{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:21:13Z","timestamp":1787728873992,"version":"build-2784847793"},"reference-count":69,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100017634","name":"Henan University of Chinese Medicine","doi-asserted-by":"publisher","award":["MP2024-54"],"award-info":[{"award-number":["MP2024-54"]}],"id":[{"id":"10.13039\/100017634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603632"],"award-info":[{"award-number":["81603632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["222300420485"],"award-info":[{"award-number":["222300420485"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023T160201"],"award-info":[{"award-number":["2023T160201"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M721068"],"award-info":[{"award-number":["2022M721068"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2021JDZX2056"],"award-info":[{"award-number":["2021JDZX2056"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["192102310159"],"award-info":[{"award-number":["192102310159"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["232102311199"],"award-info":[{"award-number":["232102311199"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.repbio.2025.101096","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T07:54:04Z","timestamp":1763625244000},"page":"101096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The mouse model of induced sperm DNA damage caused by polystyrene microplastics exhibited distinct transcriptomic and proteomic features"],"prefix":"10.1016","volume":"26","author":[{"given":"Chenming","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2025.101096_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2458-10-24","article-title":"Decreasing sperm quality: a global problem?","volume":"10","author":"Merzenich","year":"2010","journal-title":"BMC Public Health"},{"key":"10.1016\/j.repbio.2025.101096_bib2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1080\/07388551.2017.1355293","article-title":"An overview on biodegradation of polystyrene and modified polystyrene: the microbial approach","volume":"38","author":"Ho","year":"2018","journal-title":"Crit Rev Biotechnol"},{"key":"10.1016\/j.repbio.2025.101096_bib3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.etap.2018.10.009","article-title":"Microplastic in marine organism: Environmental and toxicological effects","volume":"64","author":"Guzzetti","year":"2018","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.repbio.2025.101096_bib4","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1260352","article-title":"Marine pollution. Plastic waste inputs from land into the ocean","volume":"347","author":"Jambeck","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.repbio.2025.101096_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146264","article-title":"Influence of the co-exposure of microplastics and tetrabromobisphenol A on human gut: Simulation in vitro with human cell Caco-2 and gut microbiota","volume":"778","author":"Huang","year":"2021","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.repbio.2025.101096_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ Int"},{"key":"10.1016\/j.repbio.2025.101096_bib7","doi-asserted-by":"crossref","DOI":"10.1177\/15579883221096549","article-title":"Microplastics may be a significant cause of male infertility","volume":"16","author":"Zhang","year":"2022","journal-title":"Am J Men's Health"},{"key":"10.1016\/j.repbio.2025.101096_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114297","article-title":"Polystyrene nanoparticles: Sources, occurrence in the environment, distribution in tissues, accumulation and toxicity to various organisms","volume":"262","author":"Kik","year":"2020","journal-title":"Environ Pollut (Barking Essex 1987)"},{"key":"10.1016\/j.repbio.2025.101096_bib9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.wasman.2016.10.021","article-title":"Process window for direct recycling of acrylonitrile-butadiene-styrene and high-impact polystyrene from electrical and electronic equipment waste","volume":"59","author":"Vazquez","year":"2017","journal-title":"Waste Manag"},{"key":"10.1016\/j.repbio.2025.101096_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134267","article-title":"Micro(nano)plastics pollution and human health: How plastics can induce carcinogenesis to humans?","volume":"298","author":"Kumar","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.repbio.2025.101096_bib11","article-title":"Evaluation of neurotoxicity in BALB\/c Mice following chronic exposure to polystyrene microplastics","volume":"130","author":"Jin","year":"2022","journal-title":"Environ Health Persp"},{"key":"10.1016\/j.repbio.2025.101096_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155198","article-title":"Polystyrene microplastics aggravate inflammatory damage in mice with intestinal immune imbalance","volume":"833","author":"Liu","year":"2022","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.repbio.2025.101096_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121217","article-title":"Polystyrene microplastics arrest skeletal growth in puberty through accelerating osteoblast senescence","volume":"322","author":"Pan","year":"2023","journal-title":"Environ Pollut (Barking Essex 