{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T03:02:58Z","timestamp":1786676578777,"version":"build-2736575974"},"reference-count":93,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.repbio.2022.100645","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T17:05:43Z","timestamp":1652807143000},"page":"100645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["The role of extracellular vesicles in endometrial receptivity and their potential in reproductive therapeutics and diagnosis"],"prefix":"10.1016","volume":"22","author":[{"given":"Amber Rose","family":"Hart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norhayati Liaqat Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasun","family":"Godakumara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthie","family":"Dissanayake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Piibor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhashini","family":"Muhandiram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saji","family":"Eapen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Heath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Fazeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2022.100645_bib1","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.9479.2","article-title":"Early embryo mortality in natural human reproduction: What the data say","author":"Jarvis","year":"2016","journal-title":"F1000Research"},{"key":"10.1016\/j.repbio.2022.100645_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d223","article-title":"Emotional distress in infertile women and failure of assisted reproductive technologies: meta-analysis of prospective psychosocial studies","author":"Boivin","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.repbio.2022.100645_bib3","unstructured":"Fertility treatment 2018: trends and figures. Human Fertilisation & Embryology Authority. 2020."},{"key":"10.1016\/j.repbio.2022.100645_bib4","first-page":"494","article-title":"The Vienna consensus: report of an expert meeting on the development of ART laboratory performance indicators","author":"Apter","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.repbio.2022.100645_bib5","doi-asserted-by":"crossref","DOI":"10.1056\/NEJM199906103402304","article-title":"Time of implantation of the conceptus and loss of pregnancy","author":"Wilcox","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.repbio.2022.100645_bib6","doi-asserted-by":"crossref","DOI":"10.1210\/en.2017-03082","article-title":"Embryo implantation: war in times of love","author":"Ashary","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.repbio.2022.100645_bib7","doi-asserted-by":"crossref","DOI":"10.1210\/er.2004-0021","article-title":"Endocrine regulation of menstruation","volume":"27","author":"Jabbour","year":"2006","journal-title":"Endocr Rev"},{"issue":"9","key":"10.1016\/j.repbio.2022.100645_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/8.9.841","article-title":"Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro","volume":"8","author":"Cork","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.repbio.2022.100645_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/humupd\/6.5.495","article-title":"Insulin-like growth factor binding protein-1 (IGFBP-1): A multifunctional role in the human female reproductive tract","volume":"Vol. 6","author":"Fowler","year":"2000","journal-title":"Hum Reprod Update"},{"issue":"5","key":"10.1016\/j.repbio.2022.100645_bib10","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.105.045518","article-title":"The chemokines, CX3CL1, CCL14, and CCL4, promote human trophoblast migration at the feto-maternal interface","volume":"74","author":"Hannan","year":"2006","journal-title":"Biol Reprod"},{"issue":"6","key":"10.1016\/j.repbio.2022.100645_bib11","article-title":"Osteopontin and integrin \u03b1v\u03b23 expression during the implantation window in IVF patients with elevated serum progesterone and oestradiol level","volume":"76","author":"He","year":"2016","journal-title":"Geburtshilfe Frauenheilkd"},{"issue":"6","key":"10.1016\/j.repbio.2022.100645_bib12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1530\/REP-10-0360","article-title":"A balancing act: mechanisms by which the fetus avoids rejection by the maternal immune system","volume":"141","author":"Warning","year":"2011","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2022.100645_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058419","article-title":"Endometrial receptivity: a revisit to functional genomics studies on human endometrium and creation of HGEx-ERdb","author":"Bhagwat","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.repbio.2022.100645_bib14","article-title":"Physiology of embryo-endometrial cross talk","author":"Modi","year":"2015","journal-title":"Biomed Res J"},{"issue":"1","key":"10.1016\/j.repbio.2022.100645_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56879-w","article-title":"Effects of miR-98 in intrauterine extracellular vesicles on maternal immune regulation during the peri-implantation period in cattle","volume":"9","author":"Nakamura","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2022.100645_bib16","article-title":"Molecular signaling regulating endometrium\u2013blastocyst crosstalk","volume":"21","author":"Massimiani","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2022.100645_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-019-0448-x","article-title":"Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk","author":"Es-Haghi","year":"2019","journal-title":"Cell Commun Signal"},{"issue":"5","key":"10.1016\/j.repbio.2022.100645_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/biolre\/ioaa019","article-title":"Characterization