{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:47:53Z","timestamp":1769521673356,"version":"3.49.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.reprotox.2022.01.005","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T05:20:26Z","timestamp":1643606426000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Metabolomic and transcriptomic responses of mouse testis to the dextran sulfate sodium induced colitis"],"prefix":"10.1016","volume":"108","author":[{"given":"Lei-Ning","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Bin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hao","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-Yun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Hong","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3339-7863","authenticated-orcid":false,"given":"Jun-Yu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0005","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis, nature reviews","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Dis. Primers"},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0010","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","article-title":"Crohn\u2019s disease, nature reviews","volume":"6","author":"Roda","year":"2020","journal-title":"Dis. Primers"},{"issue":"21","key":"10.1016\/j.reprotox.2022.01.005_bib0015","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"10114","key":"10.1016\/j.reprotox.2022.01.005_bib0020","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.reprotox.2022.01.005_bib0025","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.autrev.2017.02.013","article-title":"IBD immunopathogenesis: a comprehensive review of inflammatory molecules","volume":"16","author":"Park","year":"2017","journal-title":"Autoimmun. Rev."},{"issue":"Suppl 1","key":"10.1016\/j.reprotox.2022.01.005_bib0030","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000447281","article-title":"Immunopathogenesis of IBD: batf as a key driver of disease activity","volume":"34","author":"Hildner","year":"2016","journal-title":"Dig. Dis."},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0035","first-page":"13","article-title":"Immunopathogenesis of IBD: current state of the art, Nature reviews","volume":"13","author":"de Souza","year":"2016","journal-title":"Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.reprotox.2022.01.005_bib0040","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/cmi.2014.38","article-title":"Testicular defense systems: immune privilege and innate immunity","volume":"11","author":"Zhao","year":"2014","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"10.1016\/j.reprotox.2022.01.005_bib0045","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/13685538.2018.1482487","article-title":"The relationship between circulating testosterone and inflammatory cytokines in men","volume":"22","author":"Mohamad","year":"2019","journal-title":"Aging Male"},{"issue":"5","key":"10.1016\/j.reprotox.2022.01.005_bib0050","doi-asserted-by":"crossref","first-page":"E700","DOI":"10.1210\/jc.2011-2387","article-title":"Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia","volume":"97","author":"Burney","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12887-021-02496-4","article-title":"Growth, puberty, and bone health in children and adolescents with inflammatory bowel disease","volume":"21","author":"Jin","year":"2021","journal-title":"BMC Pediatr."},{"issue":"6","key":"10.1016\/j.reprotox.2022.01.005_bib0060","first-page":"1378","article-title":"Endogenous levels of circulating androgens and risk of Crohn\u2019s disease and ulcerative colitis among women: a nested case-control study from the nurses\u2019 health study cohorts","volume":"21","author":"Khalili","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"issue":"5","key":"10.1016\/j.reprotox.2022.01.005_bib0065","doi-asserted-by":"crossref","first-page":"R1483","DOI":"10.1152\/ajpregu.2001.281.5.R1483","article-title":"Delayed puberty and response to testosterone in a rat model of colitis, American journal of physiology","volume":"281","author":"Azooz","year":"2001","journal-title":"Regul. Integr. Compar. Physiol."},{"issue":"2","key":"10.1016\/j.reprotox.2022.01.005_bib0070","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/ecco-jcc\/jju006","article-title":"The second European evidenced-based consensus on reproduction and pregnancy in inflammatory bowel disease","volume":"9","author":"van der Woude","year":"2015","journal-title":"J. Crohns Colitis"},{"issue":"5","key":"10.1016\/j.reprotox.2022.01.005_bib0075","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/ecco-jcc\/jjy198","article-title":"Semen quality and sperm DNA integrity in patients with severe active inflammatory bowel disease and effects of tumour necrosis factor-alpha inhibitors","volume":"13","author":"Grosen","year":"2019","journal-title":"J. Crohns Colitis"},{"issue":"2","key":"10.1016\/j.reprotox.2022.01.005_bib0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1203\/00006450-200302000-00002","article-title":"Delayed puberty associated with inflammatory bowel disease","volume":"53","author":"Ballinger","year":"2003","journal-title":"Pediatr. Res."