{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:13:52Z","timestamp":1781795632113,"version":"3.54.5"},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.reprotox.2007.02.001","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T07:08:10Z","timestamp":1171436890000},"page":"578-587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":172,"title":["Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: Its progression and genotoxic consequences"],"prefix":"10.1016","volume":"23","author":[{"given":"B.","family":"Shrilatha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Muralidhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2007.02.001_bib1","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1021\/ja00994a053","article-title":"The structure of streptozotocin","volume":"89","author":"Herr","year":"1967","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.reprotox.2007.02.001_bib2","first-page":"1","article-title":"Genotoxicity of streptozotocin","volume":"7690","author":"Bolzan","year":"2002","journal-title":"Mutat Res"},{"key":"10.1016\/j.reprotox.2007.02.001_bib3","first-page":"427","article-title":"Streptozotocin: a review of its pharmacology, efficacy and toxicity","volume":"66","author":"Weiss","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"10.1016\/j.reprotox.2007.02.001_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1383-5718(98)00087-4","article-title":"Modulation of O6-alkylating agent induced clastogenecity by enhanced DNA repair capacity of bone marrow cells","volume":"416","author":"Chinnaswamy","year":"1998","journal-title":"Mutat Res"},{"key":"10.1016\/j.reprotox.2007.02.001_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/jrf.0.1150001","article-title":"The Amoroso lecture\u2014the human spermatozoan\u2014a cell in crisis?","volume":"115","author":"Aitken","year":"1999","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.reprotox.2007.02.001_bib6","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0094-0143(02)00081-2","article-title":"Role of oxidants in male infertility: rationale, significance and treatment","volume":"29","author":"Agarwal","year":"2002","journal-title":"Urol Clin N Am"},{"key":"10.1016\/j.reprotox.2007.02.001_bib7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1464-410X.2005.05328.x","article-title":"Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach","volume":"95","author":"Agarwal","year":"2005","journal-title":"Br J Urol Int"},{"key":"10.1016\/j.reprotox.2007.02.001_bib8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0027-5107(95)00251-0","article-title":"Smoking and low antioxidant levels increase oxidative damage to sperm DNA","volume":"351","author":"Fraga","year":"1996","journal-title":"Mutat Res"},{"key":"10.1016\/j.reprotox.2007.02.001_bib9","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/j.1939-4640.2004.tb03173.x","article-title":"Nickel induced oxidative stress in testis of mice: Evidences of DNA damage and genotoxic effects","volume":"25","author":"Doreswamy","year":"2004","journal-title":"J Androl"},{"key":"10.1016\/j.reprotox.2007.02.001_bib10","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1007\/BF01964042","article-title":"Leydig cell function in streptozotocin-induced diabetic rats","volume":"35","author":"Paz","year":"1979","journal-title":"Experentia"},{"key":"10.1016\/j.reprotox.2007.02.001_bib11","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0090-4295(96)00573-0","article-title":"Effect of diabetes mellitus upon male reproductive function","volume":"49","author":"Sexton","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.reprotox.2007.02.001_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2337\/diab.40.4.405","article-title":"Role of oxidative stress in development of complications in diabetes","volume":"40","author":"Baynes","year":"1991","journal-title":"Diabetes"},{"key":"10.1016\/j.reprotox.2007.02.001_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.48.1.1","article-title":"Role of oxidative stress in diabetic complications: a new perspective on an old paradigm","volume":"48","author":"Baynes","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.reprotox.2007.02.001_bib14","first-page":"233","article-title":"Enhanced testicular antioxidant system by ascorbic acid in alloxan diabetic rats","volume":"124","author":"El-Missiry","year":"1999","journal-title":"Comp Biochem Physiol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib15","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s002400000134","article-title":"Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism","volume":"28","author":"Cai","year":"2000","journal-title":"Urol Res"},{"key":"10.1016\/j.reprotox.2007.02.001_bib16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/abbi.2000.1876","article-title":"Testis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidine-treated diabetic rats","volume":"319","author":"Unlucerci","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.reprotox.2007.02.001_bib17","unstructured":"Shrilatha B, Muralidhara. Occurrence of oxidative impairments, response of antioxidant defenses and associated biochemical perturbations in male reproductive milieu in the streptozotocin-daibetic rat. Int J Androl; in press."},{"key":"10.1016\/j.reprotox.2007.02.001_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00293658","article-title":"Dominant lethal mutations in mice","volume":"38","author":"Ehling","year":"1977","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib19","series-title":"Environmental health criteria, no. 51. Guide to short term tests for detecting mutagenic and carcinogenic chemicals","author":"WHO","year":"1985"},{"key":"10.1016\/j.reprotox.2007.02.001_bib20","unstructured":"Shrilatha B. Diabetes associated male reproductive dysfunction : role of oxidative stress and its amelioration. PhD Thesis, total pages 218. University of Mysore, Karnataka, India; July 2006"},{"key":"10.1016\/j.reprotox.2007.02.001_bib21","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0278-6915(02)00111-4","article-title":"Antioxidaitve effects of fluvastatin and its metabolites against DNA damage in streptozotocin-treated mice","volume":"40","author":"Imaeda","year":"2002","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib22","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1073\/pnas.72.11.4425","article-title":"Chemical induction of sperm abnormalities in mice","volume":"72","author":"Wyrobeck","year":"1975","journal-title":"Proc Nat Acad Sci (USA)"},{"key":"10.1016\/j.reprotox.2007.02.001_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1258\/002367796780865862","article-title":"Incidence of spontaneous post-implantation embryonic deaths in CFT-Swiss mice: its suitability to assess dominant lethal mutations","volume":"30","author":"Muralidhara","year":"1996","journal-title":"Lab Anim (UK)"},{"key":"10.1016\/j.reprotox.2007.02.001_bib24","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(96)64044-0","article-title":"Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts and transmitochondrial cell lines","volume":"264","author":"Trounce","year":"1996","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.reprotox.2007.02.001_bib26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0892-0362(99)00069-0","article-title":"Age-related changes