{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:53:34Z","timestamp":1773903214987,"version":"3.50.1"},"reference-count":227,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ministry of Science and Higher Education","award":["K\/ZDS\/007346"],"award-info":[{"award-number":["K\/ZDS\/007346"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.reprotox.2018.06.014","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T17:39:51Z","timestamp":1530034791000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["The effects of flutamide on cell-cell junctions in the testis, epididymis, and prostate"],"prefix":"10.1016","volume":"81","author":[{"given":"Anna","family":"Hejmej","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Bilinska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2018.06.014_bib0005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00345-003-0365-9","article-title":"Androgens and male fertility","volume":"21","author":"Dohle","year":"2003","journal-title":"World J. Urol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4103\/0970-1591.42610","article-title":"5-alpha-reductase and the development of the human prostate","volume":"24","author":"Radmayr","year":"2008","journal-title":"Indian J. Urol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0015","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI34241","article-title":"Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism","volume":"118","author":"Welsh","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0020","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1098\/rstb.2009.0206","article-title":"Environmental\/lifestyle effects on spermatogenesis","volume":"365","author":"Sharpe","year":"2010","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.semcdb.2014.02.010","article-title":"Hormonal control of germ cell development and spermatogenesis","volume":"29","author":"O\u2019Shaughnessy","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0030","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1365-2605.1993.tb01191.x","article-title":"Intratesticular hormone levels and the route of secretion of hormones from the testis of the rat, guinea pig, monkey and human","volume":"16","author":"Maddocks","year":"1993","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0035","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.02.012","article-title":"The regulation of spermatogenesis by androgens","volume":"30","author":"Smith","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0040","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/humupd\/dmn055","article-title":"New insights into epididymal biology and function","volume":"15","author":"Cornwall","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/1008-682X.165946","article-title":"Regulation of epithelial function, differentiation, and remodeling in the epididymis","volume":"18","author":"Breton","year":"2016","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0050","first-page":"88","article-title":"The sperm journey in the excurrent duct: functions of microvesicles on sperm maturation and gene expression along the epididymis","volume":"12","author":"Sullivan","year":"2015","journal-title":"Anim. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0055","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1745-7262.2007.00316.x","article-title":"Androgenic regulation of novel genes in the epididymis","volume":"9","author":"Robaire","year":"2007","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0060","doi-asserted-by":"crossref","first-page":"592","DOI":"10.2164\/jandrol.111.014266","article-title":"Androgen action in the epididymis","volume":"32","author":"Robaire","year":"2011","journal-title":"J. Androl."},{"issue":"Suppl. 1","key":"10.1016\/j.reprotox.2018.06.014_bib0065","first-page":"57","article-title":"Epididymis and sperm function","volume":"28","author":"Cooper","year":"1996","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0070","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4161\/spmg.1.4.18948","article-title":"Connexins and pannexins: coordinating cellular communication in the testis and epididymis","volume":"1","author":"Cyr","year":"2011","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0075","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jsbmb.2004.10.017","article-title":"Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development","volume":"92","author":"Cunha","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0080","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0021-9258(18)52466-2","article-title":"Transcriptional activation and nuclear targeting signals of the human androgen receptor","volume":"266","author":"Simental","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0085","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1210\/endo-127-6-3180","article-title":"Immunohistochemical localization of the androgen receptor in rat and human tissues","volume":"127","author":"Sar","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0090","first-page":"1970","article-title":"Stepwise androgen receptor dimerization","volume":"125","author":"van Royen","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0095","first-page":"3","article-title":"Androgen receptor structure, function and biology: from bench to bedside","volume":"37","author":"Davey","year":"2016","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mce.2011.08.007","article-title":"Androgen receptor coregulators: recruitment via the coactivator binding groove","volume":"352","author":"van de Wijngaart","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0105","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0006-8993(79)90906-5","article-title":"Effects of testosterone on unit activity in rat hypothalamus and septum","volume":"172","author":"Yamada","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0110","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1210\/endo.136.5.7720654","article-title":"Androgens rapidly increase the cytosolic calcium concentration in Sertoli cells","volume":"136","author":"Gorczynska","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0115","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1073\/pnas.0404278101","article-title":"Testosterone activates mitogen-activated protein kinase and the cAMP response element binding protein transcription factor in Sertoli cells","volume":"101","author":"Fix","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0120","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.tem.2007.09.004","article-title":"Non-classical action of testosterone: an update","volume":"18","author":"Rahman","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4161\/spmg.1.2.16956","article-title":"Testosterone signaling and the regulation of spermatogenesis","volume":"1","author":"Walker","year":"2011","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0130","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1098\/rstb.2009.0258","article-title":"Non-classical actions of testosterone and spermatogenesis","volume":"365","author":"Walker","year":"2010","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0135","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/bj3460561","article-title":"The PI3K-PDK1 connection: more than just a road to PKB","volume":"346","author":"Vanhaesebroeck","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0140","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrm3290","article-title":"PI3K signalling: the path to discovery and understanding","volume":"13","author":"Vanhaesebroeck","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0145","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1126\/science.286.5445.1741","article-title":"Phosphorylation and regulation of Raf by Akt (protein kinase B)","volume":"26","author":"Zimmermann","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0150","doi-asserted-by":"crossref","first-page":"33630","DOI":"10.1074\/jbc.M105322200","article-title":"Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells","volume":"276","author":"Reusch","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0155","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/en.2014-1198","article-title":"Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: I. Discovery in female atlantic croaker and evidence ZIP9 mediates testosterone-induced apoptosis of ovarian follicle cells","volume":"155","author":"Berg","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0160","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1210\/en.2014-1201","article-title":"Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: II. Role of human ZIP9 in testosterone-induced prostate and breast cancer cell apoptosis","volume":"155","author":"Thomas","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0165","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.cellsig.2015.07.013","article-title":"Non-classical testosterone signaling in spermatogenic GC-2 cells is mediated through ZIP9 interacting with Gn\u03b111","volume":"27","author":"Shihan","year":"2015","journal-title":"Cell Signal."