and regulation of extracellular vesicles in the lumen of the ovine uterus","volume":"102","author":"O\u2019Neil","year":"2020","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2022.100645_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/biosci\/biv084","article-title":"Extracellular vesicles: composition, biological relevance, and methods of study","author":"Zaborowski","year":"2015","journal-title":"BioScience"},{"issue":"1","key":"10.1016\/j.repbio.2022.100645_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12958-021-00801-5","article-title":"Trophoblast derived extracellular vesicles specifically alter the transcriptome of endometrial cells and may constitute a critical component of embryo-maternal communication","volume":"19","author":"Godakumara","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.repbio.2022.100645_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030645","article-title":"MicroRNAs in small extracellular vesicles indicate successful embryo implantation during early pregnancy","author":"Tan","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.repbio.2022.100645_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2015.09.003","article-title":"Human blastocyst secreted microRNA regulate endometrial epithelial cell adhesion","author":"Cuman","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.repbio.2022.100645_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/cdd.2017.136","article-title":"MicroRNA-200c impairs uterine receptivity formation by targeting FUT4 and \u03b11,3-fucosylation","author":"Zheng","year":"2017","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.repbio.2022.100645_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s10815-020-02048-2","article-title":"Extracellular vesicles and female reproduction","volume":"Vol. 38","author":"Machtinger","year":"2021","journal-title":"J Assist Reprod Genet"},{"issue":"2","key":"10.1016\/j.repbio.2022.100645_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13360","article-title":"Extracellular vesicles in embryo implantation and disorders of the endometrium","volume":"85","author":"Mishra","year":"2021","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.repbio.2022.100645_bib26","doi-asserted-by":"crossref","DOI":"10.1172\/JCI81129","article-title":"Extracellular vesicle isolation and characterization: Toward clinical application","author":"Xu","year":"2016","journal-title":"J Clin Investig"},{"issue":"3","key":"10.1016\/j.repbio.2022.100645_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058502","article-title":"Endometrial exosomes\/microvesicles in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation","volume":"8","author":"Ng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.repbio.2022.100645_bib28","doi-asserted-by":"crossref","DOI":"10.1007\/BF00255932","article-title":"Promotive effect on human sperm progressive motility by prostasomes","author":"Stegmayr","year":"1982","journal-title":"Urol Res"},{"key":"10.1016\/j.repbio.2022.100645_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2141.1971.tb03416.x","article-title":"The presence of contractile proteins in platelet microparticles isolated from human and animal platelet\u2010free plasma","author":"Crawford","year":"1971","journal-title":"Br J Haematol"},{"key":"10.1016\/j.repbio.2022.100645_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/0005-2736(81)90512-5","article-title":"Exfoliation of membrane ecto-enzymes in the form of micro-vesicles","author":"Trams","year":"1981","journal-title":"Biochim et Biophys Acta BBA- Biomembr"},{"key":"10.1016\/j.repbio.2022.100645_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)48095-7","article-title":"Vesicle formation during reticulocyte maturation. association of plasma membrane activities with released vesicles (exosomes)","author":"Johnstone","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.repbio.2022.100645_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcancer.2014.04.009","article-title":"Sorting it out: regulation of exosome loading","author":"Villarroya-Beltri","year":"2014","journal-title":"Semin Cancer Biol"},{"issue":"8","key":"10.1016\/j.repbio.2022.100645_bib33","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/emboj.2009.45","article-title":"Acid sphingomyelinase activity triggers microparticle release from glial cells","volume":"28","author":"Bianco","year":"2009","journal-title":"EMBO J"},{"issue":"3","key":"10.1016\/j.repbio.2022.100645_bib34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.blre.2006.09.001","article-title":"Circulating microparticles: pathophysiology and clinical implications","volume":"21","author":"Piccin","year":"2007","journal-title":"Blood Rev"},{"key":"10.1016\/j.repbio.2022.100645_bib35","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J Extracell Vesicles"},{"issue":"10","key":"10.1016\/j.repbio.2022.100645_bib36","article-title":"EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles","volume":"2","author":"Kim","year":"2013","journal-title":"J Extra Vesicles"},{"issue":"1","key":"10.1016\/j.repbio.2022.100645_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-020-00669-9","article-title":"Proteomics identifies differences in fibrotic potential of extracellular vesicles from human tendon and muscle fibroblasts","volume":"18","author":"Yeung","year":"2020","journal-title":"Cell Commun Signal"},{"issue":"7","key":"10.1016\/j.repbio.2022.100645_bib38","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbagen.2012.03.017","article-title":"Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials","volume":"1820","author":"Vlassov","year":"2012","journal-title":"Biochim Biophys