{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:17:56Z","timestamp":1790803076481,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270703"],"award-info":[{"award-number":["81270703"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471461"],"award-info":[{"award-number":["81471461"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.reprotox.2015.11.005","type":"journal-article","created":{"date-parts":[[2015,11,22]],"date-time":"2015-11-22T01:34:25Z","timestamp":1448156065000},"page":"45-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Potential involvement of placental AhR in unexplained recurrent spontaneous abortion"],"prefix":"10.1016","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-3051","authenticated-orcid":false,"given":"Y","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.J.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2015.11.005_bib0005","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0140-6736(00)02535-6","article-title":"Recurrent spontaneous abortion and intrauterine fetal growth retardation as symptoms of coeliac disease","volume":"356","author":"Gasbarrini","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2015.11.005_bib0010","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0140-6736(06)69204-0","article-title":"Recurrent miscarriage","volume":"368","author":"Rai","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2015.11.005_bib0015","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1056\/NEJMcp1005330","article-title":"Clinical practice. Recurrent miscarriage","volume":"363","author":"Branch","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0020","first-page":"76","article-title":"Recurrent pregnancy loss: etiology, diagnosis, and therapy","volume":"2","author":"Ford","year":"2009","journal-title":"Rev. Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0025","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pa.22.040182.002505","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity","volume":"22","author":"Poland","year":"1982","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0030","doi-asserted-by":"crossref","first-page":"14694","DOI":"10.1073\/pnas.232562899","article-title":"A ligand for the aryl hydrocarbon receptor isolated from lung","volume":"99","author":"Song","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0035","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/taap.1998.8601","article-title":"Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse","volume":"155","author":"Abbott","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0040","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1021\/tx7001965","article-title":"The search for endogenous activators of the aryl hydrocarbon receptor","volume":"21","author":"Nguyen","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0045","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev-immunol-032713-120245","article-title":"The aryl hydrocarbon receptor: multitasking in the immune system","volume":"32","author":"Stockinger","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0050","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.bcp.2008.09.037","article-title":"The role of the aryl hydrocarbon receptor in the female reproductive system","volume":"77","author":"Hernandez-Ochoa","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0055","doi-asserted-by":"crossref","first-page":"10442","DOI":"10.1073\/pnas.190256997","article-title":"Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice","volume":"97","author":"Lahvis","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0060","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.pharmtox.43.100901.135828","article-title":"Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals","volume":"43","author":"Denison","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0065","first-page":"2366","article-title":"Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism","volume":"58","author":"Larsen","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0070","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1369\/jhc.2010.955955","article-title":"Expression of aryl hydrocarbon receptor in human placentas and fetal tissues","volume":"58","author":"Jiang","year":"2010","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0075","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0009-2797(02)00065-0","article-title":"The mechanism of AH receptor protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation","volume":"141","author":"Pollenz","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0080","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.reprotox.2005.09.008","article-title":"The early embryo loss caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin may be related to the accumulation of this compound in the uterus","volume":"21","author":"Li","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0085","doi-asserted-by":"crossref","first-page":"e86549","DOI":"10.1371\/journal.pone.0086549","article-title":"ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2015.11.005_bib0090","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1289\/ehp.6080","article-title":"Maternal serum dioxin levels and birth outcomes in women of Seveso, Italy","volume":"111","author":"Eskenazi","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0095","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0045-6535(00)00456-2","article-title":"Dioxin exposure and public health in Chapaevsk, Russia","volume":"43","author":"Revich","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2015.11.005_bib0100","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1289\/ehp.10686","article-title":"Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident","volume":"116","author":"Tsukimori","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0105","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00001648-199709000-00007","article-title":"Moderate maternal alcohol consumption and risk of spontaneous abortion","volume":"8","author":"Windham","year":"1997","journal-title":"Epidemiology"},{"key":"10.1016\/j.reprotox.2015.11.005_bib0110","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1034\/j.1600-0412.2003.00078.x","article-title":"Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion","volume":"82","author":"Rasch","year":"2003","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0115","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1111\/j.1530-0277.2012.01787.x","article-title":"Regulation of the activity and expression of aryl hydrocarbon receptor by ethanol in mouse hepatic stellate cells","volume":"36","author":"Zhang","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0120","doi-asserted-by":"crossref","first-page":"e56860","DOI":"10.1371\/journal.pone.0056860","article-title":"Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2015.11.005_bib0125","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/toxsci\/kfn011","article-title":"Newspapers and newspaper ink contain agonists for the ah receptor","volume":"102","author":"Bohonowych","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0130","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.canlet.2006.11.015","article-title":"Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway","volume":"252","author":"Kitamura","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0135","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1159\/000369662","article-title":"Decreased maternal serum 2-methoxyestradiol levels are associated with the development of preeclampsia","volume":"34","author":"Shen","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0140","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/toxsci\/kfr150","article-title":"Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures","volume":"123","author":"Stejskalova","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0145","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1089\/thy.2012.0057","article-title":"Serum from methimazole-treated patients induces activation of aryl hydrocarbon receptor, a transcription factor that binds to dioxin-response elements","volume":"22","author":"Ishikawa","year":"2012","journal-title":"Thyroid"},{"key":"10.1016\/j.reprotox.2015.11.005_bib0150","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.canlet.2013.06.026","article-title":"An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells","volume":"340","author":"Wang","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0155","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mce.2014.04.008","article-title":"Distinct roles of HIF1A in endothelial adaptations to physiological and ambient oxygen","volume":"391","author":"Jiang","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0160","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/oxfordjournals.jbchem.a022633","article-title":"Nucleocytoplasmic shuttling of the aryl hydrocarbon receptor","volume":"127","author":"Ikuta","year":"2000","journal-title":"J. Biochem."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0165","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1158\/1541-7786.MCR-12-0216","article-title":"Ah receptor antagonism represses head and neck tumor cell aggressive phenotype","volume":"10","author":"DiNatale","year":"2012","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0170","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrc3846","article-title":"Aryl hydrocarbon receptor ligands in cancer: friend and foe","volume":"14","author":"Murray","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.reprotox.2015.11.005_bib0175","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bcp.2008.08.031","article-title":"The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways","volume":"77","author":"Puga","year":"2009","journal-title":"Biochem. Pharmacol."},{"issue":"828532","key":"10.1016\/j.reprotox.2015.11.005_bib0180","article-title":"Endocrine-disrupting chemicals: some actions of POPs on female reproduction","volume":"2013","author":"Gregoraszczuk","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0185","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.3390\/molecules19044956","article-title":"Characterization of natural aryl hydrocarbon receptor agonists from cassia seed and rosemary","volume":"19","author":"Amakura","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.reprotox.2015.11.005_bib0190","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.scitotenv.2012.12.021","article-title":"Polycyclic aromatic hydrocarbons (PAHs) as determinants of various anthropometric measures of birth outcome","volume":"444","author":"Al-Saleh","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0195","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1191\/096032700671433928","article-title":"Polycyclic aromatic hydrocarbons in placenta","volume":"19","author":"Gladen","year":"2000","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.reprotox.2015.11.005_bib0200","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/bbrc.1997.6053","article-title":"Benzo(a) pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells","volume":"231","author":"Zhang","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623815300502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623815300502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:40:15Z","timestamp":1760190015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623815300502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":40,"alternative-id":["S0890623815300502"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2015.11.005","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential involvement of placental AhR in unexplained recurrent spontaneous abortion","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2015.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}