{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:14:57Z","timestamp":1790820897818,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Union's Horizon 2020 research and innovation programme","award":["681002"],"award-info":[{"award-number":["681002"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.reprotox.2020.02.010","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T02:36:10Z","timestamp":1582857370000},"page":"219-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs"],"prefix":"10.1016","volume":"93","author":[{"given":"S\u00e9gol\u00e8ne","family":"Sim\u00e9on","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Brotzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Silvester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Maclennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Braunbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic Y.","family":"Bois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2020.02.010_bib0005","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/kfi110","article-title":"Zebrafish as a model vertebrate for investigating chemical toxicity","volume":"86","author":"Hill","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0010","doi-asserted-by":"crossref","DOI":"10.1039\/C7EM00495H","article-title":"Modelling oral up-take of hydrophobic and super-hydrophobic chemicals in fish","author":"Larisch","year":"2018","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0015","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/etc.3677","article-title":"A toxicokinetic model for fish including multiphase sorption features: a high-detailed, physiologically based toxicokinetic model","volume":"36","author":"Larisch","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0020","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1051\/medsci\/20153106017","article-title":"Regard \u00e0 travers le danio pour mieux comprendre les interactions h\u00f4te\/pathog\u00e8ne","volume":"31","author":"Bernut","year":"2015","journal-title":"MdecineSciences"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/817341","article-title":"Think Small: Zebrafish as a Model System of Human Pathology","volume":"2012","author":"Goldsmith","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"issue":"Suppl 1","key":"10.1016\/j.reprotox.2020.02.010_bib0030","first-page":"38","article-title":"DarT: The embryo test with the Zebrafish Danio rerio--a general model in ecotoxicology and toxicology","volume":"19","author":"Nagel","year":"2002","journal-title":"ALTEX."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0035","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ntt.2018.01.008","article-title":"In vivo study of teratogenic and anticonvulsant effects of antiepileptics drugs in zebrafish embryo and larvae","volume":"66","author":"Martinez","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0045","doi-asserted-by":"crossref","first-page":"553","DOI":"10.4267\/10608\/4405","article-title":"Le poisson z\u00e8bre (danio rerio) un mod\u00e8le en biologie du d\u00e9veloppement","volume":"7","author":"Ekker","year":"1991","journal-title":"MdecineSciences"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0050","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.scitotenv.2017.09.257","article-title":"Modification and quantification of in vivo EROD live-imaging with zebrafish (Danio rerio) embryos to detect both induction and inhibition of CYP1A","volume":"615","author":"Kais","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0055","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.reprotox.2011.06.121","article-title":"Zebrafish embryos as an alternative to animal experiments\u2014a commentary on the definition of the onset of protected life stages in animal welfare regulations","volume":"33","author":"Str\u00e4hle","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0060","series-title":"In Vitro Toxicology Systems","first-page":"531","article-title":"Extrapolating in vitro results to predict human toxicity","author":"Quignot","year":"2014"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0065","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/etc.5620111205","article-title":"Toxicokinetics in aquatic systems: model comparisons and use in hazard assessment","volume":"11","author":"Landrum","year":"1992","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0070","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.scitotenv.2016.01.107","article-title":"Variation in predicted internal concentrations in relation to PBPK model complexity for rainbow trout","volume":"550","author":"Salmina","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0075","series-title":"Ecotoxicology Modeling","first-page":"145","article-title":"Physiologically based toxicokinetic (PBTK) modeling in ecotoxicology","author":"Krishnan","year":"2009"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0080","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.scitotenv.2018.01.068","article-title":"Predicting cadmium and lead toxicities in zebrafish (Danio rerio) larvae by using a toxicokinetic\u2013toxicodynamic model that considers the effects of cations","volume":"625","author":"Feng","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0085","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1039\/C7EM00474E","article-title":"Evaluating parameter availability for physiologically based pharmacokinetic (PBPK) modeling of perfluorooctanoic acid (PFOA) in zebrafish","volume":"20","author":"Khazaee","year":"2018","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0090","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1021\/es404301q","article-title":"A physiologically based toxicokinetic model for the zebrafish Danio rerio","volume":"48","author":"P\u00e9ry","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0095","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.scitotenv.2018.09.163","article-title":"Generic physiologically-based toxicokinetic modelling for fish: integration of environmental factors and species variability","volume":"651","author":"Grech","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0100","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1021\/acs.est.5b06158","article-title":"Cross-species extrapolation of uptake and disposition of neutral organic chemicals in fish using a multispecies physiologically-based toxicokinetic model framework","volume":"50","author":"Brinkmann","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0105","doi-asserted-by":"crossref","first-page":"10264","DOI":"10.1021\/acs.est.6b04325","article-title":"Toxicokinetics of polar chemicals in zebrafish embryo (Danio rerio): influence of physicochemical properties and of biological processes","volume":"50","author":"Brox","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0110","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/0045-6535(92)90035-P","article-title":"Measuring bioconcentration factors and rate constants of chemicals in aquatic organisms under conditions of variable water concentrations and short exposure time","volume":"25","author":"Gobas","year":"1992","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0115","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/toxsci\/kfx116","article-title":"Intrinsic xenobiotic