{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T23:14:27Z","timestamp":1767395667892,"version":"build-2065373602"},"reference-count":71,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.reprotox.2011.05.021","type":"journal-article","created":{"date-parts":[[2011,6,5]],"date-time":"2011-06-05T14:27:34Z","timestamp":1307284054000},"page":"227-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Histological characterisation of the ethanol-induced microphthalmia phenotype in a chick embryo model system"],"prefix":"10.1016","volume":"32","author":[{"given":"Kevin","family":"Kennelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kushal","family":"Chummun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seamus","family":"Giles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2011.05.021_bib0005","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(73)91092-1","article-title":"Recognition of the fetal alcohol syndrome in early infancy","volume":"7836","author":"Jones","year":"1973","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.reprotox.2011.05.021_bib0010","first-page":"1031","article-title":"Alcohol and the developing fetus","volume":"6","author":"Chaudhuri","year":"2000","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1542\/peds.2004-0259","article-title":"A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute medicine criteria","volume":"115","author":"Hoyme","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0020","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.2174\/138161206776389886","article-title":"Fetal alcohol syndrome: a cautionary note","volume":"12","author":"Abel","year":"2006","journal-title":"Curr Pharm Des"},{"issue":"4","key":"10.1016\/j.reprotox.2011.05.021_bib0025","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0892-0362(95)00005-C","article-title":"An update on the incidence of FAS: FAS is not an equal opportunity birth defect","volume":"17","author":"Abel","year":"1995","journal-title":"Neurotoxicol Teratol"},{"issue":"5","key":"10.1016\/j.reprotox.2011.05.021_bib0030","first-page":"255","article-title":"Fetal alcohol syndrome","volume":"13","author":"Altman","year":"1976","journal-title":"J Pediatr Ophthalmol"},{"issue":"4","key":"10.1016\/j.reprotox.2011.05.021_bib0035","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3928\/0191-3913-19810701-04","article-title":"Fetal alcohol syndrome","volume":"18","author":"Miller","year":"1981","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0040","first-page":"1","article-title":"Ocular abnormalities in the fetal alcohol syndrome","volume":"171","author":"Stromland","year":"1985","journal-title":"Acta Ophthalmol Suppl"},{"issue":"9","key":"10.1016\/j.reprotox.2011.05.021_bib0045","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/bjo.75.9.524","article-title":"Ocular manifestations in fetal alcohol syndrome","volume":"75","author":"Chan","year":"1991","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0050","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/alcalc\/37.1.2","article-title":"Ophthalmic involvement in the fetal alcohol syndrome: clinical and animal model studies","volume":"27","author":"Stromland","year":"2002","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0055","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1530-0277.1980.tb05626.x","article-title":"A clinical perspective of the fetal alcohol syndrome","volume":"4","author":"Rossett","year":"1980","journal-title":"Alesm Clin Exp Res"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0060","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/aja.1000100110","article-title":"The influence of alcohol and other anaesthetics on embryonic development","volume":"10","author":"Stockard","year":"1910","journal-title":"Am J Anat"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ar.1090080202","article-title":"The artificial production of eye abnormalities in the chick embryo","volume":"8","author":"Stockard","year":"1914","journal-title":"Anat Rec"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0070","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/tera.1420270211","article-title":"Some teratogenic properties of ethanol and acetaldehyde in C57BL\/6J mice: implications for the study of the fetal alcohol syndrome","volume":"27","author":"Webster","year":"1983","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0075","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1001\/archopht.1987.01060110122045","article-title":"Fetal alcohol syndrome, eye malformations in a mouse model","volume":"105","author":"Cook","year":"1987","journal-title":"Arch Opthalmol"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0080","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1111\/j.1530-0277.2006.00212.x","article-title":"Maternal oral intake mouse model for fetal alcohol spectrum disorders: ocular defects as a measure of effect","volume":"30","author":"Parnell","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0085","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/tera.1420480404","article-title":"Development changes in the optic nerve related to ethanol consumption in pregnant rats: analysis of the ethanol-exposed optic nerve","volume":"48","author":"Pinanzo-Duran","year":"1993","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0090","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/tera.1420500204","article-title":"Optic nerve hypolasia: comparative effects in children and rats exposed to alcohol during