{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:03:15Z","timestamp":1784829795066,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.repbio.2023.100850","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T14:08:19Z","timestamp":1705932499000},"page":"100850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic \u03b2 cells in gestational diabetes mellitus by upregulating ATG7"],"prefix":"10.1016","volume":"24","author":[{"given":"Qing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.repbio.2023.100850_bib1","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2337\/dc18-S002","article-title":"2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2018","volume":"41","author":"American Diabetes","year":"2018","journal-title":"Diabetes Care"},{"issue":"9","key":"10.1016\/j.repbio.2023.100850_bib2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.5603\/GP.a2018.0088","article-title":"The role of visfatin in pathogenesis of gestational diabetes (GDM)","volume":"89","author":"Radzicka","year":"2018","journal-title":"Ginekol Pol"},{"issue":"11","key":"10.1016\/j.repbio.2023.100850_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113342","article-title":"The pathophysiology of gestational diabetes mellitus","volume":"19","author":"Plows","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.repbio.2023.100850_bib4","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/jamapediatrics.2015.74","article-title":"Association of adverse pregnancy outcomes with glyburide vs insulin in women with gestational diabetes","volume":"169","author":"Camelo Castillo","year":"2015","journal-title":"JAMA Pedia"},{"issue":"10","key":"10.1016\/j.repbio.2023.100850_bib5","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.2337\/dc11-1153","article-title":"Metformin therapy during pregnancy: good for the goose and good for the gosling too?","volume":"34","author":"Feig","year":"2011","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.repbio.2023.100850_bib6","doi-asserted-by":"crossref","first-page":"807","DOI":"10.33549\/physiolres.934093","article-title":"Insulin-like growth factor axis in pregnancy and gestational diabetes mellitus","volume":"68","author":"Anderlova","year":"2019","journal-title":"Physiol Res"},{"key":"10.1016\/j.repbio.2023.100850_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.111035","article-title":"Disorders of IGFs and IGF-1R signaling pathways","volume":"518","author":"Forbes","year":"2020","journal-title":"Mol Cell Endocrinol"},{"issue":"7845","key":"10.1016\/j.repbio.2023.100850_bib8","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41586-021-03225-8","article-title":"Inceptor counteracts insulin signalling in beta-cells to control glycaemia","volume":"590","author":"Ansarullah","year":"2021","journal-title":"Nature"},{"issue":"Suppl 3","key":"10.1016\/j.repbio.2023.100850_bib9","first-page":"131","article-title":"Serum insulin-like growth factor-I levels and potential risk of type 2 diabetes","volume":"60","author":"Dunger","year":"2003","journal-title":"Horm Res"},{"issue":"5","key":"10.1016\/j.repbio.2023.100850_bib10","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1210\/jc.2011-3296","article-title":"Maternal and fetal IGF-I and IGF-II levels, fetal growth, and gestational diabetes","volume":"97","author":"Luo","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"Pt B","key":"10.1016\/j.repbio.2023.100850_bib11","article-title":"Akebia saponin D from dipsacus asper wall. Ex C.B. Clarke ameliorates skeletal muscle insulin resistance through activation of IGF1R\/AMPK signaling pathway","volume":"318","author":"Shu","year":"2024","journal-title":"J Ethnopharmacol"},{"issue":"11","key":"10.1016\/j.repbio.2023.100850_bib12","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.2337\/db21-0909","article-title":"Plasma exosomal miRNAs associated with metabolism as early predictor of gestational diabetes mellitus","volume":"71","author":"Ye","year":"2022","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.repbio.2023.100850_bib13","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114824","article-title":"Emerging roles of ATG7 in human health and disease","volume":"13","author":"Collier","year":"2021","journal-title":"EMBO Mol Med"},{"issue":"7","key":"10.1016\/j.repbio.2023.100850_bib14","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1080\/15548627.2019.1659617","article-title":"m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7","volume":"16","author":"Wang","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.repbio.2023.100850_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105324","article-title":"ATG7-dependent and independent autophagy determine the type of treatment in lung cancer","volume":"163","author":"Zhang","year":"2021","journal-title":"Pharm Res"},{"issue":"25","key":"10.1016\/j.repbio.2023.100850_bib16","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1056\/NEJMoa1915722","article-title":"Developmental consequences of defective ATG7-mediated autophagy in humans","volume":"384","author":"Collier","year":"2021","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.repbio.2023.100850_bib17","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1080\/15548627.2021.1953267","article-title":"ATG7 safeguards human neural integrity","volume":"17","author":"Collier","year":"2021","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.repbio.2023.100850_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3858\/emm.2012.44.2.030","article-title":"Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic beta-cells","volume":"44","author":"Quan","year":"2012","journal-title":"Exp Mol Med"},{"issue":"23","key":"10.1016\/j.repbio.2023.100850_bib19","doi-asserted-by":"crossref","first-page":"13899","DOI":"10.1111\/jcmm.15984","article-title":"Epigenetic alternations of microRNAs and DNA methylation contribute to gestational diabetes mellitus","volume":"24","author":"Zhu","year":"2020","journal-title":"J