Acta - Gen Subj"},{"issue":"319","key":"10.1016\/j.repbio.2022.100645_bib39","article-title":"Characterization of human plasma-derived exosomal RNAs by deep sequencing","volume":"14","author":"Huang","year":"2013","journal-title":"BMC Genom"},{"issue":"1","key":"10.1016\/j.repbio.2022.100645_bib40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.fertnstert.2015.09.014","article-title":"MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment","volume":"105","author":"Capalbo","year":"2016","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.repbio.2022.100645_bib41","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/biology6030034","article-title":"MicroRNA signaling in embryo development","volume":"6","author":"Gross","year":"2017","journal-title":"Biology"},{"key":"10.1016\/j.repbio.2022.100645_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/S0002-9440(10)64887-0","article-title":"Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells","author":"Taraboletti","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.repbio.2022.100645_bib43","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.7445","article-title":"Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation","author":"Carrasco-Ram\u00edrez","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.repbio.2022.100645_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.nano.2019.03.010","article-title":"Bronchial epithelial cell extracellular vesicles ameliorate epithelial\u2013mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization","author":"He","year":"2019","journal-title":"Nanomed Nanotechnol Biol Med"},{"issue":"6","key":"10.1016\/j.repbio.2022.100645_bib45","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2019.226209","article-title":"Placenta-derived extracellular vesicles induce preeclampsia in mouse models","volume":"105","author":"Han","year":"2020","journal-title":"Haematologica"},{"issue":"13\u201314","key":"10.1016\/j.repbio.2022.100645_bib46","article-title":"Proteomic profiling of human uterine extracellular vesicles reveal dynamic regulation of key players of embryo implantation and fertility during menstrual cycle","volume":"21","author":"Rai","year":"2021","journal-title":"Proteomics"},{"key":"10.1016\/j.repbio.2022.100645_bib47","first-page":"149","article-title":"Individually cultured bovine embryos produce extracellular vesicles that have the potential to be used as non-invasive embryo quality markers","author":"Dissanayake","year":"2020","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2022.100645_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-05549-w","article-title":"Secretome of in vitro cultured human embryos contains extracellular vesicles that are uptaken by the maternal side","author":"Giacomini","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2022.100645_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178306","article-title":"Identification and characteristics of extracellular vesicles from bovine blastocysts produced in vitro","author":"Mellisho","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.repbio.2022.100645_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/mrd.23272","article-title":"Sexual dimorphic expression and release of transcription factors in bovine embryos exposed to oxidative stress","author":"Taqi","year":"2019","journal-title":"Mol Reprod Dev"},{"issue":"2","key":"10.1016\/j.repbio.2022.100645_bib51","doi-asserted-by":"crossref","DOI":"10.1530\/jrf.0.1110259","article-title":"Permeability of the mouse zona pellucida: a structure-staining-correlation model using coloured probes","volume":"111","author":"Turner","year":"1997","journal-title":"J Reprod Fertil"},{"issue":"4","key":"10.1016\/j.repbio.2022.100645_bib52","doi-asserted-by":"crossref","DOI":"10.1080\/19396368.2019.1619858","article-title":"Ultrastructural identification of CD9 positive extracellular vesicles released from human embryos and transported through the zona pellucida","volume":"65","author":"Vyas","year":"2019","journal-title":"Syst Biol Reprod Med"},{"issue":"3","key":"10.1016\/j.repbio.2022.100645_bib53","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1089\/cell.2014.0003","article-title":"Improvement of cloned embryos development by co-culturing with parthenotes: A possible role of exosomes\/microvesicles for embryos paracrine communication","volume":"16","author":"Saadeldin","year":"2014","journal-title":"Cell Reprogram"},{"issue":"12","key":"10.1016\/j.repbio.2022.100645_bib54","first-page":"119","article-title":"Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts","author":"Pavani","year":"2022","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.repbio.2022.100645_bib55","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/mrd.23223","article-title":"Oxygen tension modulates extracellular vesicles and its miRNA contents in bovine embryo culture medium","volume":"86","author":"Andrade","year":"2019","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.repbio.2022.100645_bib56","doi-asserted-by":"crossref","first-page":"39927","DOI":"10.1038\/srep39927","article-title":"A simple and rapid flow cytometry-based assay to identify a competent embryo prior to embryo transfer","volume":"7","author":"Pallinger","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2022.100645_bib57","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1038\/s41598-017-13683-8","article-title":"Micro-ribonucleic acids and extracellular vesicles repertoire in the spent culture media is altered in women undergoing In Vitro Fertilization","volume":"7","author":"Abu-Halima","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.repbio.2022.100645_bib58","doi-asserted-by":"crossref","DOI":"10.1007\/s00109-021-02042-w","article-title":"Oviduct