{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:13:24Z","timestamp":1762161204278,"version":"build-2065373602"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Institute of Environmental Health Sciences Superfund Research Program","award":["5P42ES00738"],"award-info":[{"award-number":["5P42ES00738"]}]},{"name":"Reproductive Scientist Development Program","award":["5K12HD000849-27"],"award-info":[{"award-number":["5K12HD000849-27"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.reprotox.2016.07.005","type":"journal-article","created":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T10:17:03Z","timestamp":1468145823000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Association of prenatal and early life exposure to tetrachloroethylene (PCE) with polycystic ovary syndrome and other reproductive disorders in the cape cod health study: A retrospective cohort study"],"prefix":"10.1016","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5527-5787","authenticated-orcid":false,"given":"Shruthi","family":"Mahalingaiah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Aschengrau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2016.07.005_bib0005","unstructured":"A.f.T.S.a.D.R. ATSDR, Toxicological profile for tetrachloroethylene (update). <http:\/\/www.atsdr.cdc.gov\/toxprofiles\/tp.asp?id=265&tid=48>, 2011, 2013."},{"issue":"4","key":"10.1016\/j.reprotox.2016.07.005_bib0010","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/j.1551-8833.1983.tb05104.x","article-title":"Tetrachloroethylene leached from lined asbestos-cement pipe into drinking water","volume":"75","author":"Larson","year":"1983","journal-title":"J. Am. Water Works Assoc."},{"key":"10.1016\/j.reprotox.2016.07.005_bib0015","unstructured":"D.o.E.Q.E. Commonwealth of Massachusetts, Status report on tetrachloroethylene contamination of public drinking water supplies caused by vinyl-lined asbestos cement pipe, In: D.o.E.Q.E. Commonwealth of Massachusetts (Ed.) 1982."},{"year":"1982","series-title":"A Source of Tetrachloroethylene in the Drinking Water of New England: an Evaluation of the Toxicity of Tetrachloroethylene and the Prediction of its Leaching Rates from Vinyl-Lined Asbestos-Cement Pipe","author":"Demond","key":"10.1016\/j.reprotox.2016.07.005_bib0020"},{"issue":"2","key":"10.1016\/j.reprotox.2016.07.005_bib0025","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1600-0773.1986.tb00078.x","article-title":"Trichloroacetic acid accumulates in murine amniotic fluid after tri- and tetrachloroethylene inhalation","volume":"58","author":"Ghantous","year":"1986","journal-title":"Acta Pharmacol. Toxicol. (Copenh.)"},{"issue":"9","key":"10.1016\/j.reprotox.2016.07.005_bib0030","first-page":"1047","article-title":"Obstructive jaundice due to a chlorinated hydrocarbon in breast milk","volume":"117","author":"Bagnell","year":"1977","journal-title":"Can. Med. Assoc. J."},{"issue":"3","key":"10.1016\/j.reprotox.2016.07.005_bib0035","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/BF01608515","article-title":"Purgeable organic compounds in mother's milk","volume":"28","author":"Pellizzari","year":"1982","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.reprotox.2016.07.005_bib0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1757-2215-7-67","article-title":"Association between intrafollicular concentration of benzene and outcome of controlled ovarian stimulation in IVF\/ICSI cycles: a pilot study","volume":"7","author":"Alviggi","year":"2014","journal-title":"J. Ovarian Res."},{"issue":"Suppl. 3","key":"10.1016\/j.reprotox.2016.07.005_bib0045","first-page":"383","article-title":"Environmental agents that have the potential to trigger massive apoptotic neurodegeneration in the developing brain","volume":"108","author":"Olney","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.reprotox.2016.07.005_bib0050","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/00043764-200106000-00012","article-title":"Effects of exposure to organic solvents on menstrual cycle length","volume":"43","author":"Cho","year":"2001","journal-title":"J. Occup. Environ. Med. Am. Col. Occup. Environ. Med."},{"key":"10.1016\/j.reprotox.2016.07.005_bib0055","first-page":"156","article-title":"Menstrual disturbances and hormonal changes in women workers exposed to a mixture of organic solvents in a pharmaceutical company","volume":"28","author":"Hassani","year":"2014","journal-title":"Med. J. Islam. Repub. Iran"},{"issue":"1","key":"10.1016\/j.reprotox.2016.07.005_bib0060","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/occmed\/kqs172","article-title":"Shortened menstrual cycles in LCD manufacturing workers","volume":"63","author":"Lin","year":"2013","journal-title":"Occup. Med. (Lond.)"},{"issue":"5","key":"10.1016\/j.reprotox.2016.07.005_bib0065","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/ajim.4700270506","article-title":"Reduced fertility among women exposed to organic solvents","volume":"27","author":"Sallmen","year":"1995","journal-title":"Am. J. Ind. Med."},{"issue":"1","key":"10.1016\/j.reprotox.2016.07.005_bib0070","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1097-0274(199907)36:1<206::AID-AJIM29>3.0.CO;2-D","article-title":"Reduced fertility among female wood workers exposed to formaldehyde","volume":"36","author":"Taskinen","year":"1999","journal-title":"Am. J. Ind. Med."},{"issue":"7","key":"10.1016\/j.reprotox.2016.07.005_bib0075","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/oxfordjournals.aje.a008804","article-title":"Ethylene glycol ethers and risks of spontaneous abortion and subfertility","volume":"143","author":"Correa","year":"1996","journal-title":"Am. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.reprotox.2016.07.005_bib0080","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00001648-200203000-00014","article-title":"Prolonged time to pregnancy in female workers exposed to ethylene glycol ethers in semiconductor manufacturing","volume":"13","author":"Chen","year":"2002","journal-title":"Epidemiology"},{"issue":"12","key":"10.1016\/j.reprotox.2016.07.005_bib0085","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1001\/jama.281.12.1106","article-title":"Pregnancy outcome following gestational exposure to organic solvents: a prospective controlled study","volume":"281","author":"Khattak","year":"1999","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.reprotox.2016.07.005_bib0090","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12940-015-0021-z","article-title":"Long-term health effects of early life exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study","volume":"14","author":"Aschengrau","year":"2015","journal-title":"Environ. Health"},{"issue":"9","key":"10.1016\/j.reprotox.2016.07.005_bib0095","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1289\/ehp.1103996","article-title":"Prenatal and early childhood exposure to tetrachloroethylene and adult vision","volume":"120","author":"Getz","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.reprotox.2016.07.005_bib0100","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ntt.2012.04.001","article-title":"Adult neuropsychological performance following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water","volume":"34","author":"Janulewicz","year":"2012","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.reprotox.2016.07.005_bib0105","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1476-069X-13-72","article-title":"Prenatal drinking-water exposure to tetrachloroethylene and ischemic placental disease: a retrospective cohort study","volume":"13","author":"Carwile","year":"2014","journal-title":"Environ. Health"},{"key":"10.1016\/j.reprotox.2016.07.005_bib0110","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1289\/ehp.10414","article-title":"Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of adverse birth outcomes","volume":"116","author":"Aschengrau","year":"2008","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.reprotox.2016.07.005_bib0115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1289\/ehp.4980","article-title":"Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA","volume":"111","author":"Aschengrau","year":"2003","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.reprotox.2016.07.005_bib0120","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/00039896.1993.9936716","article-title":"Exposure to tetrachloroethylene via contaminated drinking water pipes in Massachusetts: a predictive model","volume":"48","author":"Webler","year":"1993","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.reprotox.2016.07.005_bib0125","first-page":"180","article-title":"Using water-distribution system modeling to assist epidemiologic investigations","volume":"126","author":"Maslia","year":"2000","journal-title":"Res. Plan. Manage."},{"key":"10.1016\/j.reprotox.2016.07.005_bib0130","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0013-9351(03)00131-2","article-title":"Neurobehavioral effects of exposure to trichloroethylene through a municipal water supply","volume":"9","author":"Reif","year":"2003","journal-title":"Environ. Res."},{"year":"1994","series-title":"EPANET Users Manual","author":"Rossman","key":"10.1016\/j.reprotox.2016.07.005_bib0135"},{"issue":"1","key":"10.1016\/j.reprotox.2016.07.005_bib0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","article-title":"Longitudinal data analysis using generalized linear models","volume":"73","author":"Liang","year":"1986","journal-title":"Biometrika"},{"issue":"1","key":"10.1016\/j.reprotox.2016.07.005_bib0145","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2307\/2531248","article-title":"Longitudinal data analysis for discrete and continuous outcomes","volume":"42","author":"Zeger","year":"1986","journal-title":"Biometrics"},{"issue":"3","key":"10.1016\/j.reprotox.2016.07.005_bib0150","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2105\/AJPH.79.3.340","article-title":"Modeling and variable selection in epidemiologic analysis","volume":"79","author":"Greenland","year":"1989","journal-title":"Am. J. Public Health"},{"issue":"1\u20132","key":"10.1016\/j.reprotox.2016.07.005_bib0155","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0006-8993(89)90739-7","article-title":"Maternal exposure to 1,1,2-trichloroethylene affects myelin in the hippocampal formation of the developing rat","volume":"488","author":"Isaacson","year":"1989","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.reprotox.2016.07.005_bib0160","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.fertnstert.2013.02.011","article-title":"Ontogeny of the ovary in polycystic ovary syndrome","volume":"100","author":"Dumesic","year":"2013","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.reprotox.2016.07.005_bib0165","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-2002-36706","article-title":"Regulation of gonadotropin secretion: implications for polycystic ovary syndrome","volume":"20","author":"McCartney","year":"2002","journal-title":"Semin. Reprod. Med."