Cell Mol Med"},{"issue":"10","key":"10.1016\/j.repbio.2023.100850_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046422","article-title":"The nuclear receptor NR4A1 induces a form of cell death dependent on autophagy in mammalian cells","volume":"7","author":"Bouzas-Rodriguez","year":"2012","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"10.1016\/j.repbio.2023.100850_bib21","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.2337\/dc22-S002","article-title":"2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2022","volume":"45","author":"American Diabetes Association Professional Practice C","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.repbio.2023.100850_bib22","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.2147\/DMSO.S377041","article-title":"Lower ATG7 levels are associated with a higher risk of gestational diabetes mellitus: a cross-sectional study","volume":"15","author":"Lu","year":"2022","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"12","key":"10.1016\/j.repbio.2023.100850_bib23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1301\/nr.2003.dec.397-412","article-title":"Evaluation of insulin sensitivity in clinical practice and in research settings","volume":"61","author":"Monzillo","year":"2003","journal-title":"Nutr Rev"},{"issue":"10","key":"10.1016\/j.repbio.2023.100850_bib24","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1080\/15384101.2018.1469873","article-title":"IGF1\/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cells","volume":"17","author":"Li","year":"2018","journal-title":"Cell Cycle"},{"issue":"3","key":"10.1016\/j.repbio.2023.100850_bib25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1172\/JCI200524531","article-title":"Gestational diabetes mellitus","volume":"115","author":"Buchanan","year":"2005","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.repbio.2023.100850_bib26","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.tem.2018.09.004","article-title":"Gestational diabetes mellitus: mechanisms, treatment, and complications","volume":"29","author":"Johns","year":"2018","journal-title":"Trends Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.repbio.2023.100850_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cmet.2008.08.009","article-title":"Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet","volume":"8","author":"Ebato","year":"2008","journal-title":"Cell Metab"},{"issue":"11","key":"10.1016\/j.repbio.2023.100850_bib28","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.2337\/db16-0514","article-title":"Insulin-like growth factor axis and gestational diabetes mellitus: a longitudinal study in a multiracial cohort","volume":"65","author":"Zhu","year":"2016","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.repbio.2023.100850_bib29","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.29271\/jcpsp.2021.09.1015","article-title":"Diagnostic accuracy of markers of insulin resistance (HOMA-IR) and insulin sensitivity (QUICKI) in gestational diabetes","volume":"31","author":"Paracha","year":"2021","journal-title":"J Coll Physicians Surg Pak"},{"issue":"4","key":"10.1016\/j.repbio.2023.100850_bib30","first-page":"3324","article-title":"Expression of miR-409-5p in gestational diabetes mellitus and its relationship with insulin resistance","volume":"20","author":"Tu","year":"2020","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.repbio.2023.100850_bib31","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.12659\/MSM.903565","article-title":"Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) single nucleotide polymorphisms (SNPs), inflammation and metabolism in gestational diabetes mellitus in inner mongolia","volume":"23","author":"Zhang","year":"2017","journal-title":"Med Sci Monit"},{"issue":"11","key":"10.1016\/j.repbio.2023.100850_bib32","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1007\/s00432-023-04755-6","article-title":"Association between metabolic syndrome, insulin resistance, and IGF-1 in breast cancer survivors of DIANA-5 study","volume":"149","author":"De Santi","year":"2023","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.repbio.2023.100850_bib33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/978-1-4614-5441-0_4","article-title":"Gestational diabetes mellitus","volume":"771","author":"Imam","year":"2012","journal-title":"Adv Exp Med Biol"},{"issue":"8","key":"10.1016\/j.repbio.2023.100850_bib34","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1210\/en.2016-1922","article-title":"Systematic characterization of autophagy in gestational diabetes mellitus","volume":"158","author":"Ji","year":"2017","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.repbio.2023.100850_bib35","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1172\/JCI0215276","article-title":"Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor","volume":"110","author":"Xuan","year":"2002","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.repbio.2023.100850_bib36","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1021\/acs.jafc.6b00239","article-title":"Phenolic compounds from fermented berry beverages modulated gene and protein expression to increase insulin secretion from pancreatic beta-cells in vitro","volume":"64","author":"Johnson","year":"2016","journal-title":"J Agric Food Chem"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X23001225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X23001225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:25:45Z","timestamp":1761647145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X23001225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1642431X23001225"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2023.100850","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic \u03b2 cells in gestational diabetes mellitus by upregulating ATG7","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2023.100850","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100850"}}