{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:02:22Z","timestamp":1777626142106,"version":"3.51.4"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Netherlands Genomics Initiative\/Netherlands Organization","award":["050-060-510"],"award-info":[{"award-number":["050-060-510"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.reprotox.2015.06.043","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T08:18:55Z","timestamp":1434183535000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Comparison of gene expression regulation in mouse- and human embryonic stem cell assays during neural differentiation and in response to valproic acid exposure"],"prefix":"10.1016","volume":"56","author":[{"given":"Sjors H.W.","family":"Schulpen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Theunissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen L.A.","family":"Pennings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldert H.","family":"Piersma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2015.06.043_bib0435","series-title":"Embryonic stem cells \u2013 basic biology to bioengineering","first-page":"213","article-title":"Embryonic stem cells in toxicological studies","author":"Estevan","year":"2011"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0440","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00204-010-0641-6","article-title":"Present state and future perspectives of using pluripotent stem cells in toxicology research","volume":"85","author":"Wobus","year":"2011","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0445","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-61779-867-2_10","article-title":"Embryonic stem cell test: stem cell use in predicting developmental cardiotoxicity and osteotoxicity","volume":"889","author":"Kuske","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"7","key":"10.1016\/j.reprotox.2015.06.043_bib0450","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nprot.2011.348","article-title":"The validated embryonic stem cell test to predict embryotoxicity in vitro","volume":"6","author":"Seiler","year":"2011","journal-title":"Nat Protoc"},{"issue":"4","key":"10.1016\/j.reprotox.2015.06.043_bib0455","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0887-2333(93)90064-C","article-title":"Development of an in vitro embryotoxicity test using murine embryonic stem cell cultures","volume":"7","author":"Heuer","year":"1993","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0460","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2202-4-27","article-title":"Directed neuronal differentiation of human embryonic stem cells","volume":"4","author":"Schulz","year":"2003","journal-title":"BMC Neurosci"},{"issue":"4","key":"10.1016\/j.reprotox.2015.06.043_bib0465","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.reprotox.2010.04.003","article-title":"An abbreviated protocol for multilineage neural differentiation of murine embryonic stem cells and its perturbation by methyl mercury","volume":"29","author":"Theunissen","year":"2010","journal-title":"Reprod Toxicol"},{"issue":"6","key":"10.1016\/j.reprotox.2015.06.043_bib0470","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.tiv.2012.05.015","article-title":"Osteoblast differentiation of murine embryonic stem cells as a model to study the embryotoxic effect of compounds","volume":"26","author":"de Jong","year":"2012","journal-title":"Toxicol In Vitro"},{"issue":"3","key":"10.1016\/j.reprotox.2015.06.043_bib0475","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1600-0897.2005.00354.x","article-title":"Embryonic stem cells: similarities and differences between human and murine embryonic stem cells","volume":"55","author":"Koestenbauer","year":"2006","journal-title":"Am J Reprod Immunol"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0480","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tiv.2007.07.013","article-title":"First steps in establishing a developmental toxicity test method based on human embryonic stem cells","volume":"22","author":"Adler","year":"2008","journal-title":"Toxicol In Vitro"},{"issue":"3","key":"10.1016\/j.reprotox.2015.06.043_bib0485","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.toxlet.2014.01.017","article-title":"A statistical approach towards the derivation of predictive gene sets for potency ranking of chemicals in the mouse embryonic stem cell test","volume":"225","author":"Schulpen","year":"2014","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0490","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/978-1-61779-867-2_22","article-title":"A review of toxicogenomic approaches in developmental toxicology","volume":"889","author":"Robinson","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0495","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00204-012-0967-3","article-title":"Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach","volume":"87","author":"Krug","year":"2013","journal-title":"Arch Toxicol"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0500","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.reprotox.2008.12.009","article-title":"Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate","volume":"27","author":"van Dartel","year":"2009","journal-title":"Reprod