metabolizing enzyme activities in early life stages of zebrafish (Danio rerio)","volume":"159","author":"Otte","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tiv.2018.12.017","article-title":"VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays","volume":"58","author":"Fisher","year":"2019","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0125","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/bdra.23277","article-title":"Brief report novel mechanism for valproate-induced teratogenicity: novel Mechanism for Valproate-Induced Teratogenicity","volume":"100","author":"Fathe","year":"2014","journal-title":"Birth Defects Res. Part A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043692","article-title":"Valproic acid downregulates RBP4 and elicits hypervitaminosis A-Teratogenesis\u2014a kinetic analysis on Retinol\/Retinoic acid homeostatic system","volume":"7","author":"Chuang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0135","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0140","series-title":"Fish Embryo Toxicity Assays (UBA Contract Number 20385422)","author":"Braunbeck","year":"2006"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0145","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.cbpc.2008.11.006","article-title":"Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test?","volume":"149","author":"Lammer","year":"2009","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0150","doi-asserted-by":"crossref","first-page":"16247","DOI":"10.1007\/s11356-014-3814-7","article-title":"The fish embryo test (FET): origin, applications, and future","volume":"22","author":"Braunbeck","year":"2015","journal-title":"Environ. Sci. Pollut. Res. - Int."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.aquatox.2009.12.008","article-title":"The fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research","volume":"97","author":"Embry","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0160","unstructured":"ISO, International Organization for Standardization. Water quality - Determination of the 28 acute lethal toxicity of substances to a freshwater fish [Brachydanio rerio Hamilton-Buchanan 29 (Teleostei, Cyprinidae)]. ISO 7346-3: Flow-through method. Available: [http:\/\/www.iso.org]., (1996)."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0165","series-title":"OECD Guidelines for the Testing of Chemicals. Fish Embryo Acute Toxicity (FET) Test","author":"OECD","year":"2013"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0170","first-page":"87","article-title":"Towards an alternative for the acute fish LC(50) test in chemical assessment: the fish embryo toxicity test goes multi-species -- an update","volume":"22","author":"Braunbeck","year":"2005","journal-title":"ALTEX"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0175","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1065\/jss2003.09.085","article-title":"A new sediment contact assay to assess particle-bound pollutants using zebrafish (danio rerio) embryos","volume":"3","author":"Hollert","year":"2003","journal-title":"J. Soils Sediments"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0180","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134755","article-title":"Body mass parameters, lipid profiles and protein contents of zebrafish embryos and effects of 2,4-dinitrophenol exposure","volume":"10","author":"Hachicho","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0190","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/(SICI)1097-010X(19970815)278:6<356::AID-JEZ3>3.0.CO;2-N","article-title":"Water distribution and permeability of zebrafish embryos, Brachydanio rerio","volume":"278","author":"Hagedorn","year":"1997","journal-title":"J. Exp. Zool."},{"issue":"suppl. 5","key":"10.1016\/j.reprotox.2020.02.010_bib0195","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1289\/ehp.00108s5883","article-title":"Statistical issues in toxicokinetic modeling: a Bayesian perspective","volume":"108","author":"Bernillon","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0200","first-page":"597","article-title":"Bayesian inference","volume":"Vol. II","author":"Bois","year":"2012"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.2517-6161.1993.tb01466.x","article-title":"Bayesian computation via the Gibbs sampler and related Markov chain Monte Carlo methods","volume":"55","author":"Smith","year":"1993","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0210","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1214\/ss\/1177011136","article-title":"Inference from iterative simulation using multiple sequences (with discussion)","volume":"7","author":"Gelman","year":"1992","journal-title":"Stat. Sci."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0215","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0041-008X(90)90338-U","article-title":"A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish","volume":"106","author":"Nichols","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0220","series-title":"R: a Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2013"},{"key":"10.1016\/j.reprotox.2020.02.010_bib0225","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/bioinformatics\/btp162","article-title":"Bayesian statistical inference for SBML-coded systems biology models","volume":"25","author":"Bois","year":"2009","journal-title":"Bioinformatics."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0230","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.tiv.2016.07.013","article-title":"Theoretical and mathematical foundation of the Virtual Cell based Assay \u2013 a review","volume":"45","author":"Comenges","year":"2017","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0235","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.scitotenv.2013.10.068","article-title":"Metabolic biotransformation half-lives in fish: QSAR modeling and consensus analysis","volume":"470\u2013471","author":"Papa","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0240","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1897\/08-289.1","article-title":"A Quantitative structure\u2013activity relationship for predicting metabolic biotransformation rates for organic chemicals in fish","volume":"28","author":"Arnot","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.reprotox.2020.02.010_bib0245","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1741-7007-11-69","article-title":"Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos","volume":"11","author":"Fischer","year":"2013","journal-title":"BMC Biol."}],"updated-by":[{"DOI":"10.1016\/j.reprotox.2020.10.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000}}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089062382030023X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089062382030023X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T06:46:02Z","timestamp":1722494762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089062382030023X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":49,"alternative-id":["S089062382030023X"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2020.02.010","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.reprotox.2020.10.006","asserted-by":"object"}]},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2020.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}