{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:14:07Z","timestamp":1760192047659,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21592116"],"award-info":[{"award-number":["21592116"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.reprotox.2013.10.007","type":"journal-article","created":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T17:15:34Z","timestamp":1382894134000},"page":"19-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Acute toxic effects of 3,3\u2032-iminodipropionitrile on hypothalamic-pituitary-gonadal axis in male rats"],"prefix":"10.1016","volume":"43","author":[{"given":"Noriyuki","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bunpei","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2013.10.007_bib0005","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1210\/er.2009-0023","article-title":"The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges","volume":"31","author":"Christian","year":"2010","journal-title":"Endocr Rev"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0010","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0091-3057(02)00858-4","article-title":"Attenuation of iminodipropionitrile induced behavioral syndrome by sodium salicylate in rats","volume":"73","author":"Tariq","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0015","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1021\/tx960113p","article-title":"Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers","volume":"10","author":"Bergmark","year":"1997","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0020","first-page":"87","article-title":"A review of health risks in acrylonitrile industry","volume":"6","author":"Guirguis","year":"1984","journal-title":"G Ital Med Lav"},{"year":"1977","series-title":"Registry of Toxic Effects of Chemical Substances","author":"NIOSH","key":"10.1016\/j.reprotox.2013.10.007_bib0025"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/cne.1357","article-title":"Relationship between insult intensity and mode of hair cell loss in the vestibular system of rats exposed to 3,3\u2032-iminodipropionitrile","volume":"439","author":"Seoane","year":"2001","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0035","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0892-0362(96)00216-4","article-title":"Comparison of behavioral, vestibular, and axonal effects of subchronic IDPN in the rat","volume":"19","author":"Llorens","year":"1997","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0040","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/00043764-199306000-00014","article-title":"Successful treatment of life-threatening propionitrile exposure with sodium nitrite\/sodium thiosulfate followed by hyperbaric oxygen","volume":"35","author":"Scolnick","year":"1993","journal-title":"J Occup Med"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0045","first-page":"625","article-title":"Lathyrism: a neurotoxic disease","volume":"5","author":"Spencer","year":"1983","journal-title":"Neurobehav Toxicol Teratol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0050","first-page":"533","article-title":"Action de l\u2019aminodipropionitrile sur le comportement moteur de la souris blanche","volume":"146","author":"Delay","year":"1952","journal-title":"C R S\u00e9ances M\u00e9m Soc Biol (Paris)"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0055","first-page":"1","article-title":"Lathyrism","volume":"16","author":"Selye","year":"1957","journal-title":"Rev Can Biol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0060","first-page":"17","article-title":"Beta,beta\u2032-iminodipropionitrile (IDPN) neurotoxicity: a mechanistic hypothesis for toxic activation","volume":"1","author":"Jacobson","year":"1987","journal-title":"Mol Toxicol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0065","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0892-0362(93)90070-5","article-title":"Developmental neurotoxicity following neonatal exposure to 3,3\u2032-iminodipropionitrile in the rat","volume":"15","author":"Crofton","year":"1993","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0070","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/taap.1993.1238","article-title":"The behavioral syndrome caused by 3,3\u2032-iminodipropionitrile and related nitriles in the rat is associated with degeneration of the vestibular sensory hair cells","volume":"123","author":"Llorens","year":"1993","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0075","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/0272-0590(91)90099-P","article-title":"A neurotoxicity screening battery for use in safety evaluation: effects of acrylamide and 3\u2032,3\u2032-iminodipropionitrile","volume":"16","author":"Schulze","year":"1991","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0080","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ntt.2007.06.002","article-title":"Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation\/Risk Science Institute expert working group on neurodevelopmental endpoints","volume":"30","author":"Crofton","year":"2008","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0085","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0892-0362(90)90077-P","article-title":"Neurotoxicity testing during long-term studies","volume":"12","author":"Ivens","year":"1990","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.reprotox.2011.10.010","article-title":"Acute reproductive toxicity of 3,3\u2032-iminodipropionitrile in female rats","volume":"33","author":"Takahashi","year":"2012","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0095","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1210\/en.2011-2026","article-title":"The involvement of neurofilament heavy chain phosphorylation in the maturation and degeneration of rat oocytes","volume":"153","author":"Takahashi","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0100","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0967-5868(03)00166-8","article-title":"Impaired hypothalamic endocrine function in neuroacanthocytosis","volume":"10","author":"Kontoleon","year":"2003","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0105","first-page":"57","article-title":"Disturbance of hypothalamic-pituitary hormone secretion in familial chorea-acanthocytosis","volume":"47","author":"Terao","year":"1995","journal-title":"No to shinkei"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0149-7634(89)80050-8","article-title":"The iminodipropionitrile (IDPN)-induced dyskinetic syndrome: behavioral and biochemical pharmacology","volume":"13","author":"Cadet","year":"1989","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0115","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/tox.20220","article-title":"Oral toxicity of the cyanobacterial toxin cylindrospermopsin in mice: long-term exposure to low doses","volume":"21","author":"Sukenik","year":"2006","journal-title":"Env Toxicol"},{"issue":"Suppl. 3","key":"10.1016\/j.reprotox.2013.10.007_bib0120","first-page":"76","article-title":"Role of inositol-1-phosphatase inhibition in the mechanism of action of lithium","volume":"66","author":"Belmaker","year":"1990","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0125","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1093\/humrep\/13.9.2406","article-title":"Haematocrit, leukocyte and platelet counts and the severity of the ovarian hyperstimulation syndrome","volume":"13","author":"Fabregues","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0130","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/019262301301418865","article-title":"Pathogenesis of male reproductive toxicity","volume":"29","author":"Creasy","year":"2001","journal-title":"Toxicol Pathol"},{"issue":"Suppl. 7","key":"10.1016\/j.reprotox.2013.10.007_bib0135","first-page":"87","article-title":"The reproductive toxicity of boric acid","volume":"102","author":"Chapin","year":"1994","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/15287399009531443","article-title":"Effect of acute exposure to boric acid on the male reproductive system of the rat","volume":"31","author":"Linder","year":"1990","journal-title":"J Toxicol Env Health"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0145","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1006\/faat.1994.1048","article-title":"Acute spermatogenic effects of bromoacetic acids","volume":"22","author":"Linder","year":"1994","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0150","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1210\/endo.142.9.8375","article-title":"Caspase-3 and caspase-activated deoxyribonuclease are associated with testicular germ cell apoptosis resulting from reduced intratesticular testosterone","volume":"142","author":"Kim","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0155","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1210\/endo.143.4.8724","article-title":"Effect of GABA on GnRH neurons switches from depolarization to hyperpolarization at puberty in the female mouse","volume":"143","author":"Han","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2013.10.007_bib0160","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1365-2826.2010.02027.x","article-title":"Recent discoveries on the control of gonadotrophin-releasing hormone neurones in nonhuman primates","volume":"22","author":"Terasawa","year":"2010","journal-title":"J Neuroendocrinol"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623813003626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623813003626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:36:00Z","timestamp":1760189760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623813003626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":32,"alternative-id":["S0890623813003626"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2013.10.007","relation":{},"ISSN":["0890-6238"],"issn-type":[{"type":"print","value":"0890-6238"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute toxic effects of 3,3\u2032-iminodipropionitrile on hypothalamic-pituitary-gonadal axis in male rats","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2013.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}