{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:30:54Z","timestamp":1784305854416,"version":"3.55.0"},"reference-count":101,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009615","name":"University of Agriculture in Krakow","doi-asserted-by":"publisher","award":["A943\/2024"],"award-info":[{"award-number":["A943\/2024"]}],"id":[{"id":"10.13039\/100009615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.repbio.2025.101052","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T19:00:12Z","timestamp":1753470012000},"page":"101052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cryptorchidism-induced disruption of TRPM8 expression and calcium signaling in canine testes: A potential mechanism for tumourigenesis"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2690-1459","authenticated-orcid":false,"given":"Anna","family":"Ga\u0142uszka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"\u0141opuszy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Kurowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-9475","authenticated-orcid":false,"given":"Katarzyna","family":"Kotarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Rak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-8639","authenticated-orcid":false,"given":"Piotr","family":"Pawlicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2025.101052_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.935307","article-title":"Cryptorchidism: the dog as a study model","volume":"9","author":"Hern\u00e1ndez-Jard\u00f3n","year":"2022","journal-title":"Front Vet Sci"},{"issue":"4","key":"10.1016\/j.repbio.2025.101052_bib2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/ijc.2910180413","article-title":"Canine testicular tumors: epidemiologic features of 410 dogs","volume":"18","author":"Hayes","year":"1976","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/tera.1420320108","article-title":"Canine cryptorchism and subsequent testicular neoplasia: case-control study with epidemiologic update","volume":"32","author":"Hayes","year":"1985","journal-title":"Teratology"},{"issue":"2","key":"10.1016\/j.repbio.2025.101052_bib4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/biolre\/ioae075","article-title":"Cryptorchidism and testicular cancer in the dog: unresolved questions and challenges in translating insights from human studies","volume":"111","author":"Soto-Heras","year":"2024","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2025.101052_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2013.00032","article-title":"Testicular cancer and cryptorchidism","volume":"4","author":"Ferguson","year":"2013","journal-title":"Front Endocrinol"},{"issue":"7","key":"10.1016\/j.repbio.2025.101052_bib6","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1292\/jvms.71.919","article-title":"A 12-year retrospective study of canine testicular tumors","volume":"71","author":"Liao","year":"2009","journal-title":"J Vet Med Sci"},{"issue":"16","key":"10.1016\/j.repbio.2025.101052_bib7","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.3390\/cells11162476","article-title":"Transcriptomic analysis of testicular gene expression in a dog model of experimentally induced cryptorchidism","volume":"11","author":"Jhun","year":"2022","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.repbio.2025.101052_bib8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrc2171","article-title":"Calcium and cancer: targeting Ca2+ transport","volume":"7","author":"Monteith","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"10.1016\/j.repbio.2025.101052_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrc2374","article-title":"Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival","volume":"8","author":"Roderick","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.repbio.2025.101052_bib10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10555-016-9634-0","article-title":"Calcium role in human carcinogenesis: a comprehensive analysis and critical review of literature","volume":"35","author":"Kadio","year":"2016","journal-title":"Cancer Metastas Rev"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1423-0127-20-23","article-title":"Remodeling of calcium signaling in tumor progression","volume":"20","author":"Chen","year":"2013","journal-title":"J Biomed Sci"},{"issue":"3","key":"10.1016\/j.repbio.2025.101052_bib12","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1095\/biolreprod63.3.736","article-title":"Rapid androgen actions on calcium signaling in rat sertoli cells and two human prostatic cell lines: similar biphasic responses between 1 picomolar and 100 nanomolar concentrations1","volume":"63","author":"Lyng","year":"2000","journal-title":"Biol Reprod"},{"issue":"2","key":"10.1016\/j.repbio.2025.101052_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/08977190500126272","article-title":"High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells","volume":"23","author":"Tfelt-Hansen","year":"2005","journal-title":"Growth Factors"},{"issue":"5","key":"10.1016\/j.repbio.2025.101052_bib14","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/age.12977","article-title":"Altered expression of CYP17A1 and CYP19A1 in undescended testes of dogs