{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:12:14Z","timestamp":1790611934742,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100017607","name":"Shenzhen Basic Research Program","doi-asserted-by":"publisher","award":["JCYJ20180305164706355"],"award-info":[{"award-number":["JCYJ20180305164706355"]}],"id":[{"id":"10.13039\/501100017607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830041"],"award-info":[{"award-number":["81830041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771617"],"award-info":[{"award-number":["81771617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M622806"],"award-info":[{"award-number":["2017M622806"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2021JJ30546"],"award-info":[{"award-number":["2021JJ30546"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2021JJ30547"],"award-info":[{"award-number":["2021JJ30547"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004103"],"award-info":[{"award-number":["2018YFC1004103"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.repbio.2023.100731","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T13:21:30Z","timestamp":1673356890000},"page":"100731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Trophoblast-specific knockdown of CSPG4 expression causes pregnancy complications with poor placentation in mice"],"prefix":"10.1016","volume":"23","author":[{"given":"Junfei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juzuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2023.100731_bib1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","article-title":"Pre-eclampsia","volume":"387","author":"Mol","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.repbio.2023.100731_bib2","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1172\/JCI76864","article-title":"Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications","volume":"124","author":"Fan","year":"2014","journal-title":"J Clin Investig"},{"key":"10.1016\/j.repbio.2023.100731_bib3","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0140-6736(06)69204-0","article-title":"Recurrent miscarriage","volume":"368","author":"Rai","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.repbio.2023.100731_bib4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00005-017-0474-6","article-title":"KIR, LILRB and their Ligands' Genes as Potential Biomarkers in Recurrent Implantation Failure","volume":"65","author":"Nowak","year":"2017","journal-title":"Arch Immunol Et Ther Exp"},{"key":"10.1016\/j.repbio.2023.100731_bib5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/molehr\/gax043","article-title":"Apposition to endometrial epithelial cells activates mouse blastocysts for implantation","volume":"23","author":"Ruane","year":"2017","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.repbio.2023.100731_bib6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrneph.2014.102","article-title":"Pre-eclampsia part 1: current understanding of its pathophysiology","volume":"10","author":"Chaiworapongsa","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.repbio.2023.100731_bib7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/HYPERTENSIONAHA.111.00157","article-title":"Angiotensin receptor agonistic autoantibody-mediated soluble fms-like tyrosine kinase-1 induction contributes to impaired adrenal vasculature and decreased aldosterone production in preeclampsia","volume":"61","author":"Siddiqui","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.repbio.2023.100731_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/aji.12450","article-title":"The microenvironment of human implantation: determinant of reproductive success","volume":"75","author":"Salamonsen","year":"2016","journal-title":"Am J Reprod Immunol"},{"issue":"10","key":"10.1016\/j.repbio.2023.100731_bib9","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.placenta.2013.07.065","article-title":"The chrondroitin sulfate proteoglycan (CSPG4) regulates human trophoblast function","volume":"34","author":"Van Sinderen","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.repbio.2023.100731_bib10","first-page":"245","article-title":"The NG2 chondroitin sulfate proteoglycan: a multifunctional proteoglycan associated with immature cells","volume":"3","author":"Levine","year":"1996","journal-title":"Perspect Dev Neurobiol"},{"key":"10.1016\/j.repbio.2023.100731_bib11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1023\/A:1025731428581","article-title":"The NG2 proteoglycan: past insights and future prospects","volume":"31","author":"Stallcup","year":"2002","journal-title":"J Neurocytol"},{"key":"10.1016\/j.repbio.2023.100731_bib12","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.repbio.2023.100731_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER Suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.repbio.2023.100731_bib14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1186\/s12859-018-2448-z","article-title":"Learning protein binding affinity using privileged information","volume":"19","author":"Abbasi","year":"2018","journal-title":"BMC Bioinforma"},{"key":"10.1016\/j.repbio.2023.100731_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1477-7827-12-7","article-title":"The term basal plate of the human placenta as a source of functional extravillous trophoblast