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0170","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.cellsig.2016.04.015","article-title":"Non-classical testosterone signaling mediated through ZIP9 stimulates claudin expression and tight junction formation in Sertoli cells","volume":"28","author":"Bulldan","year":"2016","journal-title":"Cell Signal."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0175","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/ijms19051359","article-title":"Recent advances in prostate cancer treatment and drug discovery","volume":"19","author":"Nevedomskaya","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0180","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1158\/1535-7163.MCT-08-0461","article-title":"Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor","volume":"7","author":"Hodgson","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0185","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1021\/bi102059z","article-title":"Mechanism of androgen receptor antagonism by bicalutamide in the treatment of prostate cancer","volume":"50","author":"Osguthorpe","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0190","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1210\/me.2005-0324","article-title":"The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor","volume":"20","author":"Yoon","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/bbrc.1998.8209","article-title":"Discovery of nonsteroidal androgens","volume":"244","author":"Dalton","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0200","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1124\/mol.63.1.211","article-title":"Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor","volume":"63","author":"Yin","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0205","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2165\/00003088-200443130-00003","article-title":"Bicalutamide: clinical pharmacokinetics and metabolism","volume":"43","author":"Cockshott","year":"2004","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0210","first-page":"23","article-title":"Enzalutamide and blocking androgen receptor in advanced prostate cancer: lessons learnt from the history of drug development of antiandrogens","volume":"10","author":"Ito","year":"2018","journal-title":"Res. Rep. Urol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0215","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.eururo.2016.08.002","article-title":"EAU-ESTRO-SIOG guidelines on prostate cancer. Part II: treatment of relapsing, metastatic, and castration-resistant prostate cancer","volume":"71","author":"Cornford","year":"2017","journal-title":"Eur. Urol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0220","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.2147\/OTT.S147168","article-title":"Profile of apalutamide in the treatment of metastatic castration-resistant prostate cancer: evidence to date","volume":"11","author":"Chong","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0225","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jsbmb.2011.04.004","article-title":"Disruption of androgen receptor signaling in males by environmental chemicals","volume":"127","author":"Luccio-Camelo","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0230","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: the Endocrine Society\u2019s second scientific statement on endocrine-disrupting chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0235","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1002\/1097-0142(19931215)72:12+<3816::AID-CNCR2820721711>3.0.CO;2-3","article-title":"Mechanism of action and pure antiandrogenic properties of flutamide","volume":"72","author":"Labrie","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0240","doi-asserted-by":"crossref","first-page":"28395","DOI":"10.1074\/jbc.M101755200","article-title":"The subnuclear threedimensional image analysis of androgen receptor fused to green fluorescence protein","volume":"276","author":"Tomura","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0245","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/bbrc.2001.4758","article-title":"Cross-talk between signal transducer and activator of transcription 3 and androgen receptor signaling in prostate carcinoma cells","volume":"283","author":"Matsuda","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0250","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0014-5793(02)02929-0","article-title":"Pure antiandrogens disrupt the recruitment of coactivator GRIP1 to colocalize with androgen receptor in nuclei","volume":"523","author":"Karvonen","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0255","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1089\/adt.2014.594","article-title":"High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions","volume":"12","author":"Hua","year":"2014","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0260","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1158\/1535-7163.MCT-05-0197","article-title":"Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft model","volume":"4","author":"Ilagan","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0265","first-page":"6039","article-title":"Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells","volume":"62","author":"Lee","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0270","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.tiv.2017.01.019","article-title":"Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K\/Akt and MAPK\/ERK1\/2 pathways","volume":"40","author":"Gorowska-Wojtowicz","year":"2017","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0275","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1038\/onc.2015.55","article-title":"Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-\u03b21","volume":"34","author":"Koch","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0280","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/j.1552-4604.1989.tb03381.x","article-title":"Single and multiple dose pharmacokinetic evaluation of flutamide in normal geriatric volunteers","volume":"29","author":"Radwanski","year":"1989","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0285","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000056592","article-title":"Optimal starting time for flutamide to prevent disease flare in prostate cancer patients treated with a gonadotropin-releasing hormone agonist","volume":"66","author":"Tsushima","year":"2001","journal-title":"Urol. Int."