{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:23:03Z","timestamp":1787728983039,"version":"build-2784847793"},"reference-count":200,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.repbio.2025.101175","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T15:58:47Z","timestamp":1767196727000},"page":"101175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exosomal ncRNAs in seminal fluid: Unraveling their regulatory roles in male infertility"],"prefix":"10.1016","volume":"26","author":[{"given":"Marwah Suliman","family":"Maashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2025.101175_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41572-023-00459-w","article-title":"Male infertility","volume":"9","author":"Eisenberg","year":"2023","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.repbio.2025.101175_bib2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/bs.acc.2019.08.004","article-title":"Exosomes of male reproduction","volume":"95","author":"Baskaran","year":"2020","journal-title":"Adv Clin Chem"},{"key":"10.1016\/j.repbio.2025.101175_bib3","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.3390\/ijms21155377","article-title":"The role of the epididymis and the contribution of epididymosomes to mammalian reproduction","volume":"21","author":"James","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib4","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ijbiomac.2019.09.218","article-title":"Human prostasomes an extracellular vesicle\u2013Biomarkers for male infertility and prostrate cancer: The journey from identification to current knowledge","volume":"146","author":"Vickram","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.repbio.2025.101175_bib5","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.3390\/ijms20225573","article-title":"Mechanisms and functions of long non-coding RNAs at multiple regulatory levels","volume":"20","author":"Zhang","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib6","article-title":"Exploring the Characters of Non-Coding RNAs in Spermatogenesis and Male Infertility","volume":"26","author":"Yan","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib7","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1007\/s43032-023-01252-6","article-title":"Assisted Reproductive Techniques and Risk of Congenital Heart Diseases in Children: a Systematic Review and Meta-analysis","volume":"30","author":"Gullo","year":"2023","journal-title":"Reprod Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib8","article-title":"Decoding the Puzzle of Male Infertility: The Role of Infection, Inflammation, and Autoimmunity","volume":"15","author":"Sciorio","year":"2025","journal-title":"Diagn (Basel)"},{"key":"10.1016\/j.repbio.2025.101175_bib9","first-page":"485","article-title":"Myo-inositol: from induction of ovulation to menopausal disorder management","volume":"67","author":"Gullo","year":"2015","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.repbio.2025.101175_bib10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.rbmo.2011.10.011","article-title":"Cryptic sperm defects may be the cause for total fertilization failure in oocyte donor cycles","volume":"24","author":"Goudakou","year":"2012","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.repbio.2025.101175_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2019.01.015","article-title":"The regulation of Endosomal Sorting Complex Required for Transport and accessory proteins in multivesicular body sorting and enveloped viral budding-An overview","volume":"127","author":"Ahmed","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.repbio.2025.101175_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202100276","article-title":"Bro1 family proteins harmonize cargo sorting with vesicle formation","volume":"44","author":"Tseng","year":"2022","journal-title":"Bioessays"},{"key":"10.1016\/j.repbio.2025.101175_bib13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1126\/science.1153124","article-title":"Ceramide triggers budding of exosome vesicles into multivesicular endosomes","volume":"319","author":"Trajkovic","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.repbio.2025.101175_bib14","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.3390\/v7092862","article-title":"Exosome biogenesis, regulation, and function in viral infection","volume":"7","author":"Alenquer","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.repbio.2025.101175_bib15","article-title":"Exosomes: New regulators of reproductive development","volume":"19","author":"Chen","year":"2023","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.repbio.2025.101175_bib16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s13238-018-0529-4","article-title":"Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes","volume":"10","author":"Cheng","year":"2019","journal-title":"Protein Cell"},{"key":"10.1016\/j.repbio.2025.101175_bib17","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/andr.12412","article-title":"Comprehensive proteomics analysis of exosomes derived from human seminal plasma","volume":"5","author":"Yang","year":"2017","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib18","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/mrd.23224","article-title":"Proteomic analysis of seminal extracellular vesicle proteins involved in asthenozoospermia by iTRAQ","volume":"86","author":"Lin","year":"2019","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.repbio.2025.101175_bib19","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.3390\/ijms21197022","article-title":"Exosome composition and seminal plasma proteome: a promising source of biomarkers of male infertility","volume":"21","author":"Candenas","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26199301","article-title":"Lipid Signature of Motile Human Sperm: Characterization of Sphingomyelin, Ceramide, and Phospholipids with a Focus on Very Long Chain Polyunsaturated Fatty Acids","volume":"26","author":"Oresti","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib21","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3390\/biology14020198","article-title":"Unlocking Gamete Quality Through Extracellular Vesicles: Emerging Perspectives","volume":"14","author":"Dlamini","year":"2025","journal-title":"Biology"},{"key":"10.1016\/j.repbio.2025.101175_bib22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.theriogenology.2020.11.015","article-title":"Changes in miRNA levels of sperm and small extracellular vesicles of seminal plasma are associated with transient scrotal heat stress in bulls","volume":"161","author":"Alves","year":"2021","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2025.101175_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112752","article-title":"Exosomes\u2013Spectacular role in reproduction","volume":"148","author":"Kowalczyk","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.repbio.2025.101175_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31202","article-title":"Regulation of spermatogonial stem cell differentiation by Sertoli cells-derived exosomes through paracrine and autocrine signaling","volume":"239","author":"Tian","year":"2024","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.repbio.2025.101175_bib25","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2741\/s450","article-title":"Epididymosomes: role of extracellular microvesicles in sperm maturation","volume":"8","author":"Sullivan","year":"2016","journal-title":"Front