{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:16:00Z","timestamp":1790738160757,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.reprotox.2010.01.007","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T02:06:53Z","timestamp":1264385213000},"page":"332-338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Reversibility of the effects of the chemotherapeutic regimen for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone, on the male rat reproductive system and progeny outcome"],"prefix":"10.1016","volume":"29","author":[{"given":"Geraldine","family":"Delb\u00e8s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Vaisheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trang","family":"Luu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara F.","family":"Hales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Robaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2010.01.007_bib1","unstructured":"Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, et al. SEER Cancer Statistics Review, 1975\u20132006. In: Edwards BK (ed.). National Cancer Institute, Bethesda, MD, 2008."},{"key":"10.1016\/j.reprotox.2010.01.007_bib2","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/1097-0142(197810)42:4<1705::AID-CNCR2820420408>3.0.CO;2-P","article-title":"Combination chemotherapy of diffuse histiocytic lymphoma with cyclophosphamide, adriamycin, vincristine and prednisone (CHOP)","volume":"42","author":"Elias","year":"1978","journal-title":"Cancer"},{"key":"10.1016\/j.reprotox.2010.01.007_bib3","first-page":"802","article-title":"Long-term outcome of localized high-grade non-Hodgkin's lymphoma treated with high dose CHOP regimen and involved field radiotherapy: results of a GOELAMS study","volume":"90","author":"Bernard","year":"2005","journal-title":"Haematologica"},{"key":"10.1016\/j.reprotox.2010.01.007_bib4","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/annonc\/mdi264","article-title":"Chemotherapy dose intensity in non-Hodgkin's lymphoma: is dose intensity an emerging paradigm for better outcomes?","volume":"16","author":"Gregory","year":"2005","journal-title":"Ann Oncol"},{"key":"10.1016\/j.reprotox.2010.01.007_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/pbc.22004","article-title":"Male gonadal toxicity","volume":"53","author":"Meistrich","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.reprotox.2010.01.007_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/jncimonographs\/lgi003","article-title":"Spermatogenesis after cancer treatment: damage and recovery","author":"Howell","year":"2005","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.reprotox.2010.01.007_bib7","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1172\/JCI106861","article-title":"Evidence for a specific seminiferous tubular factor affecting follicle-stimulating hormone secretion in man","volume":"51","author":"Van Thiel","year":"1972","journal-title":"J Clin Invest"},{"key":"10.1016\/j.reprotox.2010.01.007_bib8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/jncimonographs\/lgi002","article-title":"Hormonal approaches to preservation and restoration of male fertility after cancer treatment","author":"Shetty","year":"2005","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.reprotox.2010.01.007_bib9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/jncimonographs\/lgi028","article-title":"Impact of paternal exposure to chemotherapy on offspring in the rat","author":"Hales","year":"2005","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.reprotox.2010.01.007_bib10","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1093\/humrep\/den081","article-title":"Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy","volume":"23","author":"O\u2019Flaherty","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.reprotox.2010.01.007_bib11","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/humrep\/dem002","article-title":"Exposure of male rats to cyclophosphamide alters the chromatin structure and basic proteome in spermatozoa","volume":"22","author":"Codrington","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.reprotox.2010.01.007_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2164\/jandrol.106.001487","article-title":"Effects of the chemotherapy cocktail used to treat testicular cancer on sperm chromatin integrity","volume":"28","author":"Delbes","year":"2007","journal-title":"J Androl"},{"key":"10.1016\/j.reprotox.2010.01.007_bib13","doi-asserted-by":"crossref","unstructured":"Adachi T, Nishimura T, Imahie H, Yamamura T. Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 9). Testicular toxicity in male rats given adriamycin for two or four weeks. J Toxicol Sci 2000;25 Spec No:95\u2013101.","DOI":"10.2131\/jts.25.SpecialIssue_95"},{"key":"10.1016\/j.reprotox.2010.01.007_bib14","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1071\/RD05065","article-title":"Reproductive effects after exposure of male mice to vincristine and to a combination of X-rays and vincristine","volume":"17","author":"Dobrzynska","year":"2005","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.reprotox.2010.01.007_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0027-5107(96)90007-X","article-title":"Effect of doxorubicin and 4\u2032-epi-doxorubicin on mouse spermatogenesis","volume":"160","author":"Hacker-Klom","year":"1986","journal-title":"Mutat Res"},{"key":"10.1016\/j.reprotox.2010.01.007_bib16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2131\/jts.26.51","article-title":"Sperm motion analysis in rats treated with adriamycin and its applicability to male reproductive toxicity studies","volume":"26","author":"Kato","year":"2001","journal-title":"J Toxicol Sci"},{"key":"10.1016\/j.reprotox.2010.01.007_bib17","first-page":"51","article-title":"Ultrastructural changes in the Leydig cell on treatment with