{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:31:19Z","timestamp":1767375079115,"version":"build-2065373602"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.reprotox.2014.05.002","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T11:52:29Z","timestamp":1400759549000},"page":"115-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Embryo\u2013fetal exposure and developmental outcome of thalidomide following oral and intravaginal administration to pregnant rabbits"],"prefix":"10.1016","volume":"48","author":[{"given":"Julia Y.","family":"Hui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gondi","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2014.05.002_bib0005","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/tera.1420380303","article-title":"A short history of thalidomide embryopathy","volume":"38","author":"Lenz","year":"1988","journal-title":"Teratology"},{"year":"2005","series-title":"Thalomid\u00ae (Thalidomide)","key":"10.1016\/j.reprotox.2014.05.002_bib0010"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0015","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/2141018a0","article-title":"Thalidomide in rabbit semen","volume":"214","author":"Lutwak-Mann","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0020","first-page":"1355","article-title":"Thalidomide is distributed into human semen after oral dosing","volume":"29","author":"Teo","year":"2001","journal-title":"Drug Metabol Disposit"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0025","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2165\/00003088-199426050-00004","article-title":"Drugs in semen","volume":"26","author":"Pichini","year":"1994","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0030","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/bdrb.20031","article-title":"The transport of chemicals in semen","volume":"74","author":"Klemmt","year":"2005","journal-title":"Birth Defect Res B"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0035","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/humrep\/12.5.1073","article-title":"Targeted drug delivery in gynaecology: the first pass effect","volume":"12","author":"Bulletti","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0040","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/humupd\/5.4.365","article-title":"Transvaginal progesterone: evidence for a new functional \u2018portal system\u2019 flowing from the vagina to the uterus","volume":"5","author":"Cicinelli","year":"1999","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0045","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1749-6632.1997.tb48550.x","article-title":"The first uterine pass effect","volume":"828","author":"De Ziegler","year":"1997","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0050","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/bdrb.20115","article-title":"Evaluation of the developmental toxicity of lenalidomide in rabbits","volume":"80","author":"Christian","year":"2007","journal-title":"Birth Defect Res B"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0055","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00245415","article-title":"The effects of thalidomide on the fertility of rats studied in two generations","volume":"247","author":"Kopf","year":"1964","journal-title":"Naunyn Schmiedebergs Arch Pathol Pharmacol"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0060","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/tcm.1770040203","article-title":"Fresh visceral examination of rat and rabbit fetuses used in teratogenicity testing","volume":"4","author":"Stuckhardt","year":"1984","journal-title":"Teratog Carcinog Mutag"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0065","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/10520292609115636","article-title":"Note on the staining of skeleton of cleared specimens with Alizarin Red S","volume":"1","author":"Dawson","year":"1926","journal-title":"Stain Technol"},{"year":"1992","series-title":"Analysis of messy data","author":"Milliken","key":"10.1016\/j.reprotox.2014.05.002_bib0070"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0075","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1080\/01621459.1955.10501294","article-title":"A multiple comparison procedure for comparing several treatments with a control","volume":"50","author":"Dunnett","year":"1955","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0080","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/biomet\/29.3-4.350","article-title":"The significance of difference between two means when the population variances are unequal","volume":"29","author":"Welch","year":"1937","journal-title":"Biometrika"},{"year":"1980","series-title":"Principles, procedures of statistics. A biometrical approach","author":"Steel","key":"10.1016\/j.reprotox.2014.05.002_bib0085"},{"year":"1999","series-title":"Biostatistical analysis","author":"Zar","key":"10.1016\/j.reprotox.2014.05.002_bib0090"},{"year":"1989","series-title":"Statistical methods","author":"Snedecor","key":"10.1016\/j.reprotox.2014.05.002_bib0095"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0100","first-page":"223","article-title":"The use of thalidomide as a teratogenic agent in rabbits","volume":"3","author":"Dekker","year":"1964","journal-title":"Bull Johns Hopkins Hosp"},{"key":"10.1016\/j.reprotox.2014.05.002_bib0105","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/bdrc.20027","article-title":"Mechanisms regulating toxicant disposition to the embryo during early pregnancy: an interspecies comparison","volume":"72","author":"Carney","year":"2004","journal-title":"Birth Defect Res C"},{"issue":"3","key":"10.1016\/j.reprotox.2014.05.002_bib0110","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2164\/jandrol.106.001529","article-title":"Decreased semen volume and spermatozoa motility in HIV-1-infected patients under antiretroviral treatment","volume":"28","author":"Bujan","year":"2007","journal-title":"J Androl"},{"issue":"5","key":"10.1016\/j.reprotox.2014.05.002_bib0115","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2165\/00003088-200443050-00004","article-title":"Clinical pharmacokinetics of thalidomide","volume":"43","author":"Teo","year":"2004","journal-title":"Clin Pharmacokinet"},{"year":"2005","series-title":"Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers","author":"United States Food and Drug Administration","key":"10.1016\/j.reprotox.2014.05.002_bib0120"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623814000781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623814000781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:38:32Z","timestamp":1760189912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623814000781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":24,"alternative-id":["S0890623814000781"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2014.05.002","relation":{},"ISSN":["0890-6238"],"issn-type":[{"type":"print","value":"0890-6238"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Embryo\u2013fetal exposure and developmental outcome of thalidomide following oral and intravaginal administration to pregnant rabbits","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2014.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}