{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:11:52Z","timestamp":1782515512229,"version":"3.54.5"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.reprotox.2021.09.003","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T21:38:22Z","timestamp":1631741902000},"page":"221-231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study"],"prefix":"10.1016","volume":"105","author":[{"given":"Sumitaka","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiro","family":"Sata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3065-262X","authenticated-orcid":false,"given":"Atsuko","family":"Ikeda-Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1145-8917","authenticated-orcid":false,"given":"Houman","family":"Goudarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Mitsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiko","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8173-9269","authenticated-orcid":false,"given":"Reiko","family":"Kishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.reprotox.2021.09.003_bib0005","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1289\/EHP142","article-title":"The association of prenatal exposure to perfluorinated chemicals with glucocorticoid and androgenic hormones in cord blood samples: the Hokkaido study","volume":"125","author":"Goudarzi","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2021.09.003_bib0010","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.envint.2016.05.011","article-title":"Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido study on environment and children\u2019s health","volume":"94","author":"Itoh","year":"2016","journal-title":"Environ. Int."},{"issue":"12","key":"10.1016\/j.reprotox.2021.09.003_bib0015","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1289\/ehp.1408847","article-title":"Prenatal exposure to perfluoroalkyl acids and serum testosterone concentrations at 15 years of age in female ALSPAC study participants","volume":"123","author":"Maisonet","year":"2015","journal-title":"Environ. Health Perspect."},{"issue":"12","key":"10.1016\/j.reprotox.2021.09.003_bib0020","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1093\/humrep\/det382","article-title":"Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction","volume":"28","author":"Kristensen","year":"2013","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.reprotox.2021.09.003_bib0025","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1289\/ehp.1205118","article-title":"Associations of in utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men","volume":"121","author":"Vested","year":"2013","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.reprotox.2021.09.003_bib0030","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1289\/ehp.11681","article-title":"Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth","volume":"117","author":"Washino","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.reprotox.2021.09.003_bib0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/aje\/kwk015","article-title":"Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review","volume":"165","author":"Olson","year":"2007","journal-title":"Am. J. Epidemiol."},{"issue":"12","key":"10.1016\/j.reprotox.2021.09.003_bib0040","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/jnci\/djh167","article-title":"Polymorphisms associated with circulating sex hormone levels in postmenopausal women","volume":"96","author":"Dunning","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"issue":"5","key":"10.1016\/j.reprotox.2021.09.003_bib0045","first-page":"1015","article-title":"The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer","volume":"59","author":"Haiman","year":"1999","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.reprotox.2021.09.003_bib0050","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1021\/tx034222x","article-title":"Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450","volume":"17","author":"Xu","year":"2004","journal-title":"Chem. Res. Toxicol."},{"issue":"22","key":"10.1016\/j.reprotox.2021.09.003_bib0055","doi-asserted-by":"crossref","first-page":"8566","DOI":"10.1021\/es901915f","article-title":"Isomer-specific biotransformation rates of a perfluorooctane sulfonate (PFOS)-precursor by cytochrome P450 isozymes and human liver microsomes","volume":"43","author":"Benskin","year":"2009","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.reprotox.2021.09.003_bib0060","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1021\/tx500470f","article-title":"Transformation pathways of isomeric perfluorooctanesulfonate precursors catalyzed by the active species of P450 enzymes: in silico investigation","volume":"28","author":"Fu","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.reprotox.2021.09.003_bib0065","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.chemosphere.2016.04.070","article-title":"Transcriptional changes in steroidogenesis by perfluoroalkyl acids (PFOA and PFOS) regulate the synthesis of sex hormones in H295R cells","volume":"155","author":"Kang","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2021.09.003_bib0070","doi-asserted-by":"crossref","first-page":"114241","DOI":"10.1016\/j.envpol.2020.114241","article-title":"Effects of gestational perfluorooctane sulfonate exposure on the developments of fetal and adult Leydig cells in F1 males","volume":"262","author":"Zhang","year":"2020","journal-title":"Environ. Pollut."},{"issue":"5","key":"10.1016\/j.reprotox.2021.09.003_bib0075","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1095\/biolreprod.110.089219","article-title":"Testicular signaling is the potential target of perfluorooctanesulfonate-mediated subfertility in male mice","volume":"84","author":"Wan","year":"2011","journal-title":"Biol. Reprod."},{"issue":"10","key":"10.1016\/j.reprotox.2021.09.003_bib0080","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1080\/09513590.2016.1177015","article-title":"Increased mood symptoms in postmenopausal women related to the polymorphism rs743572 of the CYP17 A1 gene","volume":"32","author":"Loja-Chango","year":"2016","journal-title":"Gynecol. Endocrinol."