{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T02:29:35Z","timestamp":1783823375842,"version":"3.55.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.reprotox.2022.03.002","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T13:45:09Z","timestamp":1647265509000},"page":"101-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Prenatal ethanol exposure induces dynamic changes of expression and activity of hepatic cytochrome P450 isoforms in male rat offspring"],"prefix":"10.1016","volume":"109","author":[{"given":"Xiaoxiang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.reprotox.2022.03.002_bib1","first-page":"1629","article-title":"Translating dosages from animal models to human clinical trials--revisiting body surface area scaling","volume":"29","author":"Blanchard","year":"2015","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"6","key":"10.1016\/j.reprotox.2022.03.002_bib2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1515\/jbcpp-2016-0012","article-title":"Age-dependent features of CYP3A, CYP2C, and CYP2E1 functioning at metabolic syndrome","volume":"27","author":"Bondarenko","year":"2016","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"issue":"11","key":"10.1016\/j.reprotox.2022.03.002_bib3","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20165238","article-title":"Maternal protein restriction during lactation modulated the expression and activity of rat offspring hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2, and CYP2E1 during development","volume":"49","author":"Da Costa","year":"2016","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"11","key":"10.1016\/j.reprotox.2022.03.002_bib4","article-title":"Maternal protein restriction during lactation modulated the expression and activity of rat offspring hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2, and CYP2E1 during development","volume":"49","author":"Da","year":"2016","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"2\u20133","key":"10.1016\/j.reprotox.2022.03.002_bib5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000365873","article-title":"Regulation of early human growth: impact on long-term health","volume":"65","author":"Koletzko","year":"2014","journal-title":"Ann. Nutr. Metab."},{"issue":"2","key":"10.1016\/j.reprotox.2022.03.002_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1124\/dmd.113.053538","article-title":"Protein restoration in low-birth-weight rat offspring derived from maternal low-protein diet leads to elevated hepatic CYP3A and CYP2C11 activity in adulthood","volume":"42","author":"Sohi","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.reprotox.2022.03.002_bib7","doi-asserted-by":"crossref","first-page":"37426","DOI":"10.1038\/srep37426","article-title":"Imprinting of cerebral cytochrome P450s in offsprings prenatally exposed to cypermethrin augments toxicity on rechallenge","volume":"6","author":"Singh","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2022.03.002_bib8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.taap.2019.03.022","article-title":"Overexpression of cerebral cytochrome P450s in prenatally exposed offspring modify the toxicity of lindane in rechallenged offspring","volume":"371","author":"Agrahari","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"19","key":"10.1016\/j.reprotox.2022.03.002_bib9","first-page":"529","article-title":"Alcohol use among pregnant and nonpregnant women of childbearing age - United States, 1991-2005","volume":"58","author":"C. C","year":"2009","journal-title":"Morb. Mortal. Wkly. Rep."},{"issue":"2","key":"10.1016\/j.reprotox.2022.03.002_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1210\/er.2009-0039","article-title":"Child health, developmental plasticity, and epigenetic programming","volume":"32","author":"Hochberg","year":"2011","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.reprotox.2022.03.002_bib11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.2174\/1874467208666150817111846","article-title":"Alcoholic liver disease: from CYP2E1 to CYP2A5","volume":"10","author":"Leung","year":"2017","journal-title":"Curr. Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.reprotox.2022.03.002_bib12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/toxsci\/kfs164","article-title":"Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway","volume":"128","author":"Lu","year":"2012","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.reprotox.2022.03.002_bib13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ntt.2009.12.002","article-title":"Differential effects of chronic ethanol exposure on cytochrome P450 2E1 and the hypothalamic-pituitary-adrenal axis in the maternal-fetal unit of the guinea pig","volume":"32","author":"Hewitt","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"issue":"3","key":"10.1016\/j.reprotox.2022.03.002_bib14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0002-9378(72)90483-8","article-title":"Elimination and metabolic effects of ethanol in mother, fetus, and newborn infant","volume":"112","author":"Id\u00e4np\u00e4\u00e4n-Heikkil\u00e4","year":"1972","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.reprotox.2022.03.002_bib15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.toxlet.2014.01.023","article-title":"Prenatal ethanol exposure enhances the susceptibility to metabolic syndrome in offspring rats by HPA axis-associated neuroendocrine metabolic programming","volume":"226","author":"Xia","year":"2014","journal-title":"Toxicol. Lett."