1987)"},{"key":"10.1016\/j.repbio.2025.101096_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134261","article-title":"Polystyrene nanoplastics penetrate across the blood-brain barrier and induce activation of microglia in the brain of mice","volume":"298","author":"Shan","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.repbio.2025.101096_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121388","article-title":"Polystyrene microplastics-induced macrophage extracellular traps contributes to liver fibrotic injury by activating ROS\/TGF-\u03b2\/Smad2\/3 signaling axis","volume":"324","author":"Wang","year":"2023","journal-title":"Environ Pollut (Barking Essex 1987)"},{"key":"10.1016\/j.repbio.2025.101096_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.136764","article-title":"Airborne polystyrene microplastics and nanoplastics induce nasal and lung microbial dysbiosis in mice","volume":"310","author":"Zha","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.repbio.2025.101096_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153513","article-title":"Polystyrene microplastics aggravate acute pancreatitis in mice","volume":"491","author":"Zheng","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.repbio.2025.101096_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114371","article-title":"Toxicity of polystyrene nanoparticles for mouse ovary and cultured human granulosa cells","volume":"249","author":"Huang","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.repbio.2025.101096_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125537","article-title":"Adaptation of life-history traits and trade-offs in marine medaka (Oryzias melastigma) after whole life-cycle exposure to polystyrene microplastics","volume":"414","author":"Wang","year":"2021","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.repbio.2025.101096_bib20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12989-023-00546-6","article-title":"Long-term exposure to polystyrene microplastics triggers premature testicular aging","volume":"20","author":"Wu","year":"2023","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.repbio.2025.101096_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131470","article-title":"Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice","volume":"454","author":"Xu","year":"2023","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.repbio.2025.101096_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123430","article-title":"Polystyrene microplastics induced male reproductive toxicity in mice","volume":"401","author":"Jin","year":"2021","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.repbio.2025.101096_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/aja.2010.73","article-title":"Sperm chromatin structure assay (SCSA): a tool in diagnosis and treatment of infertility","volume":"13","author":"Bungum","year":"2011","journal-title":"Asian J Androl"},{"key":"10.1016\/j.repbio.2025.101096_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.anireprosci.2016.01.017","article-title":"The sperm chromatin structure assay (SCSA(\u00ae)) and other sperm DNA fragmentation tests for evaluation of sperm nuclear DNA integrity as related to fertility","volume":"169","author":"Evenson","year":"2016","journal-title":"Anim Reprod Sci"},{"key":"10.1016\/j.repbio.2025.101096_bib25","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinforma (Oxf Engl)"},{"key":"10.1016\/j.repbio.2025.101096_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.repbio.2025.101096_bib27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.repbio.2025.101096_bib28","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.repbio.2025.101096_bib29","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat Protoc"},{"key":"10.1016\/j.repbio.2025.101096_bib30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinforma"},{"key":"10.1016\/j.repbio.2025.101096_bib31","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.repbio.2025.101096_bib32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.repbio.2025.101096_bib33","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.fertnstert.2021.12.012","article-title":"The sixth edition of the WHO laboratory manual for the examination and processing of human semen: ensuring quality and standardization in basic examination of human ejaculates","volume":"117","author":"Bj\u00f6rndahl","year":"2022","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2025.101096_bib34","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s10815-021-02080-w","article-title":"Correlation between the DNA fragmentation index (DFI) and sperm morphology of infertile patients","volume":"38","author":"Ferrigno","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.repbio.2025.101096_bib35","first-page":"170","article-title":"Re: whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization\/intracytoplasmic sperm injection: a systematic review and meta-analysis","volume":"194","author":"Niederberger","year":"2015","journal-title":"J Urol"},{"key":"10.1016\/j.repbio.2025.101096_bib36","doi-asserted-by":"crossref","first-page":"7689","DOI":"10.1038\/srep07689","article-title":"Meiotic interstrand DNA damage escapes paternal repair and causes chromosomal aberrations in the zygote by maternal