{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:57:34Z","timestamp":1790434654143,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.reprotox.2013.09.004","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T13:38:09Z","timestamp":1379597889000},"page":"192-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Adverse effects of diisooctyl phthalate on the male rat reproductive development following prenatal exposure"],"prefix":"10.1016","volume":"42","author":[{"given":"Anne-Marie","family":"Saillenfait","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Sabat\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Robert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Cossec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain-Claude","family":"Roudot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavien","family":"Denis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuella","family":"Burgart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2013.09.004_bib0005","series-title":"Diisooctyl phthalate","author":"Hazardous Substance Data Bank (HSDB)","year":"2009"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0010","series-title":"Existing Chemical Hazard Assessment Report. Diisooctyl phthalate","author":"National Industrial Chemicals Notification and Assessment Scheme (NICNAS)","year":"2008"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0015","series-title":"Final toxicity review of diisooctyl phthalate. Contract No. CPSC-D-06-0006. Task order 012","author":"United States Consumer Product Safety Commission (US CPSC)","year":"2011"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1065\/espr199910.007","article-title":"Concentrations of phthalate esters and identification of other additives in PVC children's toys","volume":"7","author":"Stringer","year":"2000","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0025","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/chrsci\/49.4.337","article-title":"Simultaneous determination of nine types of phthalate residues in commercial milk products using HPLC\u2013ESI-MS\u2013MS","volume":"49","author":"Li","year":"2011","journal-title":"J Chromatogr Sci"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0030","author":"United States Food and Drug Administration (US FDA)","year":"2012"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0035","series-title":"High production volume (HPV) chemical challenge program. Test plan for the phthalate esters category. Prepared by ExxonMobil Biomedical Sciences, Inc. for the Phthalate Esters Panel, HPV Testing group of the American Chemistry Council","author":"American Chemistry Council","year":"2006"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0040","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0378-4274(93)90104-6","article-title":"Teratogenic evaluation of di-n-butyl phthalate in rats","volume":"69","author":"Ema","year":"1993","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0045","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0378-4274(98)00107-6","article-title":"Further evaluation of developmental toxicity of di-n-butyl phthalate following administration during late pregnancy in rats","volume":"98","author":"Ema","year":"1998","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0050","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0278-6915(97)00008-2","article-title":"Differential prenatal toxicity of branched phthalate esters in rats","volume":"35","author":"Hellwig","year":"1997","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0055","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jat.1436","article-title":"Differential developmental toxicities of di-n-hexyl phthalate and dicyclohexyl phthalate administered orally to rats","volume":"29","author":"Saillenfait","year":"2009","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1006\/taap.1999.8643","article-title":"Disruption of androgen-regulated male reproductive development by di-n-butyl phthalate during late gestation in rats is different from flutamide","volume":"156","author":"Mylchreest","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0065","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/toxsci\/58.2.350","article-title":"Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat","volume":"58","author":"Gray","year":"2000","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0070","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/toxsci\/55.1.143","article-title":"Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di-n-butyl phthalate during late pregnancy","volume":"55","author":"Mylchreest","year":"2000","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0075","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/toxsci\/kfm069","article-title":"Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes","volume":"99","author":"Howdeshell","year":"2007","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0080","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.reprotox.2009.06.013","article-title":"Effects of in utero exposure to di-n-hexyl phthalate on the reproductive development of the male rat","volume":"28","author":"Saillenfait","year":"2009","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0085","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/toxsci\/58.2.339","article-title":"The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat","volume":"58","author":"Parks","year":"2000","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0090","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/toxsci\/kfh169","article-title":"Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testis of male rats exposed to di(n-butyl) phthalate","volume":"81","author":"Lehmann","year":"2004","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0095","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tox.2006.03.015","article-title":"Mechanisms underlying the antiandrogenic