{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T07:14:36Z","timestamp":1786864476416,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.repbio.2024.100877","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T06:31:40Z","timestamp":1710138700000},"page":"100877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Disruption of gonocyte development following neonatal exposure to di (2-ethylhexyl) phthalate"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2566-4538","authenticated-orcid":false,"given":"Estefan\u00eda","family":"Reyes-Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7988-2231","authenticated-orcid":false,"given":"Julio C\u00e9sar","family":"Rojas-Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9226-7412","authenticated-orcid":false,"given":"Daniel Adrian","family":"Landero-Huerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Hern\u00e1ndez-Jard\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-1151","authenticated-orcid":false,"given":"Rafael","family":"Reynoso-Robles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda de Lourdes","family":"Ju\u00e1rez-Mosqueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-6890","authenticated-orcid":false,"given":"Alfredo","family":"Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-1994","authenticated-orcid":false,"given":"Rosa Mar\u00eda","family":"Vigueras-Villase\u00f1or","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2024.100877_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11154-019-09521-z","article-title":"Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention","volume":"21","author":"Yilmaz","year":"2020","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.repbio.2024.100877_bib2","first-page":"741","article-title":"Male reproductive health and environmental xenoestrogens","volume":"74","author":"Toppari","year":"1996","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.repbio.2024.100877_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.metabol.2018.03.022","article-title":"Endocrine disruptors and testicular function","volume":"86","author":"Lymperi","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.repbio.2024.100877_bib4","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI34241","article-title":"Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism","volume":"118","author":"Welsh","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.repbio.2024.100877_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.706532","article-title":"Endocrine disrupting chemicals and reproductive health in boys and men","volume":"12","author":"Rodprasert","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.repbio.2024.100877_bib6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ecoenv.2011.12.008","article-title":"Effects of di-(2-ethylhexyl) phthalate and four of its metabolites on steroidogenesis in MA-10 cells","volume":"79","author":"Pich\u00e9","year":"2012","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.repbio.2024.100877_bib7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2605.2005.00567.x","article-title":"Human exposure to phthalates via consumer products","volume":"29","author":"Schettler","year":"2006","journal-title":"Int J Androl"},{"key":"10.1016\/j.repbio.2024.100877_bib8","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1289\/ehp.00108979","article-title":"Levels of seven urinary phthalate metabolites in a human reference population","volume":"108","author":"Blount","year":"2000","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.repbio.2024.100877_bib9","doi-asserted-by":"crossref","first-page":"A440","DOI":"10.1289\/ehp.108-a440b","article-title":"Human exposure estimates for phthalates","volume":"108","author":"Kohn","year":"2000","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.repbio.2024.100877_bib10","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-020-12210-z","article-title":"Di-(2-ethylhexyl) phthalate induces testicular endoplasmic reticulum stress and germ cell apoptosis in adolescent mice","volume":"28","author":"Zhu","year":"2021","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.repbio.2024.100877_bib11","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.scitotenv.2016.04.145","article-title":"Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic-pituitary-testis axis and ERK-mediated 5\u03b1-Reductase 2","volume":"563\u2013564","author":"Ha","year":"2016","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.repbio.2024.100877_bib12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.envpol.2018.08.089","article-title":"Role of autophagy in di-2-ethylhexyl phthalate (DEHP)-induced apoptosis in mouse Leydig cells","volume":"243","author":"Sun","year":"2018","journal-title":"Environ Pollut"},{"key":"10.1016\/j.repbio.2024.100877_bib13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/taap.2000.8972","article-title":"A single dose of Di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces sertoli cell proliferation, and decreases cyclin D2 expression","volume":"166","author":"Li","year":"2000","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.repbio.2024.100877_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116262","article-title":"In utero di-(2-ethylhexyl) phthalate-induced testicular dysgenesis syndrome in male newborn rats is rescued by taxifolin through reducing oxidative stress","volume":"456","author":"Li","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.repbio.2024.100877_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-03979-0","article-title":"In utero and lactational exposure study in rats to identify replacements for di(2-ethylhexyl) phthalate","volume":"7","author":"Nardelli","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2024.100877_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1530\/ror.0.0050093","article-title":"Molecular