{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:00:24Z","timestamp":1793293224310,"version":"4.5.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008781","name":"Pomeranian Medical University in Szczecin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.repbio.2026.101235","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:22:23Z","timestamp":1782750143000},"page":"101235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paternal finasteride exposure and its impact on offspring testicular histopathology and intracellular junctions: the role of occludin and N-cadherin"],"prefix":"10.1016","volume":"26","author":[{"given":"Marika","family":"Freus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Misiakiewicz-Has","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pilutin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Podbor\u0105czy\u0144ska-Jodko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Wilk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Kolasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib1","article-title":"Exogenous testosterone, finasteride and castration effects on testosterone, insulin, zinc and chromium in adult male rats","volume":"17","author":"Yousofvand","year":"2013","journal-title":"Iran Biomed J"},{"issue":"8","key":"10.1016\/j.repbio.2026.101235_bib2","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1590\/S0004-27302009000800006","article-title":"Androgens and the male reproductive tract: an overview of classical roles and current perspectives","volume":"53","author":"Patr\u00e3o","year":"2009","journal-title":"Arq Bras De Endocrinol & Metabol"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib3","first-page":"2875","article-title":"5\u03b1-Reductase Type 2 Is Constitutively Expressed in the Dermal Papilla and Connective Tissue Sheath of the Hair Follicle in Vivo But Not during Culture in Vitro 1","volume":"86","author":"Asada","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/j.1939-4640.1999.tb02503.x","article-title":"Testosterone-dependent restoration of spermatogenesis in adult rats is impaired by a 5alpha-reductase inhibitor","volume":"20","author":"O\u2019Donnell","year":"1999","journal-title":"J Androl"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1515\/HMBCI.2010.009","article-title":"Sequential transformation of 4-androstenedione into dihydrotestosterone in prostate carcinoma (DU-145) cells indicates that 4-androstenedione and not testosterone is the substrate of 5\u03b1-reductase","volume":"1","author":"Samson","year":"2010","journal-title":"hmbci"},{"key":"10.1016\/j.repbio.2026.101235_bib6","unstructured":"Zito P.M., Bistas K.G., Patel P., Syed K. Finasteride. 2024. PubMed PMID: 30020701."},{"issue":"12","key":"10.1016\/j.repbio.2026.101235_bib7","doi-asserted-by":"crossref","DOI":"10.4067\/S0034-98872016001200010","article-title":"Efectos adversos de finasteride: Mitos y realidades. Una revisi\u00f3n actualizada","volume":"144","author":"Carre\u00f1o-Orellana","year":"2016","journal-title":"Rev Med Chil"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/1346-8138.14719","article-title":"Evaluation of long-term efficacy of finasteride in Korean men with androgenetic alopecia using the basic and specific classification system","volume":"46","author":"Shin","year":"2019","journal-title":"J Dermatol"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4103\/0378-6323.177432","article-title":"Guidelines on the use of finasteride in androgenetic alopecia","volume":"82","author":"Mysore","year":"2016","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib10","first-page":"400","article-title":"Long-term treatment with finasteride 1 mg decreases the likelihood of developing further visible hair loss in men with androgenetic alopecia (male pattern hair loss)","volume":"18","author":"Kaufman","year":"2008","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.repbio.2026.101235_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.urology.2018.06.022","article-title":"A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome","volume":"120","author":"Baas","year":"2018","journal-title":"Urology"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib12","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00345-020-03314-9","article-title":"An evaluation of the federal adverse events reporting system data on adverse effects of 5-alpha reductase inhibitors","volume":"39","author":"Harrell","year":"2021","journal-title":"World J Urol"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.abd.2020.02.001","article-title":"Post-finasteride syndrome","volume":"95","author":"Pereira","year":"2020","journal-title":"Bras Dermatol"},{"key":"10.1016\/j.repbio.2026.101235_bib14","unstructured":"L\u2019Associazione Vittime Finasteride. 2011 [Internet]. [cited 2023 Jun 29]. L\u2019Associazione Vittime Finasteride. Available from: \u3008https:\/\/www.associazionevittimefinasteride.org\/associazione\/\u3009."},{"key":"10.1016\/j.repbio.2026.101235_bib15","unstructured":"Aide aux Victimes du Finast\u00e9ride. Aide aux Victimes du Finast\u00e9ride [Internet]. [cited 2023 Jun 29]. Available from: \u3008https:\/\/sites.google.com\/view\/avfin\/accueil\u3009."},{"key":"10.1016\/j.repbio.2026.101235_bib16","unstructured":"P.F.S. Research Association. P.F.S. Research Association [Internet]. [cited 2023 Jun 29]. Available from: \u3008https:\/\/pfsresearch.org\/\u3009."},{"key":"10.1016\/j.repbio.2026.101235_bib17","unstructured":"Propecia Side Effects. Propecia Side Effects [Internet]. [cited 2023 Jun 29]. Available from: \u3008http:\/\/www.propeciasideeffects.co.uk\/\u3009."