Toxicol"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0505","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1517\/14740338.4.2.345","article-title":"Teratogenicity of sodium valproate","volume":"4","author":"Alsdorf","year":"2005","journal-title":"Expert Opin Drug Saf"},{"issue":"15","key":"10.1016\/j.reprotox.2015.06.043_bib0510","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.clinbiochem.2013.06.012","article-title":"Adverse drug reactions induced by valproic acid","volume":"46","author":"Nanau","year":"2013","journal-title":"Clin Biochem"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0515","first-page":"128","article-title":"Teratogenicity of valproic acid and related substances in the mouse: drug accumulation and pHi in the embryo during organogenesis and structure\u2013activity considerations","volume":"11","author":"Nau","year":"1987","journal-title":"Arch Toxicol Suppl"},{"issue":"3","key":"10.1016\/j.reprotox.2015.06.043_bib0520","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.tiv.2014.12.001","article-title":"Distinct gene expression responses of two anticonvulsant drugs in a novel human embryonic stem cell based neural differentiation assay protocol","volume":"29","author":"Schulpen","year":"2014","journal-title":"Toxicol In Vitro"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0525","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/toxsci\/kfr293","article-title":"Transcriptomic concentration\u2013response evaluation of valproic acid: cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn)","volume":"125","author":"Theunissen","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0530","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfv094","article-title":"Gene expression regulation and pathway analysis after valproic acid and carbamazepine exposure in a human embryonic stem cell based neuro-developmental toxicity assay","author":"Schulpen","year":"2015","journal-title":"Toxicol Sci"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0535","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"issue":"Web Server issue","key":"10.1016\/j.reprotox.2015.06.043_bib0540","article-title":"User-friendly solutions for microarray quality control and pre-processing on ArrayAnalysis.org","volume":"41","author":"Eijssen","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0545","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration: normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"issue":"20","key":"10.1016\/j.reprotox.2015.06.043_bib0550","doi-asserted-by":"crossref","first-page":"e175","DOI":"10.1093\/nar\/gni179","article-title":"Evolving gene\/transcript definitions significantly alter the interpretation of GeneChip data","volume":"33","author":"Dai","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0555","series-title":"VENNY. An interactive tool for comparing lists with Venn Diagrams","author":"Oliveros","year":"2007"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0560","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"issue":"Web Server issue","key":"10.1016\/j.reprotox.2015.06.043_bib0565","doi-asserted-by":"crossref","first-page":"W592","DOI":"10.1093\/nar\/gki484","article-title":"T-profiler: scoring the activity of predefined groups of genes using gene expression data","volume":"33","author":"Boorsma","year":"2005","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0570","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1042\/bj2720251","article-title":"Inhibition of sterol but not fatty acid synthesis by valproate in developing rat brain in vivo","volume":"272","author":"Bolanos","year":"1990","journal-title":"Biochem J"},{"issue":"6","key":"10.1016\/j.reprotox.2015.06.043_bib0575","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/0006-2952(93)90281-Z","article-title":"Effect of valproate on lipogenesis in neonatal rat brain","volume":"45","author":"Bolanos","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0580","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.biochem.68.1.157","article-title":"Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway","volume":"68","author":"Edwards","year":"1999","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0585","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2741\/S361","article-title":"Current status of human pluripotent stem cell based in vitro toxicity tests","volume":"5","author":"Klaric","year":"2013","journal-title":"Front Biosci (Schol Ed)"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0590","first-page":"7","article-title":"Focus on stem cells as sources of human target cells for in vitro research and testing","volume":"1","author":"De Kock","year":"2012","journal-title":"ALTEX"},{"issue":"4\/5","key":"10.1016\/j.reprotox.2015.06.043_bib0595","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0887-2333(99)00046-6","article-title":"Prevalidation of the Embryonic Stem Cell Test (EST) \u2013 a new in vitro embryotoxicity test","volume":"13","author":"Scholz","year":"1999","journal-title":"Toxicol In Vitro"},{"issue":"3","key":"10.1016\/j.reprotox.2015.06.043_bib0600","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.toxlet.2014.03.023","article-title":"Toxicity of TDCPP and TCEP on PC12 cell: changes in CAMKII, GAP43, tubulin and NF-H gene