},{"issue":"7\u20138","key":"10.1016\/j.reprotox.2022.03.002_bib16","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.etp.2010.04.015","article-title":"Ethanol-induced inhibition of fetal hypothalamic-pituitary-adrenal axis due to prenatal overexposure to maternal glucocorticoid in mice","volume":"63","author":"Liang","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.reprotox.2022.03.002_bib17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.taap.2018.03.007","article-title":"Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats","volume":"345","author":"Huang","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.reprotox.2022.03.002_bib18","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.taap.2015.07.005","article-title":"Prenatal ethanol exposure-induced adrenal developmental abnormality of male offspring rats and its possible intrauterine programming mechanisms","volume":"288","author":"Huang","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.reprotox.2022.03.002_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/toxsci\/kfy080","article-title":"Role of TGF\u03b2 signaling in maternal ethanol-induced fetal articular cartilage dysplasia and adult onset of osteoarthritis in male rats","volume":"164","author":"Ni","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2022.03.002_bib20","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-19-0063","article-title":"Prenatal ethanol exposure induces susceptibility to premature ovarian insufficiency","author":"Ni","year":"2019","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.reprotox.2022.03.002_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.toxlet.2020.06.008","article-title":"Glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming mediated hepatic lipid-metabolic in offspring caused by prenatal ethanol exposure","volume":"331","author":"Hu","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2022.03.002_bib22","doi-asserted-by":"crossref","first-page":"14711","DOI":"10.1038\/srep14711","article-title":"Prenatal ethanol exposure increases osteoarthritis susceptibility in female rat offspring by programming a low-functioning IGF-1 signaling pathway","volume":"5","author":"Ni","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.reprotox.2022.03.002_bib23","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.reprotox.2022.03.002_bib24","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1111\/j.1471-0528.2011.03050.x","article-title":"Dose-response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)-a systematic review and meta-analyses","volume":"118","author":"Patra","year":"2011","journal-title":"Bjog"},{"issue":"2","key":"10.1016\/j.reprotox.2022.03.002_bib25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.taap.2013.11.009","article-title":"Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats","volume":"274","author":"Shen","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9","key":"10.1016\/j.reprotox.2022.03.002_bib26","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/jp.2012.57","article-title":"Prenatal alcohol exposure, blood alcohol concentrations and alcohol elimination rates for the mother, fetus and newborn","volume":"32","author":"Burd","year":"2012","journal-title":"J. Perinatol."},{"issue":"2","key":"10.1016\/j.reprotox.2022.03.002_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00429-005-0015-7","article-title":"Localization of alkaline phosphatase and proteins related to intercellular junctions in primary cultures of fetal rat hepatocytes","volume":"210","author":"Chida","year":"2005","journal-title":"Anat. Embryol."},{"issue":"11","key":"10.1016\/j.reprotox.2022.03.002_bib28","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4161\/auto.21376","article-title":"Autophagy is a protective response to ethanol neurotoxicity","volume":"8","author":"Chen","year":"2012","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.reprotox.2022.03.002_bib29","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1530\/EJE-09-0308","article-title":"Differences in expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender","volume":"161","author":"Mericq","year":"2009","journal-title":"Eur. J. Endocrinol."},{"issue":"31","key":"10.1016\/j.reprotox.2022.03.002_bib30","first-page":"3","article-title":"Relationship between serum cortisol concentration and placental expression of 11\u03b2-HSD2 in pregnant women with FGR (in Chinese)","volume":"31","author":"Xiu","year":"2010","journal-title":"JILIN Med. J."},{"issue":"01","key":"10.1016\/j.reprotox.2022.03.002_bib31","first-page":"22","article-title":"The relationship between insulin growth hormone and cortisol in premature infants with intrauterine growth retardation and morbidity (in Chinese)","volume":"22","author":"Yao","year":"2007","journal-title":"Chin. J. Pract. Pediatr."