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0290","first-page":"1298","article-title":"Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2","volume":"25","author":"Shet","year":"1997","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0295","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1124\/dmd.105.008623","article-title":"Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients","volume":"34","author":"Goda","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0300","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0022-5347(01)66596-0","article-title":"Flutamide hepatotoxicity","volume":"155","author":"Wysowski","year":"1996","journal-title":"J. Urol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0305","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/096032719901800301","article-title":"Frequency of flutamide induced hepatotoxicity in patients with prostate carcinoma","volume":"18","author":"Cetin","year":"1999","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0310","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1021\/tx7001542","article-title":"Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites","volume":"20","author":"Kostrubsky","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0315","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1124\/dmd.108.021964","article-title":"Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced liver toxicity","volume":"37","author":"Ohbuchi","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0320","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bcp.2016.08.021","article-title":"The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4","volume":"119","author":"Gao","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0325","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.12.003","article-title":"Review of the histological effects of the anti-androgen, flutamide, on mouse testis","volume":"25","author":"Anahara","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0330","first-page":"815","article-title":"A role of junction-mediated interactions in cells of the male reproductive tract: impact of prenatal, neonatal, and prepubertal exposure to anti-androgens on adult reproduction","volume":"29","author":"Bilinska","year":"2014","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0335","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1152\/physrev.00009.2002","article-title":"Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development","volume":"82","author":"Cheng","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0340","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1098\/rstb.2009.0114","article-title":"Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis","volume":"365","author":"Pointis","year":"2010","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0345","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1210\/er.2003-0022","article-title":"Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis","volume":"25","author":"Mruk","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0350","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.semcdb.2014.08.009","article-title":"Tight junctions and the regulation of gene expression","volume":"36","author":"Gonz\u00e1lez-Mariscal","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0355","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a002899","article-title":"Adherens junction: molecular architecture and regulation","volume":"1","author":"Meng","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0360","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1039\/c5ib00070j","article-title":"The mechanotransduction machinery at work at adherens junctions","volume":"7","author":"Ladoux","year":"2015","journal-title":"Integr. Biol. (Camb.)"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0365","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1242\/jcs.00167","article-title":"Nectin and afadin: novel organizers of intercellular junctions","volume":"116","author":"Takai","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0370","doi-asserted-by":"crossref","first-page":"17286","DOI":"10.1074\/jbc.M513218200","article-title":"Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes","volume":"281","author":"Yan","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0375","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1126\/science.1071559","article-title":"C-cadherin ectodomain structure and implications for cell adhesion mechanisms","volume":"296","author":"Boggon","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0380","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1242\/jcs.02700","article-title":"Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure","volume":"118","author":"Garrod","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0385","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1002\/j.2040-4603.2012.tb00453.x","article-title":"Gap junctions","volume":"2","author":"Nielsen","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0390","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051428","article-title":"Protein-protein interactions with connexin 43: regulation and function","volume":"19","author":"Sorgen","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0395","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1095\/biolreprod.110.087452","article-title":"The blood-testis and blood-epididymis barriers are more than just their tight junctions","volume":"84","author":"Mital","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0400","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/er.2014-1101","article-title":"The mammalian blood-testis barrier: its biology and regulation","volume":"36","author":"Mruk","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0405","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.biocel.2010.02.010","article-title":"Crosstalk between desmoglein-2\/desmocollin-2\/Src kinase and coxsackie and adenovirus receptor\/ZO-1 protein complexes, regulates blood-testis barrier dynamics","volume":"42","author":"Lie","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0410","doi-asserted-by":"crossref","first-page":"10213","DOI":"10.1073\/pnas.0901700106","article-title":"Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics","volume":"106","author":"Li","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0415","first-page":"223","article-title":"The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium","volume":"286","author":"Lie","year":"2011","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0420","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1210\/endo.141.8.7625","article-title":"Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein\/claudin 11 in mouse testis","volume":"141","author":"Hellani","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0425","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2164\/jandrol.110.010611","article-title":"Postnatal changes in the expression of claudin-11 in the testes and excurrent ducts of the domestic rabbit (Oryctolagus cuniculus domesticus)","volume":"32","author":"Park","year":"2011","journal-title":"J. Androl."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0430","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.theriogenology.2015.05.009","article-title":"Characterization of the equine blood-testis barrier during tubular development in normal and cryptorchid stallions","volume":"84","author":"Rode","year":"2015","journal-title":"Theriogenology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0435","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ar.1164","article-title":"Developmental regulation of connexin 43 expression in fetal mouse testicular cells","volume":"264","author":"P\u00e9rez-Armendariz","year":"2001","journal-title":"Anat. Rec."