{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:42:07Z","timestamp":1761154927293,"version":"build-2065373602"},"reference-count":65,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.reprotox.2006.05.002","type":"journal-article","created":{"date-parts":[[2006,6,24]],"date-time":"2006-06-24T07:27:14Z","timestamp":1151134034000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Inherited and acquired thrombophilia: Pregnancy outcome and treatment"],"prefix":"10.1016","volume":"22","author":[{"given":"Marco","family":"De Santis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.F.","family":"Cavaliere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Straface","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Di Gianantonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2006.05.002_bib1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1046\/j.1365-2141.2001.02981.x","article-title":"On behalf of the haemostasis and thrombosis task force British Committee for standards in haematology. Investigation and management of heritable thrombophilia","volume":"114","author":"Walker","year":"2001","journal-title":"Br J Haematology"},{"key":"10.1016\/j.reprotox.2006.05.002_bib2","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1055\/s-0037-1613085","article-title":"Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium","volume":"87","author":"Martinelli","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.reprotox.2006.05.002_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1600-0897.1989.tb01016.x","article-title":"Antiphospholipid antibodies and reproduction","volume":"21","author":"Triplett","year":"1989","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1055\/s-0038-1650282","article-title":"The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women","volume":"75","author":"Sanson","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.reprotox.2006.05.002_bib5","doi-asserted-by":"crossref","first-page":"736","DOI":"10.7326\/0003-4819-130-9-199905040-00013","article-title":"Increased risk for fetal loss in carrierrs of the factor V Leiden mutation","volume":"130","author":"Meinardi","year":"1999","journal-title":"Ann Intern Med"},{"issue":"5","key":"10.1016\/j.reprotox.2006.05.002_bib6","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0015-0282(00)01545-4","article-title":"Primary habitual abortions are associated with high frequency of factor V Leiden mutation","volume":"74","author":"Wramsby","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.reprotox.2006.05.002_bib7","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1093\/humrep\/14.7.1872","article-title":"The factor V Leiden mutation in Japanese couples with recurrent spontaneous abortion","volume":"14","author":"Hashimoto","year":"1999","journal-title":"Hum Reprod Embr"},{"key":"10.1016\/j.reprotox.2006.05.002_bib8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/01.ATV.20.1.266","article-title":"Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylennetetrahydrofolate reductase polymorphism in pregnancy","volume":"20","author":"Murphy","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib9","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1055\/s-0037-1614519","article-title":"Activated protein C resistance (FV: Q506) and pregnancy","volume":"81","author":"Lindqvist","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.reprotox.2006.05.002_bib10","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/humrep\/16.5.961","article-title":"Factor V Leiden and acquired activated protein C resistance among women with recurrent miscarriage","volume":"16","author":"Rai","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.reprotox.2006.05.002_bib11","first-page":"447","article-title":"Prothrombotic gene mutations in women with recurrent abortions and intrauterine fetal death","volume":"57","author":"Santoro","year":"2005","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib12","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.metabol.2005.04.024","article-title":"The factor V Leiden mutation, high factor VIII, and high plasminogen activator inhibitor activity: etiologies for sporadic miscarriages","volume":"54","author":"Gluck","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.reprotox.2006.05.002_bib13","first-page":"1223","article-title":"The association between hereditary thrombophilias and pregnancy loss","volume":"90","author":"Lissalde-Lavigne","year":"2005","journal-title":"Haematologica"},{"key":"10.1016\/j.reprotox.2006.05.002_bib14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2174\/1389450054545971","article-title":"Pregnancy and delivery in protein C-deficiency","volume":"6","author":"Sugiura","year":"2005","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.reprotox.2006.05.002_bib15","first-page":"245","article-title":"Frequency of thrombophilia in patients with adverse pregnancy outcome","volume":"55","author":"Hossain","year":"2005","journal-title":"J Pak Med Assoc"},{"key":"10.1016\/j.reprotox.2006.05.002_bib16","first-page":"1","article-title":"Thrombophilic