Biosci (Sch Ed)"},{"key":"10.1016\/j.repbio.2025.101175_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/srep31794","article-title":"Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome","volume":"6","author":"Reilly","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2025.101175_bib27","doi-asserted-by":"crossref","DOI":"10.2741\/4466","article-title":"Prostasomes, post-testicular sperm maturation and fertility","volume":"21","author":"Saez","year":"2016","journal-title":"Front Biosci"},{"key":"10.1016\/j.repbio.2025.101175_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-021-00792-1","article-title":"Communication between cells: exosomes as a delivery system in prostate cancer","volume":"19","author":"Giovannelli","year":"2021","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.repbio.2025.101175_bib29","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/978-3-031-82990-1_14","article-title":"The Biology and Regulation of Spermatogonial Stem Cells in the Niche","volume":"1469","author":"Zheng","year":"2025","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.repbio.2025.101175_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.895528","article-title":"Roles of Spermatogonial Stem Cells in Spermatogenesis and Fertility Restoration","volume":"13","author":"Diao","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.repbio.2025.101175_bib31","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humrep\/deac015","article-title":"Sperm acquire epididymis-derived proteins through epididymosomes","volume":"37","author":"Barrachina","year":"2022","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib32","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3390\/genes13071291","article-title":"Further Insights on RNA Expression and Sperm Motility.","volume":"13","author":"Silva","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.repbio.2025.101175_bib33","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.fertnstert.2019.01.030","article-title":"Seminal plasma of men with severe asthenozoospermia contain exosomes that affect spermatozoa motility and capacitation","volume":"111","author":"Murdica","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2025.101175_bib34","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1095\/biolreprod.102.013771","article-title":"Inhibition of capacitation-associated tyrosine phosphorylation signaling in rat sperm by epididymal protein Crisp-1","volume":"69","author":"Roberts","year":"2003","journal-title":"Biol Reprod"},{"issue":"e0139110","key":"10.1016\/j.repbio.2025.101175_bib35","article-title":"Seminal CD38 enhances human sperm capacitation through its interaction with CD31","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.repbio.2025.101175_bib36","article-title":"Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications","volume":"12","author":"Xie","year":"2022","journal-title":"Membr (Basel)"},{"key":"10.1016\/j.repbio.2025.101175_bib37","first-page":"75","article-title":"Exosome RNA sequencing as a tool in the search for cancer biomarkers","volume":"8","author":"Elkommos-Zakhary","year":"2022","journal-title":"Noncoding RNA"},{"key":"10.1016\/j.repbio.2025.101175_bib38","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/humrep\/dey072","article-title":"Exosomal microRNAs in seminal plasma are markers of the origin of azoospermia and can predict the presence of sperm in testicular tissue","volume":"33","author":"Barcel\u00f3","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib39","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.3390\/jcm14113930","article-title":"Male Infertility and Reduced Life Expectancy: Epidemiology, Mechanisms, and Clinical Implications","volume":"14","author":"Kaltsas","year":"2025","journal-title":"J Clin Med"},{"key":"10.1016\/j.repbio.2025.101175_bib40","article-title":"Seminal Plasma Exosomes in Male Infertility: Roles, Mechanisms, and Applications\u2014A Double-EdgedSword","volume":"43","author":"Wang","year":"2025","journal-title":"World J Mens Health"},{"key":"10.1016\/j.repbio.2025.101175_bib41","first-page":"4419","article-title":"An association of boswellia, betaine and myo-inositol (Eumast\u00f3s) in the treatment of mammographic breast density: a randomized, double-blind study","volume":"19","author":"Pasta","year":"2015","journal-title":"Eur Rev Med Pharm Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib42","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2174\/1566524021666210211114453","article-title":"Regenerative Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles","volume":"22","author":"Thalakiriyawa","year":"2022","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.repbio.2025.101175_bib43","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/humrep\/dead015","article-title":"The emerging role of extracellular vesicles in the testis","volume":"38","author":"Ma","year":"2023","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib44","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12938-025-01424-2","article-title":"The synergic impact of decellularized testis scaffold and extracellular vesicles derived from human semen on spermatogonial stem cell survival and differentiation","volume":"24","author":"Afshari","year":"2025","journal-title":"Biomed Eng Online"},{"key":"10.1016\/j.repbio.2025.101175_bib45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s41065-024-00346-8","article-title":"Circular RNAs: novel noncoding players in male infertility","volume":"161","author":"Babakhanzadeh","year":"2024","journal-title":"Hereditas"},{"key":"10.1016\/j.repbio.2025.101175_bib46","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1016\/j.sjbs.2021.03.038","article-title":"Seminal exosomes - An important biological marker for various disorders and syndrome in human reproduction","volume":"28","author":"Vickram","year":"2021","journal-title":"Saudi J Biol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.736864","article-title":"MicroRNA-222 Transferred From Semen Extracellular Vesicles Inhibits Sperm Apoptosis by Targeting BCL2L11","volume":"9","author":"Ding","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.repbio.2025.101175_bib48","doi-asserted-by":"crossref","DOI":"10.1186\/s40246-025-00742-9","article-title":"A comparison of the expression patterns and diagnostic capability of the ncRNAs NEAT1 and miR-34a in non-obstructive azoospermia and severe oligospermia","volume":"19","author":"Salman","year":"2025","journal-title":"Hum Genom"},{"key":"10.1016\/j.repbio.2025.101175_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25010460","article-title":"The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?","volume":"25","author":"Klees","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib50","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.omtn.2018.11.004","article-title":"miRNA-31-5p mediates the proliferation and apoptosis of human spermatogonial stem cells via targeting JAZF1 and cyclin A2","volume":"14","author":"Fu","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.repbio.2025.101175_bib51","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/molbev\/msp284","article-title":"Evolution of an X-linked primate-specific micro RNA cluster","volume":"27","author":"Li","year":"2010","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.repbio.2025.101175_bib52","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.theriogenology.2021.09.031","article-title":"Small