{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:20:56Z","timestamp":1792099256429,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.reprotox.2012.11.010","type":"journal-article","created":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T18:32:33Z","timestamp":1354386753000},"page":"18-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"special_numbering":"C","title":["The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity"],"prefix":"10.1016","volume":"36","author":[{"given":"Mohammad Reza","family":"Safarinejad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Alaeddin","family":"Asgari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Farshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamhossein","family":"Ghaedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Asghar","family":"Kolahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh","family":"Iravani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Reza","family":"Khoshdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2012.11.010_bib0005","unstructured":"World drug reports 2012. Source: United Nations, Department of Economic and Social Affairs, Population Division, World Population Prospects: The 2012 Revision. Available from http:\/\/esa.un.org\/unpd\/wpp."},{"key":"10.1016\/j.reprotox.2012.11.010_bib0010","series-title":"Andrology: male reproductive health and dysfunction","first-page":"1","article-title":"Scopes and goals of andrology","author":"Nieschlag","year":"2000"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0015","doi-asserted-by":"crossref","first-page":"846","DOI":"10.2119\/molmed.2010.00268","article-title":"Regulation of male fertility by the opioid system","volume":"17","author":"Subir\u00e1n","year":"2011","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0020","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mce.2008.01.004","article-title":"The endocannabinoid system in vertebrate male reproduction: a comparative overview","volume":"286S","author":"Cacciola","year":"2008","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"Suppl. 2","key":"10.1016\/j.reprotox.2012.11.010_bib0025","first-page":"167","article-title":"Oligozoospermia, asthenozoospermia, and sperm abnormalities in ex-addict to heroin, morphine, and hashish","volume":"16","author":"Singer","year":"1986","journal-title":"Systems in Biological Reproductive Medicine"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0030","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1210\/er.2009-0009","article-title":"The effects of opioids and opioid analogs on animal and human endocrine systems [review]","volume":"31","author":"Vuong","year":"2010","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0035","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.1210\/jc.2006-0599","article-title":"Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility","volume":"91","author":"Agirregoitia","year":"2006","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0040","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1016\/0006-2952(82)90637-2","article-title":"Enkephalin- and substance P-like immuno-reactivities of mammalian sperm and accessory sex glands","volume":"31","author":"Sastry","year":"1982","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0045","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2605.1988.tb00984.x","article-title":"Gonadal function in male heroin and methadone addicts","volume":"11","author":"Ragni","year":"1988","journal-title":"International Journal of Andrology"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0091-3057(01)00751-1","article-title":"Chronic opiate exposure in the male rat adversely affects fertility","volume":"72","author":"Cicero","year":"2002","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0055","first-page":"73","article-title":"Effect of cocaine on testicular blood flow in rats: evaluation by percutaneous injection of xenon-133","volume":"18","author":"Li","year":"1999","journal-title":"Journal of Environmental Pathology, Toxicology and Oncology"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0060","article-title":"The insults of recreational drug abuse on male fertility","author":"Fronczak","year":"2011","journal-title":"Journal of Andrology"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0065","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/taap.2001.9330","article-title":"Methamphetamine induces apoptosis in seminiferous tubules in male mice testis","volume":"178","author":"Yamamoto","year":"2002","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0070","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.toxlet.2009.08.002","article-title":"Chronic exposure to MDMA (ecstasy) increases DNA damage in sperm and alters testes histopathology in male rats","volume":"191","author":"Barenys","year":"2009","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0075","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0015-0282(99)00567-1","article-title":"Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation","volume":"73","author":"Pasqualotto","year":"2000","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0080","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0015-0282(97)00236-7","article-title":"Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients","volume":"68","author":"Kodama","year":"1997","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0085","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/j.1939-4640.2001.tb02217.x","article-title":"Relationship between seminal white blood cell counts and oxidative stress in men treated at an infertility clinic","volume":"22","author":"Sharma","year":"2001","journal-title":"Journal of Andrology"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0090","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2174\/138920110791591436","article-title":"Mechanisms of MDMA (Ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage","volume":"11","author":"Song","year":"2010","journal-title":"Current Pharmaceutical Biotechnology"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0095","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0100","series-title":"WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction","first-page":"3","article-title":"Collection and examination of human semen","author":"World Health Organisation","year":"1992"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0105","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.urolonc.2008.10.016","article-title":"Opiate consumption and risk of bladder cancer: a case\u2013control analysis","volume":"28","author":"Hosseini","year":"2010","journal-title":"Urologic Oncology"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0110","series-title":"A comparison of urinalysis technologies for drug testing in criminal justice","author":"Visher","year":"1991"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0115","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/j.juro.2008.07.034","article-title":"Sperm DNA damage and semen quality impairment after treatment with selective serotonin reuptake inhibitors detected using semen analysis and sperm chromatin structure assay","volume":"180","author":"Safarinejad","year":"2008","journal-title":"Journal of Urology"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0120","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00240-002-0283-0","article-title":"Catalase-like and superoxide dismutase-like activities in human seminal plasma","volume":"30","author":"Zini","year":"2002","journal-title":"Urological Research"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0125","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/BF02066531","article-title":"Production of reactive oxygen species by and hydrogen peroxide scavenging activity of spermatozoa in an IVF program","volume":"13","author":"Yeung","year":"1993","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0130","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1093\/humrep\/12.7.1488","article-title":"Testicular sperm retrieval by percutaneous fine needle sperm aspiration compared with testicular sperm extraction by open biopsy in men with non-obstructive azoospermia","volume":"12","author":"Friedler","year":"1997","journal-title":"Human Reproduction"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0135","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/j.1939-4640.2002.tb02324.x","article-title":"Oxidative stress and male infertility: from research bench to clinical practice","volume":"23","author":"Saleh","year":"2002","journal-title":"Journal of Andrology"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0140","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1600-0714.2006.00469.x","article-title":"Parameters of oxidative stress in saliva from diabetic and parenteral drug addict patients","volume":"35","author":"Arana","year":"2006","journal-title":"Journal of Oral Pathology and Medicine"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0145","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/humupd\/dmg027","article-title":"Role of sperm chromatin abnormalities and DNA damage in male infertility","volume":"9","author":"Agarwal","year":"2003","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0150","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2605.2007.00764.x","article-title":"Infertility among couples in a population-based study in Iran: prevalence and associated risk factors","volume":"31","author":"Safarinejad","year":"2008","journal-title":"International Journal of Andrology"},{"issue":"Suppl. 2","key":"10.1016\/j.reprotox.2012.11.010_bib0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0015-0282(03)01188-9","article-title":"Men at risk: occupation and male infertility","volume":"81","author":"Claman","year":"2004","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0160","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0010-7824(02)00298-6","article-title":"Environmental risk factors and male fertility and reproduction","volume":"65","author":"Petrelli","year":"2002","journal-title":"Contraception"},{"key":"10.1016\/j.reprotox.2012.11.010_bib0165","unstructured":"Substance Abuse and Mental Health Services Administration. Results from the 2008. National Survey on drug use and health: National Findings. Office of Applied Studies. NSDUH Series H-36: HHS Publication SMA 09-4434. Rockville, MD."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623812003474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623812003474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:34:10Z","timestamp":1760189650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623812003474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":33,"alternative-id":["S0890623812003474"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2012.11.010","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2012.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}