with unilateral cryptorchidism","volume":"51","author":"Krzeminska","year":"2020","journal-title":"Anim Genet"},{"issue":"6876","key":"10.1016\/j.repbio.2025.101052_bib15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.repbio.2025.101052_bib16","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","article-title":"A TRP channel that senses cold stimuli and menthol","volume":"108","author":"Peier","year":"2002","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.repbio.2025.101052_bib17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/23328940.2019.1607490","article-title":"What is new about mild temperature sensing? A review of recent findings","volume":"6","author":"Garc\u00eda-\u00c1vila","year":"2019","journal-title":"Temperature"},{"issue":"2","key":"10.1016\/j.repbio.2025.101052_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4161\/23328940.2014.988524","article-title":"TRPM3 in temperature sensing and beyond","volume":"2","author":"Held","year":"2015","journal-title":"Temperature"},{"issue":"6","key":"10.1016\/j.repbio.2025.101052_bib19","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/jcp.22493","article-title":"TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction","volume":"226","author":"Mart\u00ednez-L\u00f3pez","year":"2011","journal-title":"J Cell Physiol"},{"issue":"9","key":"10.1016\/j.repbio.2025.101052_bib20","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1096\/fj.201600257R","article-title":"Cold\/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock\u2013induced oxidation","volume":"30","author":"Borowiec","year":"2016","journal-title":"FASEB J"},{"issue":"39","key":"10.1016\/j.repbio.2025.101052_bib21","doi-asserted-by":"crossref","first-page":"33048","DOI":"10.1074\/jbc.M112.366690","article-title":"Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase","volume":"287","author":"Aitken","year":"2012","journal-title":"J Biol Chem"},{"issue":"2-3\u20134","key":"10.1016\/j.repbio.2025.101052_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1387\/ijdb.130146ja","article-title":"Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development","volume":"57","author":"Aitken","year":"2013","journal-title":"Int J Dev Biol"},{"issue":"2","key":"10.1016\/j.repbio.2025.101052_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1677\/erc.1.00969","article-title":"Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement","volume":"12","author":"Bidaux","year":"2005","journal-title":"Endocr Relat Cancer"},{"issue":"5","key":"10.1016\/j.repbio.2025.101052_bib24","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1074\/jbc.M114.610873","article-title":"The TRPM8 protein is a testosterone receptor","volume":"290","author":"Asuthkar","year":"2015","journal-title":"J Biol Chem"},{"issue":"19","key":"10.1016\/j.repbio.2025.101052_bib25","doi-asserted-by":"crossref","first-page":"17221","DOI":"10.18632\/oncotarget.3948","article-title":"TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells","volume":"6","author":"Asuthkar","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02675-4","article-title":"Therapeutic potential of TRPM8 antagonists in prostate cancer","volume":"11","author":"Donato","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2025.101052_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1098448","article-title":"Therapeutic potential of TRPM8 channels in cancer treatment","volume":"14","author":"Ochoa","year":"2023","journal-title":"Front Pharm"},{"issue":"6","key":"10.1016\/j.repbio.2025.101052_bib28","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3892\/ol.2011.410","article-title":"Effects of TRPM8 on the proliferation and angiogenesis of prostate cancer PC-3 cells in vivo","volume":"2","author":"Zhu","year":"2011","journal-title":"Oncol Lett"},{"issue":"32","key":"10.1016\/j.repbio.2025.101052_bib29","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1038\/onc.2010.210","article-title":"PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression","volume":"29","author":"Gkika","year":"2010","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.repbio.2025.101052_bib30","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1083\/jcb.201506024","article-title":"TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1","volume":"216","author":"Genova","year":"2017","journal-title":"J Cell Biol"},{"issue":"46","key":"10.1016\/j.repbio.2025.101052_bib31","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1038\/sj.onc.1210487","article-title":"Inhibition of the SH3 domain-mediated binding of Src to the androgen receptor and its effect on tumor growth","volume":"26","author":"Migliaccio","year":"2007","journal-title":"Oncogene"},{"issue":"20","key":"10.1016\/j.repbio.2025.101052_bib32","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1093\/emboj\/19.20.5406","article-title":"Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation","volume":"19","author":"Migliaccio","year":"2000","journal-title":"EMBO J"},{"issue":"11","key":"10.1016\/j.repbio.2025.101052_bib33","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1158\/2767-9764.CRC-22-0170","article-title":"Protein kinase C alpha is a central node for tumorigenic transcriptional networks