RNA expression patterns in seminal plasma exosomes isolated from semen containing spermatozoa with cytoplasmic droplets versus regular exosomes in boar semen","volume":"176","author":"Sun","year":"2021","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2025.101175_bib53","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.theriogenology.2023.11.028","article-title":"Motility-related microRNAs identified in pig seminal plasma exosomes by high-throughput small RNA sequencing","volume":"215","author":"Zhao","year":"2024","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2025.101175_bib54","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1089\/bio.2023.0135","article-title":"Apoptotic-Related MiRNAs correlated with functional and flow cytometric parameters in asthenozoospermic Holstein bulls after freeze\u2013thaw process","volume":"22","author":"Taravat","year":"2024","journal-title":"Biopreservation Biobanking"},{"key":"10.1016\/j.repbio.2025.101175_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103928","article-title":"Identification of potential candidate miRNAs related to semen quality in seminal plasma extracellular vesicles and sperms of male duck (Anas platyrhynchos)","volume":"103","author":"Luo","year":"2024","journal-title":"Poult Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib56","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10815-018-1326-y","article-title":"The role of microRNAs in human embryo implantation: a review","volume":"36","author":"Paul","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.repbio.2025.101175_bib57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/andr.12714","article-title":"The role of miRNAs in male human reproduction: A systematic review","volume":"8","author":"Salas-Huetos","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib58","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s41366-018-0114-1","article-title":"MicroRNA-30 modulates metabolic inflammation by regulating Notch signaling in adipose tissue macrophages","volume":"42","author":"Miranda","year":"2018","journal-title":"Int J Obes"},{"key":"10.1016\/j.repbio.2025.101175_bib59","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mod.2016.03.002","article-title":"MicroRNA-10 modulates Hox genes expression during Nile tilapia embryonic development","volume":"140","author":"Giusti","year":"2016","journal-title":"Mech Dev"},{"issue":"5","key":"10.1016\/j.repbio.2025.101175_bib60","doi-asserted-by":"crossref","first-page":"591","DOI":"10.4103\/1008-682X.185001","article-title":"MicroRNA-27a-mediated repression of cysteine-rich secretory protein 2 translation in asthenoteratozoospermic patients","volume":"19","author":"Zhou","year":"2017","journal-title":"Asian J Androl"},{"key":"10.1016\/j.repbio.2025.101175_bib61","article-title":"Cell-free seminal mRNA and microRNA exist in different forms","volume":"7","author":"Li","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.repbio.2025.101175_bib62","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1093\/nar\/gku347","article-title":"Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions","volume":"42","author":"Vojtech","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.repbio.2025.101175_bib63","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.3390\/ani12182360","article-title":"Investigation of sperm and seminal plasma candidate microRNAs of bulls with differing fertility and in silico prediction of miRNA-mRNA interaction network of reproductive function","volume":"12","author":"Kasimanickam","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.repbio.2025.101175_bib64","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.3390\/ijms21114089","article-title":"FH. Optimization of microRNA acquirement from seminal plasma and identification of diminished seminal microRNA-34b as indicator of low semen concentration","volume":"21","author":"Eikmans","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib65","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.theriogenology.2023.06.020","article-title":"Characterization and identification of extracellular vesicles-coupled miRNA profiles in seminal plasma of fertile and subfertile rabbit bucks","volume":"209","author":"Sakr","year":"2023","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2025.101175_bib66","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1242\/bio.201410959","article-title":"mir-34b\/c and mir-449a\/b\/c are required for spermatogenesis, but not for the first cleavage division in mice","volume":"4","author":"Yuan","year":"2015","journal-title":"Biol Open"},{"key":"10.1016\/j.repbio.2025.101175_bib67","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1530\/REP-17-0441","article-title":"Profiling of miRNAs in porcine germ cells during spermatogenesis","volume":"154","author":"Chen","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2025.101175_bib68","doi-asserted-by":"crossref","first-page":"445","DOI":"10.5194\/aab-58-445-2015","article-title":"Molecular cloning, sequence identification, polymorphism and association of the porcine SPATS2L gene","volume":"58","author":"Yang","year":"2015","journal-title":"Arch Anim Breed"},{"key":"10.1016\/j.repbio.2025.101175_bib69","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1084\/jem.20131379","article-title":"Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function","volume":"211","author":"Kumar","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.repbio.2025.101175_bib70","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.3390\/ijms24043194","article-title":"Characterization of extracellular vesicle-coupled miRNA profiles in seminal plasma of boars with divergent semen quality status","volume":"24","author":"Dlamini","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.736864","article-title":"MicroRNA-222 transferred from semen extracellular vesicles inhibits sperm apoptosis by targeting BCL2L11","volume":"9","author":"Ding","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.repbio.2025.101175_bib72","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20194041","article-title":"RNA-sequencing and bioinformatics analysis of long noncoding RNAs and mRNAs in the asthenozoospermia","volume":"40","author":"Lu","year":"2020","journal-title":"Biosci Rep"},{"key":"10.1016\/j.repbio.2025.101175_bib73","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1093\/humrep\/deaa184","article-title":"A panel of extracellular vesicle long noncoding RNAs in seminal plasma for predicting testicular spermatozoa in nonobstructive azoospermia patients","volume":"35","author":"Xie","year":"2020","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib74","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/brv.12498","article-title":"Nuclear envelope dynamics during mammalian spermatogenesis: new insights on male fertility","volume":"94","author":"Pereira","year":"2019","journal-title":"Biol Rev"},{"key":"10.1016\/j.repbio.2025.101175_bib75","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3390\/ijms26031096","article-title":"Multi-Omics Sequencing Dissects the Atlas of Seminal Plasma Exosomes from Semen Containing Low or High Rates of Sperm with Cytoplasmic Droplets","volume":"26","author":"Zhang","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib76","first-page":"104","article-title":"Identification of important extracellular vesicle RNA molecules related to sperm motility and prostate