as a sensor of embryo quality: deciphering the extracellular vesicle (EV)-mediated embryo-maternal dialogue","volume":"99","author":"Dissanayake","year":"2021","journal-title":"J Mol Med"},{"issue":"56","key":"10.1016\/j.repbio.2022.100645_bib59","article-title":"Extracellular vesicles originate from the conceptus and uterus during early pregnancy in sheep","volume":"94","author":"Burns","year":"2016","journal-title":"Biol Reprod"},{"issue":"2","key":"10.1016\/j.repbio.2022.100645_bib60","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1439-0531.2010.01614.x","article-title":"Improving the quality of miniature pig somatic cell nuclear transfer blastocysts: aggregation of SCNT embryos at the four-cell stage","volume":"46","author":"Terashita","year":"2011","journal-title":"Reprod Domest Anim"},{"issue":"1","key":"10.1016\/j.repbio.2022.100645_bib61","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/ijms20010038","article-title":"Isolation and characterization of functionally active extracellular vesicles from culture medium conditioned by bovine embryos in vitro","volume":"20","author":"Pavani","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.repbio.2022.100645_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174535","article-title":"Effects of embryo-derived exosomes on the development of bovine cloned embryos","volume":"12","author":"Qu","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.repbio.2022.100645_bib63","doi-asserted-by":"crossref","DOI":"10.1530\/REP-19-0233","article-title":"Extracellular vesicles secreted during blastulation show viability of bovine embryos","volume":"158","author":"Mellisho","year":"2019","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2022.100645_bib64","first-page":"7","article-title":"Extracellular vesicle mediated intercellular communication at the porcine maternal-fetal interface: a new paradigm for conceptus-endometrial cross-talk","author":"Bidarimath","year":"2017","journal-title":"Sci Rep"},{"issue":"20","key":"10.1016\/j.repbio.2022.100645_bib65","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14592","article-title":"Activation of multiple receptors stimulates extracellular vesicle release from trophoblast cells","volume":"8","author":"Conrad","year":"2020","journal-title":"Physiol Rep"},{"issue":"13\u201314","key":"10.1016\/j.repbio.2022.100645_bib66","article-title":"Proteome reprogramming of endometrial epithelial cells by human trophectodermal small extracellular vesicles reveals key insights into embryo implantation","volume":"21","author":"Poh","year":"2021","journal-title":"Proteomics"},{"issue":"5","key":"10.1016\/j.repbio.2022.100645_bib67","doi-asserted-by":"crossref","DOI":"10.1530\/REP-19-0314","article-title":"IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle","volume":"159","author":"Nakamura","year":"2020","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.repbio.2022.100645_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020979","article-title":"Isolation and characterization of equine uterine extracellular vesicles: a comparative methodological study","volume":"22","author":"Almi\u00f1ana","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2022.100645_bib69","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.115.134890","article-title":"Human endometrial exosomes contain hormone-specific cargo modulating trophoblast adhesive capacity: insights into endometrial-embryo interactions","author":"Greening","year":"2016","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2022.100645_bib70","doi-asserted-by":"crossref","first-page":"11958","DOI":"10.1038\/ncomms11958","article-title":"Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation","volume":"7","author":"Desrochers","year":"2016","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.repbio.2022.100645_bib71","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.bbrc.2017.11.176","article-title":"Intrauterine exosomes are required for bovine conceptus implantation","volume":"495","author":"Kusama","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.repbio.2022.100645_bib72","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41391-020-0237-z","article-title":"Clinical utility of the exosome based ExoDx Prostate(IntelliScore) EPI test in men presenting for initial Biopsy with a PSA 2\u201310 ng\/mL","volume":"23","author":"Tutrone","year":"2020","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"4","key":"10.1016\/j.repbio.2022.100645_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat Biotechnol"},{"issue":"5","key":"10.1016\/j.repbio.2022.100645_bib74","doi-asserted-by":"crossref","DOI":"10.1093\/biolre\/ioy011","article-title":"Progesterone effects on extracellular vesicles in the sheep uterus","volume":"98","author":"Burns","year":"2018","journal-title":"Biol Reprod"},{"issue":"2","key":"10.1016\/j.repbio.2022.100645_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2019.06.003","article-title":"Exosome-derived uterine microRNAs isolated from cows with endometritis impede blastocyst development","volume":"19","author":"Wang","year":"2019","journal-title":"Reprod Biol"},{"issue":"4","key":"10.1016\/j.repbio.2022.100645_bib76","doi-asserted-by":"crossref","DOI":"10.1002\/mrd.23333","article-title":"Avian uterine fluid proteome: Exosomes and biological processes potentially involved in sperm survival","volume":"87","author":"Riou","year":"2020","journal-title":"Mol Reprod Dev"},{"issue":"18","key":"10.1016\/j.repbio.2022.100645_bib77","article-title":"Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome","volume":"142","author":"Vilella","year":"2015","journal-title":"Dev"},{"issue":"2309","key":"10.1016\/j.repbio.2022.100645_bib78","article-title":"Differential