effects of diethylhexyl phthalate in fetal rat testis","volume":"223","author":"Borch","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0100","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/toxsci\/kfq386","article-title":"Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates","volume":"120","author":"Hannas","year":"2011","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/toxsci\/kfr146","article-title":"Dose\u2013response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate","volume":"123","author":"Hannas","year":"2011","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0110","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/toxsci\/kfr315","article-title":"Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency","volume":"125","author":"Hannas","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0115","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/jat.2896","article-title":"Dose-dependent alterations in gene expression and testosterone production in fetal rat testis following exposure to di-n-hexyl phthalate","volume":"33","author":"Saillenfait","year":"2013","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0120","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.reprotox.2011.08.001","article-title":"Prenatal developmental toxicity studies on di-n-heptyl and di-n-octyl phthalates in Sprague-Dawley rats","volume":"32","author":"Saillenfait","year":"2011","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0125","series-title":"Vogel's text book of practical organic chemistry","first-page":"531","article-title":"The interaction of carbonyl-containing compounds with organometallic reagents","author":"Vogel","year":"1989"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0130","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF02308461","article-title":"Farbemethode zum makroskopischen Nachweis von Implantationsstellen am Uterus der Ratte","volume":"247","author":"Salewski","year":"1964","journal-title":"Naunyn Schmiedebergs Arch Exp Pathol Pharmakol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0135","series-title":"Teratology: principles and techniques","first-page":"262","article-title":"Methods for administering agents and detecting malformations in experimental animals","author":"Wilson","year":"1965"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0140","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/jmor.1051270303","article-title":"A rapid method for detecting malformations in rat fetuses","volume":"127","author":"Barrow","year":"1969","journal-title":"J Morphol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0145","first-page":"62","article-title":"Refinements in rapid clearing technique in the KOH-Alizarin red S method for bone","volume":"39","author":"Staples","year":"1964","journal-title":"Stain Technol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0150","series-title":"Pathology of the Fischer rat: reference and atlas","first-page":"405","article-title":"Testis and epididymis","author":"Boorman","year":"1990"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0155","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/toxsci\/kfn077","article-title":"A mixture of five phthalate esters inhibits fetal testicular testosterone production in the Sprague-Dawley rat in a cumulative, dose-additive manner","volume":"105","author":"Howdeshell","year":"2008","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/tera.1420480107","article-title":"Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats","volume":"48","author":"Field","year":"1993","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0165","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0890-6238(00)00120-9","article-title":"Developmental toxicity of di-(C7\u2013C9 alkyl) phthalate and di-(C9\u2013C11 alkyl) phthalate in the rat","volume":"15","author":"Fulcher","year":"2001","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0170","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.toxlet.2006.01.013","article-title":"Developmental toxic effects of diisobutyl phthalate, the methyl-branched analogue of di-n-butyl phthalate administered by gavage to rats","volume":"165","author":"Saillenfait","year":"2006","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jat.2550080205","article-title":"The post-natal fate of supernumerary ribs in rat teratogenicity studies","volume":"8","author":"Wickramaratne","year":"1988","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0180","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/0272-0590(91)90196-B","article-title":"Significance of supernumerary ribs in rodent developmental toxicity studies: postnatal persistence in rats and mice","volume":"17","author":"Chernoff","year":"1991","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0185","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/(SICI)1099-1263(200005\/06)20:3<205::AID-JAT635>3.0.CO;2-G","article-title":"Postnatal evolution of supernumerary ribs in rats after a single administration of sodium salicylate","volume":"20","author":"Foulon","year":"2000","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0190","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/10937400490512447","article-title":"Supernumerary ribs in developmental toxicity bioassays and in human populations: incidence and biological significance","volume":"7","author":"Chernoff","year":"2004","journal-title":"J Toxicol Environ Health (Part B)"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0195","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/bdrb.20134","article-title":"Altered axial skeletal development","volume":"80","author":"Tyl","year":"2007","journal-title":"Birth Defects Res (Part B)"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2004.02.018","article-title":"Molecular and genetic regulation of testis descent and external genitalia development","volume":"270","author":"Klonisch","year":"2004","journal-title":"Dev