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0440","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1177\/002215540004800608","article-title":"Connexin43 gene expression and regulation in the rodent seminiferous epithelium","volume":"48","author":"Batias","year":"2000","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0445","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mce.2009.08.004","article-title":"Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: new insights and advances","volume":"315","author":"Cheng","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0450","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1477-7827-10-27","article-title":"Tubulobulbar complex: cytoskeletal remodeling to release spermatozoa","volume":"17","author":"Upadhyay","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0455","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1095\/biolreprod.112.104851","article-title":"A novel subcellular machine contributes to basal junction remodeling in the seminiferous epithelium","volume":"88","author":"Du","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0460","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/jcp.10473","article-title":"Functional characterization of Cx43 based gap junctions during spermatogenesis","volume":"200","author":"Decrouy","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0465","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0016-6480(02)00627-5","article-title":"Ethane 1,2-dimethane sulphonate is a useful tool for studying cell-to-cell interactions in the testis of the frog, Rana esculenta","volume":"131","author":"Palmiero","year":"2003","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0470","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ygcen.2009.03.025","article-title":"Seasonal variations in testicular connexin levels and their regulation in the brook trout, Salvelinus fontinalis","volume":"162","author":"de Montgolfier","year":"2009","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0475","first-page":"1207","article-title":"Connexin 43 a check-point component of cell proliferation implicated in a wide range of human testis diseases","volume":"70","author":"Chevallier","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0480","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ydbio.2010.07.014","article-title":"Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility","volume":"346","author":"Carette","year":"2010","journal-title":"Dev. Biol"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0485","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2353\/ajpath.2007.061171","article-title":"A Sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis","volume":"171","author":"Brehm","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0490","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1095\/biolreprod.106.059212","article-title":"Proliferation of adult Sertoli cells following conditional knockout of the gap junctional protein GJA1 (connexin 43) in mice","volume":"76","author":"Sridharan","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0495","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198100","article-title":"Loss of connexin43 in murine Sertoli cells and its effect on blood-testis barrier formation and dynamics","volume":"13","author":"Hollenbach","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0500","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1677\/joe.0.1770327","article-title":"Modulation of gap junction mediated intercellular communication in TM3 Leydig cells","volume":"177","author":"Goldenberg","year":"2003","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0505","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1139\/cjpp-2012-0385","article-title":"Connexins and steroidogenesis in mouse Leydig cells","volume":"91","author":"Li","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0510","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1177\/0192623312457272","article-title":"Atypical Leydig cell hyperplasia in adult rats with low T and high LH induced by prenatal Di(n-butyl) phthalate exposure","volume":"41","author":"Wakui","year":"2013","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0515","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1210\/endo.134.2.7507830","article-title":"Cadherins and cadherin-associated molecules in the developing and maturing rat testis","volume":"134","author":"Byers","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0520","doi-asserted-by":"crossref","DOI":"10.4161\/21565562.2014.979619","article-title":"The blood-epididymis barrier and inflammation","volume":"4","author":"Gregory","year":"2014","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0525","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1210\/endo.132.3.7679970","article-title":"Developmental changes in epithelial cadherin messenger ribonucleic acid and immunocytochemical localization of epithelial cadherin during postnatal epididymal development in the rat","volume":"132","author":"Cyr","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0530","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1745-7262.2007.00308.x","article-title":"Orchestration of occludins, catenins and cadherins as players involved in maintenance of the blood-epididymal barrier in animals and humans","volume":"9","author":"Cyr","year":"2007","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0535","doi-asserted-by":"crossref","first-page":"C33","DOI":"10.1152\/ajpcell.00111.2002","article-title":"Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication","volume":"284","author":"Dufresne","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0540","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00432-007-0235-8","article-title":"New experimental markers for early detection of high-risk prostate cancer: role of cell-cell adhesion and cell migration","volume":"133","author":"Mol","year":"2007","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0545","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.2353\/ajpath.2010.090737","article-title":"Desmosomal plakophilins in the prostate and prostatic adenocarcinomas: implications for diagnosis and tumor progression","volume":"176","author":"Breuninger","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0550","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/pros.20334","article-title":"N-cadherin switching occurs in high Gleason grade prostate cancer","volume":"66","author":"Jaggi","year":"2006","journal-title":"Prostate"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0555","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrurol.2012.14","article-title":"The role of connexins in prostate cancer promotion and progression","volume":"9","author":"Czyz","year":"2012","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0560","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0022-5347(05)67685-9","article-title":"A blood-prostate barrier restricts cell and molecular movement across the rat ventral prostate epithelium","volume":"163","author":"Fulmer","year":"2000","journal-title":"J. Urol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0565","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1158\/1078-0432.CCR-04-1969","article-title":"Intraprostatic chemotherapy: distribution and transport mechanisms","volume":"11","author":"Wientjes","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0570","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00418-007-0269-7","article-title":"Expression patterns of claudin family of tight junction proteins in the mouse prostate","volume":"127","author":"Sakai","year":"2007","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0575","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1210\/en.2002-220692","article-title":"Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in utero to flutamide","volume":"144","author":"Omezzine","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0580","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1677\/JOE-07-0062","article-title":"Alterations of Sertoli cell activity in the long-term testicular germ cell death process induced by fetal androgen disruption","volume":"196","author":"Benbrahim-Tallaa","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0585","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1469-7580.1997.19040577.x","article-title":"The effect of pre- and postnatal exposure to the nonsteroidal antiandrogen flutamide on testis descent and morphology in the Albino rat","volume":"190","author":"Kassim","year":"1997","journal-title":"J. Anat."