{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:38:55Z","timestamp":1777480735854,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"the National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000139","name":"United States Environmental Protection Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.reprotox.2016.08.011","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T19:51:17Z","timestamp":1472845877000},"page":"263-271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Maternal cadmium, placental PCDHAC1, and fetal development"],"prefix":"10.1016","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2732-4550","authenticated-orcid":false,"given":"Todd M.","family":"Everson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian P.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin B.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret R.","family":"Karagas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen J.","family":"Marsit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2016.08.011_bib0005","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2009.04.020","article-title":"Current status of cadmium as an environmental health problem","volume":"238","author":"J\u00e4rup","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0010","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.reprotox.2008.02.001","article-title":"Cadmium: toxic effects on the reproductive system and the embryo","volume":"25","author":"Thompson","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0015","article-title":"Cadmium dietary exposure in the European population","volume":"10","author":"EFSA (European Food Safety Authority)","year":"2012","journal-title":"EFSA J."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0020","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10534-010-9328-y","article-title":"Heavy metal poisoning: the effects of cadmium on the kidney","volume":"23","author":"Johri","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0025","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.toxlet.2005.05.011","article-title":"Estimation of cumulative cadmium intake causing Itai-itai disease","volume":"159","author":"Inaba","year":"2005","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0030","first-page":"121","volume":"100C","author":"IARC (International Agency for Research on Cancer)","year":"2012"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0035","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.taap.2012.01.001","article-title":"Cadmium-induced teratogenicity: association with ROS-mediated endoplasmic reticulum stress in placenta","volume":"259","author":"Wang","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0040","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.toxlet.2009.04.008","article-title":"Cadmium exposure during pregnancy reduces birth weight and increases maternal and foetal glucocorticoids","volume":"188","author":"Ronco","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mce.2008.09.028","article-title":"Effects of cadmium on the expression of placental lactogens and Pit-1 genes in the rat placental trophoblast cells","volume":"298","author":"Lee","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s12011-015-0438-9","article-title":"Increased oxidative DNA damage in placenta contributes to cadmium-induced preeclamptic conditions in rat","volume":"170","author":"Zhang","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0055","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2131\/jts.37.1035","article-title":"Participation of metal transporters in cadmium transport from mother rat to fetus","volume":"37","author":"Nakamura","year":"2012","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2131\/jts.37.149","article-title":"Health effects of low-level cadmium intake and the role of metallothionein on cadmium transport from mother rats to fetus","volume":"37","author":"Nakamura","year":"2012","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0065","doi-asserted-by":"crossref","first-page":"e109661","DOI":"10.1371\/journal.pone.0109661","article-title":"Maternal cadmium levels during pregnancy associated with lower birth weight in infants in a north carolina cohort","volume":"9","author":"Johnston","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0070","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1289\/ehp.1103711","article-title":"Maternal cadmium exposure during pregnancy and size at birth: a prospective cohort study","volume":"120","author":"Kippler","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0075","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.reprotox.2008.11.057","article-title":"Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities","volume":"27","author":"Llanos","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0080","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.reprotox.2012.09.002","article-title":"Association between maternal blood cadmium during pregnancy and birth weight and the risk of fetal growth restriction: the EDEN mother-child cohort study","volume":"34","author":"Menai","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0085","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/oem.2010.059758","article-title":"Does prenatal cadmium exposure affect fetal and child growth?","volume":"68","author":"Lin","year":"2011","journal-title":"Occup. Env. Med."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuro.2012.11.006","article-title":"Prenatal lead and cadmium co-exposure and infant neurodevelopment at 6 months of age: the Mothers and Children\u2019s Environmental Health (MOCEH) study","volume":"35","author":"Kim","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0095","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/08035320600886232","article-title":"Cadmium and children: exposure and health effects","volume":"95","author":"Schoeters","year":"2006","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0100","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2486\/indhealth.40.159","article-title":"DNA microarray analysis of human gene expression induced by a non-lethal dose of cadmium","volume":"40","author":"Yamada","year":"2002","journal-title":"Ind. Health."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.etap.2009.02.007","article-title":"Cadmium-induced alterations of gene expression in human cells","volume":"28","author":"Yamada","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40360-015-0020-2","article-title":"Maternal cadmium, iron and zinc levels DNA methylation and birth weight","volume":"16","author":"Vidal","year":"2015","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0115","doi-asserted-by":"crossref","first-page":"494","DOI":"10.4161\/epi.24401","article-title":"Sex-specific effects of early life cadmium exposure on DNA methylation and implications for birth weight","volume":"8","author":"Kippler","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0120","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1289\/ehp.1104600","article-title":"Low-level environmental cadmium exposure is associated with DNA hypomethylation in argentinean women","volume":"120","author":"Hossain","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0125","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s40572-015-0049-9","article-title":"The epigenetic effects of prenatal cadmium exposure","volume":"2","author":"Vilahur","year":"2015","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0130","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.placenta.2010.06.017","article-title":"Cadherins in the human placenta \u2212 epithelial-mesenchymal transition (EMT) and placental development","volume":"31","author":"Kokkinos","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0135","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-015-0191-9","article-title":"Tight junction disruption by cadmium in an in vitro human airway tissue model","volume":"16","author":"Cao","year":"2015","journal-title":"Respir. Res."