{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:22:10Z","timestamp":1787728930637,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172724"],"award-info":[{"award-number":["32172724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573211"],"award-info":[{"award-number":["32573211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.repbio.2025.101091","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T06:32:55Z","timestamp":1761633175000},"page":"101091","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracellular vesicles derived from placental trophoblast regulate ovine endometrial receptivity by promoting the transformation of endometrial epithelial cells"],"prefix":"10.1016","volume":"26","author":[{"given":"Huijia","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4754-7498","authenticated-orcid":false,"given":"Yanshe","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhong","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.repbio.2025.101091_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi4819","article-title":"Modeling embryo-endometrial interface recapitulating human embryo implantation","volume":"10","author":"Shibata","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.repbio.2025.101091_bib2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-animal-022114-110639","article-title":"Uterine responses to the preattachment embryo in domestic ungulates: recognition of pregnancy and preparation for implantation","volume":"3","author":"Bauersachs","year":"2015","journal-title":"Annu Rev Anim Biosci"},{"issue":"1","key":"10.1016\/j.repbio.2025.101091_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13048-024-01581-3","article-title":"Administration of dehydroepiandrosterone improves endometrial thickness in women undergoing IVF\/ICSI: a systematic review and meta-analysis","volume":"18","author":"Huang","year":"2025","journal-title":"J Ovarian Res"},{"issue":"344","key":"10.1016\/j.repbio.2025.101091_bib4","doi-asserted-by":"crossref","first-page":"re8","DOI":"10.1126\/scisignal.2005189","article-title":"Signaling mechanisms of the epithelial-mesenchymal transition","volume":"7","author":"Gonzalez","year":"2014","journal-title":"Sci Signal"},{"issue":"2","key":"10.1016\/j.repbio.2025.101091_bib5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/humupd\/dmy044","article-title":"Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis","volume":"25","author":"Craciunas","year":"2019","journal-title":"Hum Reprod Update"},{"issue":"7","key":"10.1016\/j.repbio.2025.101091_bib6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41580-023-00576-0","article-title":"Context-specific regulation of extracellular vesicle biogenesis and cargo selection","volume":"24","author":"Dixson","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.repbio.2025.101091_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12964-023-01221-1","article-title":"Embryonic signals mediate extracellular vesicle biogenesis and trafficking at the embryo-maternal interface","volume":"21","author":"Guzewska","year":"2023","journal-title":"Cell Commun Signal"},{"issue":"1","key":"10.1016\/j.repbio.2025.101091_bib8","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s42003-024-06442-9","article-title":"The evolving roles of extracellular vesicles in embryo-maternal communication","volume":"7","author":"Fazeli","year":"2024","journal-title":"Commun Biol"},{"key":"10.1016\/j.repbio.2025.101091_bib9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.theriogenology.2024.12.020","article-title":"Effect of extracellular vesicles derived from oviductal and uterine fluid on the development of porcine preimplantation embryos","volume":"234","author":"Han","year":"2025","journal-title":"Theriogenology"},{"issue":"8","key":"10.1016\/j.repbio.2025.101091_bib10","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3390\/biom14080995","article-title":"Placenta extracellular vesicles: messengers connecting maternal and fetal systems","volume":"14","author":"Rosenfeld","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.repbio.2025.101091_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.944370","article-title":"New roles for EVs, miRNA and lncRNA in bovine embryo implantation","volume":"9","author":"Imakawa","year":"2022","journal-title":"Front Vet Sci"},{"issue":"1","key":"10.1016\/j.repbio.2025.101091_bib12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12958-022-01023-z","article-title":"Extracellular vesicles derived from endometrial epithelial cells deliver exogenous miR-92b-3p to affect the function of embryonic trophoblast cells via targeting TSC1 and DKK3","volume":"20","author":"Hua","year":"2022","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"10.1016\/j.repbio.2025.101091_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40104-022-00715-1","article-title":"The role of extracellular vesicles in animal reproduction