{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:06:53Z","timestamp":1791994013635,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.repbio.2023.100816","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T06:42:01Z","timestamp":1698216121000},"page":"100816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Ferroportin expression and regulation in human placenta\/fetal membranes: Implications for ferroptosis and adverse pregnancy outcomes"],"prefix":"10.1016","volume":"23","author":[{"given":"Shu-Wing","family":"Ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chungyan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Kay","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Arcuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errol R.","family":"Norwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2023.100816_bib1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2016.12.034","article-title":"A red carpet for iron metabolism","volume":"168","author":"Muckenthaler","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.repbio.2023.100816_bib2","first-page":"897","article-title":"Iron deficiency--United States, 1999-2000","volume":"51","year":"2002","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.repbio.2023.100816_bib3","doi-asserted-by":"crossref","first-page":"1280S","DOI":"10.1093\/ajcn\/71.5.1280s","article-title":"Anemia and iron deficiency: effects on pregnancy outcome","volume":"71","author":"Allen","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.repbio.2023.100816_bib4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/bmj.310.6978.489","article-title":"Relation between maternal haemoglobin concentration and birth weight in different ethnic groups","volume":"310","author":"Steer","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.repbio.2023.100816_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/ajcn\/34.1.115","article-title":"Hematological status and pregnancy outcomes","volume":"34","author":"Garn","year":"1981","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.repbio.2023.100816_bib6","doi-asserted-by":"crossref","first-page":"1694S","DOI":"10.3945\/ajcn.117.156075","article-title":"U-shaped curve for risk associated with maternal hemoglobin, iron status, or iron supplementation","volume":"106","author":"Dewey","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.repbio.2023.100816_bib7","first-page":"657","article-title":"Plasma ferritin determination as a diagnostic tool","volume":"145","author":"Finch","year":"1986","journal-title":"West J Med"},{"key":"10.1016\/j.repbio.2023.100816_bib8","doi-asserted-by":"crossref","first-page":"1567S","DOI":"10.3945\/ajcn.117.155812","article-title":"Iron homeostasis during pregnancy","volume":"106","author":"Fisher","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.repbio.2023.100816_bib9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/10245332.2016.1220120","article-title":"Comparative analysis of iron status and other hematological parameters in preeclampsia","volume":"22","author":"Gutierrez-Aguirre","year":"2017","journal-title":"Hematology"},{"key":"10.1016\/j.repbio.2023.100816_bib10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1067\/mob.2002.123895","article-title":"Abnormal iron parameters in the pregnancy syndrome preeclampsia","volume":"187","author":"Rayman","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.repbio.2023.100816_bib11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00404-010-1728-2","article-title":"Iron status parameters in preeclamptic women","volume":"284","author":"Siddiqui","year":"2011","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.repbio.2023.100816_bib12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/dom.14886","article-title":"Impact of iron supplementation on gestational diabetes mellitus: a literature review","volume":"25","author":"Liu","year":"2023","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.repbio.2023.100816_bib13","first-page":"20","article-title":"The impact of iron overload and ferroptosis on reproductive disorders in humans: implications for preeclampsia","author":"Ng","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2023.100816_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.repbio.2023.100816_bib15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.repbio.2023.100816_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.repbio.2023.100816_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: mechanisms and links with diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.repbio.2023.100816_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.repbio.2023.100816_bib19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jri.2013.09.001","article-title":"Preeclampsia and uteroplacental acute atherosis: immune and inflammatory factors","volume":"101\u2013102","author":"Staff","year":"2014","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.repbio.2023.100816_bib20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80425-6","article-title":"A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation","volume":"5","author":"McKie","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.repbio.2023.100816_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/713609210","article-title":"Iron metabolism in the reticuloendothelial system","volume":"38","author":"Knutson","year":"2003","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.repbio.2023.100816_bib22","doi-asserted-by":"crossref","first-page":"15358","DOI":"10.1039\/C4CC07996E","article-title":"Ferritin light-chain subunits: key elements for the electron transfer across the protein cage","volume":"50","author":"Carmona","year":"2014","journal-title":"Chem Commun"},{"key":"10.1016\/j.repbio.2023.100816_bib23","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1128\/IAI.00498-10","article-title":"Role of ferroportin in macrophage-mediated immunity","volume":"78","author":"Johnson","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.repbio.2023.100816_bib24","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.repbio.2023.100816_bib25","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.3390\/nu6083062","article-title":"Hepcidin