{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:43:19Z","timestamp":1772052199771,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.reprotox.2022.12.004","type":"journal-article","created":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T09:27:41Z","timestamp":1671355661000},"page":"94-101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Maternal exposure to glyphosate-based herbicide causes changes in the vascular function of offspring adult rats"],"prefix":"10.1016","volume":"115","author":[{"given":"Mariana Luiza Rodrigues","family":"de Marins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeniffer Ailane","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian Giselly","family":"Da Silva Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Santana","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Ver\u00edssimo","family":"de Oliveira Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano Augusto de","family":"Ara\u00fajo Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Barbosa","family":"de Queiroz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabr\u00edcio Souza","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2022.12.004_bib1","unstructured":"WHO. Public Health Impact of Pesticides Used in Agriculture. Geneva, Switzerland. Geneva, Switzerland.: 1990."},{"key":"10.1016\/j.reprotox.2022.12.004_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1552-6909.2009.01092.x","article-title":"Pesticides and health risks","volume":"39","author":"Gilden","year":"2010","journal-title":"J. Obstet. Gynecol. Neonatal Nurs."},{"key":"10.1016\/j.reprotox.2022.12.004_bib4","unstructured":"IBAMA. Relat\u00f3rios de comercializa\u00e7\u00e3o de agrot\u00f3xicos 2016. \u3008http:\/\/www.ibama.gov.br\/agrotoxicos\/relatorios-de-comercializacao-de-agrotoxicos#sobreosrelatorios\u3009 (accessed November 11, 2021)."},{"key":"10.1016\/j.reprotox.2022.12.004_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00244-004-0086-0","article-title":"The lethal impacts of roundup and predatory stress on six species of North American tadpoles","volume":"48","author":"Relyea","year":"2005","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib6","first-page":"589","article-title":"Glyphosate: properties, toxicity, use and legislation","volume":"25","author":"de Amarante Junior","year":"2002","journal-title":"Quim. Nova"},{"key":"10.1016\/j.reprotox.2022.12.004_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxlet.2009.07.008","article-title":"Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats","volume":"190","author":"Anad\u00f3n","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2022.12.004_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tox.2017.06.001","article-title":"Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: implication of glutamate excitotoxicity and oxidative stress","volume":"387","author":"Cattani","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2022.12.004_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.freeradbiomed.2013.06.043","article-title":"Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells","volume":"65","author":"de Liz Oliveira Cavalli","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.reprotox.2022.12.004_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/10408444.2012.749834","article-title":"Evaluation of developmental toxicity studies of glyphosate with attention to cardiovascular development","volume":"43","author":"Kimmel","year":"2013","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2478\/aiht-2018-69-3114","article-title":"Oxidative stress, cholinesterase activity, and DNA damage in the liver, whole blood, and plasma of Wistar rats following a 28-day exposure to glyphosate","volume":"69","author":"Mili\u0107","year":"2018","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.biolcel.2003.11.010","article-title":"Glyphosate-based pesticides affect cell cycle regulation","volume":"96","author":"Marc","year":"2004","journal-title":"Biol. Cell"},{"key":"10.1016\/j.reprotox.2022.12.004_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/s0100-83582020380100047","article-title":"Glyphosate impact on arthropods associated to roundup ready and conventional soybean (Glycine max l.)","volume":"38","author":"Pereira","year":"2020","journal-title":"Planta Daninha"},{"key":"10.1016\/j.reprotox.2022.12.004_bib14","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jat.2712","article-title":"Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide","volume":"33","author":"Mesnage","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/1091581814540481","article-title":"Effects of sublethal exposure to a glyphosate-based herbicide formulation on metabolic activities of different xenobiotic-metabolizing enzymes in rats","volume":"33","author":"Larsen","year":"2014","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.reprotox.2012.05.090","article-title":"Adverse effects on sexual development in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides","volume":"34","author":"Hass","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib17","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.parkreldis.2011.02.003","article-title":"Parkinsonism after chronic occupational exposure to glyphosate","volume":"17","author":"Wang","year":"2011","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.reprotox.2022.12.004_bib18","first-page":"117","article-title":"Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase","author":"Pu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.reprotox.2022.12.004_bib19","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00204-020-02677-7","article-title":"Pre- and postnatal exposure to glyphosate-based herbicide causes behavioral and cognitive impairments in adult mice: evidence of cortical ad hippocampal dysfunction","volume":"94","author":"Ait-Bali","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ijheh.2018.12.011","article-title":"Exposure to phthalate metabolites, phenols and organophosphate pesticide metabolites and blood pressure during pregnancy","volume":"222","author":"Warembourg","year":"2019","journal-title":"Int J. Hyg. Environ. Health"},{"key":"10.1016\/j.reprotox.2022.12.004_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12012-014-9282-y","article-title":"Glyphosate-based herbicides potently affect cardiovascular system in mammals: review of the literature","volume":"15","author":"Gress","year":"2015","journal-title":"Cardiovasc Toxicol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.etap.2012.09.005","article-title":"Effects of sub-lethal exposure of rats to the herbicide glyphosate in drinking water: glutathione transferase enzyme activities, levels of reduced glutathione and lipid peroxidation in liver, kidneys and small intestine","volume":"34","author":"Larsen","year":"2012","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.reprotox.2022.12.004_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.toxlet.2004.08.012","article-title":"Vascular wall damage in rats induced by organophosphorus insecticide methidathion","volume":"155","author":"Yavuz","year":"2005","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2022.12.004_bib24","first-page":"12","article-title":"Pesticides may be altering constitutive nitric oxide release, thereby compromising health","author":"Casares","year":"2006","journal-title":"Med Sci. Monit."