and diseases","volume":"13","author":"Gurunathan","year":"2022","journal-title":"J Anim Sci Biotechnol"},{"issue":"1","key":"10.1016\/j.repbio.2025.101091_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1262\/jrd.2021-077","article-title":"Exosomes derived from placental trophoblast cells regulate endometrial epithelial receptivity in dairy cows during pregnancy","volume":"68","author":"Su","year":"2022","journal-title":"J Reprod Dev"},{"issue":"8","key":"10.1016\/j.repbio.2025.101091_bib15","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.bbamcr.2018.05.011","article-title":"Circ-8073 regulates CEP55 by sponging miR-449a to promote caprine endometrial epithelial cells proliferation via the PI3K\/AKT\/mTOR pathway","volume":"1865","author":"Liu","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.repbio.2025.101091_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.theriogenology.2025.02.010","article-title":"oar-miR-29a promotes the establishment of endometrial receptivity by targeting CDC42 in sheep","volume":"237","author":"Chen","year":"2025","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2025.101091_bib17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.21451\/1984-3143-AR2018-0014","article-title":"Cellular events during ovine implantation and impact for gestation","volume":"15","author":"Johnson","year":"2018","journal-title":"Anim Reprod"},{"key":"10.1016\/j.repbio.2025.101091_bib18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-3-030-77360-1_7","article-title":"Implantation and placentation in ruminants","volume":"234","author":"Green","year":"2021","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"10.1016\/j.repbio.2025.101091_bib19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000489257","article-title":"Morphological characterization of basally located uninucleate trophoblast cells as precursors of bovine binucleate trophoblast giant cells","volume":"205","author":"Attiger","year":"2018","journal-title":"Cells Tissues Organs"},{"issue":"5","key":"10.1016\/j.repbio.2025.101091_bib20","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1038\/s41596-023-00811-0","article-title":"Comprehensive isolation of extracellular vesicles and nanoparticles","volume":"18","author":"Zhang","year":"2023","journal-title":"Nat Protoc"},{"issue":"3","key":"10.1016\/j.repbio.2025.101091_bib21","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41596-020-00466-1","article-title":"Isolation and characterization of extracellular vesicle subpopulations from tissues","volume":"16","author":"Crescitelli","year":"2021","journal-title":"Nat Protoc"},{"issue":"2","key":"10.1016\/j.repbio.2025.101091_bib22","article-title":"Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles","volume":"13","author":"Chen","year":"2024","journal-title":"J Extra Vesicles"},{"issue":"8","key":"10.1016\/j.repbio.2025.101091_bib23","doi-asserted-by":"crossref","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.repbio.2025.101091_bib24","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2214684120","article-title":"METTL3 is essential for normal progesterone signaling during embryo implantation via m6A-mediated translation control of progesterone receptor","volume":"120","author":"Zheng","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.repbio.2025.101091_bib25","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.omtn.2021.09.009","article-title":"Placental trophoblast cell-derived exosomal microRNA-1290 promotes the interaction between endometrium and embryo by targeting LHX6","volume":"26","author":"Shi","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.repbio.2025.101091_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/201514","article-title":"Leukemia inhibitory factor: roles in embryo implantation and in nonhormonal contraception","author":"Salleh","year":"2014","journal-title":"Sci World J"},{"issue":"4","key":"10.1016\/j.repbio.2025.101091_bib27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/sj.cr.7290227","article-title":"Uterine receptivity and the plasma membrane transformation","volume":"14","author":"Murphy","year":"2004","journal-title":"Cell Res"},{"key":"10.1016\/j.repbio.2025.101091_bib28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.theriogenology.2020.08.009","article-title":"miR-192-5p suppresses uterine receptivity formation through impeding epithelial transformation during embryo implantation","volume":"157","author":"Liang","year":"2020","journal-title":"Theriogenology"},{"issue":"2","key":"10.1016\/j.repbio.2025.101091_bib29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0143-4004(81)80021-5","article-title":"Conceptus attachment in the ewe: an ultrastructural study","volume":"2","author":"Guillomot","year":"1981","journal-title":"Placenta"},{"key":"10.1016\/j.repbio.2025.101091_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.110644","article-title":"Pinopodes: recent advancements, current perspectives, and future directions","volume":"501","author":"Quinn","year":"2020","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"10.1016\/j.repbio.2025.101091_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jri.2012.11.001","article-title":"Pregnancy-associated miRNA-clusters","volume":"97","author":"Morales-Prieto","year":"2013","journal-title":"J Reprod Immunol"},{"issue":"7","key":"10.1016\/j.repbio.2025.101091_bib32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3390\/biomedicines9070827","article-title":"Emerging evidence of the functional impact of the miR379\/miR656 cluster (C14MC) in breast cancer","volume":"9","author":"McCarthy","year":"2021","journal-title":"Biomedicines"},{"issue":"29","key":"10.1016\/j.repbio.2025.101091_bib33","doi-asserted-by":"crossref","first-page":"16449","DOI":"10.1021\/acs.jafc.4c02508","article-title":"Bta-miR-200a regulates milk fat biosynthesis by targeting IRS2 to inhibit the PI3K\/Akt signal pathway in bovine mammary epithelial cells","volume":"72","author":"Tan","year":"2024","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10.1016\/j.repbio.2025.101091_bib34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/alr.23215","article-title":"miR-200a-3p regulates epithelial-mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK\/p38 pathway","volume":"14","author":"Wu","year":"2024","journal-title":"Int Forum Allergy Rhinol"},{"issue":"12","key":"10.1016\/j.repbio.2025.101091_bib35","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1038\/cdd.2017.136","article-title":"MicroRNA-200c impairs uterine receptivity formation by targeting FUT4 and \u03b11,3-fucosylation","volume":"24","author":"Zheng","year":"2017","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.repbio.2025.101091_bib36","first-page":"622","article-title":"MicroRNA\u2011409 May function as a tumor suppressor in endometrial carcinoma cells by targeting Smad2","volume":"19","author":"Zhang","year":"2019","journal-title":"Mol Med Rep"},{"issue":"8","key":"10.1016\/j.repbio.2025.101091_bib37","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/humrep\/dead138","article-title":"Human blastocysts uptake extracellular vesicles secreted by endometrial cells containing miRNAs related to implantation","volume":"38","author":"Segura-Benitez","year":"2023","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.repbio.2025.101091_bib38","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/1933719112453507","article-title":"MicroRNAs miR-30b, miR-30d, and miR-494 regulate human endometrial receptivity","volume":"20","author":"Altmaee","year":"2013","journal-title":"Reprod Sci"},{"issue":"18","key":"10.1016\/j.repbio.2025.101091_bib39","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1242\/dev.124289","article-title":"Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome","volume":"142","author":"Vilella","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.repbio.2025.101091_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108340","article-title":"Sertoli cells-derived exosomal miR-30a-5p regulates ubiquitin E3 ligase Zeb2 to affect the spermatogonial stem cells proliferation and differentiation","volume":"117","author":"Wang","year":"2023","journal-title":"Reprod Toxicol"},{"issue":"1","key":"10.1016\/j.repbio.2025.101091_bib41","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12943-024-01998-w","article-title":"circ_PPAPDC1A promotes osimertinib resistance by sponging the miR-30a-3p\/IGF1R pathway in non-small cell lung cancer (NSCLC)","volume":"23","author":"Tang","year":"2024","journal-title":"Mol Cancer"},{"issue":"3","key":"10.1016\/j.repbio.2025.101091_bib42","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bbrc.2016.03.069","article-title":"miR-30a-5p\/UBE3C axis regulates breast cancer cell proliferation and migration","volume":"516","author":"Xiong","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1016\/j.repbio.2025.101091_bib43","first-page":"60","article-title":"Identification of tumor-suppressive miR-30a-3p controlled genes: ANLN as a therapeutic target in breast cancer","volume":"10","author":"Mitsueda","year":"2024","journal-title":"Noncoding RNA"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X25000981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X25000981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:27:18Z","timestamp":1787725638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X25000981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1642431X25000981"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2025.101091","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular vesicles derived from placental trophoblast regulate ovine endometrial receptivity by promoting the transformation of endometrial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2025.101091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101091"}}