misrepair","volume":"5","author":"Marchetti","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2025.101096_bib37","first-page":"343","article-title":"Effect of sperm DNA fragmentation on embryo development: clinical and biological aspects","volume":"21","author":"Alvarez Sed\u00f3","year":"2017","journal-title":"JBRA Assist Reprod"},{"key":"10.1016\/j.repbio.2025.101096_bib38","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/aja.2013.81","article-title":"Diagnostic value of sperm DNA fragmentation and sperm high-magnification for predicting outcome of assisted reproduction treatment","volume":"15","author":"L\u00f3pez","year":"2013","journal-title":"Asian J Androl"},{"key":"10.1016\/j.repbio.2025.101096_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110133","article-title":"Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway","volume":"190","author":"Xie","year":"2020","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.repbio.2025.101096_bib40","doi-asserted-by":"crossref","first-page":"47921","DOI":"10.1007\/s11356-021-13911-9","article-title":"Polystyrene microplastics induce blood-testis barrier disruption regulated by the MAPK-Nrf2 signaling pathway in rats","volume":"28","author":"Li","year":"2021","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.repbio.2025.101096_bib41","article-title":"Determination of biological and molecular attributes related to polystyrene microplastic-induced reproductive toxicity and its reversibility in male mice","volume":"19","author":"Liu","year":"2022","journal-title":"Int J Env Res Pub He"},{"key":"10.1016\/j.repbio.2025.101096_bib42","article-title":"Autophagy and apoptosis act as partners to induce germ cell death after heat stress in mice","volume":"7","author":"Zhang","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.repbio.2025.101096_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114796","article-title":"Exposure to nanoplastics induces mitochondrial impairment and cytomembrane destruction in Leydig cells","volume":"255","author":"Sun","year":"2023","journal-title":"Ecotox Environ Safe"},{"key":"10.1016\/j.repbio.2025.101096_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119789","article-title":"Microplastics-perturbed gut microbiota triggered the testicular disorder in male mice: via fecal microbiota transplantation","volume":"309","author":"Wen","year":"2022","journal-title":"Environ Pollut (Barking Essex 1987)"},{"key":"10.1016\/j.repbio.2025.101096_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.136591","article-title":"Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice","volume":"308","author":"Wang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.repbio.2025.101096_bib46","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s10930-021-10013-w","article-title":"Proteomic profile of sperm in infertile males reveals changes in metabolic pathways","volume":"40","author":"Liang","year":"2021","journal-title":"Protein J"},{"key":"10.1016\/j.repbio.2025.101096_bib47","first-page":"539","article-title":"The role of the PI3K\/AKT\/mTOR signalling pathway in male reproduction","volume":"21","author":"Deng","year":"2021","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.repbio.2025.101096_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115151","article-title":"The role of STAT3\/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat","volume":"404","author":"Fu","year":"2020","journal-title":"Toxicol Appl Pharm"},{"key":"10.1016\/j.repbio.2025.101096_bib49","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1080\/13880209.2023.2168705","article-title":"Repair mechanism of Yishen Tongluo formula on mouse sperm DNA fragmentation caused by polystyrene microplastics","volume":"61","author":"Zhang","year":"2023","journal-title":"Pharm Biol"},{"key":"10.1016\/j.repbio.2025.101096_bib50","first-page":"306","article-title":"Significant correlation between high-risk HPV DNA in semen and impairment of sperm quality in infertile men","volume":"12","author":"Moghimi","year":"2019","journal-title":"Int J Fertil Steril"},{"key":"10.1016\/j.repbio.2025.101096_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005847","article-title":"Adsorption of human papillomavirus 16 to live human sperm","volume":"4","author":"P\u00e9rez-Andino","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.repbio.2025.101096_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.643539","article-title":"Is HPV the novel target in male idiopathic infertility? A systematic review of the literature","volume":"12","author":"Muscianisi","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.repbio.2025.101096_bib53","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41598-018-19369-z","article-title":"Human papillomavirus prophylactic vaccination improves reproductive outcome in infertile patients with HPV semen infection: a retrospective study","volume":"8","author":"Garolla","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2025.101096_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107459","article-title":"Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks","volume":"168","author":"Hu","year":"2022","journal-title":"Environ Int"},{"key":"10.1016\/j.repbio.2025.101096_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167592","article-title":"Polystyrene