{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:46:22Z","timestamp":1760240782070,"version":"build-2065373602"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.reprotox.2006.05.007","type":"journal-article","created":{"date-parts":[[2006,6,5]],"date-time":"2006-06-05T14:41:59Z","timestamp":1149518519000},"page":"636-646","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cadmium-induced gene expression changes in the mouse embryo, and the influence of pretreatment with zinc"],"prefix":"10.1016","volume":"22","author":[{"given":"Kim","family":"Kultima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Est\u00edbaliz L.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birger","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Lee","family":"Gustafson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Dencker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Stigson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2006.05.007_bib1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/tera.1420210110","article-title":"Changes in the mouse neuroepithelium associated with cadmium-induced neural tube defects","volume":"21","author":"Webster","year":"1980","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2006.05.007_bib2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1600-0773.1991.tb01303.x","article-title":"Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms","volume":"69","author":"Nau","year":"1991","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.reprotox.2006.05.007_bib3","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1289\/txg.7034","article-title":"Valproic acid teratogenicity: a toxicogenomics approach","volume":"112","author":"Kultima","year":"2004","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.reprotox.2006.05.007_bib4","first-page":"429","article-title":"The relationship of cadmium and zinc in experimental mammalian teratogenesis","volume":"18","author":"Ferm","year":"1968","journal-title":"Lab Investig J Techn Meth Pathol"},{"key":"10.1016\/j.reprotox.2006.05.007_bib5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/tera.1420410606","article-title":"Marked accumulation of valproic acid in embryonic neuroepithelium of the mouse during early organogenesis","volume":"41","author":"Dencker","year":"1990","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2006.05.007_bib6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1530\/jrf.0.0440461","article-title":"Possible mechanisms of cadmium fetotoxicity in golden hamsters and mice: uptake by the embryo, placenta and ovary","volume":"44","author":"Dencker","year":"1975","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.reprotox.2006.05.007_bib7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.reprotox.2004.04.003","article-title":"Disturbing endoderm signaling to anterior neural plate of vertebrates by the teratogen cadmium","volume":"18","author":"Fernandez","year":"2004","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2006.05.007_bib8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0013-9351(87)80006-3","article-title":"Effect of cadmium on prenatal development and on tissue cadmium, copper, and zinc concentrations in rats","volume":"42","author":"Baranski","year":"1987","journal-title":"Environ Res"},{"key":"10.1016\/j.reprotox.2006.05.007_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/tera.1420220102","article-title":"Fetal toxicity of cadmium in the rat: maternal versus fetal injections","volume":"22","author":"Levin","year":"1980","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2006.05.007_bib10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/tera.1420440306","article-title":"Chemically induced alterations in maternal homeostasis and histology of conceptus: their etiologic significance in rat fetal anomalies","volume":"44","author":"Khera","year":"1991","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2006.05.007_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0300-483X(90)90102-M","article-title":"Cadmium teratogenicity and its relationship with metallothionein gene expression in midgestation mouse embryos","volume":"64","author":"De","year":"1990","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2006.05.007_bib12","first-page":"93","article-title":"Effects of cadmium on the placental uptake and transport to the fetus of nutrients","volume":"5","author":"Danielsson","year":"1984","journal-title":"Biol Res Pregnancy Perinatol"},{"key":"10.1016\/j.reprotox.2006.05.007_bib13","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0041-008X(91)90046-H","article-title":"The role of metallothionein induction and altered zinc status in maternally mediated developmental toxicity: comparison of the effects of urethane and styrene in rats","volume":"110","author":"Daston","year":"1991","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.reprotox.2006.05.007_bib14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0890-6238(94)90064-7","article-title":"Altered maternal zinc metabolism following exposure to diverse developmental toxicants","volume":"8","author":"Taubeneck","year":"1994","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2006.05.007_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0300-483X(97)00171-6","article-title":"Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid","volume":"126","author":"Bui","year":"1998","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2006.05.007_bib16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/toxsci\/kfg208","article-title":"Cadmium-induced changes in apoptotic gene expression levels and DNA damage in mouse embryos are blocked by