expression pattern of goat uterine fluids extracellular vesicles miRNAs during peri-implantation","volume":"10","author":"Xie","year":"2021","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.repbio.2022.100645_bib79","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deab123","article-title":"Global transcriptomic changes occur in uterine fluid-derived extracellular vesicles during the endometrial window for embryo implantation","volume":"36","author":"Giacomini","year":"2021","journal-title":"Hum Reprod"},{"issue":"23","key":"10.1016\/j.repbio.2022.100645_bib80","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800423","article-title":"Human endometrial extracellular vesicles functionally prepare human trophectoderm model for implantation: understanding bidirectional maternal-embryo communication","volume":"19","author":"Evans","year":"2019","journal-title":"Proteomics"},{"issue":"4","key":"10.1016\/j.repbio.2022.100645_bib81","doi-asserted-by":"crossref","DOI":"10.1007\/s10815-021-02093-5","article-title":"Endometrial extracellular vesicles of recurrent implantation failure patients inhibit the proliferation, migration, and invasion of HTR8\/SVneo cells","volume":"38","author":"Liu","year":"2021","journal-title":"J Assist Reprod Genet"},{"issue":"2","key":"10.1016\/j.repbio.2022.100645_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2020.04.005","article-title":"Endometrial extracellular vesicles from women with recurrent implantation failure attenuate the growth and invasion of embryos","volume":"114","author":"Liu","year":"2020","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1016\/j.repbio.2022.100645_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10098-3","article-title":"Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers","volume":"7","author":"Altm\u00e4e","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.repbio.2022.100645_bib84","article-title":"Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling","volume":"217","author":"Verweij","year":"2018","journal-title":"J Cell Biol"},{"key":"10.1016\/j.repbio.2022.100645_bib85","doi-asserted-by":"crossref","DOI":"10.1210\/jcem\/dgz019","article-title":"Uterine fluid proteins for minimally invasive assessment of endometrial receptivity","author":"Kasvandik","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.repbio.2022.100645_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-021-01882-z","article-title":"Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles","volume":"4","author":"Rai","year":"2021","journal-title":"Commun Biol"},{"issue":"5","key":"10.1016\/j.repbio.2022.100645_bib87","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.fertnstert.2020.10.046","article-title":"Cargo small non-coding RNAs of extracellular vesicles isolated from uterine fluid associate with endometrial receptivity and implantation success","volume":"115","author":"Li","year":"2021","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.repbio.2022.100645_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2021.07.283","article-title":"A randomized controlled trial comparing live birth from singlei euploid frozen blastocyst transfer using standardized timing versus timing by endometrial receptivity analysis","volume":"116","author":"Doyle","year":"2021","journal-title":"Fertil Steril"},{"issue":"12","key":"10.1016\/j.repbio.2022.100645_bib89","doi-asserted-by":"crossref","DOI":"10.1007\/s10815-020-01948-7","article-title":"Evaluation of the endometrial receptivity assay and the preimplantation genetic test for aneuploidy in overcoming recurrent implantation failure","volume":"37","author":"Cozzolino","year":"2020","journal-title":"J Assist Reprod Genet"},{"issue":"18","key":"10.1016\/j.repbio.2022.100645_bib90","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.128846","article-title":"Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature","volume":"4","author":"Khalaj","year":"2019","journal-title":"JCI Insight"},{"issue":"19","key":"10.1016\/j.repbio.2022.100645_bib91","doi-asserted-by":"crossref","DOI":"10.2217\/nnm.15.118","article-title":"Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin","volume":"10","author":"Toffoli","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.repbio.2022.100645_bib92","first-page":"220","article-title":"Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells","author":"Saari","year":"2015","journal-title":"J Control Release"},{"issue":"2","key":"10.1016\/j.repbio.2022.100645_bib93","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201506084","article-title":"Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER","volume":"213","author":"Heusermann","year":"2016","journal-title":"J Cell Biol"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X22000444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X22000444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:23:06Z","timestamp":1761646986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X22000444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":93,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1642431X22000444"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2022.100645","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of extracellular vesicles in endometrial receptivity and their potential in reproductive therapeutics and diagnosis","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2022.100645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V. on behalf of Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn.","name":"copyright","label":"Copyright"}],"article-number":"100645"}}