and iron homeostasis during pregnancy","volume":"6","author":"Koenig","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.repbio.2023.100816_bib26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ajh.25341","article-title":"Iron homeostasis in pregnancy and spontaneous abortion","volume":"94","author":"Guo","year":"2019","journal-title":"Am J Hematol"},{"key":"10.1016\/j.repbio.2023.100816_bib27","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1182\/blood.2020005745","article-title":"Maternal hepcidin determines embryo iron homeostasis in mice","volume":"136","author":"Sangkhae","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.repbio.2023.100816_bib28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1101\/gr.207597.116","article-title":"Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface","volume":"27","author":"Pavlicev","year":"2017","journal-title":"Genome Res"},{"key":"10.1016\/j.repbio.2023.100816_bib29","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1210\/en.2003-1606","article-title":"A novel immortalized human endometrial stromal cell line with normal progestational response","volume":"145","author":"Krikun","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.repbio.2023.100816_bib30","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.placenta.2009.08.007","article-title":"The isolation and characterization of a novel telomerase immortalized first trimester trophoblast cell line, Swan 71","volume":"30","author":"Straszewski-Chavez","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.repbio.2023.100816_bib31","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1210\/endo.133.5.8404671","article-title":"Cyclic adenosine 3\u2032,5\u2032-monophosphate induces prolactin expression in stromal cells isolated from human proliferative endometrium","volume":"133","author":"Tang","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.repbio.2023.100816_bib32","series-title":"Physiology","author":"Williams","year":"2010"},{"key":"10.1016\/j.repbio.2023.100816_bib33","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.ajog.2005.06.055","article-title":"Discriminatory proteomic biomarker analysis identifies free hemoglobin in the cerebrospinal fluid of women with severe preeclampsia","volume":"193","author":"Norwitz","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.repbio.2023.100816_bib34","first-page":"11","article-title":"Elevated levels of protein AMBP in cerebrospinal fluid of women with preeclampsia compared to normotensive pregnant women","author":"van den Berg","year":"2017","journal-title":"Proteom Clin Appl"},{"key":"10.1016\/j.repbio.2023.100816_bib35","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1056\/NEJMra000763","article-title":"Implantation and the survival of early pregnancy","volume":"345","author":"Norwitz","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.repbio.2023.100816_bib36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/humupd\/dmp046","article-title":"Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy","volume":"16","author":"Pringle","year":"2010","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.repbio.2023.100816_bib37","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s10815-013-0032-z","article-title":"The effect of two distinct levels of oxygen concentration on embryo development in a sibling oocyte study","volume":"30","author":"Kasterstein","year":"2013","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.repbio.2023.100816_bib38","first-page":"6191","article-title":"Two different concentrations of oxygen for culturing precompaction stage embryos on human embryo development competence: a prospective randomized sibling-oocyte study","volume":"7","author":"Guo","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.repbio.2023.100816_bib39","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.fertnstert.2018.02.119","article-title":"Randomized controlled trial of low (5%) versus ultralow (2%) oxygen for extended culture using bipronucleate and tripronucleate human preimplantation embryos","volume":"109","author":"Kaser","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2023.100816_bib40","doi-asserted-by":"crossref","first-page":"220","DOI":"10.24272\/j.issn.2095-8137.2020.042","article-title":"The pathological role of ferroptosis in ischemia\/reperfusion-related injury","volume":"41","author":"Yan","year":"2020","journal-title":"Zool Res"},{"key":"10.1016\/j.repbio.2023.100816_bib41","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current mechanistic concepts in ischemia and reperfusion injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.repbio.2023.100816_bib42","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s43032-020-00164-z","article-title":"Endometriosis: the role of iron overload and ferroptosis","volume":"27","author":"Ng","year":"2020","journal-title":"Reprod Sci"},{"key":"10.1016\/j.repbio.2023.100816_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101402","article-title":"miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia","volume":"29","author":"Zhang","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.repbio.2023.100816_bib44","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI6380","article-title":"Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies","volume":"103","author":"Caniggia","year":"1999","journal-title":"J Clin Investig"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X23000888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X23000888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:23:48Z","timestamp":1761647028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X23000888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1642431X23000888"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2023.100816","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroportin expression and regulation in human placenta\/fetal membranes: Implications for ferroptosis and adverse pregnancy outcomes","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2023.100816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100816"}}