{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:14:18Z","timestamp":1778634858727,"version":"3.51.4"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM103453"],"award-info":[{"award-number":["P20GM103453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD053509"],"award-info":[{"award-number":["HD053509"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE018215"],"award-info":[{"award-number":["DE018215"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE021460"],"award-info":[{"award-number":["DE021460"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.reprotox.2016.11.016","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T14:15:27Z","timestamp":1480515327000},"page":"85-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Determinants of orofacial clefting I: Effects of 5-Aza-2\u2032-deoxycytidine on cellular processes and gene expression during development of the first branchial arch"],"prefix":"10.1016","volume":"67","author":[{"given":"Partha","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratnam S.","family":"Seelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Rezzoug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis R.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Smolenkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Brock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Michele","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2016.11.016_bib0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1597\/06-233.1","article-title":"Priorities for future public health research in orofacial clefts","volume":"44","author":"Yazdy","year":"2007","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0010","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"Mossey","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1601-0825.2009.01588.x","article-title":"The impact of orofacial clefts on quality of life and healthcare use and costs","volume":"16","author":"Wehby","year":"2010","journal-title":"Oral Dis."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/bdrc.20180","article-title":"Palate morphogenesis: current understanding and future directions","volume":"90","author":"Greene","year":"2010","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dev.067082","article-title":"Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development","volume":"139","author":"Bush","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0030","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1242\/dev.122.10.3229","article-title":"Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny","volume":"122","author":"Kontges","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/0022034508327757","article-title":"The cells that fill the bill: neural crest and the evolution of craniofacial development","volume":"88","author":"Jheon","year":"2009","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0040","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ydbio.2009.07.001","article-title":"The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition","volume":"333","author":"Denaxa","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0045","doi-asserted-by":"crossref","first-page":"40671","DOI":"10.1074\/jbc.M111.271189","article-title":"Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins","volume":"286","author":"Chung","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2011.01.004","article-title":"The canonical Wnt signaling activator R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction","volume":"352","author":"Jin","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0055","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1242\/dev.075796","article-title":"Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development","volume":"139","author":"Jin","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0060","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2011.08.006","article-title":"Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood","volume":"45","author":"Lu","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0065","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1399-0004.2010.01606.x","article-title":"Clinical findings in patients with GLI2 mutations-phenotypic variability","volume":"81","author":"Bertolacini","year":"2012","journal-title":"Clin. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0070","first-page":"223","article-title":"Clinical features, treatment and genetic background of Treacher Collins syndrome","volume":"43","author":"Marszalek","year":"2002","journal-title":"J. Appl. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0075","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00247-010-1831-3","article-title":"First and second branchial arch syndromes: multimodality approach","volume":"41","author":"Senggen","year":"2011","journal-title":"Pediatr. Radiol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/bdra.20430","article-title":"Mouse genetic models of cleft lip with or without cleft palate","volume":"82","author":"Juriloff","year":"2008","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0085","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1399-0004.2009.01174.x","article-title":"Importance of gene-environment interactions in the etiology of selected birth defects","volume":"75","author":"Zhu","year":"2009","journal-title":"Clin. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0090","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/ilar.53.3-4.240","article-title":"Developmental epigenetics of the murine secondary palate","volume":"53","author":"Seelan","year":"2012","journal-title":"ILAR J."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000337521","article-title":"Genetic and environmental factors in human cleft lip and palate","volume":"16","author":"Vieira","year":"2012","journal-title":"Front. Oral Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0100","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/0973-029X.92976","article-title":"A comprehensive review of the genetic basis of cleft lip and palate","volume":"16","author":"Kohli","year":"2012","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0105","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1597\/10-178","article-title":"Genetics of nonsyndromic orofacial clefts","volume":"49","author":"Rahimov","year":"2012","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0110","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/bdra.20788","article-title":"The clf2 gene has an epigenetic role in the multifactorial etiology of cleft lip and palate in the A\/WySn mouse strain","volume":"91","author":"Plamondon","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0115","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1597\/07-134.1","article-title":"DNA