{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:18:34Z","timestamp":1788589114686,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.reprotox.2016.06.015","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T23:54:07Z","timestamp":1466898847000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Pregnancy outcome after chelation therapy in Wilson disease. Evaluation of the German Embryotox Database"],"prefix":"10.1016","volume":"65","author":[{"given":"Katarina","family":"Dathe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelin","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2016.06.015_bib0005","doi-asserted-by":"crossref","unstructured":"EASL clinical practice guidelines: Wilson\u2019s disease, J. Hepatol. 56 (2012) 671\u2013685.","DOI":"10.1016\/j.jhep.2011.11.007"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jat.2550110103","article-title":"Antidotal effects of dimercaptosuccinic acid","volume":"11","author":"Ding","year":"1991","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0015","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3748\/wjg.v4.i6.530","article-title":"Comparison of long lasting therapeutic effects between succimer and penicillamine on hepatolenticular degeneration","volume":"4","author":"Ren","year":"1998","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0020","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jtemb.2014.10.001","article-title":"Chelation in metal intoxication \u2013 principles and paradigms","volume":"31","author":"Aaseth","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0025","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1002\/hep.22261","article-title":"Diagnosis and treatment of Wilson disease: an update","volume":"47","author":"Roberts","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0030","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(07)60196-2","article-title":"Wilson's disease","volume":"369","author":"Ala","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0035","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0140-6736(83)90783-3","article-title":"Cutis laxa and low serum zinc after antenatal exposure to penicillamine","volume":"2","author":"Harpey","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0140-6736(79)90210-1","article-title":"Reversible cutis laxa due to maternal d-penicillamine treatment","volume":"2","author":"Linares","year":"1979","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0045","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/(SICI)1096-8628(19980319)76:3<274::AID-AJMG13>3.0.CO;2-E","article-title":"Prenatal exposure to penicillamine and oral clefts: case report","volume":"76","author":"Martinez-Frias","year":"1998","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0050","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0140-6736(71)92681-X","article-title":"Congenital connective-tissue defect probably due to d-penicillamine treatment in pregnancy","volume":"1","author":"Mjolnerod","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0055","doi-asserted-by":"crossref","first-page":"468","DOI":"10.5021\/ad.2010.22.4.468","article-title":"Penicillamine-induced elastosis perforans serpiginosa and Cutis laxa in a patient with Wilson's Disease","volume":"22","author":"Na","year":"2010","journal-title":"Ann. Dermatol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0060","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/ajmg.a.10871","article-title":"Infant with severe penicillamine embryopathy born to a woman with Wilson disease","volume":"128A","author":"Pinter","year":"2004","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0065","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/tera.1420330116","article-title":"Teratogen update: penicillamine","volume":"33","author":"Rosa","year":"1986","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0070","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1039\/c2dt12188c","article-title":"Chelation therapy in Wilson's disease: from d-penicillamine to the design of selective bioinspired intracellular Cu(I) chelators","volume":"41","author":"Delangle","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0075","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00204-014-1355-y","article-title":"Copper: toxicological relevance and mechanisms","volume":"88","author":"Gaetke","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0080","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/jmg.2007.052746","article-title":"Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes","volume":"44","author":"de","year":"2007","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0085","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/humu.22266","article-title":"An overview and update of ATP7A mutations leading to Menkes disease and occipital horn syndrome","volume":"34","author":"Tumer","year":"2013","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0090","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.3390\/ijerph7072745","article-title":"Chelation in metal intoxication","volume":"7","author":"Flora","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0095","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJM198007103030201","article-title":"X-linked cutis laxa: defective cross-link formation in collagen due to decreased lysyl oxidase activity","volume":"303","author":"Byers","year":"1980","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0100","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.reprotox.2008.05.064","article-title":"Using observational cohort data for studying drug effects on pregnancy outcome \u2013 methodological considerations","volume":"26","author":"Schaefer","year":"2008","journal-title":"Reprod. Toxicol."},{"issue":"Suppl. 3","key":"10.1016\/j.reprotox.2016.06.015_bib0105","first-page":"75","article-title":"Penicillamine and wound healing in rheumatoid arthritis","volume":"70","author":"Ansell","year":"1977","journal-title":"Proc. R. Soc. Med."