},{"issue":"2","key":"10.1016\/j.reprotox.2016.07.005_bib0170","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0196-9781(85)90050-6","article-title":"Synaptology of luteinizing hormone-releasing hormone neurons in rat preoptic area","volume":"6","author":"Witkin","year":"1985","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.reprotox.2016.07.005_bib0175","first-page":"582","article-title":"Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone","volume":"83","author":"Pastor","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.reprotox.2016.07.005_bib0180","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/aje\/kwh275","article-title":"Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors","volume":"160","author":"Missmer","year":"2004","journal-title":"Am. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.reprotox.2016.07.005_bib0185","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2131\/jts.36.493","article-title":"Pathological study for the effects of in utero and postnatal exposure to diesel exhaust on a rat endometriosis model","volume":"36","author":"Umezawa","year":"2011","journal-title":"J. Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.reprotox.2016.07.005_bib0190","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0197-0186(99)00053-4","article-title":"Acute effects of ethanol on GABAA and glycine receptor function","volume":"35","author":"Mihic","year":"1999","journal-title":"Neurochem. Int."},{"issue":"33","key":"10.1016\/j.reprotox.2016.07.005_bib0195","doi-asserted-by":"crossref","first-page":"23006","DOI":"10.1074\/jbc.274.33.23006","article-title":"Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors","volume":"274","author":"Yamakura","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.reprotox.2016.07.005_bib0200","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0026-895X(24)23230-2","article-title":"Glycine and gamma-aminobutyric acid(A) receptor function is enhanced by inhaled drugs of abuse","volume":"57","author":"Beckstead","year":"2000","journal-title":"Mol. Pharmacol."},{"issue":"14","key":"10.1016\/j.reprotox.2016.07.005_bib0205","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1096\/fasebj.9.14.7589987","article-title":"Actions of anesthetics on ligand-gated ion channels: role of receptor subunit composition","volume":"9","author":"Harris","year":"1995","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.reprotox.2016.07.005_bib0210","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0022-3565(24)37592-5","article-title":"Effects of the abused solvent toluene on recombinant N-methyl-d-aspartate and non-N-methyl-d-aspartate receptors expressed in Xenopus oocytes","volume":"286","author":"Cruz","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.reprotox.2016.07.005_bib0215","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12403-009-0003-x","article-title":"Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of pregnancy loss","volume":"1","author":"Aschengrau","year":"2009","journal-title":"Water Qual. Exposure Health"},{"key":"10.1016\/j.reprotox.2016.07.005_bib0220","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-069X-7-24","article-title":"Evaluation of a model for estimating tetrachloroethylene exposure from vinyl-lined asbestos-cement pipes","volume":"7","author":"Spence","year":"2008","journal-title":"Environ. Health"},{"issue":"6","key":"10.1016\/j.reprotox.2016.07.005_bib0225","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1289\/ehp.10414","article-title":"Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of adverse birth outcomes","volume":"116","author":"Aschengrau","year":"2008","journal-title":"Environ. Health Perspect."},{"year":"2008","series-title":"Modern Epidemiology","author":"Rothman","key":"10.1016\/j.reprotox.2016.07.005_bib0230"},{"issue":"2","key":"10.1016\/j.reprotox.2016.07.005_bib0235","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.reprotox.2016.07.005_bib0240","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.reprotox.2016.07.005_bib0245","first-page":"2434","article-title":"A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain","volume":"85","author":"Asuncion","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.reprotox.2016.07.005_bib0250","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jpag.2010.06.003","article-title":"Age of onset of polycystic ovarian syndrome in girls may be earlier than previously thought","volume":"24","author":"Bronstein","year":"2011","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"issue":"4","key":"10.1016\/j.reprotox.2016.07.005_bib0255","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/oxfordjournals.humrep.a019270","article-title":"Delay in the diagnosis of endometriosis: a survey of women from the USA and the UK","volume":"11","author":"Hadfield","year":"1996","journal-title":"Hum. Reprod."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623816302623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623816302623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:42:51Z","timestamp":1760190171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623816302623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":51,"alternative-id":["S0890623816302623"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2016.07.005","relation":{},"ISSN":["0890-6238"],"issn-type":[{"type":"print","value":"0890-6238"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of prenatal and early life exposure to tetrachloroethylene (PCE) with polycystic ovary syndrome and other reproductive disorders in the cape cod health study: A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2016.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}