pregnancy","volume":"50","author":"Stromland","year":"1994","journal-title":"Teratology"},{"issue":"3","key":"10.1016\/j.reprotox.2011.05.021_bib0095","first-page":"739","article-title":"Loss of myelinated axons is specific to the central nervous system in a mouse model of the fetal alcohol syndrome","volume":"187","author":"Parson","year":"1995","journal-title":"J Anat"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0100","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1469-7580.1997.19110049.x","article-title":"Morphometric analysis of the postnatal mouse optic nerve fallowing prenatal exposure to alcohol","volume":"191","author":"Dangasta","year":"1997","journal-title":"J Anat"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0105","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/cne.21320","article-title":"Ocular deficits associated with alcohol exposure during zebrafish development","volume":"502","author":"Dlugos","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0110","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ntt.2006.02.001","article-title":"Teratogenic effects of ethanol exposure on zebrafish visual system development","volume":"28","author":"Arenzana","year":"2006","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.reprotox.2006.09.006","article-title":"The effect of in ovo ethanol exposure on retina and optic nerve in a chick embryo model system","volume":"23","author":"Tufan","year":"2007","journal-title":"Reprod Toxicol"},{"issue":"16","key":"10.1016\/j.reprotox.2011.05.021_bib0120","doi-asserted-by":"crossref","first-page":"10476","DOI":"10.1073\/pnas.162356199","article-title":"Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure","volume":"99","author":"Ahlgren","year":"2002","journal-title":"PNAS"},{"issue":"9","key":"10.1016\/j.reprotox.2011.05.021_bib0125","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/bdra.20387","article-title":"Molecular changes associated with teratogen-induced cyclopia","volume":"79","author":"Loucks","year":"2007","journal-title":"Birth Defects Res A: Clin Mol Teratol"},{"issue":"3","key":"10.1016\/j.reprotox.2011.05.021_bib0130","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1017\/S0952523807070423","article-title":"Mechanisms for persistent microphthalmia following ethanol exposure during retinal neurogenesis in zebrafish embryos","volume":"24","author":"Kashyap","year":"2007","journal-title":"Vis Neurosci"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0135","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.mod.2004.06.009","article-title":"The chick embryo-past, present and future as a model system in developmental biology","volume":"121","author":"Stern","year":"2004","journal-title":"Mech Dev"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0140","first-page":"189","article-title":"Use of the chick embryo in screening for teratogenicity","volume":"42","author":"Kotwani","year":"1998","journal-title":"Indian J Physiol Pharmacol"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0145","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/bdra.20202","article-title":"Gastrulating chick embryo as a model for evaluating teratogenicity: a comparison of three approaches","volume":"76","author":"Drake","year":"2006","journal-title":"Birth Defects Res A"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0150","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/alcalc\/34.2.125","article-title":"Experimental models used to measure direct and indirect ethanol teratogenicity","volume":"34","author":"Shibley","year":"1999","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0155","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/tera.1420460206","article-title":"Embryotoxicity of T-2 toxin and Secalonic acid in embryonic chick with site of administration","volume":"46","author":"Vesely","year":"1992","journal-title":"Teratology"},{"issue":"4","key":"10.1016\/j.reprotox.2011.05.021_bib0160","first-page":"317","article-title":"Validation of the Chick Embryotoxicity Screening Test (CHEST). A comparative study","volume":"4","author":"Jelinek","year":"1994","journal-title":"Funct Dev Morphol"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0165","first-page":"324","article-title":"Teratogenic effect of windowing eggs at early stages of avian development","volume":"15","author":"Mann","year":"1978","journal-title":"Exp Pathol"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0170","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J Morphol"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0175","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ajmg.1320440210","article-title":"Experimental fetal alcohol syndrome: proposed pathogenic basis for a variety of associated craniofacial and brain anomalies","volume":"44","author":"Kotch","year":"1992","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0180","first-page":"137A","article-title":"A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy","volume":"27","author":"Karnsovsky","year":"1965","journal-title":"J Cell Biol"},{"issue":"3","key":"10.1016\/j.reprotox.2011.05.021_bib0185","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/aja.1001660303","article-title":"Sequence of developmental alterations following acute ethanol exposure in mice: craniofacial features of the fetal alcohol syndrome","volume":"166","author":"Sulik","year":"1983","journal-title":"Am J Anat"},{"issue":"6","key":"10.1016\/j.reprotox.2011.05.021_bib0190","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1111\/j.1530-0277.1995.tb01007.x","article-title":"Stage-dependent