{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:27:14Z","timestamp":1761647234468,"version":"build-2065373602"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["3224003212"],"award-info":[{"award-number":["3224003212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.repbio.2022.100652","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T12:33:24Z","timestamp":1654518804000},"page":"100652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Activation of thermogenesis pathways in testis of diet-induced obesity mice"],"prefix":"10.1016","volume":"22","author":[{"given":"Hucheng","family":"Qing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huheng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhikang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Nong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2022.100652_bib1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1542\/peds.2012-3769","article-title":"Annual summary of vital statistics: 2010-2011","volume":"131","author":"Hamilton","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.repbio.2022.100652_bib2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.amepre.2015.05.005","article-title":"Prevalence and secular trends in obesity among Chinese adults, 1991-2011","volume":"49","author":"Mi","year":"2015","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.repbio.2022.100652_bib3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41366-020-00698-x","article-title":"Trends in the prevalence of overweight, obesity, and abdominal obesity among Chinese adults between 1993 and 2015","volume":"45","author":"Ma","year":"2021","journal-title":"Int J Obes"},{"key":"10.1016\/j.repbio.2022.100652_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.puhe.2012.12.027","article-title":"Association of obesity with socio-economic factors and obesity-related chronic diseases in rural southwest China","volume":"127","author":"Cai","year":"2013","journal-title":"Public Health"},{"key":"10.1016\/j.repbio.2022.100652_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.2047-6310.2012.00115.x","article-title":"Associations of uric acid and gamma-glutamyltransferase (GGT) with obesity and components of metabolic syndrome in children and adolescents","volume":"8","author":"Kong","year":"2013","journal-title":"Pediatr Obes"},{"issue":"98-B","key":"10.1016\/j.repbio.2022.100652_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1302\/0301-620X.98B1.36415","article-title":"The obese patient: a problem of larger consequence","author":"Perry","year":"2016","journal-title":"Bone Joint J"},{"key":"10.1016\/j.repbio.2022.100652_bib7","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1037\/0022-006X.70.3.510","article-title":"Obesity: responding to the global epidemic","volume":"70","author":"Wadden","year":"2002","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.repbio.2022.100652_bib8","first-page":"9","article-title":"Diet and nutritional factors in male (in)fertility-underestimated factors","author":"Skoracka","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.repbio.2022.100652_bib9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1477-7827-11-66","article-title":"Lifestyle factors and reproductive health: taking control of your fertility","volume":"11","author":"Sharma","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.repbio.2022.100652_bib10","doi-asserted-by":"crossref","first-page":"R123","DOI":"10.1530\/REP-17-0161","article-title":"Obesity, a serious etiologic factor for male subfertility in modern society","volume":"154","author":"Liu","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2022.100652_bib11","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/obr.12226","article-title":"High-energy diets: a threat for male fertility?","volume":"15","author":"Rato","year":"2014","journal-title":"Obes Rev"},{"key":"10.1016\/j.repbio.2022.100652_bib12","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1530\/REP-17-0018","article-title":"Obesity, energy balance and spermatogenesis","volume":"153","author":"Oliveira","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2022.100652_bib13","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.fertnstert.2017.02.115","article-title":"Obesity, male infertility, and the sperm epigenome","volume":"107","author":"Craig","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2022.100652_bib14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4161\/spmg.21362","article-title":"Impact of obesity on male fertility, sperm function and molecular composition","volume":"2","author":"Palmer","year":"2012","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.repbio.2022.100652_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/and.13666","article-title":"Causes and consequences of sperm mitochondrial dysfunction","volume":"53","author":"Durairajanayagam","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.repbio.2022.100652_bib16","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/s41591-018-0102-y","article-title":"Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring","volume":"24","author":"Sun","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.repbio.2022.100652_bib17","doi-asserted-by":"crossref","first-page":"e1568","DOI":"10.1210\/clinem\/dgab845","article-title":"Lower circulating sertoli and leydig cell hormone levels during puberty in obese boys: a cross-sectional study","volume":"107","author":"Rerat","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.repbio.2022.100652_bib18","doi-asserted-by":"crossref","DOI":"10.1590\/1984-3143-ar2019-0116","article-title":"A Brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters Sertoli cell secretion and mitochondrial activity","volume":"17","author":"de Oliveira","year":"2020","journal-title":"Anim Reprod"},{"key":"10.1016\/j.repbio.2022.100652_bib19","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.1002\/jcp.30230","article-title":"Obesity-related genes are expressed in human Sertoli cells and modulated by energy homeostasis regulating hormones","volume":"236","author":"Pereira","year":"2021","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.repbio.2022.100652_bib20","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.repbio.2022.100652_bib21","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.repbio.2022.100652_bib22","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat Protoc"},{"key":"10.1016\/j.repbio.2022.100652_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157022","article-title":"SARTools: a DESeq2- and edgeR-based R pipeline for comprehensive differential analysis of RNA-seq data","volume":"11","author":"Varet","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.repbio.2022.100652_bib24","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1089\/cmb.2005.12.1047","article-title":"Comprehensive algorithm for quantitative real-time polymerase chain reaction","volume":"12","author":"Zhao","year":"2005","journal-title":"J