644"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2021.100543","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of peroxisome proliferator-activated receptor gamma (PPAR\u03b3) in the regulation of fatty acid metabolism related gene expressions in testis of men with impaired spermatogenesis","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2021.100543","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100543"}}