and protein levels","volume":"227","author":"Ta","year":"2014","journal-title":"Toxicol Lett"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0605","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.taap.2010.05.007","article-title":"Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics","volume":"247","author":"West","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"issue":"8304","key":"10.1016\/j.reprotox.2015.06.043_bib0610","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(82)90908-4","article-title":"Maternal valproic acid and congenital neural tube defects","volume":"2","author":"Robert","year":"1982","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.reprotox.2015.06.043_bib0615","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nbt1201-1129","article-title":"In vitro differentiation of transplantable neural precursors from human embryonic stem cells","volume":"19","author":"Zhang","year":"2001","journal-title":"Nat Biotechnol"},{"issue":"3","key":"10.1016\/j.reprotox.2015.06.043_bib0620","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tox.2012.06.016","article-title":"An optimized gene set for transcriptomics based neurodevelopmental toxicity prediction in the neural embryonic stem cell test","volume":"300","author":"Pennings","year":"2012","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.reprotox.2015.06.043_bib0625","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/cdd.2010.109","article-title":"Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing","volume":"18","author":"Zimmer","year":"2011","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0630","volume":"vol. xxiv","author":"Hodgson","year":"2010"},{"issue":"7","key":"10.1016\/j.reprotox.2015.06.043_bib0635","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1073\/pnas.032074999","article-title":"Endothelial cells derived from human embryonic stem cells","volume":"99","author":"Levenberg","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.reprotox.2015.06.043_bib0640","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/01.RES.0000035254.80718.91","article-title":"Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells","volume":"91","author":"Xu","year":"2002","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0645","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.RES.0000080317.92718.99","article-title":"Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization","volume":"93","author":"He","year":"2003","journal-title":"Circ Res"},{"issue":"21","key":"10.1016\/j.reprotox.2015.06.043_bib0650","doi-asserted-by":"crossref","first-page":"11307","DOI":"10.1073\/pnas.97.21.11307","article-title":"Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells","volume":"97","author":"Schuldiner","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.reprotox.2015.06.043_bib0655","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2337\/diabetes.50.8.1691","article-title":"Insulin production by human embryonic stem cells","volume":"50","author":"Assady","year":"2001","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0660","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-5793(02)03191-5","article-title":"A molecular view on pluripotent stem cells","volume":"529","author":"Eiges","year":"2002","journal-title":"FEBS Lett"},{"issue":"8","key":"10.1016\/j.reprotox.2015.06.043_bib0665","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/01.RES.0000039084.30342.9B","article-title":"High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: a novel in vitro model for the study of conduction","volume":"91","author":"Kehat","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0670","series-title":"Introduction to toxicology","author":"Timbrell","year":"2001"},{"issue":"21","key":"10.1016\/j.reprotox.2015.06.043_bib0675","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1161\/01.CIR.0000068356.38592.68","article-title":"Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells","volume":"107","author":"Mummery","year":"2003","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0680","first-page":"47","article-title":"Developmental toxicity testing from animal towards embryonic stem cells","volume":"22","author":"Pellizzer","year":"2005","journal-title":"ALTEX"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0685","volume":"vol. xvi","author":"Hodgson","year":"1997"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0690","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/026119290803600204","article-title":"Testing potential developmental toxicants with a cytotoxicity assay based on human embryonic stem cells","volume":"36","author":"Adler","year":"2008","journal-title":"Altern Lab Anim"},{"issue":"4","key":"10.1016\/j.reprotox.2015.06.043_bib0695","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/bdrb.21078","article-title":"Establishment and assessment of a new human embryonic stem cell-based biomarker assay for developmental toxicity screening","volume":"98","author":"Palmer","year":"2013","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0700","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/jat.3010","article-title":"Evaluation of developmental toxicity using undifferentiated human embryonic stem cells","volume":"35","author":"Jung","year":"2015","journal-title":"J