{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:30:14Z","timestamp":1787614214138,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.repbio.2026.101188","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:06:14Z","timestamp":1772222774000},"page":"101188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["From food to infertility: Disruption of the male reproductive axis by wheat lectin in rats"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6457-4228","authenticated-orcid":false,"given":"Ini-ibehe E.","family":"Okoko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bamidele A.","family":"Iwalokun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis I.O.","family":"Duru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham A.A.","family":"Osinubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osaretin A.T.","family":"Ebuehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-7778","authenticated-orcid":false,"given":"Edidiong N.","family":"Akang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2026.101188_bib1","series-title":"The Global Health Observatory: SDG Target 3.7 Sexual and Reproductive Health","author":"WHO","year":"2025"},{"key":"10.1016\/j.repbio.2026.101188_bib2","unstructured":"WHO. 1 in 6 people globally affected by infertility. Geneva: 2023."},{"key":"10.1016\/j.repbio.2026.101188_bib3","doi-asserted-by":"crossref","unstructured":"The Lancet Global Health. Infertility\u2014why the silence? Lancet Glob Health 2022;10:e773. https:\/\/doi.org\/10.1016\/S2214-109X(22)00215-7..","DOI":"10.1016\/S2214-109X(22)00215-7"},{"key":"10.1016\/j.repbio.2026.101188_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoab009","article-title":"A global approach to addressing the policy, research and social challenges of male reproductive health","volume":"2021","author":"Barratt","year":"2021","journal-title":"Hum Reprod Open"},{"key":"10.1016\/j.repbio.2026.101188_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/andr.12550","article-title":"An update on semen quality among young Finnish men and comparison with Danish data","volume":"7","author":"Rodprasert","year":"2019","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2026.101188_bib6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00420-018-1320-9","article-title":"Associations between sperm quality, DNA damage, and CYP1A1, GSTT1 and GSTM1 polymorphisms with 1-hydroxypyrene urinary levels in men occupationally exposed to polycyclic aromatic hydrocarbons","volume":"91","author":"Recio-Vega","year":"2018","journal-title":"Int Arch Occup Environ Health"},{"key":"10.1016\/j.repbio.2026.101188_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mefs.2017.07.006","article-title":"Effect of serum antioxidant levels on sperm function in infertile male","volume":"23","author":"Palani","year":"2018","journal-title":"Middle East Fertil Soc J"},{"key":"10.1016\/j.repbio.2026.101188_bib8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/andr.12327","article-title":"Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men","volume":"5","author":"Pullar","year":"2017","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2026.101188_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4103\/aja.aja_80_17","article-title":"Decline in semen concentration of healthy Chinese adults: Evidence from 9357 participants from 2010 to 2015","volume":"20","author":"Yuan","year":"2018","journal-title":"Asian J Androl"},{"key":"10.1016\/j.repbio.2026.101188_bib10","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1289\/EHP25","article-title":"A longitudinal study of Peripubertal serum organochlorine concentrations and semen parameters in young men: the Russian children\u2019s study","volume":"125","author":"M\u00ednguez-Alarc\u00f3n","year":"2017","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.repbio.2026.101188_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-33648-4","article-title":"Trends in semen parameters of infertile men in South Africa and Nigeria","volume":"13","author":"Akang","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2026.101188_bib12","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1093\/jxb\/erp058","article-title":"Wheat","volume":"60","author":"Shewry","year":"2009","journal-title":"J Exp Bot"},{"key":"10.1016\/j.repbio.2026.101188_bib13","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/nu5030771","article-title":"The dietary intake of wheat and other cereal grains and their role in inflammation","volume":"5","author":"de Punder","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.repbio.2026.101188_bib14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.toxicon.2004.05.005","article-title":"Antinutritional properties of plant lectins","volume":"44","author":"Vasconcelos","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.repbio.2026.101188_bib15","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1128\/IAI.67.7.3461-3468.1999","article-title":"Wheat germ agglutinin induces NADPH-oxidase activity in human neutrophils by interaction with mobilizable receptors","volume":"67","author":"Karlsson","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.repbio.2026.101188_bib16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mce.2005.12.026","article-title":"Oxidative stress, sperm survival and fertility control","volume":"250","author":"Aitken","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.repbio.2026.101188_bib17","first-page":"404","article-title":"Effect of wheat (Triticum aestivum Linn.) diet on the testes of Sprague-Dawley rats","volume":"41","author":"Idaguko","year":"2024","journal-title":"Balk Med J"},{"key":"10.1016\/j.repbio.2026.101188_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4939-1292-6_4","article-title":"Hemagglutination (inhibition) assay","volume":"1200","author":"Sano","year":"2014","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.repbio.2026.101188_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.seppur.2007.04.022","article-title":"Extraction of bio-active components from Rhodiola sachalinensis under ultrahigh hydrostatic pressure","volume":"57","author":"Zhang","year":"2007","journal-title":"Sep Purif Technol"},{"key":"10.1016\/j.repbio.2026.101188_bib20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.repbio.2026.101188_bib21","doi-asserted-by":"crossref","first-page":"130","DOI":"10.9734\/EJMP\/2011\/401","article-title":"Partial purification and characterization of lectin from the seeds of cissus poplunea","volume":"1","author":"Awoyinka","year":"2011","journal-title":"Eur J Med Plants"},{"key":"10.1016\/j.repbio.2026.101188_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm"},{"key":"10.1016\/j.repbio.2026.101188_bib23","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/and.12175","article-title":"Protective effect of Pumpkin seed extract on sperm characteristics, biochemical parameters and epididymal histology in adult male rats treated with Cyclophosphamide","volume":"46","author":"Aghaei","year":"2014","journal-title":"Andrologia"},{"key":"10.1016\/j.repbio.2026.101188_bib24","unstructured":"WHO WHO. WHO laboratory manual for the examination and processing of human semen. 