in human prostate cancer","volume":"2","author":"Cooke","year":"2022","journal-title":"Cancer Res Commun"},{"key":"10.1016\/j.repbio.2025.101052_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2017.00002","article-title":"Non-genomic actions of the androgen receptor in prostate cancer","volume":"8","author":"Leung","year":"2017","journal-title":"Front Endocrinol"},{"issue":"4","key":"10.1016\/j.repbio.2025.101052_bib35","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1210\/en.2018-00987","article-title":"Membrane androgen receptors unrelated to nuclear steroid receptors","volume":"160","author":"Thomas","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.repbio.2025.101052_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2021.106888","article-title":"Abundance of estrogen receptors involved in non-canonical signaling in the dog testis","volume":"235","author":"Galuszka","year":"2021","journal-title":"Anim Reprod Sci"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ab.2006.06.001","article-title":"Development and evaluation of canine reference genes for accurate quantification of gene expression","volume":"356","author":"Brinkhof","year":"2006","journal-title":"Anal Biochem"},{"issue":"2","key":"10.1016\/j.repbio.2025.101052_bib38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10142-023-01055-7","article-title":"RefFinder: a web-based tool for comprehensively analyzing and identifying reference genes","volume":"23","author":"Xie","year":"2023","journal-title":"Funct Integr Genom"},{"issue":"6","key":"10.1016\/j.repbio.2025.101052_bib39","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"issue":"6","key":"10.1016\/j.repbio.2025.101052_bib40","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.115.128611","article-title":"E\u0141. Regulatory role of gonadotropins and local factors produced by ovarian follicles on in vitro resistin expression and action on porcine follicular steroidogenesis1","volume":"92","author":"Rak","year":"2015","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2025.101052_bib41","article-title":"A simple method for quantitating confocal fluorescent images","volume":"25","author":"Shihan","year":"2021","journal-title":"Biochem Biophys Rep"},{"key":"10.1016\/j.repbio.2025.101052_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2020.106534","article-title":"Age-related changes of seminiferous tubule morphology, interstitial fibrosis and spermatogenesis in dogs","volume":"219","author":"Tesi","year":"2020","journal-title":"Anim Reprod Sci"},{"key":"10.1016\/j.repbio.2025.101052_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111216","article-title":"Heat stress response of somatic cells in the testis","volume":"527","author":"Aldahhan","year":"2021","journal-title":"Mol Cell Endocrinol"},{"issue":"9","key":"10.1016\/j.repbio.2025.101052_bib44","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/rda.14174","article-title":"Heat stress and hypoxia inhibit the secretion of androgens and induce epithelial-to-mesenchymal transition associated with activated <scp>TGF<\/scp> -\u03b2\/Smad signalling in canine cryptorchidism","volume":"57","author":"Wang","year":"2022","journal-title":"Reprod Domest Anim"},{"issue":"6","key":"10.1016\/j.repbio.2025.101052_bib45","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s10237-015-0682-0","article-title":"Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery","volume":"14","author":"Mpekris","year":"2015","journal-title":"Biomech Model Mechanobiol"},{"issue":"38","key":"10.1016\/j.repbio.2025.101052_bib46","doi-asserted-by":"crossref","first-page":"15101","DOI":"10.1073\/pnas.1213353109","article-title":"Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors","volume":"109","author":"Stylianopoulos","year":"2012","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib47","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s13287-024-03893-z","article-title":"Microenvironment of spermatogonial stem cells: a key factor in the regulation of spermatogenesis","volume":"15","author":"Liu","year":"2024","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"10.1016\/j.repbio.2025.101052_bib48","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3390\/ani11051379","article-title":"Effect of cryptorchidism on the histomorphometry, proliferation, apoptosis, and autophagy in boar testes","volume":"11","author":"Fan","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.repbio.2025.101052_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1305428","article-title":"The fate of germ cells in cryptorchid testis","volume":"14","author":"Thorup","year":"2024","journal-title":"Front Endocrinol"},{"issue":"2","key":"10.1016\/j.repbio.2025.101052_bib50","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.urology.2008.09.019","article-title":"Activation of NF-\u03baB associated with germ cell apoptosis in testes of experimentally induced cryptorchid rat model","volume":"73","author":"Mizuno","year":"2009","journal-title":"Urology"},{"issue":"22","key":"10.1016\/j.repbio.2025.101052_bib51","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1158\/0008-5472.CAN-21-2939","article-title":"Collagen linearization within