{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:48:05Z","timestamp":1778680085860,"version":"3.51.4"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.reprotox.2016.11.020","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:32:15Z","timestamp":1480897935000},"page":"100-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Determinants of orofacial clefting II: Effects of 5-Aza-2\u2032-deoxycytidine on gene methylation during development of the first branchial arch"],"prefix":"10.1016","volume":"67","author":[{"given":"Ratnam S.","family":"Seelan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Partha","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis R.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Smolenkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Michele","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2016.11.020_bib0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1597\/06-233.1","article-title":"Priorities for future public health research in orofacial clefts","volume":"44","author":"Yazdy","year":"2007","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0010","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"Mossey","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0015","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dev.067082","article-title":"Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development","volume":"139","author":"Bush","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/bdrc.20180","article-title":"Palate morphogenesis: current understanding and future directions","volume":"90","author":"Greene","year":"2010","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0025","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ydbio.2009.07.001","article-title":"The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition","volume":"333","author":"Denaxa","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0030","doi-asserted-by":"crossref","first-page":"40671","DOI":"10.1074\/jbc.M111.271189","article-title":"Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins","volume":"286","author":"Chung","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2011.01.004","article-title":"The canonical Wnt signaling activator R-spondin 2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction","volume":"352","author":"Jin","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0040","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1242\/dev.075796","article-title":"Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development","volume":"139","author":"Jin","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0045","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2011.08.006","article-title":"Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood","volume":"45","author":"Lu","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0050","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/bdra.20430","article-title":"Mouse genetic models of cleft lip with or without cleft palate","volume":"82","author":"Juriloff","year":"2008","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0055","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1399-0004.2009.01174.x","article-title":"Importance of gene-environment interactions in the etiology of selected birth defects","volume":"75","author":"Zhu","year":"2009","journal-title":"Clin. Genet."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0060","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1597\/13-233","article-title":"Clinical features in patients with 22q11.2 deletion syndrome ascertained by palatal abnormalities","volume":"52","author":"Vieira","year":"2015","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0065","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/0973-029X.92976","article-title":"A comprehensive review of the genetic basis of cleft lip and palate","volume":"16","author":"Kohli","year":"2012","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1597\/10-178","article-title":"Genetics of nonsyndromic orofacial clefts","volume":"49","author":"Rahimov","year":"2012","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0075","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1597\/07-134.1","article-title":"DNA methylation changes during cleft palate formation induced by retinoic acid in mice","volume":"45","author":"Kuriyama","year":"2008","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1601-0825.2009.01587.x","article-title":"Folic acid and orofacial clefts: a review of the evidence","volume":"16","author":"Wehby","year":"2010","journal-title":"Oral Dis."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0085","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ydbio.2015.07.001","article-title":"The role of folate metabolism in orofacial development and clefting","volume":"405","author":"Wahl","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0090","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3945\/an.111.000992","article-title":"Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate\u2019s role","volume":"3","author":"Crider","year":"2012","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0095","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/bdra.20788","article-title":"The clf2 gene has an epigenetic role in the multifactorial etiology of cleft lip and palate in the A\/WySn mouse strain","volume":"91","author":"Plamondon","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0100","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00412-009-0221-9","article-title":"DNA methylation and methyl-CpG binding proteins: developmental requirements and function","volume":"118","author":"Bogdanovic","year":"2009","journal-title":"Chromosoma"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0105","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4252\/wjsc.v7.i1.137","article-title":"Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries","volume":"7","author":"Wongtrakoongate","year":"2015","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0110","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1038\/sj.onc.1205699","article-title":"5-AZA-cytidine and 5-AZA-2\u2032-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy","volume":"21","author":"Christman","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2011.08.040","article-title":"Intrathecal 5-azacytidine inhibits global DNA methylation and methyl- CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury","volume":"1418","author":"Wang","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0120","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/tera.1420500504","article-title":"Cell death and cell cycle perturbation in the developmental toxicity of the demethylating agent, 5-aza-2'-deoxycytidine","volume":"50","author":"Rogers","year":"1994","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0300-483X(96)88183-2","article-title":"Teratogenic effects of the demethylating agent 5-aza-2'-deoxycytidine in the Swiss Webster mouse","volume":"112","author":"Branch","year":"1996","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0130","article-title":"Determinants of orofacial clefting I: effects of 5-Aza-2\u2019-deoxycytidine on cellular processes and gene expression during development in the first branchial arch","author":"Mukhopadhyay","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0135","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0140","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"1000 genome project data processing subgroup, the sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0145","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of chIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0150","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0155","doi-asserted-by":"crossref","first-page":"D88","DOI":"10.1093\/nar\/gkl822","article-title":"VISTA Enhancer Browser \u2013 a database of tissue-specific human enhancers","volume":"35","author":"Visel","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0160","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/bdra.20819","article-title":"MicroRNA gene expression signatures in the developing neural tube","volume":"91","author":"Mukhopadhyay","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1601-6343.2006.00356.x","article-title":"Molecular fingerprinting of BMP2- and BMP4-treated embryonic maxillary mesenchymal cells","volume":"9","author":"Mukhopadhyay","year":"2006","journal-title":"Orthod. Craniofac. Res."