{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:51:39Z","timestamp":1782496299772,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Minister of Scienti\ufb01c- Research, Tunisia, through a grant to the lab. Pharmacology (Research Unit of Pharmacology and Toxicology of Xenobiotics","award":["UR12 ES13"],"award-info":[{"award-number":["UR12 ES13"]}]},{"name":"Faculty of Medicine of Sfax"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.reprotox.2019.02.007","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T22:40:25Z","timestamp":1550788825000},"page":"75-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Safety assessment of cefuroxime on male reproductive system: Subacute toxicity and potential reversibility after a complete cycle of spermatogenesis and epididymal maturation in Wistar rats"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-8833","authenticated-orcid":false,"given":"Amal","family":"Tahri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4330-7363","authenticated-orcid":false,"given":"Salima","family":"Daoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim","family":"Kallel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilia","family":"Ksouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahia","family":"Boudawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zouheir","family":"Sahnoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2019.02.007_bib0005","series-title":"Cephalosporins: Cefuroxime Sodium. Cefuroxime Axetil","first-page":"223","author":"McEvoy","year":"2003"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0010","first-page":"209","volume":"vol. 20","author":"Wozniak","year":"1991"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0015","first-page":"304","volume":"28","author":"Alejo","year":"1982","journal-title":"Chemotherapy"},{"issue":"2","key":"10.1016\/j.reprotox.2019.02.007_bib0020","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1128\/AAC.41.2.445","article-title":"Nonlinear intestinal absorption kinetics of cefuroxime axetil in rats","volume":"41","author":"Ruiz-Balaguer","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0025","first-page":"273","article-title":"Cefuroxime treatment of bacterial meningitis in infants and children","author":"Sayomporn","year":"1984","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0030","first-page":"35","article-title":"Modification of spermatogenesis following antibiotic therapy","volume":"57","author":"Timmermans","year":"1989","journal-title":"Acta Urol."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0035","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ejps.2003.10.006","article-title":"Casab\u00f3 Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime","volume":"21","author":"Ruiz-Carretero","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0040","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1530\/reprod\/118.1.29","article-title":"Effects of an organophosphate pesticide, quinalphos, on the hypothalamo-pituitary-gonadal axis in adult male rats","volume":"118","author":"Sarkar","year":"2000","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0045","first-page":"80","article-title":"Duration of seminiferous epithelium of normal hypophysectomized and hypophysectomized hormone treated albino rats","volume":"79","author":"Clermont","year":"1964","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0050","first-page":"519","article-title":"Protection post-testiculaire des gam\u00e8tes m\u00e2les contre les dommages radicalaires, Le r\u00f4le de l\u2019\u00e9pididyme","volume":"28","author":"Noblanc","year":"2012","journal-title":"M\/S"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0055","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0020-1383(16)30599-X","article-title":"Effect of cefazolin and cefuroxime on fracture healing in rats","volume":"47S3","author":"Natividad-Pedre\u00f1oa","year":"2016","journal-title":"Injury Int. J. Care Injured"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0060","article-title":"Does cefuroxime alter fracture healing in vivo? A micro-computertomographic, biomechanical, and histomorphometric evaluation using a rat fracture model","author":"Bissinger","year":"2016","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0378-5173(00)00420-8","article-title":"Pharmacokinetics and absolute bioavailability of oral cefuroxime axetil in the rat","volume":"202","author":"Ruiz-Carretero","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0070","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1439-0272.2009.00961.x","article-title":"Long-term o\ufb02oxacin testicular toxicity: an experimental study","volume":"42","author":"EL-Harouny","year":"2010","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0075","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/humrep\/deg199","article-title":"Evaluation of the one-step eosin-nigrosin technique for human sperm vitality assessment","volume":"18","author":"Bjorndahl","year":"2003","journal-title":"Human Reprod."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0080","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1530\/jrf.0.0080149","article-title":"Factors affecting haemocytometer counts of sperm concentration in human semen","volume":"42","author":"Freund","year":"1964","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0085","series-title":"Applied Animal Reproduction","first-page":"147","article-title":"Semen collection","author":"Bearden","year":"1997"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0090","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0095","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay of lipid peroxides in animal tissues by thiobarbituric acid reactions","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0100","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","article-title":"A simple method for clinical assay of superoxide dismutase","volume":"34","author":"Sun","year":"1988","journal-title":"Clin. Chem."