},{"issue":"7","key":"10.1016\/j.reprotox.2021.09.003_bib0085","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1007\/s13277-014-1876-2","article-title":"CYP17 polymorphism (rs743572) is associated with increased risk of gallbladder cancer in tobacco users","volume":"35","author":"Rai","year":"2014","journal-title":"Tumour Biol."},{"issue":"2","key":"10.1016\/j.reprotox.2021.09.003_bib0090","doi-asserted-by":"crossref","DOI":"10.4238\/gmr.15028640","article-title":"Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women","volume":"15","author":"Pan","year":"2016","journal-title":"Genet. Mol. Res."},{"issue":"5","key":"10.1016\/j.reprotox.2021.09.003_bib0095","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1007\/s13277-013-1594-1","article-title":"Genetic polymorphisms of ESR1, ESR2, CYP17A1, and CYP19A1 and the risk of breast cancer: a case control study from North India","volume":"35","author":"Chattopadhyay","year":"2014","journal-title":"Tumour Biol."},{"issue":"11","key":"10.1016\/j.reprotox.2021.09.003_bib0100","article-title":"Functional analyses of endometriosis-related polymorphisms in the estrogen synthesis and metabolism-related genes","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.reprotox.2021.09.003_bib0105","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1158\/1055-9965.EPI-08-0689","article-title":"Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the epidemiology of endometrial cancer consortium","volume":"18","author":"Setiawan","year":"2009","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"4","key":"10.1016\/j.reprotox.2021.09.003_bib0110","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1530\/EJE-10-0428","article-title":"Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure","volume":"163","author":"Shimodaira","year":"2010","journal-title":"Eur. J. Endocrinol."},{"issue":"6","key":"10.1016\/j.reprotox.2021.09.003_bib0115","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s10815-017-0911-9","article-title":"Involvement of 17\u03b2-hydroxysteroid dehydrogenase type gene 1 937 A&G polymorphism in infertility in Polish caucasian women with endometriosis","volume":"34","author":"Osi\u0144ski","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"issue":"3","key":"10.1016\/j.reprotox.2021.09.003_bib0120","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s12253-014-9746-1","article-title":"Association of genetic polymorphisms in HSD17B1, HSD17B2 and SHBG genes with hepatocellular carcinoma risk","volume":"20","author":"Zhang","year":"2014","journal-title":"Pathol. Oncol. Res."},{"issue":"8","key":"10.1016\/j.reprotox.2021.09.003_bib0125","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1111\/j.1743-6109.2009.01641.x","article-title":"Genetic polymorphisms of 17 \u03b2-hydroxysteroid dehydrogenase 3 and the risk of hypospadias","volume":"7","author":"Sata","year":"2010","journal-title":"J. Sex. Med."},{"issue":"3","key":"10.1016\/j.reprotox.2021.09.003_bib0130","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s12020-012-9699-7","article-title":"Estrogen synthesis genes CYP19A1, HSD3B1, and HSD3B2 in hypertensive disorders of pregnancy","volume":"42","author":"Shimodaira","year":"2012","journal-title":"Endocrine"},{"key":"10.1016\/j.reprotox.2021.09.003_bib0135","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mce.2018.08.004","article-title":"Role of hydroxysteroid (17beta) dehydrogenase type 1 in reproductive tissues and hormone-dependent diseases","volume":"489","author":"Heinosalo","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.reprotox.2021.09.003_bib0140","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fendo.2014.00187","article-title":"Environmental and genetic contributors to salivary testosterone levels in infants","volume":"5","author":"Xia","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"7","key":"10.1016\/j.reprotox.2021.09.003_bib0145","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.4049\/jimmunol.1501358","article-title":"Polymorphic HLA-C receptors balance the functional characteristics of KIR haplotypes","volume":"195","author":"Hilton","year":"2015","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.reprotox.2021.09.003_bib0150","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.4049\/jimmunol.1302517","article-title":"Donor killer cell Ig-like receptor B haplotypes, recipient HLA-C1, and HLA-C mismatch enhance the clinical benefit of unrelated transplantation for acute myelogenous leukemia","volume":"192","author":"Cooley","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.reprotox.2021.09.003_bib0155","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.reprotox.2016.08.020","article-title":"Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: biomarker assessment in the Hokkaido study","volume":"65","author":"Kobayashi","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2021.09.003_bib0160","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.reprotox.2016.12.002","article-title":"Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size: the Hokkaido study","volume":"67","author":"Kobayashi","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2021.09.003_bib0165","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.reprotox.2017.09.002","article-title":"Modification of adverse health effects of maternal active and passive smoking by genetic susceptibility: dose-dependent association of plasma cotinine with infant birth size among Japanese women-the Hokkaido study","volume":"74","author":"Kobayashi","year":"2017","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.reprotox.2021.09.003_bib0170","doi-asserted-by":"crossref","first-page":"9994","DOI":"10.1038\/s41598-021-89285-2","article-title":"Associations among perfluorooctanesulfonic\/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study","volume":"11","author":"Kobayashi","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.reprotox.2021.09.003_bib0175","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/pr.2017.70","article-title":"Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study","volume":"82","author":"Sasaki","year":"2017","journal-title":"Pediatr. Res."