tumors","volume":"81","author":"Barcus","year":"2021","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib52","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s43018-021-00291-9","article-title":"A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy","volume":"3","author":"Martino","year":"2021","journal-title":"Nat Cancer"},{"issue":"6","key":"10.1016\/j.repbio.2025.101052_bib53","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1083\/jcb.108.6.2435","article-title":"Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion","volume":"108","author":"Behrens","year":"1989","journal-title":"J Cell Biol"},{"key":"10.1016\/j.repbio.2025.101052_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00431","article-title":"The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity","volume":"8","author":"Poltavets","year":"2018","journal-title":"Front Oncol"},{"issue":"8","key":"10.1016\/j.repbio.2025.101052_bib55","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1158\/2159-8290.CD-24-0002","article-title":"The interplay between extracellular matrix remodeling and cancer therapeutics","volume":"14","author":"Prakash","year":"2024","journal-title":"Cancer Discov"},{"issue":"3","key":"10.1016\/j.repbio.2025.101052_bib56","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/ijc.23936","article-title":"Risk of contralateral testicular cancer among men with unilaterally undescended testis: a meta analysis","volume":"124","author":"Akre","year":"2009","journal-title":"Int J Cancer"},{"issue":"8","key":"10.1016\/j.repbio.2025.101052_bib57","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/ncb2529","article-title":"Direct inhibition of the cold-activated TRPM8 ion channel by G\u03b1q","volume":"14","author":"Zhang","year":"2012","journal-title":"Nat Cell Biol"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1113\/jphysiol.2006.123059","article-title":"Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors","volume":"581","author":"M\u00e4lki\u00e4","year":"2007","journal-title":"J Physiol"},{"issue":"6372","key":"10.1016\/j.repbio.2025.101052_bib59","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.aan4325","article-title":"Structure of the cold- and menthol-sensing ion channel TRPM8","volume":"359","author":"Yin","year":"2018","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.repbio.2025.101052_bib60","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/cells13060523","article-title":"Steroidogenesis upregulation through mitochondria-associated endoplasmic reticulum membranes and mitochondrial dynamics in rat testes: the role of D-aspartate","volume":"13","author":"Latino","year":"2024","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.repbio.2025.101052_bib61","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2312724121","article-title":"A massive alteration of gene expression in undescended testicles of dogs and the association of KAT6A variants with cryptorchidism","volume":"121","author":"Stachowiak","year":"2024","journal-title":"Proc Natl Acad Sci"},{"issue":"6","key":"10.1016\/j.repbio.2025.101052_bib62","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1172\/JCI30168","article-title":"Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function","volume":"117","author":"Bidaux","year":"2007","journal-title":"J Clin Investig"},{"issue":"4","key":"10.1016\/j.repbio.2025.101052_bib63","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.3390\/cancers7040882","article-title":"Roles of TRPM8 ion channels in cancer: proliferation, survival, and invasion","volume":"7","author":"Yee","year":"2015","journal-title":"Cancers"},{"issue":"12","key":"10.1016\/j.repbio.2025.101052_bib64","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.3390\/ijms23126672","article-title":"TRPM8 as an anti\u2013tumoral target in prostate cancer growth and metastasis dissemination","volume":"23","author":"Grolez","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.repbio.2025.101052_bib65","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/ph9030044","article-title":"TRPM8 puts the chill on prostate cancer","volume":"9","author":"Grolez","year":"2016","journal-title":"Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.repbio.2025.101052_bib66","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1248\/bpb.b20-00934","article-title":"Involvement of TRPM8 channel in radiation-induced DNA damage repair mechanism contributing to radioresistance of B16 melanoma","volume":"44","author":"Nomura","year":"2021","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.repbio.2025.101052_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1098448","article-title":"Therapeutic potential of TRPM8 channels in cancer treatment","volume":"14","author":"Ochoa","year":"2023","journal-title":"Front Pharm"},{"issue":"9","key":"10.1016\/j.repbio.2025.101052_bib68","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.3390\/cancers14092261","article-title":"TRPM8-Rap1A interaction sites as critical determinants for adhesion and migration of prostate and other epithelial cancer cells","volume":"14","author":"Chinig\u00f2","year":"2022","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.repbio.2025.101052_bib69","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/oxfordjournals.jbchem.a003272","article-title":"Protein