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0170","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0175","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.cell.2015.07.011","article-title":"Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses","volume":"162","author":"Chiappinelli","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0180","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cell.2015.07.056","article-title":"DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts","volume":"162","author":"Roulois","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0185","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1006\/bbrc.2001.5863","article-title":"5-Aza-2'-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation","volume":"288","author":"Takebayashi","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0190","doi-asserted-by":"crossref","first-page":"39990","DOI":"10.1074\/jbc.M103181200","article-title":"Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells","volume":"276","author":"Worm","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0195","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.onc.1209763","article-title":"5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation","volume":"26","author":"Wozniak","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0200","doi-asserted-by":"crossref","first-page":"9281","DOI":"10.1038\/srep09281","article-title":"The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells","volume":"5","author":"Chowdhury","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0205","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ijc.23607","article-title":"Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine","volume":"123","author":"Stresemann","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0210","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002858","article-title":"Pseudogenes: newly discovered players in human cancer","volume":"5","author":"Poliseno","year":"2012","journal-title":"Sci. Signal"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0215","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1158\/0008-5472.CAN-08-2886","article-title":"MicroRNA-101 down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity","volume":"69","author":"Su","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0220","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/bjc.2011.220","article-title":"Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma","volume":"105","author":"Buechner","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0225","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1126\/science.1165395","article-title":"Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer","volume":"322","author":"Varambally","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0230","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.canlet.2013.08.021","article-title":"MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2","volume":"341","author":"Luo","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0235","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.18632\/oncotarget.2157","article-title":"MicroRNA-101 targets EZH2 MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells","volume":"5","author":"Konno","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0240","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cellsig.2012.10.013","article-title":"miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A","volume":"25","author":"Wei","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0245","doi-asserted-by":"crossref","first-page":"e1413","DOI":"10.1038\/cddis.2014.380","article-title":"Restoration of miR-101 suppresses lung tumorigenesis through inhibition of DNMT3a-dependent DNA methylation","volume":"5","author":"Yan","year":"2014","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0250","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1128\/MCB.22.4.1172-1183.2002","article-title":"Wnt\/\u03b2-catenin\/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway","volume":"22","author":"Jho","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0255","doi-asserted-by":"crossref","first-page":"21657","DOI":"10.1074\/jbc.M200139200","article-title":"Activation of AXIN2 expression by \u03b2-catenin-T cell factor: a feedback repressor pathway regulating Wnt signaling","volume":"277","author":"Leung","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0260","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000337619","article-title":"Wnt signaling in lip and palate development","volume":"16","author":"He","year":"2012","journal-title":"Front. Oral Biol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0265","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/0022034512440578","article-title":"Association of AXIN2 with nonsyndromic oral clefts in multiple populations","volume":"91","author":"Letra","year":"2012","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0270","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/bdra.23056","article-title":"Association of DVL2 and AXIN2 gene polymorphisms with cleft lip with or without cleft palate in a Polish population","volume":"94","author":"Mostowska","year":"2012","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0275","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/jop.12162","article-title":"The axis inhibition protein 2 polymorphisms and non-syndromic orofacial clefts susceptibility in a Chinese Han population","volume":"43","author":"Han","year":"2014","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0280","first-page":"264","article-title":"Molybdenum cofactor deficiency: report of three cases presenting as hypoxic-ischemic encephalopathy","volume":"16","author":"Topcu","year":"2001","journal-title":"J.Child Neurol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0285","doi-asserted-by":"crossref","first-page":"987","DOI":"10.4161\/cc.24003","article-title":"Tumor-suppressive effects of CDK8 in endometrial cancer cells","volume":"12","author":"Gu","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0290","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.4049\/jimmunol.1203155","article-title":"Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation","volume":"190","author":"Fukasaka","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0295","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/CIRCRESAHA.115.303300","article-title":"HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region","volume":"115","author":"Dykes","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0300","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/hmg\/9.3.413","article-title":"Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome","volume":"9","author":"Carter","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0305","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/dgd.12044","article-title":"Dlx5 and Msx2 regulate mouse anterior neural tube closure through