{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:00:15Z","timestamp":1771455615044,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R15HD066301"],"award-info":[{"award-number":["R15HD066301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NIH R01HD065939"],"award-info":[{"award-number":["NIH R01HD065939"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.reprotox.2013.12.003","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T07:00:45Z","timestamp":1387609245000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Postweaning dietary genistein exposure advances puberty without significantly affecting early pregnancy in C57BL\/6J female mice"],"prefix":"10.1016","volume":"44","author":[{"given":"Rong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglu","family":"Diao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 2","key":"10.1016\/j.reprotox.2013.12.003_bib0005","first-page":"S266","article-title":"Analytical and compositional aspects of isoflavones in food and their biological effects","volume":"53","author":"Mortensen","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0010","series-title":"USDA database for the isoflavone content of selected foods","author":"USDA","year":"2008"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0015","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jada.2008.10.055","article-title":"Urinary isoflavones and their metabolites validate the dietary isoflavone intakes in US adults","volume":"109","author":"Chun","year":"2009","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1207\/S15327914NC330204","article-title":"Dietary intake and sources of isoflavones among Japanese","volume":"33","author":"Wakai","year":"1999","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0025","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/09637480600802348","article-title":"Estimated intakes of isoflavones and coumestrol in Korean population","volume":"57","author":"Surh","year":"2006","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0030","first-page":"135","article-title":"Isoflavonoid levels in spot urine are associated with frequency of dietary soy intake in a population-based sample of middle-aged and older Chinese in Singapore","volume":"7","author":"Seow","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0035","first-page":"57700","article-title":"Food labeling: health claims: soy protein and coronary heart disease","volume":"64","author":"FDA","year":"1999","journal-title":"Fed Regist"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0040","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.yfrne.2010.03.003","article-title":"The pros and cons of phytoestrogens","volume":"31","author":"Patisaul","year":"2010","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0045","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2174\/138955712798995020","article-title":"Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease","volume":"12","author":"Gencel","year":"2012","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0050","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/mnfr.200800552","article-title":"Efficacy of isoflavones in relieving vasomotor menopausal symptoms \u2013 a systematic review","volume":"53","author":"Jacobs","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0055","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/1759720X11417749","article-title":"Soy foods: are they useful for optimal bone health","volume":"3","author":"Lanou","year":"2011","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0060","doi-asserted-by":"crossref","first-page":"2326S","DOI":"10.3945\/jn.110.124230","article-title":"Is soy consumption good or bad for the breast","volume":"140","author":"Hilakivi-Clarke","year":"2010","journal-title":"J Nutr"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0065","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0070","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1248\/bpb.24.351","article-title":"Interaction of phytoestrogens with estrogen receptors alpha and beta","volume":"24","author":"Morito","year":"2001","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0075","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/bdrb.20087","article-title":"NTP-CERHR expert panel report on the reproductive and developmental toxicity of genistein","volume":"77","author":"Rozman","year":"2006","journal-title":"Birth Defects Res B: Dev Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0080","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1210\/er.2002-0019","article-title":"The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration","volume":"24","author":"Parent","year":"2003","journal-title":"Endocr Rev"},{"issue":"Suppl. 3","key":"10.1016\/j.reprotox.2013.12.003_bib0085","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1542\/peds.2007-1813C","article-title":"Role of environmental factors in the timing of puberty","volume":"121","author":"Euling","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0090","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1365-2605.2010.01051.x","article-title":"Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty","volume":"33","author":"Mouritsen","year":"2010","journal-title":"Int J Androl"},{"issue":"Suppl. 3","key":"10.1016\/j.reprotox.2013.12.003_bib0095","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1542\/peds.2007-1813D","article-title":"Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings","volume":"121","author":"Euling","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0100","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2008-2491","article-title":"Recent decline in age at breast development: the Copenhagen puberty study","volume":"123","author":"Aksglaede","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0105","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1530\/rep.1.00367","article-title":"The neuroendocrine timing of puberty","volume":"129","author":"Ebling","year":"2005","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-3016.2011.01244.x","article-title":"Early-life soy exposure and age at menarche","volume":"26","author":"Adgent","year":"2012","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0115","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(96)09480-9","article-title":"Exposure of infants to phyto-oestrogens from soy-based infant formula","volume":"350","author":"Setchell","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0120","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1080\/10934529.2013.762734","article-title":"Association between precocious puberty and some endocrine disruptors in human plasma","volume":"48","author":"Yum","year":"2013","journal-title":"J Environ Sci Health A"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0125","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1093\/jn\/130.8.1963","article-title":"Mass spectrometric determination of genistein tissue distribution in diet-exposed Sprague-Dawley rats","volume":"130","author":"Chang","year":"2000","journal-title":"J Nutr"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.reprotox.2008.12.005","article-title":"Overlapping but distinct effects of genistein and ethinyl estradiol (EE(2)) in female Sprague-Dawley rats in multigenerational reproductive and chronic toxicity studies","volume":"27","author":"Delclos","year":"2009","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0135","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1126\/science.285.5431.1259","article-title":"Genetic variation in susceptibility to endocrine disruption by estrogen in mice","volume":"285","author":"Spearow","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0140","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.reprotox.2011.08.010","article-title":"Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice","volume":"32","author":"Xiao","year":"2011","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0145","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/toxsci\/kfs343","article-title":"Postweaning