{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:44:51Z","timestamp":1772811891913,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2017YFC1001300"],"award-info":[{"award-number":["2017YFC1001300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81430089"],"award-info":[{"award-number":["81430089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673524"],"award-info":[{"award-number":["81673524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Province Health and Family Planning Scientific Research Project","award":["WJ2017C0003"],"award-info":[{"award-number":["WJ2017C0003"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.reprotox.2018.05.005","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T12:40:30Z","timestamp":1526992830000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Influencing factors, underlying mechanism and interactions affecting hypercholesterolemia in adult offspring with caffeine exposure during pregnancy"],"prefix":"10.1016","volume":"79","author":[{"given":"Yitian","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanwen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Magdalou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liaobin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2018.05.005_bib0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2147\/vhrm.2006.2.3.285","article-title":"Metabolic syndrome: the danger signal in atherosclerosis","volume":"2","author":"Mathieu","year":"2006","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0010","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4254\/wjh.v4.i6.184","article-title":"Regulation and deregulation of cholesterol homeostasis: the liver as a metabolic power station","volume":"4","author":"Trapani","year":"2012","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0015","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/db10-1239","article-title":"Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome","volume":"60","author":"Rueda-Clausen","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.reprotox.2018.05.005_bib0020","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1210\/en.2009-1088","article-title":"Prenatal dexamethasone programs expression of genes in liver and adipose tissue and increased hepatic lipid accumulation but not obesity on a high-fat diet","volume":"151","author":"Drake","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.05.005_bib0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3164\/jcbn.13-100","article-title":"Maternal protein restriction induces alterations in hepatic tumor necrosis factor-alpha\/CYP7A1 signaling and disorders regulation of cholesterol metabolism in the adult rat offspring","volume":"55","author":"Liu","year":"2014","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0030","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1210\/me.2010-0395","article-title":"Maternal protein restriction elevates cholesterol in adult rat offspring due to repressive changes in histone modifications at the cholesterol 7alpha-hydroxylase promoter","volume":"25","author":"Sohi","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0035","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/CIRCULATIONAHA.111.034546","article-title":"Metabolic syndrome in adolescence: can it be predicted from natal and parental profile? The Prediction of Metabolic Syndrome in Adolescence (PREMA) study","volume":"125","author":"Efstathiou","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.reprotox.2018.05.005_bib0040","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.jnutbio.2011.11.007","article-title":"Maternal low-protein diet causes epigenetic deregulation of HMGCR and CYP7alpha1 in the liver of weaning piglets","volume":"23","author":"Cong","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0045","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1440-1681.2012.05676.x","article-title":"Role of p53-dependent placental apoptosis in the reproductive and developmental toxicities of caffeine in rodents","volume":"39","author":"Huang","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0050","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/oxfordjournals.aje.a116763","article-title":"Relation of caffeine intake during pregnancy to intrauterine growth retardation and preterm birth","volume":"137","author":"Fortier","year":"1993","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1071\/RD99065","article-title":"Maternal caffeine consumption during pregnancy does not affect preimplantation development but delays early postimplantation growth in rat embryos","volume":"11","author":"Jacombs","year":"1999","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-3782(95)01660-U","article-title":"Reproduction and caffeine consumption-a literature review","volume":"43","author":"Golding","year":"1995","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.taap.2014.01.007","article-title":"Maternal glucocorticoid elevation and associated blood metabonome changes might be involved in metabolic programming of intrauterine growth retardation in rats exposed to caffeine prenatally","volume":"275","author":"Kou","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0070","doi-asserted-by":"crossref","first-page":"e44497","DOI":"10.1371\/journal.pone.0044497","article-title":"Caffeine-induced activated glucocorticoid metabolism in the hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2018.05.005_bib0075","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.taap.2012.05.002","article-title":"Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways","volume":"262","author":"Liu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0080","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.taap.2012.08.016","article-title":"A hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion","volume":"264","author":"Xu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0085","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/oby.2007.608","article-title":"High-fat diets: modeling the metabolic disorders of human obesity in rodents","volume":"15","author":"Buettner","year":"2007","journal-title":"Obesity"},{"key":"10.1016\/j.reprotox.2018.05.005_bib0090","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1172\/JCI17305","article-title":"Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones","volume":"112","author":"Norris","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.taap.2015.03.002","article-title":"Gender-specific increase in susceptibility to metabolic syndrome of offspring rats after prenatal caffeine exposure with post-weaning high-fat diet","volume":"284","author":"Li","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0100","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jama.2014.732","article-title":"Prevalence of childhood and adult obesity in the United States, 2011\u20132012","volume":"311","author":"Ogden","year":"2014","journal-title":"JAMA: J. Am. Med. Assoc."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0105","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.toxlet.2013.11.006","article-title":"Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring","volume":"224","author":"Wang","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0110","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.arcmed.2013.07.006","article-title":"Prenatal food restriction induces a hypothalamic-pituitary-adrenocortical axis-associated neuroendocrine metabolic programmed alteration in adult offspring rats","volume":"44","author":"Zhang","year":"2013","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0115","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/clinchem\/44.3.522","article-title":"Homogeneous assay for measuring low-density lipoprotein cholesterol in serum with triblock copolymer and alpha-cyclodextrin sulfate","volume":"44","author":"Sugiuchi","year":"1998","journal-title":"Clin. Chem."},{"issue":"Pt 5","key":"10.1016\/j.reprotox.2018.05.005_bib0120","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1177\/000456328402100516","article-title":"Determination of HDL-cholesterol using 2,4,6-tribromo-3-hydroxybenzoic acid with a commercial CHOD-PAP reagent","volume":"21","author":"Trinder","year":"1984","journal-title":"Ann. Clin. Biochem."},{"issue":"Pt 2","key":"10.1016\/j.reprotox.2018.05.005_bib0125","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/000456328101800202","article-title":"Oxidase determination of plasma cholesterol as cholest-4-en-3-one using iso-octane extraction","volume":"18","author":"Trinder","year":"1981","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0130","first-page":"1401","article-title":"Insulin resistance early in adulthood in subjects born with intrauterine growth retardation","volume":"85","author":"Jaquet","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0135","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuroscience.2011.03.028","article-title":"Long-term exposure to high fat diet is bad for your brain: exacerbation of focal ischemic brain injury","volume":"182","author":"Langdon","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.reprotox.2018.05.005_bib0140","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1249\/MSS.0b013e3181eeb12d","article-title":"Exercise reverses metabolic syndrome in high-fat diet-induced obese rats","volume":"43","author":"Touati","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"issue":"July (1)","key":"10.1016\/j.reprotox.2018.05.005_bib0145","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/cen.12663","article-title":"Low serum adiponectin levels are associated with reduced insulin sensitivity and lipid disturbances in short children born small for gestational age","volume":"83","author":"Huang","year":"2015","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0150","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.nut.2013.06.005","article-title":"The association of birth weight with cardiovascular risk factors and mental problems among Iranian school-aged children: the CASPIAN-III study","volume":"30","author":"Azadbakht","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.reprotox.2018.05.005_bib0155","first-page":"203","article-title":"Fetal development and risk of cardiovascular diseases and diabetes type 2 in adult life","volume":"15","author":"Szostak-Wegierek","year":"2011","journal-title":"Med. Wieku Rozwoj."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0160","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.toxlet.2014.01.023","article-title":"Prenatal ethanol exposure enhances the susceptibility to metabolic syndrome in offspring rats by HPA axis-associated neuroendocrine metabolic programming","volume":"226","author":"Xia","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0165","first-page":"543","article-title":"Effects of intrauterine growth retardation with catch-up growth on sugar-lipid metabolism and adipocyte function in young rats","volume":"14","author":"Zheng","year":"2012","journal-title":"Zhongguo dang dai er ke za zhi\u202f=\u202fChin. J. Contemp. Pediatr."