{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:44:39Z","timestamp":1779201879674,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Senior CCFA Research Award","award":["#346353"],"award-info":[{"award-number":["#346353"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.reprotox.2017.10.004","type":"journal-article","created":{"date-parts":[[2017,11,12]],"date-time":"2017-11-12T12:48:08Z","timestamp":1510490888000},"page":"219-223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Birth outcomes after preconception paternal exposure to methotrexate: A nationwide cohort study"],"prefix":"10.1016","volume":"74","author":[{"given":"Rachel W.","family":"Winter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Due","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjarne","family":"Magnussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Kammerlander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente Mertz","family":"N\u00f8rg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.reprotox.2017.10.004_bib0005","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1053\/j.gastro.2016.10.013","article-title":"Drug safety and risk of adverse outcomes for pregnant patients with inflammatory bowel disease","volume":"152","author":"Mahadevan","year":"2017","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.reprotox.2017.10.004_bib0010","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/bdra.23003","article-title":"Teratogen update: methotrexate","volume":"94","author":"Hyoun","year":"2012","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2017.10.004_bib0015","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJM200011303432204","article-title":"Folic acid antagonists during pregnancy and the risk of birth defects","volume":"343","author":"Hernandes-Diaz","year":"2000","journal-title":"NEJM"},{"key":"10.1016\/j.reprotox.2017.10.004_bib0020","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1053\/j.gastro.2015.12.003","article-title":"The Toronto consensus statements for the management of inflammatory bowel disease in pregnancy","volume":"150","author":"Nguyen","year":"2016","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.reprotox.2017.10.004_bib0025","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3899\/jrheum.100600","article-title":"Paternal exposure to methotrexate and pregnancy outcomes","volume":"38","author":"Beghin","year":"2011","journal-title":"J. Rheumatol."},{"issue":"4","key":"10.1016\/j.reprotox.2017.10.004_bib0030","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/rheumatology\/ket390","article-title":"No evidence for an increased risk of adverse pregnancy outcome after paternal low-dose methotrexate: an observational cohort study","volume":"53","author":"Weber-Schoendorfer","year":"2014","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"10.1016\/j.reprotox.2017.10.004_bib0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/01485017908985067","article-title":"Methotrexate and fertility in men","volume":"3","author":"El-Beheiry","year":"1979","journal-title":"Arch. Androl."},{"issue":"5 Pt. 2","key":"10.1016\/j.reprotox.2017.10.004_bib0040","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0190-9622(93)70270-4","article-title":"Methotrexate and reproduction in men: case report and recommendations","volume":"29","author":"Morris","year":"1993","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.reprotox.2017.10.004_bib0045","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1001\/archderm.1980.01640260091025","article-title":"Psoriasis, methotrexate, and oligospermia","volume":"116","author":"Sussman","year":"1980","journal-title":"Arch. Dermatol."},{"issue":"0","key":"10.1016\/j.reprotox.2017.10.004_bib0050","first-page":"1","article-title":"The influence of methotrexate treatment on male fertility and pregnancy outcome after paternal exposure","volume":"0","author":"Grosen","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"issue":"8","key":"10.1016\/j.reprotox.2017.10.004_bib0055","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1136\/gut.2005.078097","article-title":"Fertility and pregnancy in the patient with inflammatory bowel disease","volume":"55","author":"Mahadevan","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.reprotox.2017.10.004_bib0060","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/apt.13142","article-title":"Review article: the safety of therapeutic drugs in male inflammatory bowel disease patients wishing to conceive","volume":"41","author":"Sands","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"Suppl. 7","key":"10.1016\/j.reprotox.2017.10.004_bib0065","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1403494811401482","article-title":"The Danish National Patient Register","volume":"39","author":"Lynge","year":"2011","journal-title":"Scand. J. Public Health"},{"issue":"3","key":"10.1016\/j.reprotox.2017.10.004_bib0070","first-page":"320","article-title":"The Danish Medical Birth Registry","volume":"45","author":"Knudsen","year":"1998","journal-title":"Dan. Med. Bull."},{"issue":"8","key":"10.1016\/j.reprotox.2017.10.004_bib0075","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0895-4356(96)00018-2","article-title":"Validation of the danish birth registration","volume":"49","author":"Kristensen","year":"1996","journal-title":"J. Clin. Epidemiol."