effects of ethanol on cranial neural crest cell development: partial basis for the phenotypic variations observed in fetal alcohol syndrome","volume":"19","author":"Cartwright","year":"1995","journal-title":"Alcohol Clin Exp Res"},{"issue":"4","key":"10.1016\/j.reprotox.2011.05.021_bib0195","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0741-8329(97)87948-7","article-title":"Effects of ethanol on the inner layers of chick retina during development","volume":"14","author":"Chmielewski","year":"1997","journal-title":"Alcohol"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0200","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1530-0277.1980.tb05627.x","article-title":"An animal model of the fetal alcohol syndrome in beagles","volume":"4","author":"Ellis","year":"1980","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0205","first-page":"121","article-title":"A subhuman primate model for fetal alcohol syndrome research","volume":"3","author":"Altshuler","year":"1981","journal-title":"Neurobehav Toxicol Teratol"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0210","first-page":"259","article-title":"The molecular mechanism of fetal alcohol syndrome (FAS). I. Ethanol-induced growth suppression","volume":"5","author":"Pennington","year":"1983","journal-title":"Neurobehav Toxicol Teratol"},{"issue":"3","key":"10.1016\/j.reprotox.2011.05.021_bib0215","first-page":"349","article-title":"Studies on teratological testing using chicken embryos-effects of solvents, injection sites and the age of the embryo","volume":"41","author":"Hashizume","year":"1992","journal-title":"Jikken Dobutsu"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0220","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/tera.1420460206","article-title":"Embryotoxicity of T-2 toxin and secalonic acid in embryonic chicks varies with the site of administration","volume":"46","author":"Vesely","year":"1992","journal-title":"Teratology"},{"issue":"1","key":"10.1016\/j.reprotox.2011.05.021_bib0225","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1530-0277.1998.tb03630.x","article-title":"Ethanol-induced neural crest apoptosis is coincident with their endogenous death, but is mechanistically distinct","volume":"22","author":"Cartwright","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"10.1016\/j.reprotox.2011.05.021_bib0230","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1530-0277.2001.tb02128.x","article-title":"Genetic influences on craniofacial outcome in an avian model of prenatal alcohol exposure","volume":"25","author":"Su","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"10.1016\/j.reprotox.2011.05.021_bib0235","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1530-0277.2000.tb04612.x","article-title":"Avian genetic background modulates the neural crest apoptosis induced by ethanol exposure","volume":"24","author":"Debelak","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0240","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0012-1606(74)90316-9","article-title":"A simple procedure for the long-term cultivation of chicken embryos","volume":"41","author":"Auerbach","year":"1974","journal-title":"Dev Biol"},{"issue":"1","key":"10.1016\/j.reprotox.2011.05.021_bib0245","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ar.1091990105","article-title":"Effects of varying chamber construction and embryo pre-incubation age on survival and growth of chick embryos in shell-less culture","volume":"199","author":"Dunn","year":"1974","journal-title":"Anat Rec"},{"issue":"4","key":"10.1016\/j.reprotox.2011.05.021_bib0250","first-page":"353","article-title":"Spontaneous, asymmetrical microphthalmia in C57B1\/6J mice","volume":"10","author":"Tyndall","year":"1990","journal-title":"J Craniofac Genet Dev Biol"},{"issue":"6","key":"10.1016\/j.reprotox.2011.05.021_bib0255","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ntt.2004.06.011","article-title":"Ethanol exposure alters zebrafish development: a novel model of fetal alcohol syndrome","volume":"26","author":"Bilotta","year":"2004","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"10.1016\/j.reprotox.2011.05.021_bib0260","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1600-0420.1997.tb00406.x","article-title":"Eye size in healthy Swedish children and in children with fetal alcohol syndrome","volume":"75","author":"Hellstrom","year":"1997","journal-title":"Acta Ophthalmol Scand"},{"issue":"4","key":"10.1016\/j.reprotox.2011.05.021_bib0265","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/alcalc\/35.4.400","article-title":"Diagnosing the full spectrum of fetal alcohol-exposed individuals: introducing the 4-digit diagnostic code","volume":"35","author":"Astley","year":"2000","journal-title":"Alcohol Alcohol"},{"issue":"10","key":"10.1016\/j.reprotox.2011.05.021_bib0270","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1167\/iovs.05-0971","article-title":"Effects of ethanol on photoreceptors and visual function in developing zebrafish","volume":"47","author":"Matsui","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.reprotox.2011.05.021_bib0275","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/bdra.20766","article-title":"Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish","volume":"91","author":"Zhang","year":"2011","journal-title":"Birth Defects Res A: Clin Mol Teratol"},{"issue":"1305 Suppl.","key":"10.1016\/j.reprotox.2011.05.021_bib0280","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.brainres.2009.08.057","article-title":"Altered