mechanisms involved in the differentiation of spermatogenic stem cells","volume":"5","author":"Sutton","year":"2000","journal-title":"Rev Reprod"},{"key":"10.1016\/j.repbio.2024.100877_bib17","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/nature04697","article-title":"Pluripotency of spermatogonial stem cells from adult mouse testis","volume":"440","author":"Guan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.repbio.2024.100877_bib18","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/modpathol.2013.246","article-title":"Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential","volume":"27","author":"Mitchell","year":"2014","journal-title":"Mod Pathol"},{"key":"10.1016\/j.repbio.2024.100877_bib19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1196\/annals.1411.013","article-title":"From gonocytes to testicular cancer: the role of impaired gonadal development","author":"Rajpert-De Meyts","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.repbio.2024.100877_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1530\/REP-10-0431","article-title":"Spermatogonial morphology and kinetics during testis development in mice: a high-resolution light microscopy approach","volume":"142","author":"Drumond","year":"2011","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2024.100877_bib21","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1530\/REP-14-0431","article-title":"Mammalian gonocyte and spermatogonia differentiation: recent advances and remaining challenges","volume":"149","author":"Manku","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2024.100877_bib22","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/s12864-015-1706-y","article-title":"Systematically dissecting the global mechanism of miRNA functions in mouse pluripotent stem cells","volume":"16","author":"Wang","year":"2015","journal-title":"BMC Genom"},{"key":"10.1016\/j.repbio.2024.100877_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.diff.2022.04.002","article-title":"Mouse-human species differences in early testicular development and its implications","volume":"129","author":"Cunha","year":"2023","journal-title":"Differentiation"},{"key":"10.1016\/j.repbio.2024.100877_bib24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/humrep\/dei325","article-title":"Spatial expression of germ cell markers during maturation of human fetal male gonads: an immunohistochemical study","volume":"21","author":"Pauls","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2024.100877_bib25","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/bdr2.1133","article-title":"Comparative aspects of pre- and postnatal development of the male reproductive system","volume":"110","author":"Picut","year":"2018","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.repbio.2024.100877_bib26","first-page":"2","article-title":"Testicular biopsy score count \u2013 a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Hormones"},{"key":"10.1016\/j.repbio.2024.100877_bib27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.acthis.2008.05.004","article-title":"Effect of allopurinol on damage caused by free radicals to cryptorchid testes","volume":"111","author":"Vigueras-Villase\u00f1or","year":"2009","journal-title":"Acta Histochem"},{"key":"10.1016\/j.repbio.2024.100877_bib28","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.115.129098","article-title":"In utero exposure to di-(2-ethylhexyl) phthalate induces testicular effects in neonatal rats that are antagonized by genistein cotreatment","volume":"93","author":"Jones","year":"2015","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2024.100877_bib29","first-page":"1044","article-title":"Effect of in utero exposure to di(2-ethylhexyl)phthalate on rat testes","volume":"29","author":"Tandon","year":"1991","journal-title":"Indian J Exp Biol"},{"key":"10.1016\/j.repbio.2024.100877_bib30","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.reprotox.2009.06.013","article-title":"Effects of in utero exposure to di-n-hexyl phthalate on the reproductive development of the male rat","volume":"28","author":"Saillenfait","year":"2009","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.repbio.2024.100877_bib31","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.fct.2006.07.007","article-title":"Effect of in utero exposure to di-(2-ethylhexyl) phthalate: distribution in the rat fetus and testosterone production by rat fetal testis in culture","volume":"44","author":"Stroheker","year":"2006","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.repbio.2024.100877_bib32","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1095\/biolreprod.107.065649","article-title":"In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production in the rat","volume":"78","author":"Culty","year":"2008","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2024.100877_bib33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/toxsci\/kfw063","article-title":"Di(2-ethylhexyl) phthalate exposure in utero damages sertoli cell differentiation via disturbance of sex determination pathway in fetal and postnatal mice","volume":"152","author":"Wang","year":"2016","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.repbio.2024.100877_bib34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.reprotox.2020.06.014","article-title":"Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice","volume":"96","author":"Dostalova","year":"2020","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.repbio.2024.100877_bib35","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1289\/ehp.11870","article-title":"Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat fetal testis in vitro","volume":"117","author":"Chauvign\u00e9","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.repbio.2024.100877_bib36","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.reprotox.2021.12.008","article-title":"Prenatal