},{"key":"10.1016\/j.repbio.2026.101235_bib18","unstructured":"Food and Drug Administration (FDA). Finasteride [Internet]. 2014 [cited 2023 May 9]. Available from: \u3008http:\/\/www.fda.gov\u3009."},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib19","doi-asserted-by":"crossref","DOI":"10.1007\/s11096-018-0661-5","article-title":"Finasteride use during pregnancy and early neonatal outcome: a case report","volume":"40","author":"AlSaad","year":"2018","journal-title":"Int J Clin Pharm"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib20","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jaad.2018.09.031","article-title":"Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: A systematic review","volume":"80","author":"Zakhem","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/0192623314547279","article-title":"Postnatal Development of the Testis in the Rat","volume":"43","author":"Picut","year":"2015","journal-title":"Toxicol Pathol"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1530\/rep.0.1210347","article-title":"Proliferation and differentiation of spermatogonial stem cells","volume":"121","author":"de Rooij","year":"2001","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/aja.1001000205","article-title":"Quantitative study of the cell population of the seminiferous tubules in immature rats","volume":"100","author":"CLERMONT","year":"1957","journal-title":"Am J Anat"},{"issue":"1546","key":"10.1016\/j.repbio.2026.101235_bib24","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1098\/rstb.2010.0010","article-title":"Tight junctions in the testis: new perspectives","volume":"365","author":"Mruk","year":"2010","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/aja.1001480303","article-title":"Movement of spermatocytes from the basal to the adluminal compartment of the rat testis","volume":"148","author":"Russell","year":"1977","journal-title":"Am J Anat"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1477-7827-7-39","article-title":"Luteinizing hormone induces expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells","volume":"7","author":"Wang","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib27","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1095\/biolreprod17.3.390","article-title":"Further Observations on the Blood-Testis Barrier in Monkeys","volume":"17","author":"Dym","year":"1977","journal-title":"Biol Reprod"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1124\/pr.110.002790","article-title":"The Blood-Testis Barrier and Its Implications for Male Contraception","volume":"64","author":"Cheng","year":"2012","journal-title":"Pharmacol Rev"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib29","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/ar.20417","article-title":"Apoptosis and blood\u2013testis barrier during the first spermatogenic wave in the pubertal rat","volume":"290","author":"Morales","year":"2007","journal-title":"Anat Rec"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1530\/jrf.0.0540103","article-title":"Daily sperm production and epididymal sperm reserves of pubertal and adult rats","volume":"54","author":"Robb","year":"1978","journal-title":"Reproduction"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib31","doi-asserted-by":"crossref","first-page":"572","DOI":"10.4103\/1008-682X.125401","article-title":"Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice","volume":"16","author":"Jiang","year":"2014","journal-title":"Asian J Androl"},{"issue":"12","key":"10.1016\/j.repbio.2026.101235_bib32","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1593\/neo.06559","article-title":"Altered expression of ZO-1 and ZO-2 in Sertoli cells and loss of blood-testis barrier integrity in testicular carcinoma in situ","volume":"8","author":"Fink","year":"2006","journal-title":"Neoplasia"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib33","doi-asserted-by":"crossref","first-page":"C1708","DOI":"10.1152\/ajpcell.1998.274.6.C1708","article-title":"Occludin is concentrated at tight junctions of mouse\/rat but not human\/guinea pig Sertoli cells in testes","volume":"274","author":"Moroi","year":"1998","journal-title":"Am J Physiol-Cell Physiol"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0092-8674(03)00108-9","article-title":"Sticky business: orchestrating cellular signals at adherens junctions","volume":"112","author":"Perez-Moreno","year":"2003","journal-title":"Cell"},{"issue":"5\u20136","key":"10.1016\/j.repbio.2026.101235_bib35","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1387\/ijdb.041793ld","article-title":"N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling","volume":"48","author":"Derycke","year":"2004","journal-title":"Int J Dev Biol"},{"issue":"8","key":"10.1016\/j.repbio.2026.101235_bib36","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1289\/ehp.6862","article-title":"Natural variability and the influence of concurrent control values on the detection and interpretation of low-dose or weak endocrine toxicities","volume":"112","author":"Ashby","year":"2004","journal-title":"Environ Health Perspect"},{"issue":"12","key":"10.1016\/j.repbio.2026.101235_bib37","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1210\/en.2004-0627","article-title":"Comparison of the Pharmacological Effects of a Novel Selective Androgen Receptor Modulator, the 5\u03b1-Reductase Inhibitor Finasteride, and the Antiandrogen Hydroxyflutamide in Intact Rats: New Approach for Benign Prostate Hyperplasia","volume":"145","author":"Gao","year":"2004","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2025.101044","article-title":"The postnatal offspring of finasteride-treated male rats show altered ER\u03b1 and