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0140","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0024-3205(02)02379-2","article-title":"Effects of cadmium on E-cadherin and VE-cadherin in mouse lung","volume":"72","author":"Pearson","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0145","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0041-008X(03)00130-3","article-title":"Cadmium alters the localization of N-cadherin, E-cadherin, and beta-catenin in the proximal tubule epithelium","volume":"189","author":"Prozialeck","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0150","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1242\/dev.090621","article-title":"Clustered protocadherins","volume":"3302","author":"Chen","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0155","doi-asserted-by":"crossref","first-page":"12064","DOI":"10.1074\/jbc.M709648200","article-title":"Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-alpha gene cluster","volume":"283","author":"Kawaguchi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0160","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.4161\/epi.22163","article-title":"Agglomerates of aberrant DNA methylation are associated with toxicant-induced malignant transformation","volume":"7","author":"Severson","year":"2012","journal-title":"Epigenetics"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0165","first-page":"21","article-title":"Promoter choice determines splice site selection in Protocadherin alpha and gamma Pre-mRNA Splicing","volume":"10","author":"Tasic","year":"2002","journal-title":"Cell Press"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0170","doi-asserted-by":"crossref","first-page":"9137","DOI":"10.1523\/JNEUROSCI.5478-08.2009","article-title":"Protocadherin-alpha family is required for serotonergic projections to appropriately innervate target brain areas","volume":"22","author":"Katori","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0175","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2431-13-59","article-title":"A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants","volume":"13","author":"Fenton","year":"2013","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0180","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.placenta.2004.09.009","article-title":"Evaluation of housekeeping genes in placental comparative expression studies","volume":"26","author":"Meller","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0185","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1289\/ehp.1408561","article-title":"Placental DNA methylation related to both infant toenail mercury and adverse neurobehavioral outcomes","volume":"123","author":"Maccani","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0190","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4161\/epi.23470","article-title":"Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray","volume":"8","author":"Chen","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0195","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0200","series-title":"Robustbase: Basic Robust Statistics. R Package Version 0","first-page":"92","author":"Rousseeuw","year":"2015"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0205","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v048.i02","article-title":"Lavaan: an r package for structural equation","volume":"48","author":"Rosseel","year":"2012","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0210","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1021\/acs.est.5b05316","article-title":"Placental metal concentrations in relation to maternal and infant toenails in a U.S. cohort","volume":"50","author":"Punshon","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0215","first-page":"1","article-title":"Emerging roles of protocadherins: from self-avoidance to enhancement of motility","volume":"128","author":"Hayashi","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0220","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1503\/jpn.120058","article-title":"Protocadherin alpha (PCDHA) as a novel susceptibility gene for autism","volume":"38","author":"Anitha","year":"2013","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0225","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1002\/ajmg.a.36108","article-title":"5q31.3 microdeletion syndrome: clinical and molecular characterization of two further cases","volume":"161A","author":"Brown","year":"2013","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.reprotox.2016.08.011_bib0230","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1177\/1933719108322425","article-title":"Profiling gene expression in human placentae of different gestational ages: an OPRU* network and UW SCOR study","volume":"15","author":"Mikheev","year":"2008","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0235","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/sj.clpt.6100376","article-title":"Microarray analysis of the global alterations in the gene expression in the placentas from cigarette-smoking mothers","volume":"83","author":"Huuskonen","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0240","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2362.2010.02373.x","article-title":"Trace elements in nails as biomarkers in clinical","volume":"41","author":"He","year":"2011","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0245","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.toxlet.2009.10.018","article-title":"Accumulation of cadmium in human placenta interacts with the transport of micronutrients to the fetus","volume":"192","author":"Kippler","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0250","doi-asserted-by":"crossref","first-page":"E135","DOI":"10.1152\/ajpendo.00356.2005","article-title":"Cadmium reduces 11 beta-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells","volume":"290","author":"Yang","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2016.08.011_bib0255","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1210\/er.2005-0011","article-title":"Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus","volume":"27","author":"Murphy","year":"2006","journal-title":"Endocr. Re"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623816303215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623816303215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:44:58Z","timestamp":1760190298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623816303215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":51,"alternative-id":["S0890623816303215"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2016.08.011","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal cadmium, placental PCDHAC1, and fetal development","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2016.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}