kinase C (PKC): regulation and biological function","volume":"132","author":"Nakashima","year":"2002","journal-title":"J Biochem"},{"issue":"11","key":"10.1016\/j.repbio.2025.101052_bib70","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.3748\/wjg.v9.i11.2413","article-title":"Roles of PLC-\u03b32 and PKC\u03b1 in TPA-induced apoptosis of gastric cancer cells","volume":"9","author":"Zhang","year":"2003","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib71","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13045-020-00949-4","article-title":"The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy","volume":"13","author":"Yuan","year":"2020","journal-title":"J Hematol Oncol"},{"issue":"5","key":"10.1016\/j.repbio.2025.101052_bib72","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.3390\/cancers14051104","article-title":"Targeting protein kinase C for cancer therapy","volume":"14","author":"He","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib73","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1186\/s12885-017-3401-7","article-title":"Protein kinase C-\u03b1 (PKC\u03b1) modulates cell apoptosis by stimulating nuclear translocation of NF-kappa-B p65 in urothelial cell carcinoma of the bladder","volume":"17","author":"Zheng","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.repbio.2025.101052_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2016.00053","article-title":"ERK1 and ERK2 map kinases: specific roles or functional redundancy?","volume":"4","author":"Busc\u00e0","year":"2016","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.repbio.2025.101052_bib75","article-title":"ERK\/MAPK signalling pathway and tumorigenesis (Review)","author":"Guo","year":"2020","journal-title":"Exp Ther Med"},{"issue":"15","key":"10.1016\/j.repbio.2025.101052_bib76","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.3390\/ijms20153792","article-title":"Extracellular signal-regulated kinase: a regulator of cell growth, inflammation, chondrocyte and bone cell receptor-mediated gene expression","volume":"20","author":"Lu","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.repbio.2025.101052_bib77","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3390\/ijms21031102","article-title":"Targeting MAPK signaling in cancer: mechanisms of drug resistance and sensitivity","volume":"21","author":"Lee","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.repbio.2025.101052_bib78","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3390\/cancers11101618","article-title":"A comprehensive review on MAPK: a promising therapeutic target in cancer","volume":"11","author":"Braicu","year":"2019","journal-title":"Cancers"},{"issue":"10","key":"10.1016\/j.repbio.2025.101052_bib79","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1158\/0008-5472.CAN-20-0768","article-title":"Correction: activation of MAPK signaling by CXCR7 leads to enzalutamide resistance in prostate cancer","volume":"80","author":"Li","year":"2020","journal-title":"Cancer Res"},{"key":"10.1016\/j.repbio.2025.101052_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/frph.2024.1330161","article-title":"MAPKs signaling is obligatory for male reproductive function in a development-specific manner","volume":"6","author":"Kumar","year":"2024","journal-title":"Front Reprod Health"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib81","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s12864-017-3683-9","article-title":"Reduced changes in protein compared to mRNA levels across non-proliferating tissues","volume":"18","author":"Perl","year":"2017","journal-title":"BMC Genom"},{"issue":"2","key":"10.1016\/j.repbio.2025.101052_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004049","article-title":"The roles of post-translational modifications in the context of protein interaction networks","volume":"11","author":"Duan","year":"2015","journal-title":"PLoS Comput Biol"},{"issue":"3","key":"10.1016\/j.repbio.2025.101052_bib83","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1042\/BST20220584","article-title":"The central role of translation elongation in response to stress","volume":"51","author":"Barros","year":"2023","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib84","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12967-016-0893-x","article-title":"Regulatory mechanisms of microRNA expression","volume":"14","author":"Gulyaeva","year":"2016","journal-title":"J Transl Med"},{"key":"10.1016\/j.repbio.2025.101052_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.901664","article-title":"Editorial: non-coding RNA mediated post-transcriptional regulation in human diseases","volume":"13","author":"Kumar","year":"2022","journal-title":"Front Genet"},{"issue":"4","key":"10.1016\/j.repbio.2025.101052_bib86","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00383-005-1382-0","article-title":"Germ cell development in the descended and cryptorchid testis and the effects of hormonal manipulation","volume":"21","author":"Ong","year":"2005","journal-title":"Pedia Surg Int"},{"key":"10.1016\/j.repbio.2025.101052_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1361032","article-title":"Anti-M\u00fcllerian