Appl Toxicol"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0705","first-page":"541","article-title":"Focus on stem cells as sources of human target cells for in vitro research and testing","volume":"1","author":"De kock","year":"2012","journal-title":"ALTEX"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0710","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/scd.2010.0037","article-title":"Neural differentiation from human embryonic stem cells as a tool to study early brain development and the neuroteratogenic effects of ethanol","volume":"20","author":"Talens-Visconti","year":"2011","journal-title":"Stem Cells Dev"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0715","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/toxsci\/kfr245","article-title":"Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure","volume":"124","author":"Colleoni","year":"2011","journal-title":"Toxicol Sci"},{"issue":"Suppl. 1","key":"10.1016\/j.reprotox.2015.06.043_bib0720","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1186\/scrt373","article-title":"A human pluripotent stem cell platform for assessing developmental neural toxicity screening","volume":"4","author":"Hou","year":"2013","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"10.1016\/j.reprotox.2015.06.043_bib0725","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1021\/tx400402j","article-title":"Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells","volume":"27","author":"Waldmann","year":"2014","journal-title":"Chem Res Toxicol"},{"issue":"10","key":"10.1016\/j.reprotox.2015.06.043_bib0730","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1002\/stem.179","article-title":"A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system","volume":"27","author":"Buzanska","year":"2009","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0735","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.reprotox.2003.10.015","article-title":"Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test","volume":"18","author":"Seiler","year":"2004","journal-title":"Reprod Toxicol"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0740","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.reprotox.2009.03.017","article-title":"Disentangling cellular proliferation and differentiation in the embryonic stem cell test: and its impact on the experimental protocol","volume":"28","author":"van Dartel","year":"2009","journal-title":"Reprod Toxicol"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0745","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ydbio.2011.07.032","article-title":"The core planar cell polarity gene prickle interacts with flamingo to promote sensory axon advance in the Drosophila embryo","volume":"358","author":"Mrkusich","year":"2011","journal-title":"Dev Biol"},{"issue":"12","key":"10.1016\/j.reprotox.2015.06.043_bib0750","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/humu.21589","article-title":"Identification and characterization of novel rare mutations in the planar cell polarity gene PRICKLE1 in human neural tube defects","volume":"32","author":"Bosoi","year":"2011","journal-title":"Hum Mutat"},{"issue":"42","key":"10.1016\/j.reprotox.2015.06.043_bib0755","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1021\/bi500800x","article-title":"Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: insights into the mechanism of receptor activation","volume":"53","author":"Chavent","year":"2014","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.reprotox.2015.06.043_bib0760","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ng1993","article-title":"Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis","volume":"39","author":"Baala","year":"2007","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.reprotox.2015.06.043_bib0765","doi-asserted-by":"crossref","first-page":"e64291","DOI":"10.1371\/journal.pone.0064291","article-title":"Secreted cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells","volume":"8","author":"Iwashita","year":"2013","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0770","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1101\/gad.1365406","article-title":"Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain","volume":"20","author":"Olsen","year":"2006","journal-title":"Genes Dev"},{"issue":"25","key":"10.1016\/j.reprotox.2015.06.043_bib0775","doi-asserted-by":"crossref","first-page":"15292","DOI":"10.1074\/jbc.271.25.15292","article-title":"Receptor specificity of the fibroblast growth factor family","volume":"271","author":"Ornitz","year":"1996","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.reprotox.2015.06.043_bib0780","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1089\/dna.1997.16.671","article-title":"Cloning: expression, and chromosomal localization to 11p 12-13 of a human LIM\/HOMEOBOX gene, hLim-1","volume":"16","author":"Dong","year":"1997","journal-title":"DNA Cell Biol"},{"issue":"6259","key":"10.1016\/j.reprotox.2015.06.043_bib0785","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/343657a0","article-title":"Expression pattern of the mouse T gene and its role in mesoderm formation","volume":"343","author":"Wilkinson","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0790","first-page":"78","article-title":"Action