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0590","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1677\/joe.1.05771","article-title":"The mitochondrial-dependent pathway is chronically affected in testicular germ cell death in adult rats exposed in utero to anti-androgens","volume":"183","author":"Bozec","year":"2004","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0595","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2605.2009.01005.x","article-title":"Androgen action in the masculinization programming window and development of male reproductive organs","volume":"33","author":"Macleod","year":"2010","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0600","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1108190","article-title":"Epigenetic transgenerational actions of endocrine disruptors and male fertility","volume":"308","author":"Anway","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0605","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.reprotox.2008.07.008","article-title":"Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis","volume":"26","author":"Anway","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0610","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2605.2007.00859.x","article-title":"A mixture of seven antiandrogens induces reproductive malformations in rats","volume":"31","author":"Rider","year":"2008","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0615","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/0192623308329478","article-title":"Cumulative effects of in utero administration of mixtures of \"antiandrogens\" on male rat reproductive development","volume":"37","author":"Rider","year":"2009","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0620","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an endocrine society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0625","doi-asserted-by":"crossref","first-page":"16696","DOI":"10.1073\/pnas.0506084102","article-title":"Androgens regulate the permeability of the blood-testis barrier","volume":"102","author":"Meng","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0630","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1210\/en.2006-0138","article-title":"Androgen receptor in Sertoli cell is essential for germ cell nursery and junctional complex formation in mouse testes","volume":"147","author":"Wang","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0635","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1096\/fj.06-070342","article-title":"Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells","volume":"22","author":"Yan","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0640","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1016\/j.yexcr.2010.07.018","article-title":"Differential effects of testosterone and TGF-beta3 on endocytic vesicle-mediated protein trafficking events at the blood-testis barrier","volume":"316","author":"Su","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0645","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014168","article-title":"Selective ablation of the androgen receptor in mouse Sertoli cells affects Sertoli cell maturation, barrier formation and cytoskeletal development","volume":"5","author":"Willems","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0650","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.repbio.2012.10.007","article-title":"The presence of androgen receptor in the testis of mice with a Sertoli-cell specific knock-out of the Cx43 (SCCx43KO-\/-)","volume":"4","author":"Chojnacka","year":"2012","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0655","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1210\/en.2004-0834","article-title":"Androgens and postmeiotic germ cells regulate claudin-11 expression in rat Sertoli cells","volume":"146","author":"Florin","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0660","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1095\/biolreprod.111.094318","article-title":"Androgen initiates Sertoli cell tight junction formation in the hypogonadal (hpg) mouse","volume":"87","author":"McCabe","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0665","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/19396368.2014.921738","article-title":"Connexin 43 expression in Sprague-Dawley rat seminiferous epithelium after in utero exposure to flutamide","volume":"60","author":"Cai","year":"2014","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0670","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/toxsci\/62.2.236","article-title":"Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues","volume":"62","author":"McIntyre","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0675","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1439-0531.2012.02095.x","article-title":"Environmental endocrine disruptors in farm animal reproduction: research and reality","volume":"47","author":"Magnusson","year":"2012","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0680","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.acthis.2009.07.001","article-title":"Connexin 43 gene expression in male and female gonads of porcine offspring following in utero exposure to an anti-androgen flutamide","volume":"113","author":"Durlej","year":"2011","journal-title":"Acta Histochem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0685","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4081\/ejh.2010.e15","article-title":"Effects of pre- or postnatal exposure to flutamide on connexin 43 expression in testes and ovaries of prepubertal pigs","volume":"54","author":"Kopera","year":"2010","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0690","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0303-7207(99)00031-3","article-title":"Androgen stimulates mitogen-activated protein kinase in human breast cancer cells","volume":"152","author":"Zhu","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0695","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.domaniend.2011.11.002","article-title":"Prenatal and neonatal exposure to flutamide affects function of Leydig cells in adult boar","volume":"42","author":"Kotula-Balak","year":"2012","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0700","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/j.1439-0531.2011.01783.x","article-title":"Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment","volume":"46","author":"Kopera","year":"2011","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0705","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1365-2605.2011.01206.x","article-title":"Are expression and localization of tight and adherens junction proteins in testes of adult boar affected by foetal and neonatal exposure to flutamide?","volume":"35","author":"Hejmej","year":"2012","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0710","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/jemt.20741","article-title":"Effects of di(2-ethylhexyl) phthalate on gap and tight junction protein expression in the testis of prepubertal rats","volume":"72","author":"Sobarzo","year":"2009","journal-title":"Microsc. Res. Technol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0715","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1083\/jcb.200612080","article-title":"Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization","volume":"176","author":"Ikenouchi","year":"2007","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0720","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1083\/jcb.53.3.758","article-title":"Variations in tight and gap junctions in mammalian tissues","volume":"53","author":"Friend","year":"1972","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0725","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1210\/endo.137.4.8625926","article-title":"Immunocytochemical localization and regulation of connexin43 in the adult rat epididymis","volume":"137","author":"Cyr","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0730","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2746\/042516407X169393","article-title":"Expression of connexin 43 protein in testes, epididymides, and prostates of stallions","volume":"39","author":"Hejmej","year":"2007","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0735","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.acthis.2009.08.004","article-title":"Immunohistochemical studies of the epididymal duct in Egyptian water buffalo (Bubalus