},{"issue":"Suppl. 7","key":"10.1016\/j.reprotox.2017.10.004_bib0080","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The danish civil registration system","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand. J. Public Health"},{"issue":"Suppl. 7","key":"10.1016\/j.reprotox.2017.10.004_bib0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1403494810394717","article-title":"The Danish National Prescription Registry","volume":"39","author":"Kildemoes","year":"2011","journal-title":"Scand. J. Public Health"},{"issue":"0","key":"10.1016\/j.reprotox.2017.10.004_bib0090","first-page":"1","article-title":"Reassuring results on birth outcomes in children fathered by men treated with azathioprine\/6-mercaptopurine within 3 months before conception: a nationwide cohort study","author":"N\u00f8rg\u00e5rd","year":"2016","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.reprotox.2017.10.004_bib0095","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s10198-003-0165-6","article-title":"Pricing and reimbursement of drugs in Denmark","volume":"4","author":"Pedersen","year":"2003","journal-title":"Eur. J. Health Econ."},{"key":"10.1016\/j.reprotox.2017.10.004_bib0100","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1651-2227.1996.tb14164.x","article-title":"Intrauterine growth curves based on ultrasonically estimated foetal weights","volume":"85","author":"Mar\u0161\u00e1l","year":"1996","journal-title":"Acta Paediatr."},{"issue":"4","key":"10.1016\/j.reprotox.2017.10.004_bib0105","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/AOG.0000000000001936","article-title":"Risk of adverse pregnancy outcome after paternal exposure to methotrexate within 90 days before pregnancy","volume":"129","author":"Eck","year":"2017","journal-title":"Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.reprotox.2017.10.004_bib0110","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jaad.2008.11.906","article-title":"Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference","volume":"60","author":"Kalb","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"issue":"March 1","key":"10.1016\/j.reprotox.2017.10.004_bib0115","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s40471-017-0098-8","article-title":"Fathers matter. why it\u2019s time to consider the impact of paternal environmental exposures on children\u2019s health","volume":"4","author":"Braun","year":"2017","journal-title":"Curr. Epidemiol. Rep."},{"key":"10.1016\/j.reprotox.2017.10.004_bib0120","first-page":"1","article-title":"The toxicity of methotrexate in male fertility and paternal teratogenicity","author":"Gutierrez","year":"2016","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.reprotox.2017.10.004_bib0125","first-page":"247","article-title":"Study of the seminal fluid in subjects treated with methotrexate","volume":"46","author":"De Luca","year":"1971","journal-title":"G. Ital. Dermtaol. Minerva Dermatol."},{"issue":"6","key":"10.1016\/j.reprotox.2017.10.004_bib0130","first-page":"1266","article-title":"Therapy with immunosuppressive drugs and biological agents and use of contraception in patients with rheumatic disease","volume":"34","author":"\u00d8stensen","year":"2007","journal-title":"J. Rheumatol."},{"issue":"3","key":"10.1016\/j.reprotox.2017.10.004_bib0135","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.reprotox.2010.01.008","article-title":"A pilot study of paternal drug exposure: the Motherisk experience","volume":"29","author":"Lee","year":"2010","journal-title":"Reprod. Toxicol."},{"issue":"May","key":"10.1016\/j.reprotox.2017.10.004_bib0140","first-page":"577","article-title":"Motherisk update: effect to methotrexate on male fertility","volume":"49","author":"French","year":"2003","journal-title":"Can. Fam. Phys."},{"issue":"3","key":"10.1016\/j.reprotox.2017.10.004_bib0145","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/03009742.2011.626442","article-title":"Outcomes after anti-rheumatic drug use before and during pregnancy: a cohort study among 150, 000 pregnant women and expectant fathers","volume":"41","author":"Viktil","year":"2012","journal-title":"Scand. J. Rheumatol."},{"issue":"1","key":"10.1016\/j.reprotox.2017.10.004_bib0150","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/art.38919","article-title":"Brief report: no excess risks in offspring with paternal preconception exposure to disease-modifying antirheumatic drugs","volume":"67","author":"Wallenius","year":"2015","journal-title":"Arthritis Rheumatol."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623817302575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623817302575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:47:22Z","timestamp":1760190442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623817302575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":30,"alternative-id":["S0890623817302575"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2017.10.004","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Birth outcomes after preconception paternal exposure to methotrexate: A nationwide cohort study","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2017.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}