{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:35:02Z","timestamp":1791315302114,"version":"4.3.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.reprotox.2012.09.002","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T17:23:44Z","timestamp":1348507424000},"page":"622-627","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Association between maternal blood cadmium during pregnancy and birth weight and the risk of fetal growth restriction: The EDEN mother\u2013child cohort study"],"prefix":"10.1016","volume":"34","author":[{"given":"Mehdi","family":"Menai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Heude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Slama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Forhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Sahuquillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Aline","family":"Charles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadi","family":"Yazbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2012.09.002_bib0005","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2105\/AJPH.92.2.284","article-title":"Cadmium exposure in pregnancy and lactation in relation to iron status","volume":"92","author":"Akesson","year":"2002","journal-title":"American Journal of Public Health"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.revmed.2009.02.029","article-title":"Acute and chronic cadmium poisoning","volume":"31","author":"Andujar","year":"2010","journal-title":"Revue de Medecine Interne"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10534-005-0583-2","article-title":"Metals content in placentas from moderate cigarette consumers: correlation with newborn birth weight","volume":"18","author":"Ronco","year":"2005","journal-title":"Biometals"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0020","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1095\/biolreprod60.2.234","article-title":"Dual function of 11beta-hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action","volume":"60","author":"Burton","year":"1999","journal-title":"Biology of Reproduction"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0025","doi-asserted-by":"crossref","first-page":"E135","DOI":"10.1152\/ajpendo.00356.2005","article-title":"Cadmium reduces 11 beta-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells","volume":"290","author":"Yang","year":"2006","journal-title":"American Journal of Physiology \u2013 Endocrinology and Metabolism"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0030","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0300-483X(93)90124-B","article-title":"Environmental exposure to cadmium and human birthweight","volume":"79","author":"Frery","year":"1993","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0035","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1515\/JPM.2002.061","article-title":"Cadmium concentration in maternal and cord blood and infant birth weight: a study on healthy non-smoking women","volume":"30","author":"Salpietro","year":"2002","journal-title":"Journal of Perinatal Medicine"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0040","first-page":"1468","article-title":"Maternal exposure to low-level heavy metals during pregnancy and birth size","volume":"45","author":"Shirai","year":"2010","journal-title":"Journal of Environmental Science and Health \u2013 Part A Toxic\/Hazardous Substances & Environmental Engineering"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0045","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-4274(97)03869-1","article-title":"Cadmium levels in maternal, cord and newborn blood in Mexico City","volume":"91","author":"Galicia-Garcia","year":"1997","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0050","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/oem.2010.059758","article-title":"Does prenatal cadmium exposure affect fetal and child growth?","volume":"68","author":"Lin","year":"2011","journal-title":"Occupational and Environmental Medicine"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0055","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/00039896.1992.9938357","article-title":"Placental cadmium and birthweight in women living near a lead smelter","volume":"47","author":"Loiacono","year":"1992","journal-title":"Archives of Environment Health"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0060","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3200\/AEOH.59.1.22-25","article-title":"Relationship between newborn size and mother's blood cadmium levels, Toyama, Japan","volume":"59","author":"Nishijo","year":"2004","journal-title":"Archives of Environment Health"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0065","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3402\/ijch.v63i2.17703","article-title":"Elements in placenta and pregnancy outcome in arctic and subarctic areas","volume":"63","author":"Odland","year":"2004","journal-title":"International Journal of Circumpolar Health"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0070","first-page":"852","article-title":"Blood lead and cadmium and birth weight among sub-arctic and arctic populations of Norway and Russia","volume":"78","author":"Odland","year":"1999","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0075","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ajog.2007.06.078","article-title":"In utero tobacco exposure is associated with modified effects of maternal factors on fetal growth","volume":"198","author":"Aagaard-Tillery","year":"2008","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0080","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1017\/S0007114508025038","article-title":"Maternal fatty acid intake and fetal growth: evidence for an association in overweight women. The \u2018EDEN mother-child\u2019 cohort (study of pre- and early postnatal determinants of the child's development and health)","volume":"101","author":"Drouillet","year":"2009","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0085","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1080\/15428119691014350","article-title":"Biological monitoring results for cadmium exposed workers","volume":"57","author":"McDiarmid","year":"1996","journal-title":"American Industrial Hygiene Association Journal"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0090","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/BF00194670","article-title":"Validity of hair cadmium in detecting chronic cadmium exposure in general populations","volume":"50","author":"Frery","year":"1993","journal-title":"Bulletin of Environment Contamination and