zinc","volume":"76","author":"Fernandez","year":"2003","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2006.05.007_bib17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nrg1181","article-title":"The genetic basis of mammalian neurulation","volume":"4","author":"Copp","year":"2003","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.reprotox.2006.05.007_bib18","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1242\/dev.118.4.1255","article-title":"Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope","volume":"118","author":"Downs","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2006.05.007_bib19","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrg863","article-title":"Design issues for cDNA microarray experiments","volume":"3","author":"Yang","year":"2002","journal-title":"Nat Rev Genet"},{"issue":"Suppl","key":"10.1016\/j.reprotox.2006.05.007_bib20","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ng1031","article-title":"Fundamentals of experimental design for cDNA microarrays","volume":"32","author":"Churchill","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.reprotox.2006.05.007_bib21","doi-asserted-by":"crossref","first-page":"9127","DOI":"10.1073\/pnas.97.16.9127","article-title":"Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray","volume":"97","author":"Tanaka","year":"2000","journal-title":"PNAS"},{"key":"10.1016\/j.reprotox.2006.05.007_bib22","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/30.4.e15","article-title":"Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation","volume":"30","author":"Yang","year":"2002","journal-title":"Nucl Acids Res"},{"key":"10.1016\/j.reprotox.2006.05.007_bib23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1046-2023(03)00155-5","article-title":"Normalization of cDNA microarray data","volume":"31","author":"Smyth","year":"2003","journal-title":"Methods"},{"key":"10.1016\/j.reprotox.2006.05.007_bib24","first-page":"3","article-title":"Linear models and empirical Bayes methods for assessing differential expression in microarray experiments","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"10.1016\/j.reprotox.2006.05.007_bib25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J Roy Stat Soc Ser B"},{"key":"10.1016\/j.reprotox.2006.05.007_bib26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/abio.2001.5530","article-title":"A new quantitative method of real time reverse transcription polymerase chain reaction assay based on simulation of polymerase chain reaction kinetics","volume":"302","author":"Liu","year":"2002","journal-title":"Anal Biochem"},{"key":"10.1016\/j.reprotox.2006.05.007_bib27","first-page":"1372","article-title":"Processing of gene expression data generated by quantitative real-time RT-PCR","volume":"32","author":"Muller","year":"2002","journal-title":"Biotechniques"},{"key":"10.1016\/j.reprotox.2006.05.007_bib28","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1016\/S0021-9258(18)83358-0","article-title":"Transcriptional activation of the heme oxygenase gene by heme and cadmium in mouse hepatoma cells","volume":"264","author":"Alam","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.reprotox.2006.05.007_bib29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0891-5849(01)00826-7","article-title":"Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I\/II-null mice","volume":"32","author":"Liu","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.reprotox.2006.05.007_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0006-2952(99)00301-9","article-title":"Regulation of metallothionein gene expression by oxidative stress and metal ions","volume":"59","author":"Andrews","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.reprotox.2006.05.007_bib31","doi-asserted-by":"crossref","first-page":"492","DOI":"10.2144\/04373AF02","article-title":"The ProbeLibrary\u2122\u2014expression profiling 99% of all human genes using only 90 dual-labeled real-time PCR Probes","volume":"37","author":"Mouritzen","year":"2004","journal-title":"Biotechniques"},{"key":"10.1016\/j.reprotox.2006.05.007_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1289\/ehp.0110971","article-title":"Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene","volume":"109","author":"Bartosiewicz","year":"2001","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.reprotox.2006.05.007_bib33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.pharmtox.39.1.267","article-title":"Metallothionein: an intracellular protein to protect against cadmium toxicity","volume":"39","author":"Klaassen","year":"1999","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"10.1016\/j.reprotox.2006.05.007_bib34","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1006\/bbrc.1997.7059","article-title":"Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress","volume":"236","author":"Danno","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.reprotox.2006.05.007_bib35","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1242\/jcs.01026","article-title":"Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism","volume":"117","author":"Wellmann","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1016\/j.reprotox.2006.05.007_bib36","first-page":"176","article-title":"Hydroxylation of HIF-1: oxygen sensing at the molecular level","volume":"19","author":"Semenza","year":"2004","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.reprotox.2006.05.007_bib37","first-page":"924","article-title":"Regulation of heme oxygenase-1 gene transcription: recent advances and highlights from the International Conference (Uppsala, 2003) on heme