{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:15:23Z","timestamp":1790176523695,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.reprotox.2020.12.018","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T01:58:43Z","timestamp":1609120723000},"page":"42-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature"],"prefix":"10.1016","volume":"100","author":[{"given":"Maria Cristina","family":"Budani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-2586","authenticated-orcid":false,"given":"Stefania","family":"Fensore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Di Marzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-5230","authenticated-orcid":false,"given":"Gian Mario","family":"Tiboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2020.12.018_bib0005","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1517\/17425251003592111","article-title":"Molecular aspects of azoles-induced teratogenesis","volume":"6","author":"Marotta","year":"2010","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0010","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1086\/514977","article-title":"Antifungal therapy during pregnancy","volume":"27","author":"King","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0015","series-title":"Clin Calc.","author":"Fluconazole - Drug Usage Statistics","year":"2020"},{"key":"10.1016\/j.reprotox.2020.12.018_bib0020","first-page":"381","article-title":"Second branchial arch anomalies induced by fluconazole, a bis-triazole antifungal agent, in cultured mouse embryos","volume":"79","author":"Tiboni","year":"1993","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0025","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1203\/01.PDR.0000166754.24957.73","article-title":"Murine teratology of fluconazole: evaluation of developmental phase specificity and dose dependence","volume":"58","author":"Tiboni","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.reprotox.2009.01.001","article-title":"Fluconazole alters CYP26 gene expression in mouse embryos","volume":"27","author":"Tiboni","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0035","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1097\/00006454-199211120-00017","article-title":"Congenital malformations in an infant born to a woman treated with fluconazole","volume":"11","author":"Lee","year":"1992","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0040","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/bdra.20189","article-title":"Prenatal exposure to fluconazole: an identifiable dysmorphic phenotype","volume":"73","author":"Lopez-Rangel","year":"2005","journal-title":"Birth Defects Res, A Clin. Mol. Teratol."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0045","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/clinids\/22.2.336","article-title":"Fluconazole-induced congenital anomalies in three infants","volume":"22","author":"Pursley","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0050","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/(SICI)1096-8628(19971031)72:3<253::AID-AJMG1>3.0.CO;2-S","article-title":"Multiple malformation syndrome following fluconazole use in pregnancy: report of an additional patient","volume":"72","author":"Aleck","year":"1997","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0055","first-page":"115","article-title":"Safety of fluconazole in the treatment of vaginal candidiasis. A prescription-event monitoring study, with special reference to the outcome of pregnancy","volume":"46","author":"Inman","year":"1994","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0060","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1592\/phco.19.3.221.30919","article-title":"Pregnancy outcomes after maternal exposure to fluconazole","volume":"19","author":"Jick","year":"1999","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.reprotox.2020.12.018_bib0065","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/S0002-9378(96)70119-9","article-title":"Prospective assessment of pregnancy outcomes after first-trimester exposure to fluconazole","volume":"175","author":"Mastroiacovo","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0070","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/jac\/dkn157","article-title":"Maternal use of fluconazole and risk of congenital malformations: a danish population-based cohort study","volume":"62","author":"N\u00f8rgaard","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0075","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1046\/j.1365-2125.1999.00989.x","article-title":"Risk of malformations and other outcomes in children exposed to fluconazole in utero","volume":"48","author":"Sorensen","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0080","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1056\/NEJMoa1301066","article-title":"Oral fluconazole during pregnancy and risk of birth defects","volume":"369","author":"M\u00f8lgaard-Nielsen","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"657","key":"10.1016\/j.reprotox.2020.12.018_bib0085","first-page":"e1","article-title":"National birth defects prevention study, fluconazole use and birth defects in the national birth defects prevention study","volume":"214","author":"Howley","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0090","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jama.2015.17844","article-title":"Association between use of oral fluconazole during pregnancy and risk of spontaneous abortion and stillbirth","volume":"315","author":"M\u00f8lgaard-Nielsen","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.reprotox.2020.12.018_bib0095","doi-asserted-by":"crossref","first-page":"E179","DOI":"10.1503\/cmaj.180963","article-title":"Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies","volume":"191","author":"B\u00e9rard","year":"2019","journal-title":"CMAJ"},{"key":"10.1016\/j.reprotox.2020.12.018_bib0100","doi-asserted-by":"crossref","first-page":"m1494","DOI":"10.1136\/bmj.m1494","article-title":"Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study","volume":"369","author":"Zhu","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.reprotox.2020.12.018_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.reprotox.2020.12.018_bib0110","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0890-6238(01)00185-X","article-title":"Is this drug safe in pregnancy?","volume":"15","author":"Webster","year":"2001","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0115","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12940-017-0263-z","article-title":"Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study","volume":"16","author":"Mogensen","year":"2017","journal-title":"Environ. Health"},{"key":"10.1016\/j.reprotox.2020.12.018_bib0120","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.reprotox.2015.02.009","article-title":"Exposure to fluconazole and risk of congenital malformations in the offspring: a systematic review and meta-analysis","volume":"52","author":"Alsaad","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2020.12.018_bib0125","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1111\/1471-0528.15913","article-title":"The safety of oral fluconazole during the first trimester of pregnacy: a systematic review and meta-analysis","volume":"126","author":"Zhang","year":"2019","journal-title":"BJOG"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623820302914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623820302914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:53:35Z","timestamp":1760190815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623820302914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":25,"alternative-id":["S0890623820302914"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2020.12.018","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2020.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}