{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:30:52Z","timestamp":1790188252674,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.reprotox.2003.10.007","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T05:43:35Z","timestamp":1071639815000},"page":"93-101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":210,"title":["Pregnancy outcome after first trimester exposure to corticosteroids: a prospective controlled study"],"prefix":"10.1016","volume":"18","author":[{"given":"Chamutal","family":"Gur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orna","family":"Diav-Citrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Shechtman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Arnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asher","family":"Ornoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2003.10.007_BIB1","unstructured":"Parfitt K, Sweetman SC, Blake PS, et al. Martindale: the complete drug reference, 32nd ed. Taunton, MA: Pharmaceutical Press; 1999. p. 1010\u201350."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB2","unstructured":"Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk, 6th ed. Philadelphia, PA: Lippincot, Williams & Wilkins; 2002. p. 326, 378\u201381, 662\u201370, 1380\u20132."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/pmj.77.905.157","article-title":"Pregnancy in systemic lupus erythematosus","volume":"77","author":"Mok","year":"2001","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB4","unstructured":"Schardein JL. Chemically induced birth defects, 2nd ed. New York, NY: Marcel Dekker, Inc.; 1993. p. 1\u201340, 307\u201313."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB5","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0140-6736(56)90805-4","article-title":"Cortisone therapy in early pregnancy: relation to cleft palate","volume":"1","author":"Harris","year":"1956","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB6","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0140-6736(56)92408-4","article-title":"Cleft palate following cortisone therapy in early pregnancy","volume":"2","author":"Doig","year":"1956","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/tera.1420510107","article-title":"Teratogenic potential of corticosteroids in humans","volume":"51","author":"Fraser","year":"1995","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB8","doi-asserted-by":"crossref","unstructured":"Popert AJ. Pregnancy and adrenocortical hormons: some aspects of their interaction in rheumatic diseases. BMJ 1962:967\u201372.","DOI":"10.1136\/bmj.1.5283.967"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(68)92723-2","article-title":"Outcome for the foetus of mothers receiving prednisolone during pregnancy","volume":"1","author":"Warrell","year":"1968","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB10","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1001\/jama.1975.03260070062025","article-title":"Corticosteroid therapy for the pregnant asthmatic patient","volume":"233","author":"Schatz","year":"1975","journal-title":"JAMA"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB11","unstructured":"Heinonen OP, Slone D, Shapiro S. Birth defects and drugs in pregnancy. Littleton, MA: Publishing Sciences Group; 1977. p. 389\u201391."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0016-5085(81)90193-1","article-title":"Pregnancy in inflammatory bowel disease: effect of sulfasalazine and corticosteroid on fetal outcome","volume":"80","author":"Mogadam","year":"1981","journal-title":"Gastroentrology"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB13","first-page":"732","article-title":"Prospective study of pregnancy in systemic lupus erythematosus: result of a multidisciplinary approach","volume":"13","author":"Mintz","year":"1986","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0091-6749(86)80088-4","article-title":"Outcome of pregnancy in women requiring corticosteroids for severe asthma","volume":"78","author":"Fitzsimons","year":"1986","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB15","first-page":"365","article-title":"Outcome of children born to women treated during pregnancy for the antiphospholipid syndrome","volume":"80","author":"Pollard","year":"1992","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1056\/NEJM199707173370302","article-title":"Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss","volume":"337","author":"Laskin","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/1096-9926(200012)62:6<385::AID-TERA5>3.0.CO;2-Z","article-title":"Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies","volume":"62","author":"Park-Wyllie","year":"2000","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JRS-1994-6201","article-title":"Malformation surveillance and maternal drug exposure: the MADRE project","volume":"6","author":"Robert","year":"1994","journal-title":"Int. J. Risk Safety Med."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/(SICI)1096-9926(199711)56:5<335::AID-TERA7>3.0.CO;2-W","article-title":"Population-based case-control study of teratogenic potential of corticosteroids","volume":"56","author":"Czeizel","year":"1997","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/(SICI)1096-9926(199807)58:1<2::AID-TERA2>3.0.CO;2-4","article-title":"Corticosteroids during pregnancy and oral clefts: a case-control study","volume":"58","author":"Rodriguez-Pinilla","year":"1998","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/(SICI)1096-8628(19990917)86:3<242::AID-AJMG9>3.0.CO;2-U","article-title":"Maternal corticosteroid use and risk of selected congenital anomalies","volume":"86","author":"Carmichael","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/tera.1033","article-title":"Pregnancy outcome after gestational exposure to metronidazole: a prospective controlled cohort study","volume":"63","author":"Diav-Citrin","year":"2001","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1096-9926(199901)59:1<1::AID-TERA1>3.0.CO;2-L","article-title":"Need for inclusion and exclusion criteria for the structural abnormalities recorded in children born from exposed pregnancies","volume":"59","author":"Holmes","year":"1999","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB24","unstructured":"Rudolph AM, Hoffman JIE. Pediatrics, 18th ed. Norwalk, CT: Appleton & Lange; 1987. p. 1291."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB25","unstructured":"Behrman RE, Vaughan VC. Nelson textbook of pediatrics, 13th ed. Philadelphia, PA: W.B. Saunders Company; 1987. p. 268\u20139."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB26","unstructured":"Harper PS. Practical genetic counselling, 5th ed. Oxford: Butterworth-Heinemann; 1998. p. 210\u20131."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.7326\/0003-4819-94-5-667","article-title":"Systemic lupus erythematosus in pregnancy","volume":"94","author":"Fine","year":"1981","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB28","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.705336","article-title":"Prenatal exposure to prednisone in humans and animals retards intrauterine growth","volume":"202","author":"Reinisch","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/tera.1420060206","article-title":"Postnatal effects of maternal hypercortisonism on skeletal development in newborn rats","volume":"6","author":"Ornoy","year":"1972","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2003.10.007_BIB30","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1056\/NEJM198508013130516","article-title":"Retardation of fetal growth in patients receiving immunosuppresive therapy","volume":"313","author":"Pirson","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0091-6749(97)70241-0","article-title":"The safety of asthma and allergy medications during pregnancy","volume":"100","author":"Schatz","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.reprotox.2003.10.007_BIB32","unstructured":"Cunningham FG, MacDonald PC, Gant NF, et al. Williams obstetrics, 20th ed. London: Appleton & Lange; 1997. p. 2, 579\u2013605, 797\u2013816, 839\u201353."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623803001539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623803001539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:02Z","timestamp":1760188862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623803001539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0890623803001539"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2003.10.007","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnancy outcome after first trimester exposure to corticosteroids: a prospective controlled study","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2003.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}