cancer","volume":"2","author":"Zhang","year":"2021","journal-title":"Extracell Vesicles Circ Nucleic Acids"},{"key":"10.1016\/j.repbio.2025.101175_bib77","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1038\/s41598-020-64711-z","article-title":"Identification of circular RNAs in porcine sperm and evaluation of their relation to sperm motility","volume":"10","author":"G\u00f2dia","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2025.101175_bib78","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1128\/MCB.00160-16","article-title":"BAR domain-containing FAM92 proteins interact with Chibby1 to facilitate ciliogenesis","volume":"36","author":"Li","year":"2016","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.repbio.2025.101175_bib79","doi-asserted-by":"crossref","first-page":"5774","DOI":"10.3168\/jds.2014-8951","article-title":"Genome-wide association study for semen production traits in Holstein-Friesian bulls","volume":"98","author":"Suchocki","year":"2015","journal-title":"J Dairy Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib80","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.stem.2012.12.014","article-title":"ACTL6a enforces the epidermal progenitor state by suppressing SWI\/SNF-dependent induction of KLF4","volume":"12","author":"Bao","year":"2013","journal-title":"Cell stem Cell"},{"key":"10.1016\/j.repbio.2025.101175_bib81","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1242\/jcs.02326","article-title":"Evidence of the presence of calcium\/calmodulin-dependent protein kinase IV in human sperm and its involvement in motility regulation","volume":"118","author":"Mar\u00edn-Briggiler","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib82","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/mrd.22536","article-title":"Spata19 is critical for sperm mitochondrial function and male fertility","volume":"82","author":"Mi","year":"2015","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.repbio.2025.101175_bib83","doi-asserted-by":"crossref","DOI":"10.1111\/and.13814","article-title":"Preliminary investigation of the function of hsa_circ_0049356 in nonobstructive azoospermia patients","volume":"52","author":"Liu","year":"2020","journal-title":"Andrologia"},{"key":"10.1016\/j.repbio.2025.101175_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26062614","article-title":"Epididymal-Born circRNA Cargo and Its Implications in Male Fertility","volume":"26","author":"Manfrevola","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib85","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.repbio.2025.101175_bib86","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00018-021-04054-8","article-title":"FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development","volume":"79","author":"Chioccarelli","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1293368","article-title":"MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers","volume":"15","author":"Shi","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.repbio.2025.101175_bib88","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/humrep\/dey072","article-title":"Exosomal microRNAs in seminal plasma are markers of the origin of azoospermia and can predict the presence of sperm in testicular tissue","volume":"33","author":"Barcel\u00f3","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib89","doi-asserted-by":"crossref","first-page":"56839","DOI":"10.18632\/oncotarget.18076","article-title":"Dysregulation of an X-linked primate-specific epididymal microRNA cluster in unexplained asthenozoospermia","volume":"8","author":"Qing","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.repbio.2025.101175_bib90","doi-asserted-by":"crossref","DOI":"10.1038\/srep17743","article-title":"Mitochondria-related miR-151a-5p reduces cellular ATP production by targeting CYTB in asthenozoospermia","volume":"5","author":"Zhou","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2025.101175_bib91","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.gene.2018.04.022","article-title":"Down-regulated let-7b-5p represses glycolysis metabolism by targeting AURKB in asthenozoospermia","volume":"663","author":"Zhou","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.repbio.2025.101175_bib92","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1530\/REP-13-0656","article-title":"Expressions of miR-15a and its target gene HSPA1B in the spermatozoa of patients with varicocele","volume":"147","author":"Ji","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2025.101175_bib93","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.fertnstert.2012.11.054","article-title":"Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments","volume":"99","author":"Abu-Halima","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2025.101175_bib94","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.bbrc.2018.05.017","article-title":"Bisphenol A-elicited miR-146a-5p impairs murine testicular steroidogenesis through negative regulation of Mta3 signaling","volume":"501","author":"Gao","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.repbio.2025.101175_bib95","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/andr.12913","article-title":"Seminal exosomal miR-210-3p as a potential marker of Sertoli cell damage in Varicocele","volume":"9","author":"Ma","year":"2021","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/genes11030320","article-title":"Genome-Wide Analysis and Function Prediction of Long Noncoding RNAs in Sheep Pituitary Gland Associated with Sexual Maturation","volume":"11","author":"Yang","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.repbio.2025.101175_bib97","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.theriogenology.2021.09.031","article-title":"Small RNA expression patterns in seminal plasma exosomes isolated from semen containing spermatozoa with cytoplasmic droplets versus regular exosomes in boar semen","volume":"176","author":"Sun","year":"2021","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2025.101175_bib98","first-page":"686","article-title":"[The miR-184 level in the seminal plasma exosome of male infertility patients and its clinical significance","volume":"26","author":"Zhu","year":"2020","journal-title":"Zhonghua Nan Ke Xue"},{"key":"10.1016\/j.repbio.2025.101175_bib99","article-title":"miR-424\/322 is downregulated in the semen of patients with severe DNA damage and may regulate sperm DNA damage","author":"Zhao","year":"2015","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.repbio.2025.101175_bib100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.theriogenology.2020.11.015","article-title":"Changes in miRNA levels of sperm and small extracellular vesicles of seminal plasma are associated with transient scrotal heat stress in bulls","volume":"161","author":"Alves","year":"2021","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2025.101175_bib101","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/andr.13295","article-title":"Altered non-coding RNA profiles of seminal plasma extracellular vesicles of men with poor semen quality undergoing in vitro fertilization treatment","volume":"11","author":"Oluwayiose","year":"2023","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib102","article-title":"The Role of Long Noncoding RNAs on Male Infertility: A Systematic Review and In Silico Analysis","volume":"11","author":"Kyrgiafini","year":"2022","journal-title":"Biol (Basel)"},{"key":"10.1016\/j.repbio.2025.101175_bib103","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/biolre\/ioy253","article-title":"Expression profiles and characteristics of human lncRNA in normal and asthenozoospermia sperm","volume":"100","author":"Zhang","year":"2019","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib104","first-page":"14198","article-title":"Low long non-coding RNA HOTAIR expression is associated with down-regulation of Nrf2 in the spermatozoa of patients with asthenozoospermia or oligoasthenozoospermia","volume":"8","author":"Zhang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.repbio.2025.101175_bib105","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.4149\/neo_2020_191010N1024","article-title":"LncRNA RUSC1-AS1 promotes the proliferation of hepatocellular carcinoma cells through modulating NOTCH signaling","volume":"67","author":"Chen","year":"2020","journal-title":"Neoplasma"},{"key":"10.1016\/j.repbio.2025.101175_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2024.110819","article-title":"Integrated analysis of lncRNA, miRNA and mRNA expression profiles reveals regulatory pathways associated with pig testis function","volume":"116","author":"Wang","year":"2024","journal-title":"Genomics"},{"key":"10.1016\/j.repbio.2025.101175_bib107","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3892\/etm.2022.11586","article-title":"Functional prediction and profiling of exosomal circRNAs derived from seminal plasma for the diagnosis and treatment of oligoasthenospermia","volume":"24","author":"Yue","year":"2022","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.repbio.2025.101175_bib108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12958-019-0541-4","article-title":"CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia","volume":"17","author":"Ge","year":"2019","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.repbio.2025.101175_bib109","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/15548627.2019.1628539","article-title":"Group A Streptococcus modulates RAB1-and PIK3C3 complex-dependent autophagy","volume":"16","author":"Toh","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.repbio.2025.101175_bib110","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/andr.12874","article-title":"Dx. Over-expression of hsa_circ_0000116 in patients with non-obstructive azoospermia and its predictive value in testicular sperm retrieval","volume":"8","author":"Lv","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib111","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.18632\/aging.102765","article-title":"Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia","volume":"12","author":"Bo","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.repbio.2025.101175_bib112","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1038\/s41598-020-64711-z","article-title":"Identification of circular RNAs in porcine sperm and evaluation of their relation to sperm motility","volume":"10","author":"G\u00f2dia","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2025.101175_bib113","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S1472-6483(10)60677-3","article-title":"Male infertility: role of genetic background","volume":"14","author":"Ferlin","year":"2007","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.repbio.2025.101175_bib114","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fendo.2019.00435","article-title":"Expression Patterns of Circular RNAs in High Quality and Poor Quality Human Spermatozoa","volume":"10","author":"Chioccarelli","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.repbio.2025.101175_bib115","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.ygeno.2021.04.022","article-title":"Trace the profile and function of circular RNAs in Sertoli cell only syndrome","volume":"113","author":"Zhu","year":"2021","journal-title":"Genomics"},{"key":"10.1016\/j.repbio.2025.101175_bib116","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb7426","article-title":"Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline","volume":"6","author":"Gao","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.repbio.2025.101175_bib117","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4842316","article-title":"The Role of Cell and Gene Therapies in the Treatment of Infertility in Patients with Thyroid Autoimmunity","volume":"2022","author":"Medenica","year":"2022","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.repbio.2025.101175_bib118","first-page":"6809","article-title":"Fresh vs. frozen embryo transfer in assisted reproductive techniques: a single center retrospective cohort study and ethical-legal implications","volume":"27","author":"Gullo","year":"2023","journal-title":"Eur Rev Med Pharm Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib119","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065447","article-title":"Using Small Non-Coding RNAs in Extracellular Vesicles of Semen as Biomarkers of Male Reproductive System Health: Opportunities and Challenges","volume":"24","author":"Larriba","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib120","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/biolre\/ioae130","article-title":"Profiling of circulating extracellular vesicle microRNAs reveals diagnostic potential and pathways in non-obstructive and obstructive azoospermia","volume":"111","author":"Qi","year":"2024","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib121","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.fertnstert.2016.06.030","article-title":"Altered micro-ribonucleic acid expression profiles of extracellular microvesicles in the seminal plasma of patients with oligoasthenozoospermia","volume":"106","author":"Abu-Halima","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2025.101175_bib122","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/andr.13461","article-title":"Seminal extracellular vesicle sncRNA sequencing reveals altered miRNA\/isomiR profiles as sperm retrieval biomarkers for azoospermia","volume":"12","author":"Larriba","year":"2024","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib123","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.3390\/ijms21175949","article-title":"Impact of extracellular vesicle isolation methods on downstream mirna analysis in semen: a comparative study","volume":"21","author":"Mercadal","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib124","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50172-6","article-title":"Semen miRNAs contained in exosomes as non-invasive biomarkers for prostate cancer diagnosis","volume":"9","author":"Barcel\u00f3","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2025.101175_bib125","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/andr.12276","article-title":"Spermatozoa from normozoospermic fertile and infertile individuals convey a distinct miRNA cargo","volume":"4","author":"Salas-Huetos","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib126","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/andr.12246","article-title":"Micro RNA expression profiles in testicular biopsies of patients with impaired spermatogenesis","volume":"4","author":"Noveski","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib127","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.fertnstert.2015.06.015","article-title":"Spermatozoa from patients with seminal alterations exhibit a differential micro-ribonucleic acid