bubalis)","volume":"113","author":"Alkafafy","year":"2011","journal-title":"Acta Histochem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0740","doi-asserted-by":"crossref","DOI":"10.1186\/1751-0147-53-12","article-title":"Morphological and functional alterations in adult boar epididymis: effects of prenatal and postnatal administration of flutamide","volume":"53","author":"Lydka","year":"2011","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0745","doi-asserted-by":"crossref","first-page":"e630","DOI":"10.1111\/j.1365-2605.2011.01224.x","article-title":"Male reproductive system defects and subfertility in a mutant mouse model of oculodentodigital dysplasia","volume":"34","author":"Gregory","year":"2011","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0750","doi-asserted-by":"crossref","first-page":"349","DOI":"10.12717\/DR.2016.20.4.349","article-title":"Effects of exposure to estradiol benzoate or flutamide at the weaning age on expression of connexins in the caudal epididymis of adult rat","volume":"4","author":"Lee","year":"2016","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0755","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1210\/endo.130.1.1727709","article-title":"Distribution and regulation of epithelial cadherin messenger ribonucleic acid and immunocytochemical localization of epithelial cadherin in the rat epididymis","volume":"130","author":"Cyr","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0760","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1095\/biolreprod60.6.1392","article-title":"Segment-specific changes with age in the expression of junctional proteins and the permeability of the blood-epididymis barrier in rats","volume":"60","author":"Levy","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0765","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1439-0531.2011.01935.x","article-title":"Administration of flutamide alters sperm ultrastructure, sperm plasma membrane integrity, and mitochondrial diaphorase activity of boar spermatozoa: in vivo and in vitro approach","volume":"47","author":"Lydka","year":"2012","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0770","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.theriogenology.2014.07.013","article-title":"Hydroxyflutamide alters the characteristics of live boar spermatozoa","volume":"82","author":"Zarzycka","year":"2014","journal-title":"Theriogenology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0775","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.2047-2927.2013.00172.x","article-title":"Postnatal exposure to flutamide affects CTNNB1 and CDH1 gene expression in adult pig epididymis and prostate and alters metabolism of testosterone","volume":"2","author":"Gorowska","year":"2014","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0780","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/jme.0.0260001","article-title":"Regulation of the gap junction connexin 43 gene by androgens in the prostate","volume":"26","author":"Huynh","year":"2001","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0785","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1530\/ror.0.0050053","article-title":"Cadherins: crucial regulators of structure and function in reproductive tissues","volume":"5","author":"Rowlands","year":"2000","journal-title":"Rev. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0790","doi-asserted-by":"crossref","first-page":"407678","DOI":"10.1155\/2013\/407678","article-title":"Androgen signaling disruption during fetal and postnatal development affects androgen receptor and connexin 43 expression and distribution in adult boar prostate","volume":"2013","author":"Hejmej","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0795","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.beem.2015.04.006","article-title":"Androgen receptor roles in spermatogenesis and infertility","volume":"29","author":"O\u2019Hara","year":"2015","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0800","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1172\/JCI96794","article-title":"Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis","volume":"128","author":"Oduwole","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0805","first-page":"246","article-title":"Endocrinological and histological changes induced by flutamide treatment on the hypothalamo-hypophyseal testicular axis of the adult male rat and their incidences on fertility","volume":"104","author":"Viguier-Martinez","year":"1983","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0810","first-page":"547","article-title":"Comparative effects of chronic administration of the non-steroidal antiandrogens flutamide and Casodex on the reproductive system of the adult male rat","volume":"125","author":"Chandolia","year":"1991","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0815","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0378-4274(03)00178-4","article-title":"Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions","volume":"143","author":"Gye","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0820","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1530\/REP-06-0385","article-title":"Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro","volume":"133","author":"Kaitu\u2019u-Lino","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0825","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1016\/j.bbamcr.2017.09.012","article-title":"Testosterone\/bicalutamide antagonism at the predicted extracellular androgen binding site of ZIP9","volume":"1864","author":"Bulldan","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0830","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12958-016-0144-2","article-title":"Flutamide induces alterations in the cell-cell junction ultrastructure and reduces the expression of Cx43 at the blood-testis barrier with no disturbance in the rat seminiferous tubule morphology","volume":"14","author":"Chojnacka","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0835","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1210\/en.2007-1093","article-title":"Effect of heat stress on expression of junction-associated molecules and upstream factors androgen receptor and Wilms\u2019 tumor 1 in monkey Sertoli cells","volume":"149","author":"Chen","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0840","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1095\/biolreprod.113.109405","article-title":"The heat-induced reversible change in the blood-testis barrier (BTB) is regulated by the androgen receptor (AR) via the partitioning-defective protein (Par) polarity complex in the mouse","volume":"89","author":"Li","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0845","doi-asserted-by":"crossref","DOI":"10.1097\/01.LAB.0000059928.82702.6D","article-title":"Impaired gap junction connexin 43 in Sertoli cells of patients with secretory azoospermia: a marker of undifferentiated Sertoli cells","volume":"83","author":"Defamie","year":"2003","journal-title":"Lab. Invest."