exposure to the phthalate DEHP impacts reproduction-related gene expression in the pituitary","volume":"108","author":"Ge","year":"2022","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.repbio.2024.100877_bib37","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1071\/RD17100","article-title":"Mouse minipuberty coincides with gonocyte transformation into spermatogonial stem cells: a model for human minipuberty","volume":"29","author":"Li","year":"2017","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.repbio.2024.100877_bib38","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0022-5347(17)35562-3","article-title":"Germ cell development in neonatal mouse testes in vitro requires m\u00fcllerian inhibiting substance","volume":"150","author":"Zhou","year":"1993","journal-title":"J Urol"},{"key":"10.1016\/j.repbio.2024.100877_bib39","doi-asserted-by":"crossref","DOI":"10.1007\/s00383-020-04737-6","article-title":"The role of gonadotrophins in gonocyte transformation during minipuberty","volume":"36","author":"Burton","year":"2020","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.repbio.2024.100877_bib40","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/toxsci\/kfm049","article-title":"Fetal mouse phthalate exposure shows that gonocyte multinucleation is not associated with decreased testicular testosterone","volume":"97","author":"Gaido","year":"2007","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.repbio.2024.100877_bib41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.taap.2012.03.016","article-title":"Effect of mono-(2-ethylhexyl) phthalate on human and mouse fetal testis: in vitro and in vivo approaches","volume":"261","author":"Muczynski","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.repbio.2024.100877_bib42","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1095\/biolreprod.103.018895","article-title":"Effects of mono-(2-ethylhexyl) phthalate on fetal and neonatal rat testis organ cultures","volume":"69","author":"Li","year":"2003","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2024.100877_bib43","first-page":"589","article-title":"Antagonistic effect of vitamin E on di-2-ethylhexyl phthalate-induced reproductive toxicity in male rats","volume":"24","author":"Wang","year":"2018","journal-title":"Zhonghua Nan Ke Xue"},{"key":"10.1016\/j.repbio.2024.100877_bib44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1095\/biolreprod.104.039404","article-title":"Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis","volume":"73","author":"Liu","year":"2005","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2024.100877_bib45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0070-2153(00)50006-4","article-title":"Gonocyte-sertoli cell interactions during development of the neonatal rodent testis","volume":"50","author":"Orth","year":"2000","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.repbio.2024.100877_bib46","article-title":"Disruption of retinol (Vitamin A) signaling by phthalate esters: Sar and mechanism studies","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.repbio.2024.100877_bib47","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1210\/en.2006-1206","article-title":"Identification and distribution of a novel platelet-derived growth factor receptor \u03b2 variant: effect of retinoic acid and involvement in cell differentiation","volume":"148","author":"Wang","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.repbio.2024.100877_bib48","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1210\/en.2014-1524","article-title":"Role of retinoic acid and platelet-derived growth factor receptor cross talk in the regulation of neonatal gonocyte and embryonal carcinoma cell differentiation","volume":"156","author":"Manku","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.repbio.2024.100877_bib49","doi-asserted-by":"crossref","first-page":"21672","DOI":"10.1073\/pnas.0912432106","article-title":"Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules","volume":"106","author":"Wu","year":"2009","journal-title":"Proc Natl Acad Sci Usa"},{"key":"10.1016\/j.repbio.2024.100877_bib50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/ar.1092200206","article-title":"Changes in the distribution of microtubules and intermediate filaments in mammalian Sertoli cells during spermatogenesis","volume":"220","author":"Amlani","year":"1988","journal-title":"Anat Rec"},{"key":"10.1016\/j.repbio.2024.100877_bib51","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1439-0264.2010.00993.x","article-title":"Di(n-butyl) phthalate induces vimentin filaments disruption in rat sertoli cells: a possible relation with spermatogenic cell apoptosis","volume":"39","author":"Alam","year":"2010","journal-title":"Anat Histol Embryol"},{"key":"10.1016\/j.repbio.2024.100877_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2023.152046","article-title":"Immunohistochemical analysis of the vimentin filaments in Sertoli cells is a powerful tool for the prediction of spermatogenic dysfunction","volume":"125","author":"Saito","year":"2023","journal-title":"Acta Histochem"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X24000238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X24000238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T08:33:14Z","timestamp":1717662794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X24000238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S1642431X24000238"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2024.100877","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of gonocyte development following neonatal exposure to di (2-ethylhexyl) phthalate","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2024.100877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100877"}}