profile","volume":"104","author":"Salas-Huetos","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2025.101175_bib128","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/molehr\/gas022","article-title":"Seminal plasma microRNAs: potential biomarkers for spermatogenesis status","volume":"18","author":"Wu","year":"2012","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib129","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1093\/humrep\/det099","article-title":"Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p","volume":"28","author":"Wu","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib130","first-page":"246","article-title":"Seminal plasma ExLncRNA pairs: updating perspectives in the search for testicular spermatozoa retrieval biomarkers in nonobstructive azoospermia patients with mTESE by WGCNA","volume":"20","author":"Cao","year":"2023","journal-title":"Urol J"},{"key":"10.1016\/j.repbio.2025.101175_bib131","first-page":"1","article-title":"Evaluation of circANKLE2 & circL3MBTL4-RNAs Expression in Fertile and Infertile Men","author":"El-Gamal","year":"2024","journal-title":"Biochem Genet"},{"key":"10.1016\/j.repbio.2025.101175_bib132","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7555\/JBR.37.20230296","article-title":"Human circBOULE RNAs as potential biomarkers for sperm quality and male infertility","volume":"38","author":"Cheng","year":"2024","journal-title":"J Biomed Res"},{"key":"10.1016\/j.repbio.2025.101175_bib133","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1093\/humrep\/deab196","article-title":"Potential of testis-derived circular RNAs in seminal plasma to predict the outcome of microdissection testicular sperm extraction in patients with idiopathic non-obstructive azoospermia","volume":"36","author":"Ji","year":"2021","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib134","article-title":"Expression Analysis of Circular RNAs in Young and Sexually Mature Boar Testes","volume":"11","author":"Zhang","year":"2021","journal-title":"Anim (Basel)"},{"key":"10.1016\/j.repbio.2025.101175_bib135","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.785622","article-title":"Mesenchymal stem-cell derived exosome therapy as a potential future approach for treatment of male infertility caused by Chlamydia infection","volume":"12","author":"Izadi","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.repbio.2025.101175_bib136","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.reprotox.2013.07.024","article-title":"Mesenchymal stem cell derived microvesicles: trophic shuttles for enhancement of sperm quality parameters","volume":"42","author":"Mokarizadeh","year":"2013","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.repbio.2025.101175_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.758206","article-title":"The Emerging Roles and Therapeutic Potential of Extracellular Vesicles in Infertility","volume":"12","author":"Zhou","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.repbio.2025.101175_bib138","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092460","article-title":"The Role of Stem Cells and Their Derived Extracellular Vesicles in Restoring Female and Male Fertility","volume":"10","author":"Qamar","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.repbio.2025.101175_bib139","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s10565-025-10006-w","article-title":"The microRNA-mediated apoptotic signaling axis in male reproduction: a possible and targetable culprit in male infertility","volume":"41","author":"Yu","year":"2025","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.repbio.2025.101175_bib140","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/1471-2164-14-319","article-title":"Characterization of human plasma-derived exosomal RNAs by deep sequencing","volume":"14","author":"Huang","year":"2013","journal-title":"BMC Genom"},{"key":"10.1016\/j.repbio.2025.101175_bib141","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.theriogenology.2023.02.011","article-title":"Exosome-derived Small RNAs in mouse Sertoli cells inhibit spermatogonial apoptosis","volume":"200","author":"Gao","year":"2023","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2025.101175_bib142","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s11626-016-0102-5","article-title":"LncRNA AK015322 promotes proliferation of spermatogonial stem cell C18-4 by acting as a decoy for microRNA-19b-3p","volume":"53","author":"Hu","year":"2017","journal-title":"Vitr Cell Dev Biol Anim"},{"key":"10.1016\/j.repbio.2025.101175_bib143","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.267","article-title":"Downregulation of miR-320a\/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation","volume":"6","author":"L\u00fc","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.repbio.2025.101175_bib144","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.700290","article-title":"Structural and Functional Characterization of a Testicular Long Non-coding RNA (4930463O16Rik) Identified in the Meiotic Arrest of the Mouse Topaz1 (-\/-) Testes","volume":"9","author":"Chadourne","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.repbio.2025.101175_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104528","article-title":"Investigating the regulatory function of the ANO1-AS2 on the ANO1 gene in infertile men with asthenozoospermia and terato-asthenozoospermia","volume":"117","author":"Saberiyan","year":"2020","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.repbio.2025.101175_bib146","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s43032-020-00275-7","article-title":"Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility","volume":"28","author":"Saberiyan","year":"2021","journal-title":"Reprod Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2023.103833","article-title":"Exosome- based technologies as a platform for diagnosis and treatment of male and female infertility-related diseases","volume":"156","author":"Jahanbani","year":"2023","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.repbio.2025.101175_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116840","article-title":"Recent advances in exosomal RNAs analysis towards diagnostic and therapeutic applications","volume":"158","author":"Yin","year":"2023","journal-title":"TrAC Trends Anal Chem"},{"key":"10.1016\/j.repbio.2025.101175_bib149","article-title":"Artificial Intelligence in Assisted Reproductive Technology: A New Era in Fertility Treatment","volume":"17","author":"Orovou","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.repbio.2025.101175_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2023.103833","article-title":"Exosome-based technologies as a platform for diagnosis and treatment of male and female infertility-related diseases","volume":"156","author":"Jahanbani","year":"2023","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.repbio.2025.101175_bib151","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.fsigen.2017.12.010","article-title":"Semen-specific miRNAs: Suitable for the distinction of infertile semen in the body fluid identification?","volume":"33","author":"Tian","year":"2018","journal-title":"Forensic Sci Int Genet"},{"key":"10.1016\/j.repbio.2025.101175_bib152","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1089\/dna.2023.0314","article-title":"MicroRNAs in Male Fertility","volume":"43","author":"Bahmyari","year":"2024","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.repbio.2025.101175_bib153","doi-asserted-by":"crossref","DOI":"10.1111\/and.14298","article-title":"Using