nanoparticle exposure accelerates ovarian cancer development in mice by altering the tumor microenvironment","volume":"906","author":"Chen","year":"2024","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.repbio.2025.101096_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156391","article-title":"Nano-sized polystyrene plastic particles affect many cancer-related biological processes even in the next generations; zebrafish modeling","volume":"838","author":"Sulukan","year":"2022","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.repbio.2025.101096_bib57","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.18632\/aging.100418","article-title":"GSTT1 is upregulated by oxidative stress through P38-MK2 signaling pathway in human granulosa cells: possible association with mitochondrial activity","volume":"3","author":"Ito","year":"2011","journal-title":"Aging"},{"key":"10.1016\/j.repbio.2025.101096_bib58","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/jhg.2010.59","article-title":"The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility","volume":"55","author":"Safarinejad","year":"2010","journal-title":"J Hum Genet"},{"key":"10.1016\/j.repbio.2025.101096_bib59","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.urology.2005.01.005","article-title":"Glutathione S-transferase T1-1 activity upregulated in transitional cell carcinoma of urinary bladder","volume":"65","author":"Simic","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.repbio.2025.101096_bib60","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.2147\/IJGM.S351662","article-title":"AGT may serve as a prognostic biomarker and correlated with immune infiltration in gastric cancer","volume":"15","author":"Wu","year":"2022","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.repbio.2025.101096_bib61","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s10147-015-0924-2","article-title":"Stromal markers AKR1C1 and AKR1C2 are prognostic factors in primary human breast cancer","volume":"21","author":"Wenners","year":"2016","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.repbio.2025.101096_bib62","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3892\/etm.2022.11500","article-title":"LTBP2 inhibits prostate cancer progression and metastasis via the PI3K\/AKT signaling pathway","volume":"24","author":"Zhang","year":"2022","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.repbio.2025.101096_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17111808","article-title":"PPIC, EMP3 and CHI3L1 are novel prognostic markers for high grade glioma","volume":"17","author":"Gao","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101096_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122282","article-title":"Small polystyrene microplastics interfere with the breakdown of milk proteins during static in vitro simulated human gastric digestion","volume":"335","author":"Krishna de Guzman","year":"2023","journal-title":"Environ Pollut (Barking Essex 1987)"},{"key":"10.1016\/j.repbio.2025.101096_bib65","first-page":"12","article-title":"Nano- and microplastics migration from plastic food packaging into dairy products: impact on nutrient digestion, absorption, and metabolism","author":"Kaseke","year":"2023","journal-title":"Foods (Basel Switz)"},{"key":"10.1016\/j.repbio.2025.101096_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.168254","article-title":"Gut toxicity of polystyrene microplastics and polychlorinated biphenyls to Eisenia fetida: single and co-exposure effects with a focus on links between gut bacteria and bacterial translocation stemming from gut barrier damage","volume":"908","author":"Li","year":"2024","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.repbio.2025.101096_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115000","article-title":"Polystyrene micro- and nanoparticles exposure induced anxiety-like behaviors, gut microbiota dysbiosis and metabolism disorder in adult mice","volume":"259","author":"Chen","year":"2023","journal-title":"Ecotox Environ Safe"},{"key":"10.1016\/j.repbio.2025.101096_bib68","article-title":"Polystyrene microplastics exacerbate systemic inflammation in high-fat diet-induced obesity","volume":"24","author":"Lee","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101096_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124028","article-title":"Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice","volume":"405","author":"Hou","year":"2021","journal-title":"J Hazard Mater"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X25001032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X25001032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:29:15Z","timestamp":1787725755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X25001032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1642431X25001032"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2025.101096","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mouse model of induced sperm DNA damage caused by polystyrene microplastics exhibited distinct transcriptomic and proteomic features","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2025.101096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn.","name":"copyright","label":"Copyright"}],"article-number":"101096"}}