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0170","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1677\/joe.0.1480501","article-title":"Effect of corticosterone on protein degradation in isolated rat soleus and extensor digitorum longus muscles","volume":"148","author":"Bowes","year":"1996","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0175","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cbpa.2014.07.010","article-title":"Cholesterol deregulation induced by chronic corticosterone (CORT) stress in pectoralis major of broiler chickens","volume":"176","author":"Duan","year":"2014","journal-title":"Comparat. Biochem. Physiol. Part A, Mol. Integrat. Physiol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0180","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0022-2275(20)41435-X","article-title":"Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression","volume":"33","author":"Hwa","year":"1992","journal-title":"J. Lipid Res."},{"issue":"8","key":"10.1016\/j.reprotox.2018.05.005_bib0185","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0022-2275(20)40771-0","article-title":"Differing efforts of cholesterol and taurocholate on steady state hepatic HMG-CoA reductase and cholesterol 7alpha-hydroxylase activities and mRNA levels in the rat","volume":"33","author":"Shefer","year":"1992","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.reprotox.2018.05.005_bib0190","doi-asserted-by":"crossref","first-page":"R275","DOI":"10.1152\/ajpregu.00413.2009","article-title":"The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction","volume":"298","author":"Van Straten","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0195","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/FBP.0b013e328333b27c","article-title":"Sex differences in reinforcing value of caffeinated beverages in adolescents","volume":"20","author":"Temple","year":"2009","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0200","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3233\/JAD-2011-110431","article-title":"Gender differences in tea, coffee, and cognitive decline in the elderly: the Cardiovascular Health Study","volume":"27","author":"Arab","year":"2011","journal-title":"J. Alzheimer's Dis.: JAD"},{"key":"10.1016\/j.reprotox.2018.05.005_bib0205","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1007\/s11033-014-3605-8","article-title":"Gender differences in the expression of genes involved during cardiac development in offspring from dams on high fat diet","volume":"41","author":"Elahi","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0210","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/MOL.0b013e3283613ba2","article-title":"Dietary fatty acids and lipoprotein metabolism: new insights and updates","volume":"24","author":"Ooi","year":"2013","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0215","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ejcn.2011.161","article-title":"Risk of metabolic syndrome in adults exposed to the great Chinese famine during the fetal life and early childhood","volume":"66","author":"Zheng","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0220","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/ajcn\/70.5.811","article-title":"Obesity at the age of 50 y in men and women exposed to famine prenatally","volume":"70","author":"Ravelli","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0225","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000054647","article-title":"A short period of maternal nutrient restriction in late gestation modifies pituitary-adrenal function in adult guinea pig offspring","volume":"73","author":"Lingas","year":"2001","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.reprotox.2018.05.005_bib0230","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12944-015-0014-5","article-title":"Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet","volume":"14","author":"Cai","year":"2015","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0235","doi-asserted-by":"crossref","first-page":"812610","DOI":"10.1155\/2015\/812610","article-title":"Predictors of subclinical cardiovascular disease in women with polycystic ovary syndrome: interrelationship of dyslipidemia and arterial blood pressure","volume":"2015","author":"Macut","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0240","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuroscience.2008.02.023","article-title":"Post weaning high fat feeding affects rats' behavior and hypothalamic pituitary adrenal axis at the onset of puberty in a sexually dimorphic manner","volume":"153","author":"Boukouvalas","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.reprotox.2018.05.005_bib0245","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.lfs.2014.06.007","article-title":"Testosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient mice","volume":"109","author":"Kelly","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.reprotox.2018.05.005_bib0250","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.metabol.2011.12.016","article-title":"Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity","volume":"61","author":"Amengual-Cladera","year":"2012","journal-title":"Metabolism"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623817306536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623817306536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:47:00Z","timestamp":1760190420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623817306536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":50,"alternative-id":["S0890623817306536"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2018.05.005","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influencing factors, underlying mechanism and interactions affecting hypercholesterolemia in adult offspring with caffeine exposure during pregnancy","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2018.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}