microRNAs as molecular biomarkers for the evaluation of male infertility","volume":"54","author":"Asadpour","year":"2022","journal-title":"Andrologia"},{"key":"10.1016\/j.repbio.2025.101175_bib154","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1111\/jcmm.16347","article-title":"Sertoli cell-derived exosomal MicroRNA-486-5p regulates differentiation of spermatogonial stem cell through PTEN in mice","volume":"25","author":"Li","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.repbio.2025.101175_bib155","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1186\/s12864-024-10836-8","article-title":"Whole transcriptome sequencing of testis and epididymis reveals genes associated with sperm development in roosters","volume":"25","author":"Guo","year":"2024","journal-title":"BMC Genom"},{"key":"10.1016\/j.repbio.2025.101175_bib156","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3389\/fcell.2020.00791","article-title":"From Sperm Motility to Sperm-Borne microRNA Signatures: New Approaches to Predict Male Fertility Potential","volume":"8","author":"Alves","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.repbio.2025.101175_bib157","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/14647273.2018.1562241","article-title":"Altered microRNAs expression levels of sperm and seminal plasma in patients with infertile ejaculates compared with normozoospermic males","volume":"23","author":"Mok\u00e1nszki","year":"2020","journal-title":"Hum Fertil (Camb)"},{"key":"10.1016\/j.repbio.2025.101175_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108414","article-title":"MicroRNA\u201130a\u20115p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro","volume":"119","author":"Wang","year":"2023","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.repbio.2025.101175_bib159","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/genes11030320","article-title":"Genome-wide analysis and function prediction of long noncoding RNAs in sheep pituitary gland associated with sexual maturation","volume":"11","author":"Yang","year":"2020","journal-title":"Genes"},{"key":"10.1016\/j.repbio.2025.101175_bib160","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103895","article-title":"Comprehensive analysis of the differential expression of mRNAs, lncRNAs, and miRNAs in Zi goose testis with high and low sperm mobility","volume":"103","author":"Hao","year":"2024","journal-title":"Poult Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib161","first-page":"961","article-title":"Hsa-miR-27a-3p overexpression in men with nonobstructive azoospermia: A case-control study","volume":"18","author":"Norioun","year":"2020","journal-title":"Int J Reprod Biomed"},{"key":"10.1016\/j.repbio.2025.101175_bib162","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/andr.12714","article-title":"The role of miRNAs in male human reproduction: a systematic review","volume":"8","author":"Salas-Huetos","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib163","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s43032-019-00025-4","article-title":"Expression and Methylation Pattern of hsa-miR-34 Family in Sperm Samples of Infertile Men","volume":"27","author":"Momeni","year":"2020","journal-title":"Reprod Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib164","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.709943","article-title":"Investigating the Role of the microRNA-34\/449 Family in Male Infertility: A Critical Analysis and Review of the Literature","volume":"12","author":"Pantos","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.repbio.2025.101175_bib165","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1210\/en.2018-00015","article-title":"An miR-200 Cluster on Chromosome 23 Regulates Sperm Motility in Zebrafish","volume":"159","author":"Xiong","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.repbio.2025.101175_bib166","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13508","article-title":"miR-125a-5p increases cellular DNA damage of aging males and perturbs stage-specific embryo development via Rbm38-p53 signaling","volume":"20","author":"Liang","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.repbio.2025.101175_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101558","article-title":"Epididymal mRNA and miRNA transcriptome analyses reveal important genes and miRNAs related to sperm motility in roosters","volume":"101","author":"Xing","year":"2022","journal-title":"Poult Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib168","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.703101","article-title":"A Combined Flow Cytometric Semen Analysis and miRNA Profiling as a Tool to Discriminate Between High- and Low-Fertility Bulls","volume":"8","author":"Turri","year":"2021","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib169","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20194041","article-title":"RNA-sequencing and bioinformatics analysis of long noncoding RNAs and mRNAs in the asthenozoospermia","volume":"40","author":"Lu","year":"2020","journal-title":"Biosci Rep"},{"key":"10.1016\/j.repbio.2025.101175_bib170","article-title":"Exploring the regulatory role of Linc00893 in asthenozoospermia: Insights into sperm motility and SSC viability","volume":"29","author":"Lu","year":"2024","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.repbio.2025.101175_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.humgen.2025.201431","article-title":"Investigating expression pattern of SPATA3-AS1 and SPATA42 lncRNAs in azoospermia","author":"Muttwaqi","year":"2025","journal-title":"Hum Gene"},{"key":"10.1016\/j.repbio.2025.101175_bib172","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12610-023-00184-0","article-title":"Seminal plasma biomarkers for predicting successful sperm retrieval in patients with nonobstructive azoospermia: a narrative review of human studies","volume":"33","author":"Li","year":"2023","journal-title":"Basic Clin Androl"},{"key":"10.1016\/j.repbio.2025.101175_bib173","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s43032-022-00885-3","article-title":"Circular RNAs: novel biomarkers in spermatogenesis defects and male infertility","volume":"30","author":"Saberiyan","year":"2023","journal-title":"Reprod Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib174","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/s42003-022-04263-2","article-title":"Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p","volume":"5","author":"Ding","year":"2022","journal-title":"Commun Biol"},{"key":"10.1016\/j.repbio.2025.101175_bib175","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/ijms26031128","article-title":"Exploring the characters of non-coding RNAs in spermatogenesis and male infertility","volume":"26","author":"Yan","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib176","doi-asserted-by":"crossref","first-page":"6865","DOI":"10.3390\/ijms24076865","article-title":"Novel insights into circRNA saga coming from spermatozoa and epididymis of HFD mice","volume":"24","author":"Manfrevola","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib177","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201617","article-title":"Loss of circSRY reduces \u03b3H2AX level in germ cells and impairs mouse