},{"key":"10.1016\/j.reprotox.2022.12.004_bib25","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.toxlet.2013.12.009","article-title":"Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers","volume":"225","author":"Wunnapuk","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2022.12.004_bib26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/enrs.2000.4229","article-title":"Effect of the herbicide glyphosate on enzymatic activity in pregnant rats and their fetuses","volume":"85","author":"Daruich","year":"2001","journal-title":"Environ. Res"},{"key":"10.1016\/j.reprotox.2022.12.004_bib27","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.tiv.2006.12.007","article-title":"Cardiovascular effects of herbicides and formulated adjuvants on isolated rat aorta and heart","volume":"21","author":"Chan","year":"2007","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.reprotox.2022.12.004_bib28","first-page":"307","article-title":"UV-B filter octylmethoxycinnamate-induced vascular endothelial disruption on rat aorta: in silico and in vitro approach","author":"Lorigo","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2022.12.004_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0899-9007(97)00391-2","article-title":"Intrauterine programming of cardiovascular disease by maternal nutritional status","volume":"14","author":"Langley-Evans","year":"1998","journal-title":"Nutrition"},{"key":"10.1016\/j.reprotox.2022.12.004_bib30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.envint.2012.06.007","article-title":"Reduced birth weight in relation to pesticide mixtures detected in cord blood of full-term infants","volume":"47","author":"Wickerham","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2022.12.004_bib31","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.scitotenv.2016.09.009","article-title":"Exposure to pesticides and the associated human health effects","volume":"575","author":"Kim","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.reprotox.2022.12.004_bib32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/oem.2009.047811","article-title":"Neurobehavioral effects of long-term exposure to pesticides: results from the 4-year follow-up of the PHYTONER study","volume":"68","author":"Baldi","year":"2011","journal-title":"Occup. Environ. Med"},{"key":"10.1016\/j.reprotox.2022.12.004_bib33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/rtph.1999.1371","article-title":"Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans","volume":"31","author":"Williams","year":"2000","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.reprotox.2022.12.004_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/10937404.2012.632361","article-title":"Developmental and reproductive outcomes in humans and animals after glyphosate exposure: a critical analysis","volume":"15","author":"Williams","year":"2012","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.reprotox.2022.12.004_bib35","doi-asserted-by":"crossref","DOI":"10.1080\/10408444.2016.1214678","article-title":"Glyphosate in the general population and in applicators: a critical review of studies on exposures","author":"Solomon","year":"2016","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.chembiol.2016.12.013","article-title":"Mapping proteome-wide targets of glyphosate in mice","volume":"24","author":"Ford","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib37","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuro.2015.11.015","article-title":"Exposure to a glyphosate-based herbicide during pregnancy and lactation induces neurobehavioral alterations in rat offspring","volume":"53","author":"Gallegos","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.reprotox.2022.12.004_bib38","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.reprotox.2004.09.009","article-title":"Effect of the herbicide glyphosate on liver lipoperoxidation in pregnant rats and their fetuses","volume":"19","author":"Beuret","year":"2005","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2022.12.004_bib39","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1152\/ajpheart.00292.2006","article-title":"Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)","volume":"291","author":"F\u00e9l\u00e9tou","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.reprotox.2022.12.004_bib40","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.2337\/diab.46.6.1054","article-title":"Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats","volume":"46","author":"Siman","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.reprotox.2022.12.004_bib41","doi-asserted-by":"crossref","first-page":"12043","DOI":"10.1073\/pnas.89.24.12043","article-title":"Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging","volume":"89","author":"Vlassara","year":"1992","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623822001733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623822001733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:00:13Z","timestamp":1760191213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623822001733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":40,"alternative-id":["S0890623822001733"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2022.12.004","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal exposure to glyphosate-based herbicide causes changes in the vascular function of offspring adult rats","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2022.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}