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0850","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/REP-15-0366","article-title":"Blood-testis barrier and Sertoli cell function: lessons from SCCx43KO mice","volume":"151","author":"Gerber","year":"2016","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0855","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.biochi.2004.05.003","article-title":"A proposed role for ZO-1 in targeting connexin 43 gap junctions to the endocytic pathway","volume":"86","author":"Segretain","year":"2004","journal-title":"Biochimie"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0860","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/andr.12028","article-title":"Flutamide alters the distribution of c-Src and affects the N-cadherin-\u03b2-catenin complex in the seminiferous epithelium of adult rat","volume":"3","author":"Zarzycka","year":"2015","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0865","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4161\/cib.7626","article-title":"Connexin 43 gap junction plaque endocytosis implies molecular remodelling of ZO-1 and c-Src partners","volume":"2","author":"Gilleron","year":"2009","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0870","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tiv.2015.09.027","article-title":"Hydroxyflutamide affects connexin 43 via the activation of PI3K\/Akt-dependent pathway but has no effect on the crosstalk between PI3K\/Akt and ERK1\/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells","volume":"31","author":"Chojnacka","year":"2016","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0875","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1210\/en.2004-1194","volume":"146","author":"Zhang","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0880","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jcp.20377","article-title":"Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-testis barrier integrity: an in vivo study using an androgen suppression model","volume":"205","author":"Xia","year":"2005","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0885","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbamem.2007.08.032","article-title":"Accelerated internalization of junctional membrane proteins (connexin 43, N-cadherin and ZO-1) within endocytic vacuoles: an early event of DDT carcinogenicity","volume":"1778","author":"Fiorini","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0890","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.biocel.2009.05.016","article-title":"Disruption of the blood-testis barrier integrity by bisphenol A in vitro: is this a suitable model for studying blood-testis barrier dynamics?","volume":"41","author":"Li","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0895","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.reprotox.2004.02.011","article-title":"Flutamide induces ultrastructural changes in spermatids and the ectoplasmic specialization between the Sertoli cell and spermatids in mouse testes","volume":"18","author":"Anahara","year":"2004","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0900","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.bbrc.2006.05.125","article-title":"Anti-estrogen ICI 182.780 and anti-androgen flutamide induce tyrosine phosphorylation of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis","volume":"346","author":"Anahara","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0905","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.fct.2005.12.010","article-title":"Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids in the mouse testis","volume":"44","author":"Anahara","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0910","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1210\/en.2004-1275","article-title":"Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes","volume":"146","author":"Wong","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0915","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1242\/dev.00957","article-title":"Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids","volume":"131","author":"Holdcraft","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0920","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2605.2011.01150.x","article-title":"Androgen receptor signalling in peritubular myoid cells is essential for normal differentiation and function of adult Leydig cells","volume":"35","author":"Welsh","year":"2012","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0925","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1096\/fj.14-255729","article-title":"Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men","volume":"29","author":"O\u2019Hara","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0930","first-page":"215","article-title":"Immunoexpression of androgen receptors and aromatase in testes of patient with Klinefelter\u2019s syndrome","volume":"42","author":"Kotula-Balak","year":"2004","journal-title":"Folia Histochem. Cytobiol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0935","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.reprotox.2013.03.004","article-title":"Androgen deprivation from pre-puberty to peripuberty interferes in proteins expression in pubertal and adult rat epididymis","volume":"38","author":"Perobelli","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0940","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1530\/REP-12-0510","article-title":"Plasticity of basal cells during postnatal development in the rat epididymis","volume":"146","author":"Shum","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0945","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1095\/biolreprod.114.123943","article-title":"Role of testicular luminal factors on basal cell elongation and proliferation in the mouse epididymis","volume":"92","author":"Kim","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0950","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1210\/en.2010-0023","article-title":"Identification of early response genes and pathway activated by androgens in the initial segment and caput regions of the regressed rat epididymis","volume":"151","author":"Hamzeh","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0955","doi-asserted-by":"crossref","DOI":"10.1210\/en.2002-0139","article-title":"Catenins in the rat epididymis: their expression and regulation in adulthood and during postnatal development","volume":"144","author":"DeBellefeuille","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0960","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.humpath.2006.11.007","article-title":"Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas","volume":"38","author":"Sheehan","year":"2007","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0965","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1746-1596-6-12","article-title":"Immunohistochemical profiles of claudin-3 in primary and metastatic prostatic adenocarcinoma","volume":"6","author":"Bartholow","year":"2011","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0970","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/PAT.0b013e3283428099","article-title":"Claudin expression is dysregulated in prostate adenocarcinomas but does not correlate with main clinicopathological parameters","volume":"43","author":"Coutinho-Camillo","year":"2011","journal-title":"Pathology"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0975","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/cas.13269","article-title":"CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration","volume":"108","author":"Ashikari","year":"2017","journal-title":"Cancer Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0980","first-page":"367","article-title":"The claudin family of proteins in human malignancy: a clinical perspective","volume":"5","author":"Ding","year":"2013","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0985","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbamem.2005.09.017","article-title":"Gap junctional communication in the male reproductive system","volume":"1719","author":"Pointis","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.reprotox.2018.06.014_bib0990","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1520-6408(1999)24:1\/2<91::AID-DVG10>3.0.CO;2-#","article-title":"Suppression of human prostate cancer cell growth by forced expression of connexin genes","volume":"110","author":"Mehta","year":"1999","journal-title":"Dev. Genet."