},{"issue":"4","key":"10.1016\/j.reprotox.2022.03.002_bib32","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1124\/dmd.117.079186","article-title":"Maternal-fetal disposition and metabolism of retrorsine in pregnant rats","volume":"46","author":"Li","year":"2018","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"10.1016\/j.reprotox.2022.03.002_bib33","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/rcm.2881","article-title":"Rapid determination of six metabolites from multiple cytochrome P450 probe substrates in human liver microsome by liquid chromatography\/mass spectrometry: application to high-throughput inhibition screening of terpenoids","volume":"21","author":"He","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"5\u20136","key":"10.1016\/j.reprotox.2022.03.002_bib34","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1440-1681.2007.04582.x","article-title":"Establishment of rat precision-cut fibrotic liver slice technique and its application in verapamil metabolism","volume":"34","author":"Guo","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.reprotox.2022.03.002_bib35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.taap.2018.05.029","article-title":"cAMP\/PKA\/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11\u03b2-HSD2 expression","volume":"352","author":"Yu","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2022.03.002_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152848","article-title":"Prenatal ethanol exposure increases maternal bile acids through placental transport pathway","volume":"458","author":"Liu","year":"2021","journal-title":"Toxicology"},{"issue":"23","key":"10.1016\/j.reprotox.2022.03.002_bib37","doi-asserted-by":"crossref","first-page":"23847","DOI":"10.1074\/jbc.R400004200","article-title":"Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer","volume":"279","author":"Nebert","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"52","key":"10.1016\/j.reprotox.2022.03.002_bib38","doi-asserted-by":"crossref","first-page":"36061","DOI":"10.1074\/jbc.R800053200","article-title":"Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology","volume":"283","author":"Nebert","year":"2008","journal-title":"J. Biol Chem."},{"key":"10.1016\/j.reprotox.2022.03.002_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/792934","article-title":"Fetal programming of the neuroendocrine-immune system and metabolic disease","volume":"2012","author":"Fisher","year":"2012","journal-title":"J. Pregnancy"},{"issue":"11","key":"10.1016\/j.reprotox.2022.03.002_bib40","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/aogs.12504","article-title":"Impact of fetal and neonatal environment on beta cell function and development of diabetes","volume":"93","author":"Nielsen","year":"2014","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"7","key":"10.1016\/j.reprotox.2022.03.002_bib41","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1124\/dmd.106.013748","article-title":"Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat","volume":"35","author":"Cherala","year":"2007","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"10.1016\/j.reprotox.2022.03.002_bib42","unstructured":"R.C. Richmond, S. Matthew, L. Ryan, C.L. Relton, D.S. George, DNA methylation as a marker for prenatal smoke exposure in adults, Int J Epidemiol (4) 4."},{"issue":"8","key":"10.1016\/j.reprotox.2022.03.002_bib43","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1242\/bio.20147765","article-title":"MiR-153 targets the nuclear factor-1 family and protects against teratogenic effects of ethanol exposure in fetal neural stem cells","volume":"3","author":"Tsai","year":"2014","journal-title":"Biol. Open"},{"issue":"4","key":"10.1016\/j.reprotox.2022.03.002_bib44","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s13311-013-0211-8","article-title":"Epigenetic landscape of Parkinson's disease: emerging role in disease mechanisms and therapeutic modalities","volume":"10","author":"Ammal Kaidery","year":"2013","journal-title":"Neurotherapeutics"},{"issue":"12","key":"10.1016\/j.reprotox.2022.03.002_bib45","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00204-010-0520-1","article-title":"Age-related changes in hepatic expression and activity of cytochrome P450 in male rats","volume":"84","author":"Yun","year":"2010","journal-title":"Arch. Toxicol."},{"issue":"12","key":"10.1016\/j.reprotox.2022.03.002_bib46","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.2217\/epi-2016-0078","article-title":"Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases","volume":"8","author":"Li","year":"2016","journal-title":"Epigenomics"},{"issue":"R1","key":"10.1016\/j.reprotox.2022.03.002_bib47","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1093\/hmg\/ddt375","article-title":"Age-associated epigenetic drift: implications, and a case of epigenetic thrift?","volume":"22","author":"Teschendorff","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.reprotox.2022.03.002_bib48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.taap.2015.02.009","article-title":"Permanent uncoupling of male-specific CYP2C11 transcription\/translation by perinatal glutamate","volume":"284","author":"Banerjee","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.reprotox.2022.03.002_bib49","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1101\/gad.1284105","article-title":"Perspective: machines for RNAi","volume":"19","author":"Tomari","year":"2005","journal-title":"Genes Dev."