Toxicology"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0095","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF00380764","article-title":"Assessment of exposure to lead of the general population in the French community through biological monitoring","volume":"58","author":"Huel","year":"1986","journal-title":"International Archives of Occupational and Environmental Health"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0100","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1289\/ehp.0800488","article-title":"Maternal blood lead levels and the risk of pregnancy-induced hypertension: the EDEN cohort study","volume":"117","author":"Yazbeck","year":"2009","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0105","first-page":"311","article-title":"Variations in birth weight as a function of various fetal and maternal characteristics. The application to the diagnosis of hypotrophy","volume":"43","author":"Mamelle","year":"1986","journal-title":"Archives Francaises de Pediatrie"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0110","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/bdra.20127","article-title":"Teratogen update: lead and pregnancy","volume":"73","author":"Bellinger","year":"2005","journal-title":"Birth Defects Research \u2013 Part A Clinical and Molecular Teratology"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0115","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0002-9378(82)90786-4","article-title":"Cadmium levels in maternal blood, fetal cord blood, and placental tissues of pregnant women who smoke","volume":"142","author":"Kuhnert","year":"1982","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0120","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.scitotenv.2004.12.012","article-title":"Effect of maternal manganese blood levels on erythrocyte calcium-pump activity in newborns","volume":"354","author":"Yazbeck","year":"2006","journal-title":"Science of the Total Environment"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0125","first-page":"49","article-title":"Levels of lead and cadmium in pregnant women and newborns and evaluation of their impact on child development","volume":"47","author":"Durska","year":"2001","journal-title":"Annales Academiae Medicae Stetinensis"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0130","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0048-9697(85)90142-1","article-title":"The combined effect of tobacco and alcohol consumption on the level of lead and cadmium in blood","volume":"41","author":"Grasmick","year":"1985","journal-title":"Science of the Total Environment"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0135","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0009-9120(00)00052-7","article-title":"Toxic and essential elements in placentas of Swedish women","volume":"33","author":"Osman","year":"2000","journal-title":"Clinical Biochemistry"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0140","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1476-069X-10-105","article-title":"Relation between dietary cadmium intake and biomarkers of cadmium exposure in premenopausal women accounting for body iron stores","volume":"10","author":"Julin","year":"2011","journal-title":"Environmental Health"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0145","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.bone.2012.03.018","article-title":"Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women","volume":"50","author":"Engstr\u00f6m","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0150","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.placenta.2007.10.010","article-title":"Placental 11beta-hydroxysteroid dehydrogenase type 2 is reduced in pregnancies complicated with idiopathic intrauterine growth Restriction: evidence that this is associated with an attenuated ratio of cortisone to cortisol in the umbilical artery","volume":"29","author":"Dy","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0155","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1210\/jc.2002-021378","article-title":"Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol\/cortisone shuttle in small preterm infants","volume":"88","author":"Kajantie","year":"2003","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0160","first-page":"4979","article-title":"Reduced placental 11beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms","volume":"86","author":"McTernan","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0165","first-page":"1660","article-title":"Reduced 11beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma","volume":"87","author":"Murphy","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/A:1018362603065","article-title":"Zinc protection against cadmium-induced infertility in female rats. Effect of zinc and cadmium on the progesterone production of cultured granulosa cells","volume":"10","author":"Paksy","year":"1997","journal-title":"Biometals"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0175","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0890-6238(94)90032-9","article-title":"Acute cadmium exposure and ovarian steroidogenesis in cycling and pregnant rats","volume":"8","author":"Piasek","year":"1994","journal-title":"Reproductive Toxicology"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0180","first-page":"1313","article-title":"Decreased gene expression of 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia","volume":"86","author":"Schoof","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.reprotox.2012.09.002_bib0185","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jtemb.2007.10.004","article-title":"Selenium in placenta predicts birth weight in normal but not intrauterine growth restriction pregnancy","volume":"22","author":"Klapec","year":"2008","journal-title":"Journal of Trace Elements in Medicine and Biology"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623812002961?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623812002961?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:35:06Z","timestamp":1760189706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623812002961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0890623812002961"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2012.09.002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717960865.793463745","asserted-by":"object"}]},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between maternal blood cadmium during pregnancy and birth weight and the risk of fetal growth restriction: The EDEN mother\u2013child cohort study","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2012.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}