hormone, testicular descent and cryptorchidism","volume":"15","author":"Rey","year":"2024","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.repbio.2025.101052_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2019.00906","article-title":"Hypogonadism and Cryptorchidism","volume":"10","author":"Rodprasert","year":"2020","journal-title":"Front Endocrinol"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib89","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12943-021-01428-1","article-title":"Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives","volume":"20","author":"Mao","year":"2021","journal-title":"Mol Cancer"},{"issue":"5","key":"10.1016\/j.repbio.2025.101052_bib90","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1007\/s13277-013-0803-2","article-title":"TF\/FVIIa\/PAR2 promotes cell proliferation and migration via PKC\u03b1 and ERK-dependent c-Jun\/AP-1 pathway in colon cancer cell line SW620","volume":"34","author":"Hu","year":"2013","journal-title":"Tumor Biol"},{"issue":"8","key":"10.1016\/j.repbio.2025.101052_bib91","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.1167\/iovs.13-12473","article-title":"Role of PKC\u03b1 activation of Src, PI-3K\/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells","volume":"54","author":"Li","year":"2013","journal-title":"Invest Opthalmology Vis Sci"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib92","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1477-5956-4-15","article-title":"Phosphoprotein analysis: from proteins to proteomes","volume":"4","author":"Delom","year":"2006","journal-title":"Proteome Sci"},{"issue":"6","key":"10.1016\/j.repbio.2025.101052_bib93","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00726-021-02994-w","article-title":"Lyophilization and homogenization of biological samples improves reproducibility and reduces standard deviation in molecular biology techniques","volume":"53","author":"Molnar","year":"2021","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib94","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12014-020-09306-6","article-title":"Time dependent effect of cold ischemia on the phosphoproteome and protein kinase activity in fresh-frozen colorectal cancer tissue obtained from patients","volume":"18","author":"Buffart","year":"2021","journal-title":"Clin Proteom"},{"issue":"8","key":"10.1016\/j.repbio.2025.101052_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072457","article-title":"Total protein analysis as a reliable loading control for quantitative fluorescent western blotting","volume":"8","author":"Eaton","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.repbio.2025.101052_bib96","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1010092","article-title":"PKC-mediated phosphorylation and activation of the MEK\/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer","volume":"13","author":"Scerri","year":"2022","journal-title":"Front Endocrinol"},{"issue":"5","key":"10.1016\/j.repbio.2025.101052_bib97","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4161\/cc.8.5.7734","article-title":"Total ERK1\/2 activity regulates cell proliferation","volume":"8","author":"Lefloch","year":"2009","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.repbio.2025.101052_bib98","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1476-4598-9-76","article-title":"PKC\u03b1 expression is a marker for breast cancer aggressiveness","volume":"9","author":"L\u00f8nne","year":"2010","journal-title":"Mol Cancer"},{"issue":"22","key":"10.1016\/j.repbio.2025.101052_bib99","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1038\/sj.onc.1210421","article-title":"MAP kinase signalling pathways in cancer","volume":"26","author":"Dhillon","year":"2007","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.repbio.2025.101052_bib100","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrc2110","article-title":"Protein kinase C and other diacylglycerol effectors in cancer","volume":"7","author":"Griner","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.repbio.2025.101052_bib101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000542245","article-title":"Exploring testicular descent: recent findings and future prospects in canine cryptorchidism","author":"Krzeminska","year":"2024","journal-title":"Sex Dev"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X25000592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X25000592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:48:56Z","timestamp":1772765336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X25000592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":101,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1642431X25000592"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2025.101052","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cryptorchidism-induced disruption of TRPM8 expression and calcium signaling in canine testes: A potential mechanism for tumourigenesis","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2025.101052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn.","name":"copyright","label":"Copyright"}],"article-number":"101052"}}