},{"issue":"12","key":"10.1016\/j.reprotox.2022.03.002_bib50","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1007\/s00125-006-0466-2","article-title":"Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight: potential link to increased risk of diabetes?","volume":"49","author":"Ozanne","year":"2006","journal-title":"Diabetologia"},{"issue":"11","key":"10.1016\/j.reprotox.2022.03.002_bib51","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1074\/jbc.M110.176685","article-title":"Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.reprotox.2022.03.002_bib52","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbagrm.2016.02.016","article-title":"A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1","volume":"1859","author":"Miao","year":"2016","journal-title":"Biochim. Et Biophys. Acta"},{"key":"10.1016\/j.reprotox.2022.03.002_bib53","unstructured":"J.F. Menez, T.K. Machu, B.J. Song, M.D. Browning, R.A. Deitrich, Phosphorylation of cytochrome P4502E1 (CYP2E1) by calmodulin dependent protein kinase, protein kinase C and cAMP dependent protein kinase, 28(4) (1993) 445."},{"key":"10.1016\/j.reprotox.2022.03.002_bib54","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.redox.2017.09.018","article-title":"Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver","volume":"14","author":"Zeng","year":"2018","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.reprotox.2022.03.002_bib55","first-page":"238","article-title":"Motor function deficits following chronic prenatal ethanol exposure are linked to impairments in insulin\/IGF, notch and Wnt signaling in the cerebellum","volume":"4","author":"Tong","year":"2013","journal-title":"J. Diabetes Metab."},{"issue":"11","key":"10.1016\/j.reprotox.2022.03.002_bib56","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1681\/ASN.2010040368","article-title":"Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny","volume":"21","author":"Gray","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.reprotox.2022.03.002_bib57","doi-asserted-by":"crossref","first-page":"15189","DOI":"10.1038\/s41598-017-15033-0","article-title":"Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology","volume":"7","author":"Abe","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2022.03.002_bib58","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/bcp.13517","article-title":"Pharmacokinetic\/pharmacodynamic drug-drug interactions of avatrombopag when co-administered with dual or selective CYP2C9 and CYP3A interacting drugs","volume":"84","author":"Nomoto","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"4","key":"10.1016\/j.reprotox.2022.03.002_bib59","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.bcp.2014.09.025","article-title":"Identification of CYP3A7 for glyburide metabolism in human fetal livers","volume":"92","author":"Shuster","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.reprotox.2022.03.002_bib60","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/BF03026797","article-title":"Case report: fatal hepatic failure after aortic valve replacement and sevoflurane exposure","volume":"54","author":"Lehmann","year":"2007","journal-title":"Can. J. Anesthesia"},{"issue":"8","key":"10.1016\/j.reprotox.2022.03.002_bib61","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1074\/jbc.M706299200","article-title":"Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice","volume":"283","author":"Chen","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.reprotox.2022.03.002_bib62","doi-asserted-by":"crossref","first-page":"15284","DOI":"10.1074\/jbc.M111.314062","article-title":"Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes","volume":"287","author":"Bansal","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.reprotox.2022.03.002_bib63","first-page":"307","article-title":"Cytochrome P450 polymorphism--molecular, metabolic, and pharmacogenetic aspects. II. Participation of CYP isoenzymes in the metabolism of endogenous substances and drugs","volume":"65","author":"Tomaszewski","year":"2008","journal-title":"Acta Pol. Pharm."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623822000284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623822000284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:57:59Z","timestamp":1760191079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623822000284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":63,"alternative-id":["S0890623822000284"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2022.03.002","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal ethanol exposure induces dynamic changes of expression and activity of hepatic cytochrome P450 isoforms in male rat offspring","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2022.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}