{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:17:43Z","timestamp":1791415063760,"version":"4.3.3"},"reference-count":38,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017949","name":"Health Commission of Shanxi Province","doi-asserted-by":"publisher","award":["2023XM021"],"award-info":[{"award-number":["2023XM021"]}],"id":[{"id":"10.13039\/100017949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170398"],"award-info":[{"award-number":["82170398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Portuguesa de Cardiologia"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.repc.2025.05.008","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T18:00:36Z","timestamp":1758132036000},"page":"673-687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dapagliflozin alleviates isoprenaline-induced cardiac hypertrophy by promoting mitophagy via AMPK\u03b12 signaling pathway"],"prefix":"10.1016","volume":"44","author":[{"given":"Yue","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repc.2025.05.008_bib0195","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1002\/ehf2.14915","article-title":"Global trends in heart failure from 1990 to 2019: An age-period-cohort analysis from the Global Burden of Disease study","volume":"11","author":"Liu","year":"2024","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.repc.2025.05.008_bib0200","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cardfail.2024.05.014","article-title":"Heart failure pharmacotherapy over the past 30 years: boats against the current","volume":"30","author":"Beavers","year":"2024","journal-title":"J Card Fail"},{"key":"10.1016\/j.repc.2025.05.008_bib0205","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI120849","article-title":"Mitochondrial dysfunction in pathophysiology of heart failure","volume":"128","author":"Zhou","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.repc.2025.05.008_bib0210","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.3390\/ijms25052667","article-title":"Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities","volume":"25","author":"Gallo","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repc.2025.05.008_bib0215","doi-asserted-by":"crossref","first-page":"e14138","DOI":"10.1111\/eci.14138","article-title":"Metabolic control of mitophagy","volume":"54","author":"Zimmermann","year":"2024","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.repc.2025.05.008_bib0220","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.febslet.2015.05.020","article-title":"Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy","volume":"589","author":"Tian","year":"2015","journal-title":"FEBS Lett"},{"key":"10.1016\/j.repc.2025.05.008_bib0225","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/CIRCRESAHA.117.312317","article-title":"AMPK\u03b12 protects against the development of heart failure by enhancing mitophagy via PINK1 phosphorylation","volume":"122","author":"Wang","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.repc.2025.05.008_bib0230","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1056\/NEJMoa2206286","article-title":"Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction","volume":"387","author":"Solomon","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.repc.2025.05.008_bib0235","doi-asserted-by":"crossref","first-page":"6798","DOI":"10.3390\/jcm12216798","article-title":"Current Role of SLGT2 Inhibitors in the Management of the Whole Spectrum of Heart Failure: Focus on Dapagliflozin","volume":"12","author":"Escobar","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.repc.2025.05.008_bib0240","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13578-021-00547-y","article-title":"Dapagliflozin attenuates hypoxia\/reoxygenation-caused cardiac dysfunction and oxidative damage through modulation of AMPK","volume":"11","author":"Tsai","year":"2021","journal-title":"Cell Biosci"},{"key":"10.1016\/j.repc.2025.05.008_bib0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126116","article-title":"Dapagliflozin protects heart function against type-4 cardiorenal syndrome through activation of PKM2\/PP1\/FUNDC1-dependent mitophagy","volume":"250","author":"Shen","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.repc.2025.05.008_bib0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115125","article-title":"Dapagliflozin attenuates myocardial hypertrophy via activating the SIRT1\/HIF-1\u03b1 signaling pathway","volume":"165","author":"Yang","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.repc.2025.05.008_bib0255","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.abb.2016.07.006","article-title":"Chronic intermittent hypoxia induces cardiac hypertrophy by impairing autophagy through the adenosine 5\u2032-monophosphate-activated protein kinase pathway","volume":"606","author":"Xie","year":"2016","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.repc.2025.05.008_bib0260","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/CIRCRESAHA.124.323800","article-title":"Mitochondrial structure and function in human heart failure","volume":"135","author":"Hinton","year":"2024","journal-title":"Circ Res"},{"key":"10.1016\/j.repc.2025.05.008_bib0265","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41419-022-04906-6","article-title":"Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.repc.2025.05.008_bib0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114669","article-title":"Cardioprotective effect of ethanol extracts of Sugemule-3 decoction on isoproterenol-induced heart failure in Wistar rats through regulation of mitochondrial dynamics","volume":"292","author":"Zhen","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.repc.2025.05.008_bib0275","first-page":"892","article-title":"Protective efficacy of Shenge San on mitochondria in H9c2 cardiomyocytes","volume":"42","author":"Lingyan","year":"2022","journal-title":"J Tradit Chin Med"},{"key":"10.1016\/j.repc.2025.05.008_bib0280","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.molmed.2022.06.007","article-title":"Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment","volume":"28","author":"Ajoolabady","year":"2022","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.repc.2025.05.008_bib0285","doi-asserted-by":"crossref","first-page":"11824","DOI":"10.1038\/s41598-024-62465-6","article-title":"Semaglutide ameliorates pressure overload-induced cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome","volume":"14","author":"He","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.repc.2025.05.008_bib0290","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41580-022-00547-x","article-title":"New insights into activation and function of the AMPK","volume":"24","author":"Steinberg","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.repc.2025.05.008_bib0295","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.repc.2025.05.008_bib0300","doi-asserted-by":"crossref","first-page":"109321","DOI":"10.1016\/j.isci.2024.109321","article-title":"AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis","volume":"27","author":"Zhao","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.repc.2025.05.008_bib0305","doi-asserted-by":"crossref","first-page":"18388","DOI":"10.1002\/jcb.29150","article-title":"Ginsenoside Rg1 protects H9c2 cells against nutritional stress-induced injury via aldolase\/AMPK\/PINK1 signalling","volume":"120","author":"Xu","year":"2019","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.repc.2025.05.008_bib0310","doi-asserted-by":"crossref","first-page":"170","DOI":"10.2174\/1570159X18666200522202319","article-title":"The dawn of mitophagy: what do we know by now?","volume":"19","author":"Belousov","year":"2021","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.repc.2025.05.008_bib0315","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1097\/FJC.0000000000001046","article-title":"Dual role of mitophagy in cardiovascular diseases","volume":"78","author":"Li","year":"2021","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.repc.2025.05.008_bib0320","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13293-021-00394-z","article-title":"Spatiotemporal AMPK\u03b12 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only","volume":"12","author":"Grimbert","year":"2021","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.repc.2025.05.008_bib0325","doi-asserted-by":"crossref","first-page":"786","DOI":"10.2337\/db06-0187","article-title":"AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function","volume":"56","author":"Ath\u00e9a","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.repc.2025.05.008_bib0330","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/aps.2010.229","article-title":"Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation","volume":"32","author":"Fu","year":"2011","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.repc.2025.05.008_bib0335","doi-asserted-by":"crossref","first-page":"115001","DOI":"10.1016\/j.celrep.2024.115001","article-title":"AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection","volume":"43","author":"Murakawa","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.repc.2025.05.008_bib0340","doi-asserted-by":"crossref","first-page":"1078205","DOI":"10.3389\/fphar.2023.1078205","article-title":"Dapagliflozin alleviates myocardial ischemia\/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition","volume":"14","author":"Chen","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.repc.2025.05.008_bib0345","doi-asserted-by":"crossref","first-page":"e29160","DOI":"10.1016\/j.heliyon.2024.e29160","article-title":"Dapagliflozin ameliorates myocardial infarction injury through AMPK\u03b1-dependent regulation of oxidative stress and apoptosis","volume":"10","author":"Peng","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.repc.2025.05.008_bib0350","doi-asserted-by":"crossref","first-page":"823","DOI":"10.2147\/TCRM.S275076","article-title":"The role of dapagliflozin in the management of heart failure: an update on the emerging evidence","volume":"17","author":"Gupta","year":"2021","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.repc.2025.05.008_bib0355","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.3390\/ijms23105371","article-title":"Mitochondria-Mediated Cardiovascular Benefits of Sodium-Glucose Co-Transporter 2 Inhibitors","volume":"23","author":"Dabravolski","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repc.2025.05.008_bib0360","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/FJC.0000000000001518","article-title":"Dapagliflozin suppresses isoprenaline-induced cardiac hypertrophy through inhibition of mitochondrial fission","volume":"83","author":"Yang","year":"2024","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.repc.2025.05.008_bib0365","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/cells11010030","article-title":"Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK\/ULK1 Axis","volume":"11","author":"Iorio","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.repc.2025.05.008_bib0370","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.1111\/jcmm.16601","article-title":"Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK\u03b1\/TGF-\u03b2\/Smad signalling in type 2 diabetic rats","volume":"25","author":"Tian","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.repc.2025.05.008_bib0375","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/0115701611269801231211104905","article-title":"Dapagliflozin alleviates myocardial ischaemia reperfusion injury by activating mitophagy via the AMPK-PINK1\/Parkin signalling pathway","volume":"22","author":"Zuo","year":"2024","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.repc.2025.05.008_bib0380","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/13813455.2023.2252200","article-title":"Dapagliflozin attenuates high glucose-and hypoxia\/reoxygenation-induced injury via activating AMPK\/mTOR-OPA1-mediated mitochondrial autophagy in H9c2 cardiomyocytes","volume":"130","author":"Tu","year":"2024","journal-title":"Arch Physiol Biochem"}],"container-title":["Revista Portuguesa de Cardiologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0870255125002902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0870255125002902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:24:49Z","timestamp":1762201489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0870255125002902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0870255125002902"],"URL":"https:\/\/doi.org\/10.1016\/j.repc.2025.05.008","relation":{},"ISSN":["0870-2551"],"issn-type":[{"value":"0870-2551","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dapagliflozin alleviates isoprenaline-induced cardiac hypertrophy by promoting mitophagy via AMPK\u03b12 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Revista Portuguesa de Cardiologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repc.2025.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}