Comput Biol"},{"key":"10.1016\/j.repbio.2022.100652_bib25","doi-asserted-by":"crossref","first-page":"E768","DOI":"10.1152\/ajpendo.00401.2011","article-title":"Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function","volume":"302","author":"Palmer","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.repbio.2022.100652_bib26","doi-asserted-by":"crossref","first-page":"E1061","DOI":"10.1152\/ajpendo.00235.2020","article-title":"Diet during early life defines testicular lipid content and sperm quality in adulthood","volume":"319","author":"Crisostomo","year":"2020","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.repbio.2022.100652_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1530\/REP-19-0259","article-title":"A switch from high-fat to normal diet does not restore sperm quality but prevents metabolic syndrome","volume":"158","author":"Crisostomo","year":"2019","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2022.100652_bib28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrendo.2016.87","article-title":"The role of diet and exercise in the transgenerational epigenetic landscape of T2DM","volume":"12","author":"Barres","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.repbio.2022.100652_bib29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.repbio.2022.100652_bib30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.orcp.2016.06.001","article-title":"Brown adipose tissue transplantation ameliorates male fertility impairment caused by diet-induced obesity","volume":"11","author":"Liu","year":"2017","journal-title":"Obes Res Clin Pract"},{"key":"10.1016\/j.repbio.2022.100652_bib31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/obr.12520","article-title":"Factors involved in white-to-brown adipose tissue conversion and in thermogenesis: a review","volume":"18","author":"Montanari","year":"2017","journal-title":"Obes Rev"},{"key":"10.1016\/j.repbio.2022.100652_bib32","first-page":"11","article-title":"Brown adipose tissue, diet-induced thermogenesis, and thermogenic food ingredients: from mice to men","author":"Saito","year":"2020","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.repbio.2022.100652_bib33","first-page":"7","article-title":"Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice","author":"Alcala","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2022.100652_bib34","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.beem.2012.06.002","article-title":"Mitochondria and endocrine function of adipose tissue","volume":"26","author":"Medina-Gomez","year":"2012","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.repbio.2022.100652_bib35","doi-asserted-by":"crossref","first-page":"R163","DOI":"10.1530\/REP-13-0178","article-title":"Mitochondria functionality and sperm quality","volume":"146","author":"Amaral","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2022.100652_bib36","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1093\/emboj\/17.23.6979","article-title":"Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha)","volume":"17","author":"Reyes","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.repbio.2022.100652_bib37","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1074\/jbc.M111.288167","article-title":"Insights into role of bromodomain, testis-specific (Brdt) in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis","volume":"287","author":"Dhar","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.repbio.2022.100652_bib38","first-page":"146","article-title":"Mammalian SWI\/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse","author":"Menon","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.repbio.2022.100652_bib39","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1095\/biolreprod.111.097097","article-title":"Essential roles of the chromatin remodeling factor BRG1 in spermatogenesis in mice","volume":"86","author":"Wang","year":"2012","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2022.100652_bib40","first-page":"21","article-title":"BRG1 is dispensable for sertoli cell development and functions in mice","author":"Wang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2022.100652_bib41","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1242\/dev.02019","article-title":"Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation","volume":"132","author":"Indra","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.repbio.2022.100652_bib42","doi-asserted-by":"crossref","first-page":"24074","DOI":"10.1038\/s41598-021-03538-8","article-title":"SWI\/SNF chromatin remodeling complex is required for initiation of sex-dependent differentiation in mouse germline","volume":"11","author":"Ito","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2022.100652_bib43","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/rda.12511","article-title":"Differences between high- and low-motility buffalo sperm identified by comparative proteomics","volume":"50","author":"Huang","year":"2015","journal-title":"Reprod Domest Anim"},{"issue":"1609\u201317","key":"10.1016\/j.repbio.2022.100652_bib44","first-page":"e1","article-title":"Acute epididymitis induces alterations in sperm protein composition","volume":"101","author":"Pilatz","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2022.100652_bib45","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.eururo.2012.04.048","article-title":"European association of urology guidelines on male infertility: the 2012 update","volume":"62","author":"Jungwirth","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.repbio.2022.100652_bib46","doi-asserted-by":"crossref","first-page":"E762","DOI":"10.1016\/j.ejrad.2013.08.050","article-title":"Acute epididymitis in ultrasound: results of a prospective study with baseline and follow-up investigations in 134 patients","volume":"82","author":"Pilatz","year":"2013","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.repbio.2022.100652_bib47","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/rda.13426","article-title":"Comparative proteomic analysis of high- and low-fertile buffalo bull spermatozoa for identification of fertility-associated proteins","volume":"54","author":"M","year":"2019","journal-title":"Reprod Domest Anim"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X22000511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X22000511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:22:16Z","timestamp":1761646936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X22000511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S1642431X22000511"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2022.100652","relation":{},"ISSN":["1642-431X"],"issn-type":[{"type":"print","value":"1642-431X"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of thermogenesis pathways in testis of diet-induced obesity mice","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2022.100652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100652"}}