{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:29:14Z","timestamp":1789529354107,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.reprotox.2009.11.002","type":"journal-article","created":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T00:35:33Z","timestamp":1257986133000},"page":"225-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"title":["Reproductive toxicity of acrylamide-treated male rats"],"prefix":"10.1016","volume":"29","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tietao","family":"Lie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold J.","family":"Hutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangxiong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2009.11.002_bib1","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1016\/0006-2952(70)90009-2","article-title":"Biochemical studies on acrylamide, a neurotoxic agent","volume":"19","author":"Hashimoto","year":"1970","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.reprotox.2009.11.002_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mrgentox.2004.11.010","article-title":"Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population","volume":"580","author":"Boettcher","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.reprotox.2009.11.002_bib3","unstructured":"EIMS (Environmental Information Management System). IRIS toxicological review and summary documents for acrylamide. EIMS Metadata Report 52015.Washington, DC: U.S. Environment Protection Agency; 2002."},{"key":"10.1016\/j.reprotox.2009.11.002_bib4","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1021\/jf0261506","article-title":"Why asparagine needs carbohydrates to generate acrylamide","volume":"51","author":"Yaylayan","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.reprotox.2009.11.002_bib5","doi-asserted-by":"crossref","first-page":"5556","DOI":"10.1021\/jf034344v","article-title":"Potential of acrylamide formation, sugars, and free asparagine in potatoes: a comparison of cultivars and farming systems","volume":"51","author":"Amrein","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.reprotox.2009.11.002_bib6","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/419448a","article-title":"Acrylamide formed in the Maillard reaction","volume":"419","author":"Mottram","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2009.11.002_bib7","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/419449a","article-title":"Acrylamide from Maillard reaction products","volume":"419","author":"Stadler","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2009.11.002_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/toxsci\/kfg165","article-title":"Risk assessment of acrylamide in foods","volume":"75","author":"Dybing","year":"2003","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2009.11.002_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jcs.2007.06.016","article-title":"Acrylamide in cereal products: a review","volume":"47","author":"Claus","year":"2008","journal-title":"J Cereal Sci"},{"key":"10.1016\/j.reprotox.2009.11.002_bib10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.lwt.2004.03.001","article-title":"Reduction of acrylamide formation in potato slices during frying","volume":"37","author":"Pedreschi","year":"2004","journal-title":"LWT-Food Sci Technol"},{"key":"10.1016\/j.reprotox.2009.11.002_bib11","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1021\/jf8004492","article-title":"Acrylamide carcinogenicity","volume":"56","author":"Klaunig","year":"2008","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.reprotox.2009.11.002_bib12","first-page":"157","article-title":"Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery","volume":"4","author":"Burek","year":"1980","journal-title":"J Environ Pathol Toxicol"},{"key":"10.1016\/j.reprotox.2009.11.002_bib13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/faat.1995.1112","article-title":"A lifetime oncogenicity study in rats with acrylamide","volume":"27","author":"Friedman","year":"1995","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.reprotox.2009.11.002_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mrgentox.2004.09.010","article-title":"Transmitted mutational events induced in mouse germ cells following acrylamide or glycidamide exposure","volume":"580","author":"Favor","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.reprotox.2009.11.002_bib15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0890-6238(99)00011-8","article-title":"Smith MT Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice","volume":"13","author":"Holland","year":"1999","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2009.11.002_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0890-6238(00)00066-6","article-title":"Relationship between acrylamide reproductive and neurotoxicity in male rats","volume":"14","author":"Tyl","year":"2000","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2009.11.002_bib17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/10937400600681430","article-title":"A review of the toxicology of acrylamide","volume":"9","author":"Exon","year":"2006","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"10.1016\/j.reprotox.2009.11.002_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0890-6238(02)00078-3","article-title":"Effects of acrylamide on rodent reproductive performance","volume":"17","author":"Tyl","year":"2003","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2009.11.002_bib19","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.reprotox.2004.10.006","article-title":"Toxicological effects of acrylamide on rat testicular gene expression profile","volume":"19","author":"Yang","year":"2005","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2009.11.002_bib20","first-page":"492","article-title":"Oral