exposure to dietary zearalenone, a mycotoxin, promotes premature onset of puberty and disrupts early pregnancy events in female mice","volume":"132","author":"Zhao","year":"2013","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0150","doi-asserted-by":"crossref","first-page":"e35538","DOI":"10.1371\/journal.pone.0035538","article-title":"Mouse estrous cycle identification tool and images","volume":"7","author":"Byers","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0155","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/toxsci\/67.1.63","article-title":"Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)","volume":"67","author":"Fenton","year":"2002","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0160","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.fertnstert.2011.02.024","article-title":"Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantation","volume":"95","author":"Ye","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0165","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1095\/biolreprod.110.086942","article-title":"Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus","volume":"84","author":"Diao","year":"2011","journal-title":"Biol Reprod"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0170","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature03505","article-title":"LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing","volume":"435","author":"Ye","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0175","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1210\/er.2006-0022","article-title":"The molecular control of corpus luteum formation, function, and regression","volume":"28","author":"Stocco","year":"2007","journal-title":"Endocr Rev"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0180","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1095\/biolreprod48.3.669","article-title":"Correlations among three measures of puberty in mice and relationships with estradiol concentration and ovulation","volume":"48","author":"Safranski","year":"1993","journal-title":"Biol Reprod"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0185","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1023\/A:1026499523505","article-title":"An atlas of mouse mammary gland development","volume":"5","author":"Richert","year":"2000","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0190","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.fertnstert.2011.01.160","article-title":"Temporal expression pattern of progesterone receptor in the uterine luminal epithelium suggests its requirement during early events of implantation","volume":"95","author":"Diao","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0195","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1095\/biolreprod67.4.1285","article-title":"Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions","volume":"67","author":"Jefferson","year":"2002","journal-title":"Biol Reprod"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0200","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1095\/biolreprod.105.041277","article-title":"Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant doses","volume":"73","author":"Jefferson","year":"2005","journal-title":"Biol Reprod"},{"issue":"Pt 2","key":"10.1016\/j.reprotox.2013.12.003_bib0205","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1113\/jphysiol.1995.sp020830","article-title":"Acceleration of puberty onset in female mice by male urinary proteins","volume":"486","author":"Mucignat-Caretta","year":"1995","journal-title":"J Physiol"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0210","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.anireprosci.2012.10.004","article-title":"Ovulation-inducing factor in seminal plasma: a review","volume":"136","author":"Adams","year":"2013","journal-title":"Anim Reprod Sci"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0215","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1095\/biolreprod.108.073171","article-title":"Neonatal exposure to genistein disrupts ability of female mouse reproductive tract to support preimplantation embryo development and implantation","volume":"80","author":"Jefferson","year":"2009","journal-title":"Biol Reprod"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0220","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.mce.2006.04.002","article-title":"Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: a review of rodent and human data","volume":"254\u2013255","author":"Rasier","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0225","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/jne.12020","article-title":"Genistein excitation of gonadotrophin-releasing hormone neurones in juvenile female mice","volume":"25","author":"Bhattarai","year":"2013","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0230","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.taap.2004.08.009","article-title":"In vitro effects of diethylstilbestrol, genistein, 4-tert-butylphenol, and 4-tert-octylphenol on steroidogenic activity of isolated immature rat ovarian follicles","volume":"204","author":"Myllymaki","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0235","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jsbmb.2006.06.021","article-title":"Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells","volume":"101","author":"Rice","year":"2006","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0240","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/humrep\/16.5.997","article-title":"Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium","volume":"16","author":"Diel","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0245","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00026.2006","article-title":"Estrogen receptors: how do they signal and what are their targets","volume":"87","author":"Heldring","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0250","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1073\/pnas.0307864100","article-title":"Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland","volume":"101","author":"Cheng","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0255","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1242\/dev.126.12.2739","article-title":"Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development","volume":"126","author":"Luetteke","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0260","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1073\/pnas.0611647104","article-title":"Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development","volume":"104","author":"Ciarloni","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.reprotox.2013.12.003_bib0265","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10911-008-9084-6","article-title":"The ADAM17-amphiregulin-EGFR axis in mammary development and cancer","volume":"13","author":"Sternlicht","year":"2008","journal-title":"J Mammary Gland Biol Neoplasia"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623813003845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623813003845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:37:25Z","timestamp":1760189845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623813003845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":53,"alternative-id":["S0890623813003845"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2013.12.003","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postweaning dietary genistein exposure advances puberty without significantly affecting early pregnancy in C57BL\/6J female mice","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2013.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}