6th ed. 2021."},{"key":"10.1016\/j.repbio.2026.101188_bib25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/j.1939-4640.1992.tb03343.x","article-title":"Antioxidant enzyme activity in the maturing rat testis","volume":"13","author":"Peltola","year":"1992","journal-title":"J Androl"},{"key":"10.1016\/j.repbio.2026.101188_bib26","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.repbio.2026.101188_bib27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","article-title":"Colorimetric assay of catalase","volume":"47","author":"Sinha","year":"1972","journal-title":"Anal Biochem"},{"key":"10.1016\/j.repbio.2026.101188_bib28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.repbio.2026.101188_bib29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal Biochem"},{"key":"10.1016\/j.repbio.2026.101188_bib30","article-title":"Histomorphometric studies of the effects of Telfairia occidentalis on alcohol-induced gonado-toxicity in male rats","volume":"2","author":"Akang","year":"2015","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.repbio.2026.101188_bib31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/1874070701913010068","article-title":"Antinutrients in plant-based foods: a review","volume":"13","author":"Popova","year":"2019","journal-title":"Open Biotechnol J"},{"key":"10.1016\/j.repbio.2026.101188_bib32","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1089\/jmf.2014.0120","article-title":"Toxicity assessment of common beans (phaseolus vulgaris l.) widely consumed by tunisian population","volume":"18","author":"Nciri","year":"2015","journal-title":"J Med Food"},{"key":"10.1016\/j.repbio.2026.101188_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/foods10112796","article-title":"Lectin activity in commonly consumed plant-based foods: calling for method harmonization and risk assessment","volume":"10","author":"Adamcov\u00e1","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.repbio.2026.101188_bib34","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.yexcr.2006.03.020","article-title":"Synchronous modulation of cell surface lectin and its receptor in a homologous cell population: A novel mechanism of cellular regulation","volume":"312","author":"Banerjee","year":"2006","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.repbio.2026.101188_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/srep15321","article-title":"Lectin staining and flow cytometry reveals female-induced sperm acrosome reaction and surface carbohydrate reorganization","volume":"5","author":"Kek\u00e4l\u00e4inen","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2026.101188_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/andr.13700","article-title":"Epididymal mRNA expression profiles for the protein disulfide isomerase gene family: modulation by development and androgens","author":"Fernandes","year":"2024","journal-title":"Andrology"},{"key":"10.1016\/j.repbio.2026.101188_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12958-024-01333-4","article-title":"The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice","volume":"23","author":"Esteves","year":"2025","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.repbio.2026.101188_bib38","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/j.fertnstert.2014.12.103","article-title":"Diagnostic evaluation of the infertile male: a committee opinion","volume":"103","author":"Pfeifer","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2026.101188_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.648141","article-title":"The molecular mechanism of sex hormones on sertoli cell development and proliferation","volume":"12","author":"Shah","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.repbio.2026.101188_bib40","doi-asserted-by":"crossref","first-page":"19623","DOI":"10.1073\/pnas.1111414108","article-title":"P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin\/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK)","volume":"108","author":"Su","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.repbio.2026.101188_bib41","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00441-024-03894-7","article-title":"Blood-testis barrier: a review on regulators in maintaining cell junction integrity between Sertoli cells","volume":"396","author":"Wanjari","year":"2024","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.repbio.2026.101188_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101456","article-title":"Lectin-induced oxidative stress in human platelets","volume":"32","author":"Signorello","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.repbio.2026.101188_bib43","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrurol.2017.69","article-title":"Oxidative stress and male infertility","volume":"14","author":"Bisht","year":"2017","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.repbio.2026.101188_bib44","doi-asserted-by":"crossref","DOI":"10.1210\/er.2014-1101","article-title":"The mammalian blood-testis barrier: its biology and regulation","volume":"36","author":"Mruk","year":"2015","journal-title":"Endocr Rev"},{"key":"10.1016\/j.repbio.2026.101188_bib45","doi-asserted-by":"crossref","DOI":"10.1186\/s12958-018-0406-2","article-title":"Reactive oxygen species and male reproductive hormones","volume":"16","author":"Darbandi","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.repbio.2026.101188_bib46","doi-asserted-by":"crossref","DOI":"10.1530\/RAF-23-0024","article-title":"Role of oxidative stress in male infertility","volume":"4","author":"Takalani","year":"2023","journal-title":"Reprod Fertil"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X26000100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X26000100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:29:43Z","timestamp":1785842983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X26000100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1642431X26000100"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2026.101188","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From food to infertility: Disruption of the male reproductive axis by wheat lectin in rats","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2026.101188","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn.","name":"copyright","label":"Copyright"}],"article-number":"101188"}}