{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T01:21:48Z","timestamp":1773624108575,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.reprotox.2010.08.001","type":"journal-article","created":{"date-parts":[[2010,8,21]],"date-time":"2010-08-21T05:25:38Z","timestamp":1282368338000},"page":"312-318","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prenatal TCDD in mice increases adult autoimmunity"],"prefix":"10.1016","volume":"31","author":[{"given":"Steven D.","family":"Holladay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amjad","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Robert M.","family":"Gogal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2010.08.001_bib0005","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/15287397709529578","article-title":"Impairment of thymus-dependent immune functions by exposure of the developing immune system to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"3","author":"Faith","year":"1997","journal-title":"J Toxicol Environ Health"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0026-895X(25)10104-1","article-title":"Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"35","author":"Fine","year":"1989","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/tera.1420440405","article-title":"Perinatal thymocyte antigen expression and postnatal immune development altered by gestational exposure to tetrachlorodibenzo-p-dioxin (TCDD)","volume":"44","author":"Holladay","year":"1991","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0300-483X(99)00024-4","article-title":"Persistent suppression of delayed-type hypersensitivity in adult F344 rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"134","author":"Gehrs","year":"1999","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0025","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0041-008X(85)90373-4","article-title":"Evidence for direct action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymic epithelium","volume":"79","author":"Greenlee","year":"1985","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0030","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0192-0561(92)90166-I","article-title":"Chemicals trophic for the thymus: risk for immunodeficiency and autoimmunity","volume":"14","author":"Schuurman","year":"1992","journal-title":"Int J Immunopharmacol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0035","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0041-008X(92)90370-8","article-title":"Alterations in the cortical thymic epithelium of rats after in vivo exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): an (immuno)histological study","volume":"115","author":"DeWaal","year":"1992","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0040","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1124\/mol.104.005868","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin enhances negative selection of T cells in the thymus but allows autoreactive T cells to escape deletion and migrate to the periphery","volume":"67","author":"Fisher","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0045","series-title":"Developmental immunotoxicology","first-page":"215","article-title":"Perinatal immunotoxicant exposure and postnatal autoimmune disease","author":"Blaylock","year":"2005"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0050","first-page":"94","article-title":"Alternate immune system targets for TCDD: lymphocyte stem cells and extrathymic T-cell development","volume":"11","author":"Silverstone","year":"1994","journal-title":"Exp Clin Immunogenet"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0055","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jbspin.2009.03.012","article-title":"Interferons and autoimmune disorders","volume":"76","author":"Meyer","year":"2009","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0060","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2249.2009.04087.x","article-title":"Islet inflammation and CXCL10 in recent-onset type 1 diabetes","volume":"159","author":"Roep","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0065","first-page":"123","article-title":"Overexpression of T-bet in T cells accelerates autoimmune glomerulonephritis in mice with a dominant Th1 background","volume":"22","author":"Shimohata","year":"2009","journal-title":"J Nephrol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2009.04031.x","article-title":"Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis","volume":"159","author":"Wang","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0075","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4049\/jimmunol.144.4.1169","article-title":"Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"144","author":"Fine","year":"1990","journal-title":"J Immunol"},{"issue":"Suppl. 3","key":"10.1016\/j.reprotox.2010.08.001_bib0080","first-page":"463","article-title":"Development of the immune system: differential effects depending on time of exposure","volume":"108","author":"Holladay","year":"2000","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0085","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/ni.1794","article-title":"Checkpoints in lymphocyte development and autoimmune disease","volume":"11","author":"vonBoehmer","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0090","doi-asserted-by":"crossref","first-page":"4116","DOI":"10.4049\/jimmunol.0803391","article-title":"Identification and characterization of a human CD5+ pre-na\u00efve B cell population","volume":"182","author":"Lee","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1365-2249.2002.01953.x","article-title":"The dual function of the splenic marginal zone: essential for initiation of anti-T1-2 responses but also vital in the general first-line defense against blood-borne antigens","volume":"130","author":"Zandvoort","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0100","doi-asserted-by":"crossref","first-page":"360","DOI":"10.5414\/CNP72360","article-title":"IgG nephropathy\u2014confusion and overlap with Cq nephropathy","volume":"72","author":"Lim","year":"2009","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0105","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.177.5.1367","article-title":"Mucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus","volume":"177","author":"Mohan","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0110","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/bdra.20603","article-title":"Developmental exposure to 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) alters postnatal T cell phenotypes and exacerbates autoimmune lupus in 24-week-old SNF1 mice","volume":"85","author":"Mustafa","year":"2009","journal-title":"Birth Defects Res A: Clin Mol Teratol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0115","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.taap.2008.04.015","article-title":"An enhanced postnatal autoimmune profile in 24 week-old C57BL\/6 mice developmentally exposed to TCDD","volume":"232","author":"Mustafa","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.reprotox.2010.08.001_bib0120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/toxsci\/kfp177","article-title":"Prenatal exposure to 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) alters adult B cell lymphopoiesis and exacerbates autoimmune lupus in 24-week-old SNF1 mice","volume":"112","author":"Mustafa","year":"2009","journal-title":"Toxicol Sci"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623810002662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623810002662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:30:40Z","timestamp":1760189440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623810002662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0890623810002662"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2010.08.001","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal TCDD in mice increases adult autoimmunity","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2010.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}