ephrinA5-EphA7","volume":"55","author":"Lee","year":"2013","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0310","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.celrep.2014.07.051","article-title":"Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer","volume":"8","author":"Caballero","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0315","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/jcb.24417","article-title":"Identification of candidate downstream targets of TGF\u03b2 signaling during palate development by genome-wide transcript profiling","volume":"114","author":"Pelikan","year":"2013","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0320","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1038\/sj.onc.1206594","article-title":"Epigenetic silencing of multiple interferon pathway genes after cellular immortalization","volume":"22","author":"Kulaeva","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0325","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.onc.1208018","article-title":"Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway","volume":"24","author":"Missiaglia","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0330","first-page":"1788","article-title":"Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells","volume":"143","author":"Pasquarella","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0335","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1128\/MCB.01799-07","article-title":"DNA methylation inhibitor 5-Aza-2\u2019-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B","volume":"28","author":"Palii","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0340","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1038\/onc.2012.9","article-title":"5-Aza-2\u2019-deoxycytidine-induced genome rearrangements are mediated by DNMT1","volume":"31","author":"Maslov","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0345","doi-asserted-by":"crossref","first-page":"9108","DOI":"10.1093\/nar\/gku638","article-title":"The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2\u2019-deoxycytidine lesions","volume":"42","author":"Orta","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0350","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.onc.1209763","article-title":"5-Aza-2\u2019-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation","volume":"26","author":"Wozniak","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0355","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ng.159","article-title":"Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation","volume":"40","author":"Kondo","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0360","series-title":"Langman\u2019s Medical Embryology","first-page":"115","author":"Sadler","year":"1990"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0365","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/(SICI)1097-0223(199912)19:12<1119::AID-PD716>3.0.CO;2-X","article-title":"Prenatal diagnosis of congenital parvovirus B19 infection: value of serological and PCR techniques in maternal and fetal serum","volume":"19","author":"Dieck","year":"1999","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0370","first-page":"1019","article-title":"Coxsackie virus infection of the placenta associated with neurodevelopmental delays in the newborn","volume":"98","author":"Euscher","year":"2001","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0375","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1067\/mob.2002.126297","article-title":"Lymphocytic choriomeningitis virus: emerging fetal teratogen","volume":"187","author":"Barton","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0380","first-page":"428","article-title":"Outcome of pregnancies with vertical transmission of primary cytomegalovirus infection","volume":"100","author":"Lipitz","year":"2002","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0385","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.siny.2007.01.017","article-title":"Rubella","volume":"12","author":"Best","year":"2007","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0390","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3949\/ccjm.74.4.290","article-title":"Managing varicella zoster infection in pregnancy","volume":"74","author":"Gardella","year":"2007","journal-title":"Cleve. Clin. J. Med."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0395","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00430-006-0031-0","article-title":"Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 1: herpes simplex virus infections","volume":"196","author":"Sauerbrei","year":"2007","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0400","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1080\/01443610903104478","article-title":"The rationale for the use of measles post-exposure prophylaxis in pregnant women: a review","volume":"29","author":"Manikkavasagan","year":"2009","journal-title":"J. Obstet. Gynaecol."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0405","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature18296","article-title":"The Brazilian Zika virus strain causes birth defects in experimental models","volume":"534","author":"Cugola","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0410","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/pd.1970140305","article-title":"A fetus with a parvovirus B19 infection and congenital anomalies","volume":"14","author":"Tiessen","year":"1994","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0415","doi-asserted-by":"crossref","first-page":"e537","DOI":"10.1542\/peds.2005-2024","article-title":"Birth outcomes following West Nile Virus infection of pregnant women in the United States: 2003\u20132004","volume":"117","author":"O'Leary","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.reprotox.2016.11.020_bib0420","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1097\/AOG.0000000000000010","article-title":"Safety of influenza A (H1N1) 2009 live attenuated monovalent vaccine in (2005) pregnant women","volume":"122","author":"Moro","year":"2013","journal-title":"Obstet. Gynecol."},{"issue":"Suppl. 1","key":"10.1016\/j.reprotox.2016.11.020_bib0425","first-page":"102","article-title":"Cleft palate in HIV-exposed newborns of mothers on highly active antiretroviral therapy","volume":"7","author":"James","year":"2014","journal-title":"Oral Surg."},{"key":"10.1016\/j.reprotox.2016.11.020_bib0430","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/humrep\/det455","article-title":"Influenza and congenital anomalies: a systematic review and meta-analysis","volume":"29","author":"Luteijn","year":"2014","journal-title":"Hum. Reprod."},{"issue":"4 Suppl. 3","key":"10.1016\/j.reprotox.2016.11.020_bib0435","doi-asserted-by":"crossref","first-page":"19699","DOI":"10.7448\/IAS.17.4.19699","article-title":"Severe birth defects in children perinatal exposed to HIV from a real-world setting: Infectious Diseases National Institute, Bucharest, Romania","volume":"17","author":"Tudor","year":"2014","journal-title":"J. Int. AIDS Soc."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623816304543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623816304543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:43:03Z","timestamp":1760190183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623816304543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":87,"alternative-id":["S0890623816304543"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2016.11.020","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determinants of orofacial clefting II: Effects of 5-Aza-2\u2032-deoxycytidine on gene methylation during development of the first branchial arch","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2016.11.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}