in reactive oxygen species production in rat brain homogenates","volume":"2","author":"Driver","year":"2000","journal-title":"Neurotox Teratol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0076-6879(84)05013-8","article-title":"Superoxide dismutase assays","volume":"105","author":"Flohe","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib29","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","article-title":"Assays of glutathione peroxidase","volume":"105","author":"Flohe","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib30","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0076-6879(85)13067-3","article-title":"Glutathione S-transferase from rat testis","volume":"113","author":"Guthenberg","year":"1985","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib31","first-page":"507","article-title":"Glutathione reductase","volume":"113","author":"Carlberg","year":"1985","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.reprotox.2007.02.001_bib33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A fluorimetric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"Hissin","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.reprotox.2007.02.001_bib34","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib35","first-page":"1889","article-title":"Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation","volume":"41","author":"Birnboim","year":"1981","journal-title":"Cancer Res"},{"key":"10.1016\/j.reprotox.2007.02.001_bib36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2164\/jandrol.106.000265","article-title":"Induction of oxidative stress by organic hydroperoxides in testis and epididymal sperm of rats","volume":"28","author":"Rajeshkumar","year":"2007","journal-title":"J Androl"},{"key":"10.1016\/j.reprotox.2007.02.001_bib37","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2164\/jandrol.05016","article-title":"Prevention of oxidative stress injury to sperm","volume":"26","author":"Agarwal","year":"2005","journal-title":"J Androl"},{"key":"10.1016\/j.reprotox.2007.02.001_bib38","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0006-2952(98)00370-0","article-title":"Site-specific DNA methylation and apoptosis: induction by diabetogenic streptozotocin","volume":"57","author":"Murata","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib39","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0014-5793(94)00709-8","article-title":"Antioxidant system in rat testicular cells","volume":"349","author":"Bauche","year":"1994","journal-title":"FEBS Lett"},{"key":"10.1016\/j.reprotox.2007.02.001_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1210\/endo.137.1.8536600","article-title":"Induction of lipid peroxidation during steroidogenesis in the rat testis","volume":"137","author":"Peltola","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2007.02.001_bib41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0014-5793(03)00103-0","article-title":"Functional role of sperm surface glutathione S-transferases and extra cellular glutathione in the haploid spermatozoa under oxidative stress","volume":"538","author":"Hemachand","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1016\/j.reprotox.2007.02.001_bib42","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0891-5849(02)01010-9","article-title":"Impaired ascorbic acid metabolism in streptozotocin-induced diabetic rats","volume":"33","author":"Kashiba","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.reprotox.2007.02.001_bib43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1081\/ERC-120004537","article-title":"The impact of vitamin C on diabetes induced alterations at murine neuromuscular junction","volume":"28","author":"Hassan","year":"2002","journal-title":"Endocrinol Res"},{"key":"10.1016\/j.reprotox.2007.02.001_bib44","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0015-0282(03)00983-X","article-title":"Alterations in mitochondria membrane potential and oxidative stress in infertile men: a prospective observational study","volume":"80","author":"Wang","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.reprotox.2007.02.001_bib45","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0015-0282(16)55456-9","article-title":"Effect of ascorbic acid supplementation on the sperm quality of smokers","volume":"58","author":"Dawson","year":"1992","journal-title":"Fertil Steril"},{"key":"10.1016\/j.reprotox.2007.02.001_bib46","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev.bi.55.070186.002235","article-title":"Taurine: biological update","volume":"55","author":"Wright","year":"1986","journal-title":"Ann Rev Biochem"},{"key":"10.1016\/j.reprotox.2007.02.001_bib47","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2337\/diabetes.52.2.499","article-title":"Comparative trial of N-acetyl-cysteine, taurine and oxerutin on skin and kidney damage in long-term experimental diabetes","volume":"53","author":"Odetti","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.reprotox.2007.02.001_bib48","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0891-5849(98)00238-X","article-title":"Lipid peroxidation in hepatic sub cellular compartments of diabetic rats","volume":"26","author":"Traverso","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.reprotox.2007.02.001_bib49","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2337\/diabetes.53.1.185","article-title":"Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats","volume":"53","author":"Raza","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.reprotox.2007.02.001_bib50","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0278-6915(02)00014-5","article-title":"DNA damage and the effect of antioxidants in streptozotocin-treated mice","volume":"40","author":"Imaeda","year":"2002","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.reprotox.2007.02.001_bib51","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1081\/ERC-100107174","article-title":"Impaired testicular function in rats with diet-induced hypercholesterolemia and\/or streptozotocin-induced diabetes mellitus","volume":"27","author":"Tanaka","year":"2001","journal-title":"Endocrinol Res"},{"key":"10.1016\/j.reprotox.2007.02.001_bib52","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2174\/0929867013373039","article-title":"Relative impact of oxidative stress on male reproductive function","volume":"8","author":"Sikka","year":"2001","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.reprotox.2007.02.001_bib53","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.fertnstert.2005.03.080","article-title":"Sperm DNA damage assessment: a test whose time has come","volume":"84","author":"Agarwal","year":"2005","journal-title":"Fertil Steril"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623807000305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623807000305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:24:47Z","timestamp":1760189087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623807000305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0890623807000305"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2007.02.001","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: Its progression and genotoxic consequences","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2007.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}