PCNA expression in the liver","volume":"25","author":"Kolasa","year":"2025","journal-title":"Reprod Biol"},{"issue":"17","key":"10.1016\/j.repbio.2026.101235_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26178645","article-title":"A Digital Image Analysis of the Morphology and Immunolocalization of Catalase and Caspase-3 in the Skin of Adult Male Rats After Treatment with Letrozole and Vitamin C","volume":"26","author":"Pilutin","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib40","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3390\/cimb43020062","article-title":"Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring-Preliminary Study","volume":"43","author":"Kolasa","year":"2021","journal-title":"Curr Issues Mol Biol"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib41","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.shaw.2017.04.003","article-title":"Reproductive Toxic Chemicals at Work and Efforts to Protect Workers\u2019 Health: A Literature Review","volume":"8","author":"Rim","year":"2017","journal-title":"Saf Health Work"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib42","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.fertnstert.2023.10.013","article-title":"Diet and recreational drug use in relation to male reproductive health","volume":"120","author":"LaPointe","year":"2023","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2026.101235_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/em.22583","article-title":"Effect of smoking on methylation and semen parameters","author":"Naeimi","year":"2024","journal-title":"Environ Mol Mutagen"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib44","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12940-017-0291-8","article-title":"Does air pollution play a role in infertility?: a systematic review","volume":"16","author":"Carr\u00e9","year":"2017","journal-title":"Environ Health"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"issue":"10271","key":"10.1016\/j.repbio.2026.101235_bib46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(20)32667-2","article-title":"Male infertility","volume":"397","author":"Agarwal","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.repbio.2026.101235_bib47","unstructured":"Merck & Co. Inc. PROPECIA\u00ae (finasteride) Tablets for oral use. 2012."},{"key":"10.1016\/j.repbio.2026.101235_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116710","article-title":"Comparative effects of finasteride and minoxidil on the male reproductive organs: A systematic review of in vitro and in vivo evidence","volume":"478","author":"Santana","year":"2023","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"10.1016\/j.repbio.2026.101235_bib49","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1210\/jc.2006-2203","article-title":"The Effect of 5\u03b1-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men","volume":"92","author":"Amory","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib50","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s12020-020-02219-2","article-title":"Androgenetic alopecia: effects of oral finasteride on hormone profile, reproduction and sexual function","volume":"68","author":"Pallotti","year":"2020","journal-title":"Endocrine"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib51","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1590\/S0041-87812004000400009","article-title":"Finasteride-associated male infertility","volume":"59","author":"Glina","year":"2004","journal-title":"Rev Hosp Clin Fac Med Sao Paulo"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib52","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11255-012-0315-9","article-title":"Secondary infertility due to use of low-dose finasteride","volume":"45","author":"\u015ealvarci","year":"2013","journal-title":"Int Urol Nephrol"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib53","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.fertnstert.2010.12.061","article-title":"Finasteride-induced secondary infertility associated with sperm DNA damage","volume":"95","author":"Tu","year":"2011","journal-title":"Fertil Steril"},{"issue":"5","key":"10.1016\/j.repbio.2026.101235_bib54","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.fertnstert.2010.12.001","article-title":"Finasteride-associated male infertility","volume":"95","author":"Chiba","year":"2011","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib55","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0890-6238(91)90094-V","article-title":"Decreased fertility in male rats administered the 5\u03b1-reductase inhibitor, finasteride, is due to deficits in copulatory plug formation","volume":"5","author":"Cukierski","year":"1991","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.repbio.2026.101235_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2025.154278","article-title":"Long-term oral exposure to finasteride and different doses of minoxidil induces testicular and epididymal alterations in adult Balb\/c mice","volume":"518","author":"Santana","year":"2025","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib57","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfg128","article-title":"Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat","volume":"74","author":"Bowman","year":"2003","journal-title":"Toxicol Sci"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib58","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1096-9926(199702)55:2<119::AID-TERA1>3.0.CO;2-Z","article-title":"Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta)","volume":"55","author":"Prahalada","year":"1997","journal-title":"Teratology"},{"key":"10.1016\/j.repbio.2026.101235_bib59","first-page":"216","article-title":"Evaluation