{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:13:54Z","timestamp":1784913234922,"version":"3.55.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.reprotox.2018.08.010","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T12:30:36Z","timestamp":1533904236000},"page":"188-195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Potential hazards of bisphenol A exposure to semen quality and sperm DNA integrity among infertile men"],"prefix":"10.1016","volume":"81","author":[{"given":"Ghada Ali","family":"Omran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham Diab","family":"Gaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa Ahmed Mohamad","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham Maher","family":"Abdel-Gaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emadeldeen Ali","family":"Salah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2018.08.010_bib0005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"Bisphenol A and human health: a review of the literature","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0010","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.toxlet.2007.11.001","article-title":"Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons","volume":"176","author":"Le","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0015","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1289\/ehp.7505","article-title":"Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-\u03b1\u2013mediated Ca(2+) fluxes and prolactin release in GH3\/B6 pituitary tumor cells","volume":"113","author":"Wozniak","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/toxsci\/kfg150","article-title":"Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor","volume":"75","author":"Lee","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0025","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jsbmb.2006.09.017","article-title":"Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption","volume":"102","author":"Thomas","year":"2006","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0030","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.steroids.2006.11.002","article-title":"Xenoestrogens are potent activators of nongenomic estrogenic responses","volume":"72","author":"Watson","year":"2007","journal-title":"Steroids"},{"key":"10.1016\/j.reprotox.2018.08.010_bib0035","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1210\/en.2003-1174","article-title":"Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol a is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat leydig cells","volume":"145","author":"Akingbemi","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2018.08.010_bib0040","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1050","article-title":"Prostate cancer risk and DNA methylation signatures in aging rats following developmental BPA exposure: a dose\u2013response analysis","volume":"125","author":"Prins","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0045","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1158\/0008-5472.CAN-06-0516","article-title":"Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4","volume":"66","author":"Ho","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0050","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1210\/er.2008-0021","article-title":"Bisphenol-a and the great divide: a review of controversies in the field of endocrine disruption","volume":"30","author":"Vandenberg","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tox.2006.06.009","article-title":"Human exposure to bisphenol A","volume":"226","author":"Kang","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2018.08.010_bib0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.envres.2006.04.006","article-title":"An observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol-A, and nonylphenol at home and daycare","volume":"103","author":"Wilson","year":"2007","journal-title":"Environ. Res."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0065","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1289\/ehp.5494","article-title":"Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity","volume":"111","author":"Welshons","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0070","article-title":"4\u2019-isopropylidenediphe European Union Risk Assessment Report: 4, V. 37. E.C. nol (BPA) \u2013 3rd Priority List","year":"2003","journal-title":"J. Res."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0075","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1021\/tx025548t","article-title":"Metabolism and kinetics of bisphenol a in humans at low doses following oral administration","volume":"15","author":"V\u00f6lkel","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0080","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.taap.2007.12.008","article-title":"Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures","volume":"228","author":"Dekant","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0085","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0015-0282(02)03105-9","article-title":"Best practice policies for male infertility","volume":"77","author":"Sharlip","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0090","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0095","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1289\/ehp.1307728","article-title":"Bisphenol A and reproductive health: update of experimental and human evidence, 2007\u20132013","volume":"122","author":"Peretz","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0100","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1001\/jama.2013.283735","article-title":"Handling of thermal receipts as a source of exposure to bisphenol A","volume":"311","author":"Ehrlich","year":"2014","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0105","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1289\/ehp.1002037","article-title":"Are environmental levels of bisphenol A associated with reproductive function in fertile men?","volume":"118","author":"Mendiola","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0110","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.envint.2016.01.021","article-title":"Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic","volume":"89\u201390","author":"Vitku","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0115","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.reprotox.2014.11.003","article-title":"Urinary bisphenol A and semen quality, the LIFE study","volume":"51","author":"Goldstone","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0120","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.reprotox.2010.07.005","article-title":"Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic","volume":"30","author":"Meeker","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0125","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.33549\/physiolres.933090","article-title":"Differences in bisphenol A and estrogen levels in the plasma and seminal plasma of men with different degrees of infertility","volume":"64","author":"Vitku","year":"2015","journal-title":"Physiol. Res."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0130","series-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010"},{"key":"10.1016\/j.reprotox.2018.08.010_bib0135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.toxlet.2008.05.002","article-title":"Determination of free and total bisphenol A in human urine to assess daily uptake as a basis for a valid risk assessment","volume":"179","author":"V\u00f6lkel","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0140","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.envres.2010.10.001","article-title":"Determination of free and total bisphenol A in urine of infants","volume":"111","author":"V\u00f6lkel","year":"2011","journal-title":"Environ. Res."