mutations in Iranian patients with infertility and recurrent spontaneous abortion","volume":"1","author":"Behjati","year":"2006","journal-title":"Ann Hematol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib17","first-page":"23","article-title":"Genetic thrombophilic mutations among couples with recurrent miscarriage","author":"Jivray","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.reprotox.2006.05.002_bib18","doi-asserted-by":"crossref","unstructured":"Weintraub AY, Sheiner E, Levy A, Yerushalmi R, Mazor M. Pregnancy complications in women with inherited thrombophilia. Arch Gynecol Obstet; 2006.","DOI":"10.1007\/s00404-006-0133-3"},{"key":"10.1016\/j.reprotox.2006.05.002_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2141.2005.05847.x","article-title":"Thrombophilia in pregnancy: a aystematic review","volume":"132","author":"Robertson","year":"2006","journal-title":"Br J Haematol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib20","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/0002-9378(95)91324-6","article-title":"Underlying disorders associated with severe early onset preeclampsia","volume":"173","author":"Dekker","year":"1995","journal-title":"Am J Obstet Gnnecol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/00003081-199909000-00002","article-title":"Risk factor for preeclampsia","volume":"42","author":"Dekker","year":"1999","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib22","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0002-9378(96)80022-6","article-title":"The factor V Leiden mutation may predispose women to severe preeclampsia","volume":"175","author":"Dizon-Townson","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib23","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1055\/s-0038-1656110","article-title":"Factor V Leiden, C>T MTHFR polymorphism and genetic susceptibility to preeclampsia","volume":"77","author":"Grandone","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.reprotox.2006.05.002_bib24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1399-0004.1998.tb02599.x","article-title":"Detection of factor V Leiden mutation in severe preeclamtic Hungarian women","volume":"53","author":"Nagy","year":"1998","journal-title":"Clin Genet"},{"key":"10.1016\/j.reprotox.2006.05.002_bib25","first-page":"45","article-title":"Severe preeclampsia and high frequency of genetic thrombophilic mutations","volume":"96","author":"Kupferminc","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0002-9378(97)70515-5","article-title":"Preeclampsia is associated with a reduced response to activated protein C","volume":"176","author":"Lindoff","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib27","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/jmg.34.6.525","article-title":"Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia","volume":"34","author":"Sohda","year":"1997","journal-title":"J Med Genet"},{"key":"10.1016\/j.reprotox.2006.05.002_bib28","first-page":"1052","article-title":"Elevated homocysteine levels with preeclampsia","volume":"77","author":"Rajkovic","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.reprotox.2006.05.002_bib29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/ajcn\/77.2.467","article-title":"Plasma total cysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordland Homocysteine Study","volume":"77","author":"El-Khairy","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.reprotox.2006.05.002_bib30","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0002-9378(00)70362-0","article-title":"High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia","volume":"182","author":"Van Pampus","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1081\/PRG-100107831","article-title":"Prothrombin 20210 G: a mutation and factor V Leiden mutation in women with a history of severe preeclampsia and (H)ELLP syndrome","volume":"20","author":"Van Pampus","year":"2001","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.reprotox.2006.05.002_bib32","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/00004872-200307000-00002","article-title":"Association of Leiden mutation in factor V gene with hypertension in pregnancy and preeclampsia: a meta-analysis","volume":"21","author":"Kosmas","year":"2003","journal-title":"J Hypertens"},{"key":"10.1016\/j.reprotox.2006.05.002_bib33","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1097\/00004872-200409000-00004","article-title":"Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and preeclampsia: a meta-analysis","volume":"22","author":"Kosmas","year":"2004","journal-title":"J Hypertens"},{"key":"10.1016\/j.reprotox.2006.05.002_bib34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.0001-6349.2004.00291.x","article-title":"Plasma homocysteine in early and late pregnancies complicated with preeclampsia and isolated intrauterine growth