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0110","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1097\/01.mcg.0000225670.91722.59","article-title":"Diagnosis and management of Wilson's disease: results of a single center experience","volume":"40","author":"Medici","year":"2006","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0115","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1056\/NEJM196802152780702","article-title":"Prevention of Wilson's disease in asymptomatic patients","volume":"278","author":"Sternlieb","year":"1968","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0120","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/0002-9378(90)90619-I","article-title":"Pregnancy in a patient with treated Wilson's disease: a case report","volume":"163","author":"Dupont","year":"1990","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0125","series-title":"Comprehensive Clinical Hepatology","first-page":"351","article-title":"Wilson\u2019 disease","author":"Ferenci","year":"2005"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0130","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1756-0500-6-421","article-title":"Wilson's disease in pregnancy: case series and review of literature","volume":"6","author":"Malik","year":"2013","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0135","first-page":"77","article-title":"Wilson disease and pregnancy. Review of the literature and case report","volume":"202","author":"Messner","year":"1998","journal-title":"Z. Geburtshilfe Neonatol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0140","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1056\/NEJM197512182932507","article-title":"Pregnancy in penicillamine-treated patients with Wilson's disease","volume":"293","author":"Scheinberg","year":"1975","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0145","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jns.2003.08.007","article-title":"Successful pregnancies and abortions in symptomatic and asymptomatic Wilson's disease","volume":"217","author":"Sinha","year":"2004","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0150","first-page":"73","article-title":"Pregnancy in Wilson's disease","volume":"46","author":"Walshe","year":"1977","journal-title":"Q. J. Med."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0155","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0041-008X(82)90010-2","article-title":"d-Penicillamine toxicity in mice. III. Pathological study of offspring of penicillamine-fed pregnant and lactating mice","volume":"65","author":"Irino","year":"1982","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0160","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jat.2550120108","article-title":"Oral administration of d-penicillamine causes neonatal mortality without morphological defects in CD-1 mice","volume":"12","author":"Rousseaux","year":"1992","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0165","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jaad.2008.09.018","article-title":"Penicillamine-induced elastosis of the mucosal lip","volume":"60","author":"Lewis","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0170","series-title":"The Developing Human","first-page":"437","article-title":"Integumentary system","year":"2016"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0175","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.jpeds.2008.06.015","article-title":"Hypothyroidism and dyshormonogenesis induced by d-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease","volume":"153","author":"Hanukoglu","year":"2008","journal-title":"J. Pediatr."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0180","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00431-008-0886-8","article-title":"Triethylene tetramine dihydrochloride (trientine) in children with Wilson disease: experience at King's College Hospital and review of the literature","volume":"168","author":"Taylor","year":"2009","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0185","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0140-6736(82)92313-3","article-title":"Low tissue copper and teratogenesis in trientine-treated rats","volume":"1","author":"Keen","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0190","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3177\/jnsv.38.545","article-title":"Low copper and brain abnormalities in fetus from triethylene tetramine dihydrochloride-treated pregnant mouse","volume":"38","author":"Tanaka","year":"1992","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"10.1016\/j.reprotox.2016.06.015_bib0195","first-page":"81","article-title":"The management of pregnancy in Wilson's disease treated with trientine","volume":"58","author":"Walshe","year":"1986","journal-title":"Q. J. Med."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0200","first-page":"102","article-title":"Wilson's disease treated with trientine during pregnancy","volume":"20","author":"Devesa","year":"1995","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.reprotox.2016.06.015_bib0205","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/pds.3744","article-title":"Does the average drug exposure in pregnant women affect pregnancy outcome? A comparison of two approaches to estimate the baseline risks of adverse pregnancy outcome","volume":"24","author":"Wacker","year":"2015","journal-title":"Pharmacoepidemiol. Drug Saf"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089062381630154X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089062381630154X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:42:21Z","timestamp":1760190141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089062381630154X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":41,"alternative-id":["S089062381630154X"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2016.06.015","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnancy outcome after chelation therapy in Wilson disease. Evaluation of the German Embryotox Database","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2016.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}