acrylamide affects the development and reproductive performance of male rats","volume":"13","author":"Wang","year":"2007","journal-title":"Zhonghua Nan Ke Xue"},{"key":"10.1016\/j.reprotox.2009.11.002_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/15287398609530840","article-title":"Reproductive toxicity associated with acrylamide treatment in male and female rats","volume":"17","author":"Zenick","year":"1986","journal-title":"J Toxicol Environ Health"},{"key":"10.1016\/j.reprotox.2009.11.002_bib22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1254\/jphs.FPJ06017X","article-title":"Acrylamide analog as a novel nitric oxide-independent soluble guanylyl cyclase activator","volume":"102","author":"Nakane","year":"2006","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.reprotox.2009.11.002_bib23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/j.1939-4640.2005.tb01093.x","article-title":"Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis","volume":"26","author":"Shi","year":"2005","journal-title":"J Androl"},{"key":"10.1016\/j.reprotox.2009.11.002_bib24","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0015-0282(98)00382-3","article-title":"Human sperm endothelial nitric oxide synthase expression: correlation with sperm motility","volume":"70","author":"O\u2019Bryan","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.reprotox.2009.11.002_bib25","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1095\/biolreprod55.5.935","article-title":"Immunohistochemical localization of endothelial nitric oxide synthase in human testis, epididymis, and vas deferens suggests a possible role for nitric oxide in spermatogenesis, sperm maturation, and programmed cell death","volume":"55","author":"Zini","year":"1996","journal-title":"Biol Reprod"},{"key":"10.1016\/j.reprotox.2009.11.002_bib26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1095\/biolreprod.103.021329","article-title":"Nitric oxide\/nitric oxide synthase, spermatogenesis, and tight junction dynamics","volume":"70","author":"Lee","year":"2004","journal-title":"Biol Reprod"},{"key":"10.1016\/j.reprotox.2009.11.002_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/01485019808988547","article-title":"Germ cell apoptosis and endothelial nitric oxide synthase (eNOS) expression following ischemia-reperfusion injury to testis","volume":"41","author":"Zini","year":"1998","journal-title":"Arch Androl"},{"key":"10.1016\/j.reprotox.2009.11.002_bib28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1262\/jrd.19191","article-title":"Leydig cell hyperplasia in an ENU-induced mutant mouse with germ cell depletion","volume":"54","author":"Khalaj","year":"2008","journal-title":"J Reprod Dev"},{"key":"10.1016\/j.reprotox.2009.11.002_bib29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00306048","article-title":"Changes in surface area and number of Leydig cells in relation to the 6 stages of the cycle of the human seminiferous epithelium","volume":"178","author":"Paniagua","year":"1988","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.reprotox.2009.11.002_bib30","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0041-008X(86)90109-2","article-title":"Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats","volume":"85","author":"Johnson","year":"1986","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.reprotox.2009.11.002_bib31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/toxsci\/47.2.151","article-title":"Changes in thyroid gland morphology after acute acrylamide exposure","volume":"47","author":"Khan","year":"1999","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2009.11.002_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4142\/jvs.2005.6.2.103","article-title":"Genotoxicity and toxicological effects of acrylamide on reproductive system in male rats","volume":"6","author":"Yang","year":"2005","journal-title":"J Vet Sci"},{"key":"10.1016\/j.reprotox.2009.11.002_bib33","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s10495-006-6981-2","article-title":"Blockage of testicular connexins induced apoptosis in rat seminiferous epithelium","volume":"11","author":"Lee","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.reprotox.2009.11.002_bib34","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1152\/physrev.00009.2002","article-title":"Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development","volume":"82","author":"Cheng","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1016\/j.reprotox.2009.11.002_bib35","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1210\/en.2005-1324","article-title":"Regulation of spontaneous contractile activity in the bovine epididymal duct by cyclic guanosine 5-monophosphate-dependent pathways","volume":"147","author":"Mewe","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2009.11.002_bib36","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1095\/biolreprod.106.059246","article-title":"Gene expression profiling and its relevance to the blood\u2013epididymal barrier in the human epididymis","volume":"76","author":"Dub\u00e9","year":"2007","journal-title":"Biol Reprod"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623809003207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623809003207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:29:59Z","timestamp":1760189399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623809003207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0890623809003207"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2009.11.002","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reproductive toxicity of acrylamide-treated male rats","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2009.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}