oxygenase","volume":"6","author":"Alam","year":"2004","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.reprotox.2006.05.007_bib38","first-page":"974","article-title":"Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells","volume":"51","author":"Applegate","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/j.reprotox.2006.05.007_bib39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1089\/ars.2005.7.80","article-title":"Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models","volume":"7","author":"Ryter","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.reprotox.2006.05.007_bib40","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1210\/endo.138.12.5628","article-title":"Identification and characterization of a mouse homolog for decidual\/trophoblast prolactin-related protein","volume":"138","author":"Orwig","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2006.05.007_bib41","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1095\/biolreprod56.3.647","article-title":"Dual expression of prolactin-related protein in decidua and trophoblast tissues during pregnancy in rats","volume":"56","author":"Rasmussen","year":"1997","journal-title":"Biol Reprod"},{"key":"10.1016\/j.reprotox.2006.05.007_bib42","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1210\/endo.138.12.5636","article-title":"Two novel members of the prolactin\/growth hormone family are expressed in the mouse placenta","volume":"138","author":"Lin","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2006.05.007_bib43","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/S0022-3476(98)70522-0","article-title":"Nutritional studies of the embryo during early organogenesis with normal embryos and embryos exhibiting yolk sac dysfunction","volume":"132","author":"Brent","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.reprotox.2006.05.007_bib44","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1002\/j.1460-2075.1994.tb06807.x","article-title":"Cyclin G is a transcriptional target of the p53 tumor suppressor protein","volume":"13","author":"Okamoto","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.reprotox.2006.05.007_bib45","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1038\/sj.onc.1204270","article-title":"Cyclin G1 is involved in G2\/M arrest in response to DNA damage and in growth control after damage recovery","volume":"20","author":"Kimura","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.reprotox.2006.05.007_bib46","first-page":"195","article-title":"Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways","volume":"1","author":"Zhao","year":"2003","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.reprotox.2006.05.007_bib47","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1046\/j.1471-4159.1996.66052213.x","article-title":"Characterization of a novel platelet-derived growth factor-associated protein","volume":"66","author":"Fischer","year":"1996","journal-title":"J Neurochem"},{"key":"10.1016\/j.reprotox.2006.05.007_bib48","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1242\/dev.124.14.2691","article-title":"The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites","volume":"124","author":"Soriano","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2006.05.007_bib49","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1242\/dev.00241","article-title":"Cell autonomous requirement for PDGFR{alpha} in populations of cranial and cardiac neural crest cells","volume":"130","author":"Tallquist","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2006.05.007_bib50","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.toxlet.2004.07.015","article-title":"Cadmium at a non-toxic dose alters gene expression in mouse testes","volume":"154","author":"Zhou","year":"2004","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.reprotox.2006.05.007_bib51","first-page":"bti737","article-title":"Integrating time-course microarray gene expression profiles with cytotoxicity for identification of biomarkers in primary rat hepatocytes exposed to cadmium","author":"Tan","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.reprotox.2006.05.007_bib52","doi-asserted-by":"crossref","unstructured":"Gurvich N, Berman MG, Wittner BS, Gentleman RC, Klein PS, Green JB, Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo. Faseb J 2005.","DOI":"10.1096\/fj.04-3425fje"},{"key":"10.1016\/j.reprotox.2006.05.007_bib53","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1158\/0008-5472.CAN-03-0799","article-title":"Histone deacetylase is a target of valproic acid-mediated cellular differentiation","volume":"64","author":"Gurvich","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.reprotox.2006.05.007_bib54","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"G\u00f6ttlicher","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.reprotox.2006.05.007_bib55","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.reprotox.2006.05.007_bib56","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1038\/sj.onc.1208662","article-title":"Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A","volume":"24","author":"Reid","year":"2005","journal-title":"Oncogene"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623806001304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623806001304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:40Z","timestamp":1760189020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623806001304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0890623806001304"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2006.05.007","relation":{},"ISSN":["0890-6238"],"issn-type":[{"type":"print","value":"0890-6238"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium-induced gene expression changes in the mouse embryo, and the influence of pretreatment with zinc","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2006.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}