vincristine","volume":"79","author":"Stanley","year":"1994","journal-title":"Cytobios"},{"key":"10.1016\/j.reprotox.2010.01.007_bib18","doi-asserted-by":"crossref","first-page":"578","DOI":"10.2164\/jandrol.106.002428","article-title":"Effects of the chemotherapeutic agents for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), on the male rat reproductive system and progeny outcome","volume":"28","author":"Vaisheva","year":"2007","journal-title":"J Androl"},{"key":"10.1016\/j.reprotox.2010.01.007_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2164\/jandrol.05103","article-title":"Effects of chemotherapeutic agents for testicular cancer on the male rat reproductive system, spermatozoa, and fertility","volume":"27","author":"Bieber","year":"2006","journal-title":"J Androl"},{"key":"10.1016\/j.reprotox.2010.01.007_bib20","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1095\/biolreprod.108.072108","article-title":"Impact of the chemotherapy cocktail used to treat testicular cancer on the gene expression profile of germ cells from male Brown-Norway rats","volume":"80","author":"Delbes","year":"2009","journal-title":"Biol Reprod"},{"key":"10.1016\/j.reprotox.2010.01.007_bib21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.2164\/jandrol.107.004218","article-title":"Reversibility of the effects of subchronic exposure to cancer chemotherapeutics, bleomycin, etoposide and cisplatin (BEP), on spermatogenesis, fertility and progeny outcome in the male rat","volume":"29","author":"Marcon","year":"2008","journal-title":"J Androl"},{"key":"10.1016\/j.reprotox.2010.01.007_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1530\/jrf.0.0540103","article-title":"Daily sperm production and epididymal sperm reserves of pubertal and adult rats","volume":"54","author":"Robb","year":"1978","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.reprotox.2010.01.007_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0027-5107(84)90034-4","article-title":"Induction of congenital malformations in the offspring of male mice treated with X-rays at pre-meiotic and post-meiotic stages","volume":"125","author":"Kirk","year":"1984","journal-title":"Mutat Res"},{"key":"10.1016\/j.reprotox.2010.01.007_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1200\/JCO.1993.11.2.239","article-title":"Long-term reduction in sperm count after chemotherapy with and without radiation therapy for non-Hodgkin's lymphomas","volume":"11","author":"Pryzant","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.reprotox.2010.01.007_bib25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF01727413","article-title":"Long-term gonadal toxicity after therapy for Hodgkin's and non-Hodgkin's lymphoma","volume":"68","author":"Bokemeyer","year":"1994","journal-title":"Ann Hematol"},{"key":"10.1016\/j.reprotox.2010.01.007_bib26","first-page":"771","article-title":"Cyclophosphamide-induced structural and biochemical changes in testis and epididymidis of rats","volume":"35","author":"Kaur","year":"1997","journal-title":"Indian J Exp Biol"},{"key":"10.1016\/j.reprotox.2010.01.007_bib27","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/j.1939-4640.1988.tb01026.x","article-title":"Effects of cyclophosphamide on selected cytosolic and mitochondrial enzymes in the epididymis of the rat","volume":"9","author":"Trasler","year":"1988","journal-title":"J Androl"},{"key":"10.1016\/j.reprotox.2010.01.007_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1095\/biolreprod38.2.463","article-title":"Morphological changes in the testis and epididymis of rats treated with cyclophosphamide: a quantitative approach","volume":"38","author":"Trasler","year":"1988","journal-title":"Biol Reprod"},{"key":"10.1016\/j.reprotox.2010.01.007_bib29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/oxfordjournals.humrep.a137880","article-title":"Potential genetic risks of using semen collected during chemotherapy","volume":"8","author":"Meistrich","year":"1993","journal-title":"Hum Reprod"},{"key":"10.1016\/j.reprotox.2010.01.007_bib30","unstructured":"O\u2019Flaherty C, Hales BF, Chan P, Robaire B. Impact of chemotherapeutics and advanced testicular cancer or Hodgkin lymphoma on sperm deoxyribonucleic acid integrity. Fertil Steril July 8, 2009 [Epub ahead of print] PMID: 19591994 [PubMed]."},{"key":"10.1016\/j.reprotox.2010.01.007_bib31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.urology.2008.08.474","article-title":"Male fertility after cancer","volume":"73","author":"Sabanegh","year":"2009","journal-title":"Urology"},{"key":"10.1016\/j.reprotox.2010.01.007_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1365-2605.2008.00943.x","article-title":"Biological and clinical significance of DNA damage in the male germ line","volume":"32","author":"Aitken","year":"2009","journal-title":"Int J Androl"},{"key":"10.1016\/j.reprotox.2010.01.007_bib33","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.fertnstert.2007.06.018","article-title":"Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates","volume":"90","author":"Lin","year":"2008","journal-title":"Fertil Steril"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623810000092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623810000092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:29:46Z","timestamp":1760189386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623810000092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0890623810000092"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2010.01.007","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reversibility of the effects of the chemotherapeutic regimen for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone, on the male rat reproductive system and progeny outcome","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2010.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}