gene expression in neural crest cells exposed to ethanol in vitro","volume":"11","author":"Wentzel","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.reprotox.2011.05.021_bib0285","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1196\/annals.1432.006","article-title":"Prenatal ethanol exposure reduces the expression of the transcriptional factor Pax6 in the developing rat brain","volume":"1139","author":"Aronne","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"10.1016\/j.reprotox.2011.05.021_bib0290","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1006\/dbio.1994.1077","article-title":"Pax-6 is first expressed in a region of ectoderm anterior to the early neural plate: implications for stepwise determination of the lens","volume":"162","author":"Li","year":"1994","journal-title":"Dev Biol"},{"issue":"21","key":"10.1016\/j.reprotox.2011.05.021_bib0295","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1101\/gad.184000","article-title":"Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye","volume":"14","author":"Ashery-Padan","year":"2000","journal-title":"Genes Dev"},{"issue":"5","key":"10.1016\/j.reprotox.2011.05.021_bib0300","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1242\/dev.127.5.945","article-title":"Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye","volume":"127","author":"Collinson","year":"2000","journal-title":"Development"},{"issue":"8","key":"10.1016\/j.reprotox.2011.05.021_bib0305","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1440-169X.2009.01132.x","article-title":"Generation of a second eye by embryonic transplantation of the antero-ventral hemicephalon","volume":"51","author":"Kobayashi","year":"2009","journal-title":"Dev Growth Differ"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0310","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ydbio.2008.03.010","article-title":"Anteroventrally localized activity in the optic vesicle plays a crucial role in the optic development","volume":"317","author":"Hirashima","year":"2008","journal-title":"Dev Biol"},{"issue":"1","key":"10.1016\/j.reprotox.2011.05.021_bib0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(01)00616-9","article-title":"Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles","volume":"111","author":"Ohkubo","year":"2002","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"10.1016\/j.reprotox.2011.05.021_bib0320","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0925-4773(00)00320-8","article-title":"Multiple functions of fibroblast growth factor-8 (FGF-8) in chick eye development","volume":"94","author":"Vogel-H\u00f6pker","year":"2000","journal-title":"Mech Dev"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0325","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0306-4522(01)00411-0","article-title":"Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles","volume":"108","author":"Crossley","year":"2001","journal-title":"Neuroscience"},{"issue":"19","key":"10.1016\/j.reprotox.2011.05.021_bib0330","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1242\/dev.02884","article-title":"Bone morphogenetic proteins specify the retinal pigment epithelium in the chick embryo","volume":"134","author":"M\u00fcller","year":"2007","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0335","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0012-1606(03)00205-7","article-title":"Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation","volume":"259","author":"Hyer","year":"2003","journal-title":"Dev Biol"},{"issue":"6","key":"10.1016\/j.reprotox.2011.05.021_bib0340","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/bdra.20564","article-title":"Deciphering the role of Shh signaling in axial defects produced by ethanol exposure","volume":"85","author":"Loucks","year":"2009","journal-title":"Birth Defects Res A: Clin Mol Teratol"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0345","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/dbio.1998.8995","article-title":"Ethanol impairs migration of the prechordal plate in the zebrafish embryo","volume":"201","author":"Blader","year":"1998","journal-title":"Dev Biol"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0350","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.reprotox.2010.05.050","article-title":"Sonic hedgehog expression is perturbed following ethanol treatment in a chick embryo model of fetal alcohol syndrome","volume":"30","author":"Brennan","year":"2010","journal-title":"Reprod Toxicol"},{"issue":"2","key":"10.1016\/j.reprotox.2011.05.021_bib0355","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/dbio.2000.0195","article-title":"Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis","volume":"233","author":"Zhang","year":"2001","journal-title":"Dev Biol"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623811001705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623811001705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:32:11Z","timestamp":1760189531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623811001705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0890623811001705"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2011.05.021","relation":{},"ISSN":["0890-6238"],"issn-type":[{"type":"print","value":"0890-6238"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histological characterisation of the ethanol-induced microphthalmia phenotype in a chick embryo model system","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2011.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}