restriction","volume":"83","author":"D\u2019Anna","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.reprotox.2006.05.002_bib35","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/01.HYP.0000188979.74172.4d","article-title":"Trombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study","volume":"46","author":"Mello","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.reprotox.2006.05.002_bib36","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/01.HYP.0000188904.47575.7e","article-title":"Thrombophilia and severe preeclampsia: time to screen and treat in future pregnancies?","volume":"46","author":"Sibai","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.reprotox.2006.05.002_bib37","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0140-6736(05)74935-7","article-title":"Acquired activated protein-C resistance in pregnancy and association with increased thrombin generation and fetal weight","volume":"353","author":"Clark","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2006.05.002_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJM199901073400102","article-title":"Increased frequency of genetic trombophilia in women with complications of pregnancy","volume":"340","author":"Kupferminc","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.reprotox.2006.05.002_bib39","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1034\/j.1600-0412.2000.079011963.x","article-title":"High prevalence of the prothromin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss","volume":"79","author":"Kupferminc","year":"2000","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.reprotox.2006.05.002_bib40","first-page":"428","article-title":"Familial thrombophilia and the occurrence of fetal growth restriction","volume":"86","author":"Martinelli","year":"2001","journal-title":"Haematologica"},{"key":"10.1016\/j.reprotox.2006.05.002_bib41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1056\/NEJM200207043470105","article-title":"Absence of association of thrombophilia polymorphism with intrauterine growth restriction","volume":"347","author":"Infante-Rivard","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.reprotox.2006.05.002_bib42","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1373\/49.9.1476","article-title":"Unexpected relationship between plasma homocysteine and intrauterine growth restriction","volume":"49","author":"Infante-Rivard","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.reprotox.2006.05.002_bib43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/01.ede.0000158199.64871.b9","article-title":"Thrombophlic polymorphisms and intrauterine growth restriction. Thrombophilic polymorphism and intrauterine growth restriction","volume":"16","author":"Infante-Rivard","year":"2005","journal-title":"Epidemiology"},{"key":"10.1016\/j.reprotox.2006.05.002_bib44","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.ajog.2004.09.011","article-title":"A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction","volume":"192","author":"Howley","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib45","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0002-9378(98)70025-0","article-title":"Resistance to activated protein C and the Leiden mutation: high prevalence in patients with abruptio placentae","volume":"179","author":"Wiener-Megnagi","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.reprotox.2006.05.002_bib46","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1471-0528.2000.tb13341.x","article-title":"Hyperhomocysteinemia and other thrombotic risk factors in women with placental vasculopathy","volume":"107","author":"Van der Molen","year":"2000","journal-title":"BJOG"},{"key":"10.1016\/j.reprotox.2006.05.002_bib47","first-page":"785","article-title":"Thrombophilic mutations are a main risk factor for placental abruption","volume":"88","author":"Facchinetti","year":"2003","journal-title":"Haematologica"},{"key":"10.1016\/j.reprotox.2006.05.002_bib48","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1046\/j.1471-0528.2003.02369.x","article-title":"Factor V Leiden in pregnancies complicated by placental abruption","volume":"110","author":"Prochazka","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.reprotox.2006.05.002_bib49","doi-asserted-by":"crossref","first-page":"627S","DOI":"10.1378\/chest.126.3_suppl.627S","article-title":"Use of antithrombotic agents during pregnancy. The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Bates","year":"2004","journal-title":"Chest"},{"issue":"S12","key":"10.1016\/j.reprotox.2006.05.002_bib50","first-page":"1","article-title":"Linee guida sull\u2019uso dei farmaci anticoagulanti e antiaggreganti in ostetricia e ginecologia","volume":"87","author":"Grandone","year":"2002","journal-title":"Haematologica"},{"key":"10.1016\/j.reprotox.2006.05.002_bib51","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1182\/blood-2005-02-0626","article-title":"Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy","volume":"106","author":"Greer","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.reprotox.2006.05.002_bib52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/s-0038-1642376","article-title":"Comparison