of the 5\u03b1-reductase inhibitor finasteride on reproduction and gonadal development in medaka, Oryzias latipes","author":"Lee","year":"2015","journal-title":"Gen Comp Endocrinol"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib60","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5603\/fhc.a2015.0025","article-title":"Androgen levels and apoptosis in the testis during postnatal development of finasteride-treated male rat offspring","volume":"53","author":"Kolasa-Wolosiuk","year":"2015","journal-title":"Folia Histochem Cytobiol"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1477-7827-6-18","article-title":"Morphological evidences indicate that the interference of cimetidine on the peritubular components is responsible for detachment and apoptosis of Sertoli cells","volume":"6","author":"Sasso-Cerri","year":"2008","journal-title":"Reprod Biol Endocrinol"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib62","doi-asserted-by":"crossref","DOI":"10.1017\/S1431927620024514","article-title":"Resveratrol Ameliorates the Seminiferous Tubules Damages Induced by Finasteride in Adult Male Rats","volume":"26","author":"Shalaby","year":"2020","journal-title":"Microsc Microanal"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.18544\/EP-01.12.01.1442","article-title":"Testicular Dysgenesis Syndrome: Pathogenesis and Clinical Consequences","volume":"12","author":"S\u0142owikowska-Hilczer","year":"2013","journal-title":"Pediatr Endocrinol"},{"issue":"6_","key":"10.1016\/j.repbio.2026.101235_bib64","article-title":"Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System","volume":"40","author":"Creasy","year":"2012","journal-title":"Toxicol Pathol"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib65","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/019262301301418865","article-title":"Pathogenesis of Male Reproductive Toxicity","volume":"29","author":"Creasy","year":"2001","journal-title":"Toxicol Pathol"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib66","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1095\/biolreprod65.6.1771","article-title":"Disruption of Spermatogenesis and Sertoli Cell Structure and Function by the Indenopyridine CDB-4022 in Rats1","volume":"65","author":"Ann Hild","year":"2001","journal-title":"Biol Reprod"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib67","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1095\/biolreprod28.4.1007","article-title":"Effects of gossypol on the seminiferous epithelium in the rat: a light and electron microscope study","volume":"28","author":"Hoffer","year":"1983","journal-title":"Biol Reprod"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib68","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2164\/jandrol.106.002295","article-title":"Acute Adverse Effects of the Indenopyridine CDB-4022 on the Ultrastructure of Sertoli Cells, Spermatocytes, and Spermatids in Rat Testes: Comparison to the Known Sertoli Cell Toxicant Di-n-pentylphthalate (DPP)","volume":"28","author":"Hild","year":"2007","journal-title":"J Androl"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib69","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.5114\/aoms.2016.63022","article-title":"Connexin 43 expression in the testes during postnatal development of finasteride-treated male rat offspring","volume":"14","author":"Kolasa-Wo\u0142osiuk","year":"2018","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.repbio.2026.101235_bib70","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.2741\/2168","article-title":"Junction interaction in the seminiferous epithelium: regulatory roles of connexin-based gap junction","volume":"12","author":"Lee","year":"2007","journal-title":"Front Biosci"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib71","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1096\/fj.06-070342","article-title":"Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells","volume":"22","author":"Yan","year":"2008","journal-title":"FASEB J"},{"issue":"9","key":"10.1016\/j.repbio.2026.101235_bib72","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1210\/endo.137.9.8756560","article-title":"Hormonal dependency of neural cadherin in the binding of round spermatids to Sertoli cells in vitro","volume":"137","author":"Perryman","year":"1996","journal-title":"Endocrinology"},{"issue":"21","key":"10.1016\/j.repbio.2026.101235_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218264","article-title":"The Central Role of Cadherins in Gonad Development, Reproduction, and Fertility","volume":"21","author":"Piprek","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib74","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/j.1939-4640.1999.tb02511.x","article-title":"Adhesion and signaling proteins spatiotemporally associated with spermiation in the rat","volume":"20","author":"Wine","year":"1999","journal-title":"J Androl"},{"issue":"5","key":"10.1016\/j.repbio.2026.101235_bib75","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1210\/er.2003-0022","article-title":"Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis","volume":"25","author":"Mruk","year":"2004","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib76","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1124\/pr.107.07105","article-title":"Anchoring Junctions As Drug Targets: Role in Contraceptive Development","volume":"60","author":"Mruk","year":"2008","journal-title":"Pharmacol Rev"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib77","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbamem.2007.11.006","article-title":"Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis","volume":"1778","author":"Wong","year":"2008","journal-title":"Biochim