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0145","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bbrc.2003.10.135","article-title":"Gender differences in the levels of bisphenol A metabolites in urine","volume":"312","author":"Kim","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0150","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jchromb.2005.11.024","article-title":"High-performance liquid chromatographic analysis of bisphenol A and 4-nonylphenol in serum, liver and testis tissues after oral administration to rats and its application to toxicokinetic study","volume":"830","author":"Xiao","year":"2006","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.reprotox.2018.08.010_bib0155","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mrfmmm.2009.02.017","article-title":"DNA integrity and semen quality in men with low seminal antioxidant levels","volume":"665","author":"Shamsi","year":"2009","journal-title":"Mutat. Res. - Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0165","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.theriogenology.2004.08.004","article-title":"DNA integrity in sexed bull sperm assessed by neutral Comet assay and sperm chromatin structure assay","volume":"63","author":"Boe-Hansen","year":"2005","journal-title":"Theriogenology"},{"key":"10.1016\/j.reprotox.2018.08.010_bib0170","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/toxsci\/54.1.104","article-title":"The influence of antioxidants on cigarette smoke-induced DNA single-strand breaks in mouse organs: a preliminary study with the alkaline single cell gel electrophoresis assay","volume":"54","author":"Tsuda","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0175","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1383-5718(02)00251-6","article-title":"A cross-platform public domain PC image-analysis program for the comet assay","volume":"534","author":"Ko\u0144ca","year":"2003","journal-title":"Mutat. Res. - Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0180","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ymeth.2009.02.016","article-title":"The comet assay: a sensitive method for detecting DNA damage in individual cells","volume":"48","author":"Liao","year":"2009","journal-title":"Methods"},{"key":"10.1016\/j.reprotox.2018.08.010_bib0185","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2307\/3577587","article-title":"Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the \u201ccomet\u201d assay","volume":"122","author":"Olive","year":"1990","journal-title":"Radiat. Res."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0190","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/jcp.54.5.356","article-title":"Papers method for the measurement of antioxidant activity in human fluids","volume":"54","author":"Koracevic","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0195","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0200","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1289\/ehp.10753","article-title":"Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0205","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1289\/ehp.7534","article-title":"Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population","volume":"113","author":"Calafat","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0210","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.envres.2009.04.003","article-title":"Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels","volume":"109","author":"He","year":"2009","journal-title":"Environ. Res."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0215","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1006\/bbrc.2000.3710","article-title":"Estrogenic alkylphenols induce cell death by inhibiting testis endoplasmic reticulum Ca(2+) pumps","volume":"277","author":"Hughes","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0220","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.reprotox.2004.08.003","article-title":"Effects of neonatal administration of 17\u03b2-estradiol, \u03b2-estradiol 3-benzoate, or bisphenol A on mouse and rat spermatogenesis","volume":"19","author":"Toyama","year":"2004","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0225","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2164\/jandrol.110.010413","article-title":"Relationship between urine bisphenol-A Level and declining male sexual function","volume":"31","author":"Li","year":"2010","journal-title":"J. Androl."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0230","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0300-483X(02)00597-8","article-title":"Induction of oxidative stress by bisphenol A in the epididymal sperm of rats","volume":"185","author":"Chitra","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2018.08.010_bib0235","first-page":"172","article-title":"Oxidative stress and sperm mitochondrial DNA mutation in idiopathic oligoasthenozoospermic men","volume":"46","author":"Kumar","year":"2009","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0240","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1093\/humrep\/deh444","article-title":"Urinary levels of insecticide metabolites and DNA damage in human sperm","volume":"19","author":"Meeker","year":"2004","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0245","first-page":"675","article-title":"Comet assay: a prognostic tool for DNA integrity assessment in infertile men opting for assisted reproduction","volume":"131","author":"Shamsi","year":"2010","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0250","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jhazmat.2013.01.061","article-title":"Association of exposure to phenols and idiopathic male infertility","volume":"250\u2013251","author":"Chen","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0255","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jbt.21459","article-title":"Fetal liver bisphenol A concentrations and biotransformation gene expression reveal variable exposure and altered capacity for metabolism in humans","volume":"27","author":"Nahar","year":"2013","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055387","article-title":"Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations","volume":"8","author":"Manikkam","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2018.08.010_bib0265","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrendo.2015.206","article-title":"Endocrine disruptors in 2015: epigenetic transgenerational inheritance","volume":"12","author":"Skinner","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.reprotox.2018.08.010_bib0270","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1152\/physrev.00017.2015","article-title":"Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility","volume":"96","author":"Skakkebaek","year":"2015","journal-title":"Physiol. Rev."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623818300789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623818300789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:51:44Z","timestamp":1760190704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623818300789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":54,"alternative-id":["S0890623818300789"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2018.08.010","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential hazards of bisphenol A exposure to semen quality and sperm DNA integrity among infertile men","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2018.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}