},{"issue":"2","key":"10.1016\/j.reprotox.2022.01.005_bib0085","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s003840100334","article-title":"Association of dehydroepiandrosterone sulfate and testosterone deficiency with bone turnover in men with inflammatory bowel disease","volume":"17","author":"Szathmari","year":"2002","journal-title":"Int. J. Colorectal Dis."},{"key":"10.1016\/j.reprotox.2022.01.005_bib0090","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jpeds.2016.01.003","article-title":"Increases in sex hormones during anti-tumor necrosis factor alpha therapy in adolescents with Crohn\u2019s disease","volume":"171","author":"DeBoer","year":"2016","journal-title":"J. Pediatr."},{"issue":"2","key":"10.1016\/j.reprotox.2022.01.005_bib0095","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jcmgh.2015.01.006","article-title":"Experimental models of inflammatory bowel diseases","volume":"1","author":"Kiesler","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.reprotox.2022.01.005_bib0100","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-394596-9.00009-3","article-title":"Animal models of inflammatory bowel disease","volume":"105","author":"Mizoguchi","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.reprotox.2022.01.005_bib0105","article-title":"Intestinal microbiota defines the GUT-TESTIS axis","author":"Martinot","year":"2021","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12859-017-1579-y","article-title":"metaX: a flexible and comprehensive software for processing metabolomics data","volume":"18","author":"Wen","year":"2017","journal-title":"BMC Bioinformatics"},{"issue":"D1","key":"10.1016\/j.reprotox.2022.01.005_bib0115","first-page":"D440","article-title":"MetaboLights: a resource evolving in response to the needs of its scientific community","volume":"48","author":"Haug","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.reprotox.2022.01.005_bib0120","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.reprotox.2022.01.005_bib0125","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"issue":"12","key":"10.1016\/j.reprotox.2022.01.005_bib0130","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.reprotox.2022.01.005_bib0140","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1210\/en.2009-0917","article-title":"7alpha-hydroxytestosterone affects 1 beta-hydroxysteroid dehydrogenase 1 direction in rat Leydig cells","volume":"151","author":"Hu","year":"2010","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0005-2760(77)90122-9","article-title":"Production and effects of 7 alpha-hydroxytestosterone on testosterone and dihydrotestosterone metabolism in rat testis","volume":"488","author":"Rosness","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.reprotox.2022.01.005_bib0150","first-page":"741","article-title":"Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion","volume":"33","author":"Zhang","year":"2015","journal-title":"Restor. Neurol. Neurosci."},{"issue":"6","key":"10.1016\/j.reprotox.2022.01.005_bib0155","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.dnarep.2010.03.004","article-title":"Oxygen as a friend and enemy: how to combat the mutational potential of 8-oxo-guanine","volume":"9","author":"van Loon","year":"2010","journal-title":"DNA Repair"},{"key":"10.1016\/j.reprotox.2022.01.005_bib0160","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2164-13-28","article-title":"Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA","volume":"13","author":"Mastrokolias","year":"2012","journal-title":"BMC Genomics"},{"issue":"6235","key":"10.1016\/j.reprotox.2022.01.005_bib0165","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1126\/science.aaa0355","article-title":"Human genomics. The human transcriptome across tissues and individuals","volume":"348","author":"Mel\u00e9","year":"2015","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1210\/en.2005-0953","article-title":"Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis","volume":"147","author":"Vernet","year":"2006","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0175","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1210\/mend.15.1.0586","article-title":"Targeted disruption of luteinizing hormone\/human chorionic gonadotropin receptor gene","volume":"15","author":"Lei","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.reprotox.2022.01.005_bib0180","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1749-6632.1989.tb25899.x","article-title":"Sertoli-Leydig cell communications","volume":"564","author":"Saez","year":"1989","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.reprotox.2022.01.005_bib0185","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1095\/biolreprod36.3.769","article-title":"Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure","volume":"36","author":"Klinefelter","year":"1987","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2022.01.005_bib0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2020.103193","article-title":"Impact of lipopolysaccharide administration on luteinizing hormone\/choriogonadotropin receptor (Lhcgr) expression in mouse ovaries","volume":"142","author":"Adetunji","year":"2020","journal-title":"J. Reprod. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.reprotox.2022.01.005_bib0195","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.anireprosci.2013.11.005","article-title":"Lipopolysaccharide in ovarian follicular fluid influences the steroid production in large follicles of dairy cows","volume":"144","author":"Magata","year":"2014","journal-title":"Anim. Reprod. Sci."},{"issue":"4","key":"10.1016\/j.reprotox.2022.01.005_bib0200","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1262\/jrd.2020-021","article-title":"Lipopolysaccharide-induced mechanisms of ovarian dysfunction in cows with uterine inflammatory diseases","volume":"66","author":"Magata","year":"2020","journal-title":"J. Reprod. Dev."},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0205","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/s42003-021-02849-w","article-title":"Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development","volume":"4","author":"Kawai","year":"2021","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0210","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1530\/REP-17-0053","article-title":"Follicular expression of pro-inflammatory cytokines tumour necrosis factor-alpha (TNFalpha), interleukin 6 (IL6) and their receptors in cattle: TNFalpha, IL6 and macrophages suppress thecal androgen production in vitro","volume":"154","author":"Samir","year":"2017","journal-title":"Reproduction"},{"issue":"47","key":"10.1016\/j.reprotox.2022.01.005_bib0215","doi-asserted-by":"crossref","first-page":"32952","DOI":"10.1074\/jbc.M114.610998","article-title":"Structures of human steroidogenic cytochrome P450 17A1 with substrates","volume":"289","author":"Petrunak","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"25","key":"10.1016\/j.reprotox.2022.01.005_bib0220","doi-asserted-by":"crossref","first-page":"10139","DOI":"10.1073\/pnas.1019441108","article-title":"Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system","volume":"108","author":"Strushkevich","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.reprotox.2022.01.005_bib0225","article-title":"Androgen and luteinizing hormone stimulate the function of rat immature leydig cells through different transcription signals","volume":"12","author":"Li","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.reprotox.2022.01.005_bib0230","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12958-016-0224-3","article-title":"Human LH and hCG stimulate differently the early signalling pathways but result in equal testosterone synthesis in mouse Leydig cells in vitro","volume":"15","author":"Riccetti","year":"2017","journal-title":"Reprod. Biol. Endocrinol.: RB&E"},{"issue":"10","key":"10.1016\/j.reprotox.2022.01.005_bib0235","first-page":"626","article-title":"Sex differences in immune responses, Nature reviews","volume":"16","author":"Klein","year":"2016","journal-title":"Immunology"},{"issue":"8","key":"10.1016\/j.reprotox.2022.01.005_bib0240","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1093\/ibd\/izy086","article-title":"Rising incidence of intestinal infections in inflammatory bowel disease: a nationwide analysis","volume":"24","author":"Barber","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"issue":"2","key":"10.1016\/j.reprotox.2022.01.005_bib0245","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1053\/j.gastro.2016.10.019","article-title":"Diet as a trigger or therapy for inflammatory bowel diseases","volume":"152","author":"Lewis","year":"2017","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.reprotox.2022.01.005_bib0250","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8050654","article-title":"Risk of anxiety and depression in patients with inflammatory bowel disease: a nationwide, population-based study","volume":"8","author":"Choi","year":"2019","journal-title":"J. Clin. Med."},{"issue":"10","key":"10.1016\/j.reprotox.2022.01.005_bib0255","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3748\/wjg.v19.i10.1611","article-title":"Cognitive functioning and depressive symptoms in adolescents with inflammatory bowel disease","volume":"19","author":"Castaneda","year":"2013","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.reprotox.2022.01.005_bib0260","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21030740","article-title":"Interplay of heme with macrophages in homeostasis and inflammation","volume":"21","author":"Pradhan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.reprotox.2022.01.005_bib0265","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2014.01.069","article-title":"Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages","volume":"156","author":"Haldar","year":"2014","journal-title":"Cell"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623822000119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623822000119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:56:03Z","timestamp":1760190963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623822000119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":53,"alternative-id":["S0890623822000119"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2022.01.005","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomic and transcriptomic responses of mouse testis to the dextran sulfate sodium induced colitis","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2022.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}