methylation changes during cleft palate formation induced by retinoic acid in mice","volume":"45","author":"Kuriyama","year":"2008","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.anireprosci.2012.08.010","article-title":"Chromatin and epigenetic modifications during early mammalian development","volume":"134","author":"Mason","year":"2012","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0125","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/molehr\/gas014","article-title":"Active DNA demethylation in mammalian preimplantation embryos: new insights and new perspectives","volume":"18","author":"Ma","year":"2012","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0130","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00412-012-0365-x","article-title":"Establishment of epigenetic patterns in development","volume":"121","author":"Leeb","year":"2012","journal-title":"Chromosoma"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0135","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00412-009-0221-9","article-title":"DNA methylation and methyl-CpG binding proteins: developmental requirements and function","volume":"118","author":"Bogdanovic","year":"2009","journal-title":"Chromosoma"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0140","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/B978-0-12-387685-0.00012-3","article-title":"Biological functions of methyl-CpG-binding proteins","volume":"101","author":"Defossez","year":"2011","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0145","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1038\/sj.onc.1205699","article-title":"5-Aza-cytidine and 5-Aza-2\u2032-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy","volume":"21","author":"Christman","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0150","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2011.08.040","article-title":"Intrathecal 5-azacytidine inhibits global DNA methylation and methyl-CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury","volume":"1418","author":"Wang","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0155","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1387\/ijdb.7540035","article-title":"5-Azacytidine changes gene expression and causes developmental arrest of early chick embryo","volume":"38","author":"Zagris","year":"1994","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1078\/0940-2993-00239","article-title":"5-Azacytidine (5AzC)-induced histopathological changes in the central nervous system of rat fetuses","volume":"54","author":"Ueno","year":"2002","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0165","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.expneurol.2005.11.024","article-title":"Cell cycle and cell death regulation of neural progenitor cells in the 5-azacytidine (5AzC)-treated developing fetal brain","volume":"198","author":"Ueno","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0170","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1017\/S0967199408005133","article-title":"The developmental potential of mouse somatic cell nuclear-transferred oocytes treated with trichostatin A and 5-aza-2\u2032-deoxycytidine","volume":"17","author":"Tsuji","year":"2009","journal-title":"Zygote"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0175","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1017\/S0967199408005169","article-title":"5-AZA-2\u2032-deoxycytidine (5-AZA-CdR) leads to down-regulation of Dnmt1o and gene expression in preimplantation mouse embryos","volume":"17","author":"Yu","year":"2009","journal-title":"Zygote"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0180","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/tera.1420500504","article-title":"Cell death and cell cycle perturbation in the developmental toxicity of the demethylating agent, 5-aza-2'-deoxycytidine","volume":"50","author":"Rogers","year":"1994","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0185","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0300-483X(96)88183-2","article-title":"Teratogenic effects of the demethylating agent 5-aza-2'-deoxycytidine in the Swiss Webster mouse","volume":"112","author":"Branch","year":"1996","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0190","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/bdra.20819","article-title":"MicroRNA gene expression signatures in the developing neural tube","volume":"91","author":"Mukhopadhyay","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0195","doi-asserted-by":"crossref","first-page":"e9758","DOI":"10.1371\/journal.pone.0009758","article-title":"Cleft palate is caused by CNS dysfunction in Gad1 and Viaat knockout mice","volume":"5","author":"Oh","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0200","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/bdra.22890","article-title":"Strain-specific modifier genes governing craniofacial phenotypes","volume":"94","author":"Mukhopadhyay","year":"2012","journal-title":"Birth Defects Res. A Clin. Mol .Teratol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0205","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/bdra.23126","article-title":"Developmental profiles of the murine palatal methylome","volume":"97","author":"Seelan","year":"2013","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0210","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/bioinformatics\/17.6.520","article-title":"Missing value estimation methods for DNA microarrays","volume":"17","author":"Troyanskaya","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0215","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0220","series-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor","first-page":"397","article-title":"Limma: linear models for microarray data","author":"Smyth","year":"2005"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0225","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s004120050256","article-title":"Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation","volume":"106","author":"Hendzel","year":"1997","journal-title":"Chromosoma"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0230","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/nar\/gkg176","article-title":"Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk\/ZIP kinase","volume":"31","author":"Preuss","year":"2003","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0235","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1101\/gr.6.10.995","article-title":"A novel method for real time quantitative RT-PCR","volume":"6","author":"Gibson","year":"1996","journal-title":"Genome Res."