Et Biophys Acta (BBA) - Biomembr"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib78","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbamem.2007.11.006","article-title":"Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis","volume":"1778","author":"Wong","year":"2008","journal-title":"Biochim Et Biophys Acta (BBA) - Biomembr"},{"issue":"7","key":"10.1016\/j.repbio.2026.101235_bib79","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrendo.2010.71","article-title":"A local autocrine axis in the testes that regulates spermatogenesis","volume":"6","author":"Cheng","year":"2010","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"10.1016\/j.repbio.2026.101235_bib80","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/10409230903061207","article-title":"An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: a biochemical and molecular perspective","volume":"44","author":"Cheng","year":"2009","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib81","doi-asserted-by":"crossref","first-page":"C1708","DOI":"10.1152\/ajpcell.1998.274.6.C1708","article-title":"Occludin is concentrated at tight junctions of mouse\/rat but not human\/guinea pig Sertoli cells in testes","volume":"274","author":"Moroi","year":"1998","journal-title":"Am J Physiol"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib82","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1530\/REP-06-0385","article-title":"Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro","volume":"133","author":"Kaitu\u2019u-Lino","year":"2007","journal-title":"Reproduction"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib83","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.biocel.2011.01.008","article-title":"c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes","volume":"43","author":"Xiao","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"10.1016\/j.repbio.2026.101235_bib84","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0378-4274(03)00178-4","article-title":"Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions","volume":"143","author":"Gye","year":"2003","journal-title":"Toxicol Lett"},{"issue":"3","key":"10.1016\/j.repbio.2026.101235_bib85","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.reprotox.2004.01.002","article-title":"Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants","volume":"18","author":"Fiorini","year":"2004","journal-title":"Reprod Toxicol"},{"issue":"11","key":"10.1016\/j.repbio.2026.101235_bib86","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.biocel.2009.05.016","article-title":"Disruption of the blood-testis barrier integrity by bisphenol A in vitro: Is this a suitable model for studying blood-testis barrier dynamics?","volume":"41","author":"Li","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"issue":"1\u20132","key":"10.1016\/j.repbio.2026.101235_bib87","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tox.2009.09.012","article-title":"Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis","volume":"265","author":"Salian","year":"2009","journal-title":"Toxicology"},{"issue":"12","key":"10.1016\/j.repbio.2026.101235_bib88","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084354","article-title":"Impaired function of the blood-testis barrier during aging is preceded by a decline in cell adhesion proteins and GTPases","volume":"8","author":"Paul","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.repbio.2026.101235_bib89","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1002\/jor.22172","article-title":"Age-related changes in gap junctional intercellular communication in osteoblastic cells","volume":"30","author":"Genetos","year":"2012","journal-title":"J Orthop Res"},{"issue":"6","key":"10.1016\/j.repbio.2026.101235_bib90","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1095\/biolreprod.111.094219","article-title":"Aging results in differential regulation of DNA repair pathways in pachytene spermatocytes in the Brown Norway rat","volume":"85","author":"Paul","year":"2011","journal-title":"Biol Reprod"},{"issue":"1","key":"10.1016\/j.repbio.2026.101235_bib91","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/1471-2164-9-246","article-title":"Correlation of mRNA and protein levels: Cell type-specific gene expression of cluster designation antigens in the prostate","volume":"9","author":"Pascal","year":"2008","journal-title":"BMC Genom"},{"issue":"4","key":"10.1016\/j.repbio.2026.101235_bib92","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1074\/mcp.M200008-MCP200","article-title":"Discordant Protein and mRNA Expression in Lung Adenocarcinomas","volume":"1","author":"Chen","year":"2002","journal-title":"Mol & Cell Proteom"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X26000574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X26000574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:23:09Z","timestamp":1784776989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X26000574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":92,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1642431X26000574"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2026.101235","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paternal finasteride exposure and its impact on offspring testicular histopathology and intracellular junctions: the role of occludin and N-cadherin","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2026.101235","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn.","name":"copyright","label":"Copyright"}],"article-number":"101235"}}