spermatogenesis","volume":"6","author":"Song","year":"2023","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.repbio.2025.101175_bib178","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00018-021-04054-8","article-title":"FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development","volume":"79","author":"Chioccarelli","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib179","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/andr.13286","article-title":"Experimental validation of seminal miR-31-5p as biomarker for azoospermia and evaluation of the effect of preanalytical variables","volume":"11","author":"Plata-Pe\u00f1a","year":"2023","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib180","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/19396368.2021.1951890","article-title":"microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials","volume":"67","author":"Rastgar Rezaei","year":"2021","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.repbio.2025.101175_bib181","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/andr.12913","article-title":"Seminal exosomal miR-210-3p as a potential marker of Sertoli cell damage in Varicocele","volume":"9","author":"Ma","year":"2021","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2025.101175_bib182","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.7150\/jca.41888","article-title":"MiR-142-3p functions as an oncogene in prostate cancer by targeting FOXO1","volume":"11","author":"Tan","year":"2020","journal-title":"J Cancer"},{"key":"10.1016\/j.repbio.2025.101175_bib183","doi-asserted-by":"crossref","DOI":"10.3390\/cells13010084","article-title":"miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities","volume":"13","author":"Huang","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.repbio.2025.101175_bib184","doi-asserted-by":"crossref","DOI":"10.3390\/biom15081156","article-title":"A Brief Review of MicroRNA Profiling in Human Prostate Cancer Tissues and Plasma","volume":"15","author":"Kallinikas","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.repbio.2025.101175_bib185","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1111\/jcmm.14219","article-title":"The latest progress on miR-374 and its functional implications in physiological and pathological processes","volume":"23","author":"Bian","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.repbio.2025.101175_bib186","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.21037\/apm-21-343","article-title":"The role of miR-27b-3p\/HOXA10 axis in the pathogenesis of endometriosis","volume":"10","author":"Li","year":"2021","journal-title":"Ann Palliat Med"},{"key":"10.1016\/j.repbio.2025.101175_bib187","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.fertnstert.2016.06.030","article-title":"Altered micro-ribonucleic acid expression profiles of extracellular microvesicles in the seminal plasma of patients with oligoasthenozoospermia","volume":"106","author":"Abu-Halima","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2025.101175_bib188","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26083537","article-title":"The Small RNA Landscape in Azoospermia: Implications for Male Infertility and Sperm Retrieval-A Preliminary Study","volume":"26","author":"Kyrgiafini","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2025.101175_bib189","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/1878-0261.13784","article-title":"MicroRNAs in seminal plasma are able to discern infertile men at increased risk of developing testicular cancer","volume":"19","author":"Ferrara","year":"2025","journal-title":"Mol Oncol"},{"key":"10.1016\/j.repbio.2025.101175_bib190","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1473825","article-title":"Differential abundance of microRNAs in seminal plasma extracellular vesicles (EVs) in Sahiwal cattle bull related to male fertility","volume":"12","author":"Chauhan","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.repbio.2025.101175_bib191","doi-asserted-by":"crossref","DOI":"10.1002\/uro2.70002","article-title":"Emerging trends in the management of non-obstructive azoospermia","author":"Saad","year":"2025","journal-title":"UroPrecision"},{"key":"10.1016\/j.repbio.2025.101175_bib192","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70288","article-title":"Transcriptomic miRNA and mRNA signatures in primary prostate cancer that are associated with lymph-node invasion","volume":"15","author":"Bustos","year":"2025","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.repbio.2025.101175_bib193","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/biolre\/ioae130","article-title":"Profiling of circulating extracellular vesicle microRNAs reveals diagnostic potential and pathways in non-obstructive and obstructive azoospermia\u2020","volume":"111","author":"Qi","year":"2024","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2025.101175_bib194","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12958-025-01497-7","article-title":"Genetic and epigenetic insights into non-obstructive azoospermia: mechanisms, biomarkers, and clinical perspectives","volume":"23","author":"Wang","year":"2025","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.repbio.2025.101175_bib195","article-title":"The gene regulatory role of non-coding RNAs in non-obstructive azoospermia","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.repbio.2025.101175_bib196","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.eururo.2017.03.010","article-title":"Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas Dataset","volume":"72","author":"Choi","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.repbio.2025.101175_bib197","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1007\/s10528-024-10963-7","article-title":"Evaluation of circANKLE2 & circL3MBTL4 -RNAs Expression in Fertile and Infertile Men","volume":"63","author":"El-Gamal","year":"2025","journal-title":"Biochem Genet"},{"key":"10.1016\/j.repbio.2025.101175_bib198","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s43043-024-00186-6","article-title":"Circular RNA regulates male spermatogenesis: a narrative review","volume":"29","author":"Peng","year":"2024","journal-title":"Middle East Fertil Soc J"},{"key":"10.1016\/j.repbio.2025.101175_bib199","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s12864-025-11556-3","article-title":"CircRNA profiling reveals circSMC1B that promotes bovine male germline stem cells proliferation and apoptosis via sponging let-7i","volume":"26","author":"Gao","year":"2025","journal-title":"BMC Genom"},{"key":"10.1016\/j.repbio.2025.101175_bib200","first-page":"527","article-title":"The Role of Circular RNAs in Male Infertility and Reproductive Cancers: A Narrative Review","volume":"48","author":"Derakhshan","year":"2023","journal-title":"Iran J Med Sci"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X25001913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X25001913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:28:55Z","timestamp":1787725735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X25001913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":200,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1642431X25001913"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2025.101175","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomal ncRNAs in seminal fluid: Unraveling their regulatory roles in male infertility","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2025.101175","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101175"}}