},{"issue":"3","key":"10.1016\/j.reprotox.2021.09.003_bib0180","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/ije\/dyq071","article-title":"Cohort profile: the Hokkaido study on environment and children\u2019s health in Japan","volume":"40","author":"Kishi","year":"2011","journal-title":"Int. J. Epidemiol."},{"issue":"6","key":"10.1016\/j.reprotox.2021.09.003_bib0185","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12199-013-0357-3","article-title":"Ten years of progress in the Hokkaido birth cohort study on environment and children\u2019s health: cohort profile--updated 2013","volume":"18","author":"Kishi","year":"2013","journal-title":"Environ. Health Prev. Med."},{"issue":"1","key":"10.1016\/j.reprotox.2021.09.003_bib0190","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12199-017-0654-3","article-title":"The Hokkaido birth cohort study on environment and children\u2019s health: cohort profile-updated 2017","volume":"22","author":"Kishi","year":"2017","journal-title":"Environ. Health Prev. Med."},{"issue":"11","key":"10.1016\/j.reprotox.2021.09.003_bib0195","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1289\/ehp.6864","article-title":"Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy","volume":"112","author":"Inoue","year":"2004","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.reprotox.2021.09.003_bib0200","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.toxlet.2013.03.013","article-title":"Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women","volume":"219","author":"Kobayashi","year":"2013","journal-title":"Toxicol. Lett."},{"issue":"10","key":"10.1016\/j.reprotox.2021.09.003_bib0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109039","article-title":"Association between maternal exposure to di(2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: the Hokkaido study on environment and children\u2019s health","volume":"9","author":"Araki","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2021.09.003_bib0210","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.envint.2018.04.046","article-title":"Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: the Hokkaido study","volume":"117","author":"Miyashita","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2021.09.003_bib0215","series-title":"Haploview 4.2. Software","author":"Broad Institute of Massachusetts Institute of Technology and Harvard, US","year":"2021"},{"issue":"5","key":"10.1016\/j.reprotox.2021.09.003_bib0220","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1095\/biolreprod.110.089219","article-title":"Testicular signaling is the potential target of perfluorooctanesulfonate-mediated subfertility in male mice","volume":"84","author":"Wan","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2021.09.003_bib0225","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chemosphere.2017.09.116","article-title":"Perfluorooctane sulfonate impairs rat Leydig cell development during puberty","volume":"190","author":"Li","year":"2018","journal-title":"Chemosphere"},{"issue":"10","key":"10.1016\/j.reprotox.2021.09.003_bib0230","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/hmg\/3.10.1873","article-title":"Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17","volume":"3","author":"Carey","year":"1994","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.reprotox.2021.09.003_bib0235","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0968-0004(86)90226-4","article-title":"Promoter-specific activation of RNA polymerase II transcription by Sp1","volume":"11","author":"Kadonaga","year":"1986","journal-title":"Trends Biochem. Sci."},{"issue":"10","key":"10.1016\/j.reprotox.2021.09.003_bib0240","first-page":"3955","article-title":"A polymorphism in CYP17 and endometrial cancer risk","volume":"61","author":"Haiman","year":"2001","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.reprotox.2021.09.003_bib0245","first-page":"585","article-title":"Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations","volume":"58","author":"Feigelson","year":"1998","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.reprotox.2021.09.003_bib0250","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10549-004-0780-7","article-title":"Association between the T27C polymorphism in the cytochrome P450 c17alpha (CYP17) gene and risk factors for breast cancer","volume":"88","author":"Hong","year":"2004","journal-title":"Breast Cancer Res. Treat."},{"issue":"2","key":"10.1016\/j.reprotox.2021.09.003_bib0255","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ijc.10651","article-title":"Relationship between serum hormone concentrations, reproductive history, alcohol consumption and genetic polymorphisms in pre-menopausal women","volume":"102","author":"Garc\u00eda-Closas","year":"2002","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.reprotox.2021.09.003_bib0260","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1158\/1055-9965.EPI-03-0026","article-title":"Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women","volume":"13","author":"Tworoger","year":"2004","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"1","key":"10.1016\/j.reprotox.2021.09.003_bib0265","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.rbmo.2013.03.009","article-title":"Reproductive hormone concentrations in pregnancy and neonates: a systematic review","volume":"27","author":"Kuijper","year":"2013","journal-title":"Reprod. Biomed. Online"},{"issue":"3","key":"10.1016\/j.reprotox.2021.09.003_bib0270","doi-asserted-by":"crossref","first-page":"176","DOI":"10.5582\/bst.2014.01014","article-title":"Effects of lifestyle factors on urinary oxidative stress and serum antioxidant markers in pregnant Japanese women: a cohort study","volume":"8","author":"Matsuzaki","year":"2014","journal-title":"Biosci. Trends"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623821001404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623821001404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:57:44Z","timestamp":1760191064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623821001404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":54,"alternative-id":["S0890623821001404"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2021.09.003","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2021.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}