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0240","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1242\/dev.125.16.3005","article-title":"A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme","volume":"125","author":"Thomas","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0245","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1242\/dev.00337","article-title":"Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development","volume":"130","author":"Yanagisawa","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0250","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ydbio.2009.03.021","article-title":"Hand2 is required in the epithelium for palatogenesis in mice","volume":"330","author":"Xiong","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0255","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1074\/jbc.M111.280974","article-title":"Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor \u03b2 (TGF\u03b2) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis","volume":"287","author":"Iwata","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0260","doi-asserted-by":"crossref","first-page":"e0136951","DOI":"10.1371\/journal.pone.0136951","article-title":"Altered FGF signaling pathways impair cell proliferation and elevation of palate shelves","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0265","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s13105-013-0262-7","article-title":"Down-regulation of Wnt10a by RNA interference inhibits proliferation and promotes apoptosis in mouse embryonic palatal mesenchymal cells through Wnt\/\u03b2-catenin signaling pathway","volume":"69","author":"Feng","year":"2013","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0270","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1172\/JCI72688","article-title":"Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis","volume":"124","author":"Kurosaka","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0275","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1073\/pnas.0607956104","article-title":"Impaired FGF signaling contributes to cleft lip and palate","volume":"104","author":"Riley","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0280","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1597\/11-132","article-title":"The FGF and FGFR gene family and risk of cleft lip with or without cleft palate","volume":"50","author":"Wang","year":"2013","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0285","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/bdra.20302","article-title":"Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A\/WySn mice, as confirmed by a genetic complementation test","volume":"76","author":"Juriloff","year":"2006","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0290","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/bdra.20720","article-title":"Studies with Wnt genes and nonsyndromic cleft lip and palate","volume":"88","author":"Menezes","year":"2010","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0295","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1242\/dev.083352","article-title":"Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes","volume":"139","author":"Yu","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0300","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ydbio.2009.04.021","article-title":"Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome","volume":"331","author":"Cobourne","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0305","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/ajmg.a.33903","article-title":"Holoprosencephaly in a family segregating novel variants in ZIC2 and GLI2","volume":"155A","author":"Wannasilp","year":"2011","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0310","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.modgep.2005.06.005","article-title":"Expression patterns of Hedgehog signalling pathway members during mouse palate development","volume":"6","author":"Rice","year":"2006","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0315","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1387\/ijdb.052101xn","article-title":"BMP signaling in craniofacial development","volume":"50","author":"Nie","year":"2006","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0320","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1601-0825.2011.01806.x","article-title":"The mechanism of TGF-\u03b2 signaling during palate development","volume":"17","author":"Iwata","year":"2011","journal-title":"Oral Dis."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0325","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000337617","article-title":"Roles of BMP signaling pathway in lip and palate development","volume":"16","author":"Parada","year":"2012","journal-title":"Front. Oral Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0330","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ydbio.2010.05.004","article-title":"Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects","volume":"344","author":"Tang","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0335","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng1295-415","article-title":"Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction","volume":"11","author":"Kaartinen","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0340","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng1511","article-title":"A syndrome of altered cardiovascular craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2","volume":"37","author":"Loeys","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0345","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.mod.2003.12.003","article-title":"Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells","volume":"121","author":"Dudas","year":"2004","journal-title":"Mech. Dev."