of the Brachyury gene in mouse embryogenesis","volume":"165","author":"Herrmann","year":"1992","journal-title":"Ciba Found Symp"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0795","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1634\/stemcells.2008-1008","article-title":"Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation","volume":"27","author":"Lim","year":"2009","journal-title":"Stem Cells"},{"issue":"5","key":"10.1016\/j.reprotox.2015.06.043_bib0800","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1242\/dev.01657","article-title":"The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells","volume":"132","author":"Ng","year":"2005","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.reprotox.2015.06.043_bib0805","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1086\/302289","article-title":"Characterization and mutation analysis of human LEFTY A and LEFTY B: homologues of murine genes implicated in left-right axis development","volume":"64","author":"Kosaki","year":"1999","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0810","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2013.01.007","article-title":"Dner inhibits neural progenitor proliferation and induces neuronal and glial differentiation in zebrafish","volume":"375","author":"Hsieh","year":"2013","journal-title":"Dev Biol"},{"issue":"7","key":"10.1016\/j.reprotox.2015.06.043_bib0815","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/cm.21021","article-title":"Dyrk kinases regulate phosphorylation of doublecortin: cytoskeletal organization, and neuronal morphology","volume":"69","author":"Slepak","year":"2012","journal-title":"Cytoskeleton (Hoboken)"},{"key":"10.1016\/j.reprotox.2015.06.043_bib0820","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1749-8104-5-23","article-title":"Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early\/posterior-born Purkinje cells in the developing mouse lateral cerebellum","volume":"5","author":"Miyata","year":"2010","journal-title":"Neural Dev"},{"issue":"3","key":"10.1016\/j.reprotox.2015.06.043_bib0825","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1385\/MN:30:3:225","article-title":"Neuronal migration and the role of reelin during early development of the cerebral cortex","volume":"30","author":"Jossin","year":"2004","journal-title":"Mol Neurobiol"},{"issue":"18","key":"10.1016\/j.reprotox.2015.06.043_bib0830","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1093\/nar\/20.18.4919","article-title":"A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system","volume":"20","author":"Collum","year":"1992","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0835","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cell.2009.12.011","article-title":"Human TUBB3 mutations perturb microtubule dynamics: kinesin interactions, and axon guidance","volume":"140","author":"Tischfield","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.reprotox.2015.06.043_bib0840","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1471-4159.2011.07523.x","article-title":"Phosphorylation of microtubule-associated protein tau by AMPK-related kinases","volume":"120","author":"Yoshida","year":"2012","journal-title":"J Neurochem"},{"issue":"3","key":"10.1016\/j.reprotox.2015.06.043_bib0845","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1006\/bbrc.1996.0957","article-title":"Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture","volume":"223","author":"Bain","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"10.1016\/j.reprotox.2015.06.043_bib0850","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nn1301","article-title":"Differentiation of mouse embryonic stem cells into a defined neuronal lineage","volume":"7","author":"Bibel","year":"2004","journal-title":"Nat Neurosci"},{"issue":"4","key":"10.1016\/j.reprotox.2015.06.043_bib0855","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.eplepsyres.2014.02.005","article-title":"Valproic acid in normal therapeutic concentration has no neuroprotective or differentiation influencing effects on long term expanded murine neural stem cells","volume":"108","author":"Brunn","year":"2014","journal-title":"Epilepsy Res"},{"issue":"2","key":"10.1016\/j.reprotox.2015.06.043_bib0860","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.neuropharm.2008.09.019","article-title":"Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation","volume":"56","author":"Yu","year":"2009","journal-title":"Neuropharmacology"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623815001525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623815001525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:41:21Z","timestamp":1760190081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623815001525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":86,"alternative-id":["S0890623815001525"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2015.06.043","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of gene expression regulation in mouse- and human embryonic stem cell assays during neural differentiation and in response to valproic acid exposure","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2015.06.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}