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0110","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidise","author":"Paglia","year":"1967","journal-title":"S. Afr. J. Lab. Clin. Med."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0115","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2165\/00003088-199426050-00004","article-title":"Drugs in semen","volume":"26","author":"Pichini","year":"1994","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0120","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.clpt.2006.04.013","article-title":"Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a noninvasive method","volume":"80","author":"Ndovi","year":"2006","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0125","series-title":"The Effects of perinatal\/juvenile Methoxychlor Exposure on Adult Rat Nervous, Immune and Reproductive System Function","author":"Chapin","year":"1997"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0130","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0015-0282(16)54108-9","article-title":"Antibiotics: potential hazards to male fertility","volume":"55","author":"Schlegel","year":"1991","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0135","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/and.12303","article-title":"Recovery of lead-induced suppressed reproduction in male rats by testosterone","volume":"47","author":"Reshma Anjum","year":"2015","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0140","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1210\/er.2008-0025","article-title":"Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell- specificandrogenreceptorsknockoutsmice","volume":"30","author":"Wang","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0145","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/toxsci\/69.1.79","article-title":"Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators","volume":"69","author":"O\u2019Connor","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0150","first-page":"757","article-title":"Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: A promising male contraceptive approach","volume":"81","author":"Bebb","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0155","first-page":"36","article-title":"Serum concentration of testosterone, epididymal mast cell population and histamine content in relation to sperm count and their motility in albino rats following H2 receptor blocker treatment","volume":"8","author":"Sinha","year":"2006","journal-title":"Nepal. Med. Coll.J"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0160","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2605.1986.tb00886.x","article-title":"Increase in fluid viscosity during epididymal transit and the immobilization of rat epididymal spermatozoa","volume":"3","author":"Eksittikul","year":"1986","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0165","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s11626-016-0061-x","article-title":"Mitochondrial membrane potential (MMP) regulates sperm motility","volume":"9","author":"Agnihotri","year":"2016","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0170","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2174\/1381612043384664","article-title":"Oxygen, reactive oxygen species and tissue damage","volume":"10","author":"Bergamini","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0175","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/mrd.1120240202","article-title":"Lipid peroxidation in human spermatozoa as related to midpiece abnormalities and motality","volume":"24","author":"Rao","year":"1989","journal-title":"Gamete Res."},{"issue":"2","key":"10.1016\/j.reprotox.2019.02.007_bib0180","first-page":"73","article-title":"Role of free radical in male infertility","volume":"70","author":"Pandev","year":"2000","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0185","series-title":"Toxicology of Organophosphates and Carbamate Compounds, 5th Edn. Boston, USA","first-page":"411","author":"Gupta","year":"2006"},{"key":"10.1016\/j.reprotox.2019.02.007_bib0190","doi-asserted-by":"crossref","first-page":"24407","DOI":"10.1074\/jbc.M701589200","article-title":"Catalase takes part in rat liver mitochondria oxidative stress defense","volume":"282","author":"Salvi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0195","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pestbp.2010.11.002","article-title":"Subacute chlorpyrifos-induced oxidative stress in rat erythrocytes and the protective effects of catechin and quercetin","volume":"99","author":"Demir","year":"2011","journal-title":"Pesticide Biochem. Physiol."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0200","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ecoenv.2007.12.018","article-title":"Antioxidant effect of propolis against exposure to propetamphos in rats","volume":"72","author":"Kanbur","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.reprotox.2019.02.007_bib0205","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.biopha.2017.08.039","article-title":"A carbapenem antibiotic imipenem\/cilastatin induces an oxidative stress-status and gonadotoxic effects in \u00abwistar \u00bb rats","author":"Tahri","year":"2017","journal-title":"Biomed. Pharmacother."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623818305161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623818305161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:44:24Z","timestamp":1782139464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623818305161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":41,"alternative-id":["S0890623818305161"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2019.02.007","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety assessment of cefuroxime on male reproductive system: Subacute toxicity and potential reversibility after a complete cycle of spermatogenesis and epididymal maturation in Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2019.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}