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0350","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1242\/dev.01676","article-title":"Distinct functions for Bmp signaling in lip and palate fusion in mice","volume":"132","author":"Liu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0355","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/ajmg.a.34063","article-title":"Microdeletion 20p12.3 involving BMP2 contributes to syndromic forms of cleft palate","volume":"155A","author":"Sahoo","year":"2011","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0360","doi-asserted-by":"crossref","first-page":"e35347","DOI":"10.1371\/journal.pone.0035347","article-title":"BMP4 was associated with NSCL\/P in an Asian population","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0365","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/humu.21280","article-title":"Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular brain, ear, palate, and skeletal anomalies","volume":"31","author":"Wyatt","year":"2010","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0370","first-page":"1","article-title":"Role of skeletal muscle in palate development","volume":"28","author":"Rot","year":"2013","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0375","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1006\/dbio.2002.0716","article-title":"The latent-TGFbeta-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling","volume":"248","author":"Altman","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0380","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ajhg.2009.09.013","article-title":"Mutations in LTBP4 cause a syndrome of impaired pulmonary gastrointestinal, genitourinary, musculoskeletal, and dermal development","volume":"85","author":"Urban","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0385","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/jmg.39.7.478","article-title":"Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24","volume":"39","author":"Brice","year":"2002","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0390","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/bdra.20791","article-title":"Variation in FGF1 FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate","volume":"91","author":"Nikopensius","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0395","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbrc.2009.06.071","article-title":"The forkhead transcription factor Foxc2 stimulates osteoblast differentiation","volume":"386","author":"Kim","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0400","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/jez.b.21298","article-title":"SForkhead transcription factor foxe1 regulates chondrogenesis in zebrafish","volume":"312","author":"Nakada","year":"2009","journal-title":"J. Exp. Zool. B Mol. Dev. Evol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0405","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1034\/j.1399-0004.2002.620608.x","article-title":"FOXC2 truncating mutation in distichiasis lymphedema, and cleft palate","volume":"62","author":"Bahuau","year":"2002","journal-title":"Clin. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0410","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/lary.23394","article-title":"Association of candidate genes with nonsyndromic clefts in Honduran and Colombian populations","volume":"122","author":"Lennon","year":"2012","journal-title":"Laryngoscope"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0415","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/odi.12435","article-title":"FOXE1 polymorphisms and non-syndromic orofacial cleft susceptibility in a Chinese Han population","volume":"22","author":"Yin","year":"2016","journal-title":"Oral Dis."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0420","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/hmg\/ddq547","article-title":"MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1","volume":"20","author":"Venza","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0425","first-page":"488","article-title":"Molecular signaling along the anterior-posterior axis of early palate development","volume":"3","author":"Smith","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0430","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1242\/dev.02013","article-title":"Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate","volume":"132","author":"Yu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.016_bib0435","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/dvdy.20641","article-title":"Analysis of Meox-2 mutant mice reveals a novel postfusion-based cleft palate","volume":"235","author":"Jin","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0440","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1086\/508214","article-title":"Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development","volume":"79","author":"Britanova","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0445","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/hmg\/ddm341","article-title":"DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function","volume":"17","author":"Jin","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0450","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejmg.2012.09.005","article-title":"Duplication 16p13.3 and the CREBBP gene: confirmation of the phenotype","volume":"56","author":"Demeer","year":"2013","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0455","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1172\/JCI43428","article-title":"Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice","volume":"121","author":"Kraft","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0460","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-213X-12-16","article-title":"Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton","volume":"12","author":"DeLaurier","year":"2012","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0465","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.taap.2012.08.022","article-title":"The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic","volume":"264","author":"Tsang","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0470","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.reprotox.2016.11.020","article-title":"Determinants of orofacial clefting II: Effects of 5-Aza-2(-deoxycytidine on gene methylation during development of the first branchial arch","volume":"67","author":"Seelan","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2016.11.016_bib0475","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/s13059-014-0469-0","article-title":"Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes","volume":"15","author":"Blattler","year":"2014","journal-title":"Genome Biol."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623816304531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623816304531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:44:58Z","timestamp":1778633098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623816304531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":95,"alternative-id":["S0890623816304531"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2016.11.016","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determinants of orofacial clefting I: Effects of 5-Aza-2\u2032-deoxycytidine on cellular processes and gene expression during development of the first branchial arch","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2016.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}