Biol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0205","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.toxlet.2007.03.004","article-title":"Differential expression of the phthalate syndrome in male Sprague-Dawley and Wistar rats after in utero DEHP exposure","volume":"170","author":"Wilson","year":"2007","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0210","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0890-6238(00)00099-X","article-title":"Two-generation reproduction toxicity studies of di-(C7\u2013C9 alkyl) phthalate and di (C9\u2013C11 alkyl) phthalate in the rat","volume":"14","author":"Willoughby","year":"2000","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0215","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.reprotox.2012.07.008","article-title":"A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development","volume":"35","author":"Clewell","year":"2013","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0220","series-title":"Hazard characterization document. Screening-level hazard characterization. Phthalate esters category. Sponsored chemicals. 19 different chemicals","author":"United States Environmental Protection Agency (US EPA)","year":"2010"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0225","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.reprotox.2008.07.006","article-title":"Diisobutyl phthalate impairs the androgen-dependent reproductive development of the male rat","volume":"26","author":"Saillenfait","year":"2008","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0230","series-title":"Final toxicity review of diisobutyl phthalate. Contract No. CPSC-D-06-0006. Task order 012","author":"United States Consumer Product Safety Commission (US CPSC)","year":"2011"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0235","series-title":"24th meeting of the Committee for Risk Assessment. RAC\/24\/2013\/08 rev. 2. DNEL setting for bis(2-ethylhexyl) phthalate (DEHP). For agreement","author":"European Chemicals Agency (ECHA)","year":"2013"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0240","series-title":"Reference Dose (RfD): description and use in health risk assessments. Background document 1A","author":"United States Environmental Protection Agency (US EPA)","year":"1993"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0245","series-title":"Guidance on information requirements and chemical safety assessment","article-title":"Chapter 8 R8: characterization of dose [concentration]\u2013response for human health. Version 2","author":"European Chemicals Agency (ECHA)","year":"2010"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0250","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1539-6924.2006.00770.x","article-title":"What are the sources of exposure of eight frequently used phthalic acid esters in Europeans?","volume":"26","author":"Wormuth","year":"2006","journal-title":"Risk Anal"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0255","series-title":"Fourth national report on human exposure to environmental chemicals","author":"Centers for Disease Control and Prevention","year":"2009"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0260","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12199-009-0078-9","article-title":"Exposure assessment of phthalate esters in Japanese pregnant women by using urinary metabolite analysis","volume":"14","author":"Suzuki","year":"2009","journal-title":"Environ Health Prev Med"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0265","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ijheh.2009.04.001","article-title":"Fetal exposure to phthalates \u2013 a pilot study","volume":"212","author":"Wittassek","year":"2009","journal-title":"Int J Hyg Environ Health"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0270","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1021\/es103879m","article-title":"Occurrence of phthalate metabolites in human urine from several Asian countries","volume":"45","author":"Guo","year":"2011","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0275","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.chemosphere.2010.10.073","article-title":"Phthalate exposure in pregnant women and their children in central Taiwan","volume":"82","author":"Lin","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0280","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1289\/ehp.10749","article-title":"Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples","volume":"116","author":"Adibi","year":"2008","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0285","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.201000121","article-title":"Assessing exposure to phthalates \u2013 the human biomonitoring approach","volume":"55","author":"Wittassek","year":"2011","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.reprotox.2013.09.004_bib0290","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1021\/es2002106","article-title":"Comparative assessment of human exposure to phthalates esters from house dust in China and the United States","volume":"45","author":"Guo","year":"2011","journal-title":"Environ Sci Technol"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089062381300350X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089062381300350X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:38:20Z","timestamp":1760189900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089062381300350X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":58,"alternative-id":["S089062381300350X"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2013.09.004","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adverse effects of diisooctyl phthalate on the male rat reproductive development following prenatal exposure","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2013.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}