cells","volume":"12","author":"Borbely","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.repbio.2023.100731_bib16","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1172\/JCI60561","article-title":"Macrophages regulate corpus luteum development during embryo implantation in mice","volume":"123","author":"Care","year":"2013","journal-title":"J Clin Investig"},{"key":"10.1016\/j.repbio.2023.100731_bib17","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.7150\/thno.22904","article-title":"Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.repbio.2023.100731_bib18","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/jcb.25808","article-title":"MiR-892a promotes hepatocellular carcinoma cells proliferation and invasion through targeting CD226","volume":"118","author":"Jia","year":"2017","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.repbio.2023.100731_bib19","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.3892\/mmr.2017.6903","article-title":"Peroxisome proliferatoractivated receptor gamma mediates porcine placental angiogenesis through hypoxia inducible factor, vascular endothelial growth factor and angiopoietinmediated signaling","volume":"16","author":"Zhang","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.repbio.2023.100731_bib20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-61779-207-6_2","article-title":"Scratch-wound assay","volume":"769","author":"Cory","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.repbio.2023.100731_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-61779-207-6_8","article-title":"Transwell((R)) invasion assays","volume":"769","author":"Marshall","year":"2011","journal-title":"Methods Mol Biol"},{"issue":"4","key":"10.1016\/j.repbio.2023.100731_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s13353-013-0173-x","article-title":"Reference genes in real-time PCR","volume":"54","author":"Kozera","year":"2013","journal-title":"J Appl Genet"},{"key":"10.1016\/j.repbio.2023.100731_bib23","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1096\/fj.201801670R","article-title":"Structural deciphering of the NG2\/CSPG4 proteoglycan multifunctionality","volume":"33","author":"Tamburini","year":"2019","journal-title":"FASEB J: Publ Fed Am Soc Exp Biol"},{"key":"10.1016\/j.repbio.2023.100731_bib24","doi-asserted-by":"crossref","first-page":"530","DOI":"10.7150\/thno.10824","article-title":"Theranostic impact of NG2\/CSPG4 proteoglycan in cancer","volume":"5","author":"Nicolosi","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.repbio.2023.100731_bib25","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1074\/jbc.M117.805051","article-title":"Effects of chondroitin sulfate proteoglycan 4 (NG2\/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage","volume":"293","author":"Hsu","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.repbio.2023.100731_bib26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/jb\/mvy008","article-title":"Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion","volume":"163","author":"Tang","year":"2018","journal-title":"J Biochem"},{"key":"10.1016\/j.repbio.2023.100731_bib27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/(SICI)1097-4644(19961215)63:4<463::AID-JCB8>3.0.CO;2-R","article-title":"Interaction of the NG2 proteoglycan with the actin cytoskeleton","volume":"63","author":"Lin","year":"1996","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.repbio.2023.100731_bib28","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1172\/JCI200422991","article-title":"Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface","volume":"114","author":"Red-Horse","year":"2004","journal-title":"J Clin Investig"},{"key":"10.1016\/j.repbio.2023.100731_bib29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/aji.12347","article-title":"mRNA destabilizing factors: tristetraprolin expression at the porcine maternal-fetal interface","volume":"73","author":"Khalaj","year":"2015","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.repbio.2023.100731_bib30","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.repbio.2023.100731_bib31","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0959-440X(00)00125-1","article-title":"Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans","volume":"10","author":"Sugahara","year":"2000","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.repbio.2023.100731_bib32","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.sbi.2003.09.011","article-title":"Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate","volume":"13","author":"Sugahara","year":"2003","journal-title":"Curr Opin Struct Biol"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X23000037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X23000037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:39:24Z","timestamp":1778621964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X23000037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1642431X23000037"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2023.100731","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trophoblast-specific knockdown of CSPG4 expression causes pregnancy complications with poor placentation in mice","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2023.100731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100731"}}