{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:36:57Z","timestamp":1788791817959,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.reprotox.2005.02.007","type":"journal-article","created":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T08:01:32Z","timestamp":1115280092000},"page":"261-266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tofupill lacks peripheral estrogen-like actions in the rat reproductive tract"],"prefix":"10.1016","volume":"20","author":[{"given":"Martha V.","family":"Oropeza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Orozco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Ponce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda G.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2005.02.007_bib1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1056\/NEJMra000471","article-title":"Production and action of estrogens","volume":"346","author":"Gruber","year":"2002","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.reprotox.2005.02.007_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0026-895X(25)13162-3","article-title":"Commonly occurring plant flavonoids have estrogenic activity","volume":"44","author":"Miksicek","year":"1993","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.reprotox.2005.02.007_bib3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1079\/BJN19980068","article-title":"Phyto-oestrogens: Where are we now?","volume":"79","author":"Bingham","year":"1998","journal-title":"Br J Nutr"},{"key":"10.1016\/j.reprotox.2005.02.007_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/ajcn\/60.3.333","article-title":"Biological effects of a diet soy protein rich in isoflavones on the menstrual cycle of premenopausal women","volume":"60","author":"Cassidy","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.reprotox.2005.02.007_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00053261","article-title":"Ambiguities of aging: Japanese experience and perceptions of menopause","volume":"10","author":"Lock","year":"1986","journal-title":"Culture Med Psych"},{"key":"10.1016\/j.reprotox.2005.02.007_bib6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/bmj.301.6757.905-a","article-title":"Oestrogenic effects of plant foods on postmenopausal women","volume":"301","author":"Wilcox","year":"1990","journal-title":"Br Med J"},{"key":"10.1016\/j.reprotox.2005.02.007_bib7","first-page":"1685","article-title":"Dietary intervention study to assess estrogenicity of dietary soy, among postmenopausal women","volume":"80","author":"Baird","year":"1995","journal-title":"Clin Endocr"},{"key":"10.1016\/j.reprotox.2005.02.007_bib8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5122(95)00899-V","article-title":"Dietary flour supplementation decreases postmenopausal hot flushes: effect of soy and wheat","volume":"21","author":"Murkies","year":"1995","journal-title":"Maturitas"},{"key":"10.1016\/j.reprotox.2005.02.007_bib9","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0015-0282(01)01777-0","article-title":"Lack of effect of isoflavonic phytoestrogen intake on leptin concentrations in premenopausal and postmenopausal women","volume":"75","author":"Phipps","year":"2001","journal-title":"Fert Steril"},{"key":"10.1016\/j.reprotox.2005.02.007_bib10","first-page":"297","article-title":"Phytoestrogens clinical review","volume":"82","author":"Murkies","year":"1998","journal-title":"J Clin Endocr Metab"},{"key":"10.1016\/j.reprotox.2005.02.007_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0039-128X(92)90066-I","article-title":"Effects of a normal, human-concentration, phytoestrogen diet on rat uterine growth","volume":"57","author":"Whitten","year":"1992","journal-title":"Steroids"},{"key":"10.1016\/j.reprotox.2005.02.007_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0960-0760(00)00179-5","article-title":"Genistein and daidzein modulate in vitro rat uterine contractile activity","volume":"75","author":"Picherit","year":"2000","journal-title":"J Steroid Pharm Mol Biol"},{"issue":"5","key":"10.1016\/j.reprotox.2005.02.007_bib13","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0015-0282(16)58282-X","article-title":"Effects of hormonal therapies and dietary soy phytoestrogens on vaginal cytology in surgically postmenopausal macaques","volume":"65","author":"Cline","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.reprotox.2005.02.007_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/02652038509373531","article-title":"Naturally occurring oestrogens in foods\u2014a review","volume":"2","author":"Price","year":"1985","journal-title":"Food Addit Contam"},{"key":"10.1016\/j.reprotox.2005.02.007_bib15","first-page":"71","article-title":"The sensitivity of rat uterus to serotonin in vitro is a late estrogenic response","volume":"21","author":"Campos-Lara","year":"1990","journal-title":"Arch Invest Med (Mex)"},{"key":"10.1016\/j.reprotox.2005.02.007_bib16","doi-asserted-by":"crossref","first-page":"13438","DOI":"10.1016\/S0021-9258(17)43933-0","article-title":"Increase of serotonin receptors in rat uterus induced by estradiol","volume":"258","author":"Ichida","year":"1983","journal-title":"J Biol Chem"},{"key":"10.1016\/j.reprotox.2005.02.007_bib17","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0022-3565(25)21839-0","article-title":"Mechanisms of specific change by estradiol in sensitivity of rat uterus to serotonin","volume":"229","author":"Ichida","year":"1984","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.reprotox.2005.02.007_bib18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0014-2999(85)90447-9","article-title":"Estradiol-induced increase of specific [3H]-ketanserin binding sites on rat uterine membranes","volume":"108","author":"Ichida","year":"1985","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.reprotox.2005.02.007_bib19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0014-2999(02)01827-7","article-title":"Anatomical differences in uterine sensitivity to prostaglandin F2a and serotonin in non-pregnant rats","volume":"446","author":"Oropeza","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.reprotox.2005.02.007_bib20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000146639","article-title":"Effects of ovarian steroids on vaginal smears in the rat","volume":"133","author":"Montes","year":"1988","journal-title":"Acta Anatomica"},{"key":"10.1016\/j.reprotox.2005.02.007_bib21","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1093\/nar\/15.6.2499","article-title":"Molecular cloning and characterization of rat estrogen receptor cDNA","volume":"15","author":"Saiki","year":"1987","journal-title":"Nucleic Acid Res"},{"key":"10.1016\/j.reprotox.2005.02.007_bib22","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1210\/mend-1-10-735","article-title":"Structural organization and expression of the mouse estrogen receptor","volume":"1","author":"White","year":"1987","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.reprotox.2005.02.007_bib23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0039-128X(94)90014-0","article-title":"Influence of phytoestrogen diets on estradiol action in the rat uterus","volume":"59","author":"Whitten","year":"1994","journal-title":"Steroids"},{"key":"10.1016\/j.reprotox.2005.02.007_bib24","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3181\/00379727-217-44242","article-title":"Effects of dietary soybean estrogens on the reproductive tract in the female rats","volume":"217","author":"Tansey","year":"1998","journal-title":"Proc Soc Exp Biol Med"},{"issue":"6","key":"10.1016\/j.reprotox.2005.02.007_bib25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/01.GME.0000064864.58809.77","article-title":"Tofupill\/Femarelle (DT56a): a new phyto-selective estrogen receptor modulator-like substance for the treatment of postmenopausal bone loss","volume":"10","author":"Yoles","year":"2003","journal-title":"Menopause"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623805000717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623805000717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:22:31Z","timestamp":1760188951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623805000717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0890623805000717"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2005.02.007","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tofupill lacks peripheral estrogen-like actions in the rat reproductive tract","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2005.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}