of subcutaneos unfractionated heparin with a low-molecular weight heparin (Fragmin) in patients with venous thromoembolism and contraindications for coumarin","volume":"71","author":"Monreal","year":"1994","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.reprotox.2006.05.002_bib53","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-0037-1612970","article-title":"Postpartum bone mineral density in women treated for thromboprophylaxis with unfractionated heparin or LMW heparin","volume":"87","author":"Pettila","year":"2002","journal-title":"Thromb Haemost"},{"issue":"5","key":"10.1016\/j.reprotox.2006.05.002_bib54","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1055\/s-0037-1614550","article-title":"Safety of low-molecular-weight heparin in pregnancy: a systematic review","volume":"81","author":"Sanson","year":"1999","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1016\/j.reprotox.2006.05.002_bib55","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1055\/s-0038-1650538","article-title":"Low molecular weight heparin as thromboprophylaxis in familial thrombophilia during the whole period of pregnancy","volume":"76","author":"Boda","year":"1996","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1016\/j.reprotox.2006.05.002_bib56","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-0038-1655903","article-title":"Thromboprophylaxis with low molecular weight heparin (Fragmin) in high risk pregnancies","volume":"77","author":"Hunt","year":"1997","journal-title":"Throm Haemost"},{"issue":"1","key":"10.1016\/j.reprotox.2006.05.002_bib57","first-page":"140","article-title":"Bleeding complications associated with low molecular weight heparin prophylaxis during pregnancy","volume":"84","author":"Lindqvist","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.reprotox.2006.05.002_bib58","unstructured":"Reports of epidural or spinal haematomas with the concurrent use of low molecular weight heparin and spinal\/epidural anesthesia or spinal puncture. Food and Drug Administration, Washington; December 1997."},{"issue":"2","key":"10.1016\/j.reprotox.2006.05.002_bib59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0049-3848(92)90027-8","article-title":"Study on neutralization of low molecular weight heparin (LHG) by protamine sulfate and its neutralization characteristics","volume":"68","author":"Sugiyama","year":"1992","journal-title":"Thromb Res"},{"issue":"2","key":"10.1016\/j.reprotox.2006.05.002_bib60","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1001\/archinte.160.2.191","article-title":"Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature","volume":"160","author":"Chan","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.reprotox.2006.05.002_bib61","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2174\/1389450054546024","article-title":"The role of factor V Leiden in maternal health and the outcome of pregnancy","volume":"6","author":"Calderwood","year":"2005","journal-title":"Curr Drug Targets"},{"issue":"14","key":"10.1016\/j.reprotox.2006.05.002_bib62","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1056\/NEJM200010053431405","article-title":"Mutations in coagulation factors in women with unexplained late fetal loss","volume":"343","author":"Martinelli","year":"2000","journal-title":"N Engl J Med"},{"issue":"9361","key":"10.1016\/j.reprotox.2006.05.002_bib63","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0140-6736(03)12771-7","article-title":"Thrombophilic disorders and fetal loss: a meta-analysis","volume":"361","author":"Rey","year":"2003","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.reprotox.2006.05.002_bib64","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0015-0282(00)01595-8","article-title":"Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis","volume":"74","author":"Nelen","year":"2000","journal-title":"Fertil Steril"},{"issue":"10","key":"10.1016\/j.reprotox.2006.05.002_bib65","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1182\/blood-2003-01-0320","article-title":"Antiphospholipid\/antiprotein antibodies, hemostasis-related autoantibodies, and plasma homocysteine as risk factors for a first early pregnancy loss: a matched case\u2013control study","volume":"102","author":"Gris","year":"2003","journal-title":"Blood"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623806001249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623806001249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:25:15Z","timestamp":1760189115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623806001249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0890623806001249"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2006.05.002","relation":{},"ISSN":["0890-6238"],"issn-type":[{"type":"print","value":"0890-6238"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inherited and acquired thrombophilia: Pregnancy outcome and treatment","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2006.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}