},{"key":"10.1016\/j.reprotox.2018.06.014_bib0995","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/pros.20317","article-title":"Changes in gap junctional connexin isoforms during prostate cancer progression","volume":"66","author":"Tate","year":"2006","journal-title":"Prostate"},{"key":"10.1016\/j.reprotox.2018.06.014_bib1000","doi-asserted-by":"crossref","first-page":"11640","DOI":"10.18632\/oncotarget.3449","article-title":"Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration","volume":"6","author":"Zhang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.reprotox.2018.06.014_bib1005","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1091\/mbc.e06-04-0280","article-title":"Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells","volume":"17","author":"Mitra","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.reprotox.2018.06.014_bib1010","first-page":"514234","article-title":"AR pathway is involved in the regulation of Cx43 in prostate cancer","volume":"2015","author":"Chen","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1015","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/jat.3441","article-title":"Role of connexin 43 in cadmium-induced proliferation of human prostate epithelial cells","volume":"37","author":"Liu","year":"2017","journal-title":"Appl. Toxicol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1020","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.yexcr.2017.04.006","article-title":"A central role for cadherin signaling in cancer","volume":"358","author":"Kourtidis","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1025","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1006\/bbrc.1995.2015","article-title":"Sex steroids up-regulate E-cadherin expression in hormone-responsive LNCaP human prostate cancer cells","volume":"212","author":"Carruba","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1030","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1078\/0344-0338-00477","article-title":"Elevated E-cadherin and alpha\/beta-catenin expression after androgen deprivation therapy in prostate adenocarcinoma","volume":"199","author":"Patriarca","year":"2003","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1035","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11010-016-2794-y","article-title":"Androgens induce a distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells","volume":"421","author":"Colditz","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1040","doi-asserted-by":"crossref","first-page":"35376","DOI":"10.18632\/oncotarget.15686","article-title":"Epithelial-mesenchymal transition in prostate cancer: an overview","volume":"8","author":"Montanari","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.reprotox.2018.06.014_bib1045","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1677\/ERC-10-0015","article-title":"N-cadherin increases after androgen deprivation and is associated with metastasis in prostate cancer","volume":"17","author":"Jennbacken","year":"2010","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.reprotox.2018.06.014_bib1050","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1158\/0008-5472.CAN-16-2169","article-title":"Disrupting androgen receptor signaling induces snail-mediated epithelial-mesenchymal plasticity in prostate cancer","volume":"77","author":"Miao","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1055","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrurol.2017.144","article-title":"WNT signalling in prostate cancer","volume":"14","author":"Murillo-Garz\u00f3n","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1060","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1210\/me.2003-0436","article-title":"Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells","volume":"18","author":"Masiello","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1065","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2121-9-4","article-title":"The androgen receptor can signal through Wnt\/beta-catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens","volume":"9","author":"Schweizer","year":"2008","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137103","article-title":"Similarities and distinctions in actions of surface-directed and classic androgen receptor antagonists","volume":"10","author":"Suh","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2018.06.014_bib1075","first-page":"303","article-title":"Phospho-regulation of beta-catenin adhesion and signaling functions","volume":"22","author":"Daugherty","year":"2007","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.reprotox.2018.06.014_bib1080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10930-017-9696-z","article-title":"Phosphorylation: implications in cancer","volume":"36","author":"Singh","year":"2017","journal-title":"Protein J."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1085","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1074\/jbc.275.7.5090","article-title":"Casein kinase II phosphorylation of E-cadherin increases E-cadherin\/beta-catenin interaction and strengthens cell-cell adhesion","volume":"275","author":"Lickert","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1090","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2174\/0929867311302010014","article-title":"Increased Akt signaling resulting from the loss of androgen responsiveness in prostate cancer","volume":"20","author":"Dulinska-Litewka","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2131\/jts.27.19","article-title":"Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats","volume":"27","author":"Miyata","year":"2002","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1100","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/toxsci\/kfi159","article-title":"Changes in androgen-mediated reproductive development in male rat offspring following exposure to a single oral dose of flutamide at different gestational ages","volume":"85","author":"Foster","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1105","doi-asserted-by":"crossref","first-page":"293","DOI":"10.12717\/DR.2014.18.4.293","article-title":"Expressional modulation of connexin isoforms in the initial segment of male rat treated with estradiol benzoate or flutamide","volume":"18","author":"Lee","year":"2014","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.12717\/DR.2015.19.1.043","article-title":"Exogenous exposure to estradiol benzoate or flutamide at the weaning age alters expression of connexin isoforms in the initial segment of male rat","volume":"19","author":"Lee","year":"2015","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.12717\/DR.2015.19.2.069","article-title":"Modification of gene expression of connexins in the rat corpus epididymis by estradiol benzoate or flutamide exposure at the early neonatal age","volume":"19","author":"Lee","year":"2015","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.12717\/DR.2015.19.4.217","article-title":"Aberrant expression of connexin isoforms in the corpus epididymis of the adult rat by exposure to estradiol benzoate or flutamide at the weaning age","volume":"19","author":"Lee","year":"2015","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1125","doi-asserted-by":"crossref","first-page":"237","DOI":"10.12717\/DR.2016.20.3.237","article-title":"Changes in expression of connexin isoforms in the caudal epididymis of adult sprague-dawley rats exposed to estradiol benzoate or flutamide at the neonatal age","volume":"20","author":"Lee","year":"2016","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.12717\/DR.2017.21.3.317","article-title":"Expressional changes of connexin isoform genes in the rat caput epididymis exposed to flutamide or estradiol benzoate at the early postnatal age","volume":"21","author":"Lee","year":"2017","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.reprotox.2018.06.014_bib1135","doi-asserted-by":"crossref","first-page":"379","DOI":"10.12717\/DR.2017.21.4.379","article-title":"Aberrant expression of Cx isoforms in the adult caput epididymis exposed to estradiol benzoate or flutamide at the weaning","volume":"21","author":"Lee","year":"2017","journal-title":"Dev. Reprod."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623818301266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623818301266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:48:21Z","timestamp":1760190501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623818301266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":227,"alternative-id":["S0890623818301266"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2018.06.014","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of flutamide on cell-cell junctions in the testis, epididymis, and prostate","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2018.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}