{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:54:45Z","timestamp":1760241285871,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:00:00Z","timestamp":1684540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.reprotox.2023.108396","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T11:12:19Z","timestamp":1684581139000},"page":"108396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Maternal alcohol intake in early pregnancy and biomarkers of fecundity in adult sons: A cohort study"],"prefix":"10.1016","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8600-662X","authenticated-orcid":false,"given":"Anne Hjorth","family":"Thomsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Gaml-S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nis","family":"Brix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra S\u00f8gaard","family":"T\u00f8ttenborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin S\u00f8rig","family":"Hougaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linn H\u00e5konsen","family":"Arendt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Toft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Peter","family":"Bonde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia H\u00f8st","family":"Ramlau-Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.reprotox.2023.108396_bib1","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoac051","article-title":"Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis","volume":"2022","author":"Cox","year":"2022","journal-title":"Hum. Reprod. Open"},{"issue":"4","key":"10.1016\/j.reprotox.2023.108396_bib2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3390\/cells9040990","article-title":"Male infertility is a women\u2019s health issue-research and clinical evaluation of male infertility is needed","volume":"9","author":"Turner","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.reprotox.2023.108396_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1152\/physrev.00017.2015","article-title":"Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility","volume":"96","author":"Skakkebaek","year":"2016","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.reprotox.2023.108396_bib4","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1093\/humrep\/deh687","article-title":"The social epidemiology of coping with infertility","volume":"20","author":"Schmidt","year":"2005","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.reprotox.2023.108396_bib5","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/humupd\/dmac005","article-title":"Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine","volume":"28","author":"S\u00e1nchez-Garrido","year":"2022","journal-title":"Hum. Reprod. Update"},{"issue":"7","key":"10.1016\/j.reprotox.2023.108396_bib6","article-title":"Alcohol and fetal damage","volume":"22","author":"Allebeck","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"4","key":"10.1016\/j.reprotox.2023.108396_bib7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1530\/REP-18-0607","article-title":"Adverse reproductive outcomes associated with fetal alcohol exposure: a systematic review","volume":"157","author":"Akison","year":"2019","journal-title":"Reproduction"},{"issue":"4","key":"10.1016\/j.reprotox.2023.108396_bib8","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1365-2826.2008.01669.x","article-title":"Prenatal alcohol exposure: foetal programming, the hypothalamic-pituitary-adrenal axis and sex differences in outcome","volume":"20","author":"Weinberg","year":"2008","journal-title":"J. Neuroendocrinol."},{"issue":"11","key":"10.1016\/j.reprotox.2023.108396_bib9","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1111\/j.1651-2227.2007.00506.x","article-title":"Prenatal alcohol exposure and cryptorchidism","volume":"96","author":"Jensen","year":"2007","journal-title":"Acta Paediatr."},{"issue":"2","key":"10.1016\/j.reprotox.2023.108396_bib10","doi-asserted-by":"crossref","DOI":"10.1289\/ehp.9608","article-title":"Cryptorchidism and maternal alcohol consumption during pregnancy","volume":"115","author":"Damgaard","year":"2007","journal-title":"Environ. Health Perspect."},{"issue":"12","key":"10.1016\/j.reprotox.2023.108396_bib11","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1093\/humrep\/dep325","article-title":"Alcohol binge drinking during pregnancy and cryptorchidism","volume":"24","author":"Strandberg-Larsen","year":"2009","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.reprotox.2023.108396_bib12","first-page":"249","article-title":"Fertility after unilateral cryptorchidism","volume":"55","author":"Miller","year":"2001","journal-title":"HRP"},{"issue":"5","key":"10.1016\/j.reprotox.2023.108396_bib13","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1651-2227.2007.00241.x","article-title":"Cryptorchidism: classification, prevalence and long-term consequences","volume":"96","author":"Virtanen","year":"2007","journal-title":"Acta Paediatr."},{"issue":"6","key":"10.1016\/j.reprotox.2023.108396_bib14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1017\/S2040174411000584","article-title":"Effect of maternal coffee, smoking and drinking behavior on adult son\u2019s semen quality: prospective evidence from the child health and development studies","volume":"2","author":"Cirillo","year":"2011","journal-title":"J. Dev. Orig. Health Dis."},{"issue":"9","key":"10.1016\/j.reprotox.2023.108396_bib15","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1093\/humrep\/deq140","article-title":"Maternal alcohol consumption during pregnancy and semen quality in the male offspring: two decades of follow-up","volume":"25","author":"Ramlau-Hansen","year":"2010","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108396_bib16","article-title":"Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure","volume":"14","author":"Bonthius","year":"1990","journal-title":"Alcohol.: Clin. Exp. Res."},{"issue":"8","key":"10.1016\/j.reprotox.2023.108396_bib17","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/aje\/154.8.777","article-title":"Binge drinking in pregnancy--frequency and methodology","volume":"154","author":"Kesmodel","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.reprotox.2023.108396_bib18","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CLEP.S242631","article-title":"Fetal programming of semen quality (FEPOS) cohort \u2013 a DNBC male-offspring cohort","volume":"12","author":"Keglberg H\u00e6rvig","year":"2020","journal-title":"Clin. Epidemiol."},{"issue":"4","key":"10.1016\/j.reprotox.2023.108396_bib19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/14034948010290040201","article-title":"The Danish national birth cohort--its background, structure and aim","volume":"29","author":"Olsen","year":"2001","journal-title":"Scand. J. Public Health"},{"key":"10.1016\/j.reprotox.2023.108396_bib20","unstructured":"World Health Organization, WHO laboratory manual for the examination and processing of human semen, p. 271, 2010."},{"issue":"6","key":"10.1016\/j.reprotox.2023.108396_bib21","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.fertnstert.2006.11.032","article-title":"Is self-measuring of testicular volume by a Prader orchidometer a valid method","volume":"87","author":"Ramlau-Hansen","year":"2007","journal-title":"Fertil. Steril."},{"issue":"17","key":"10.1016\/j.reprotox.2023.108396_bib22","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1289\/ehp.7199","article-title":"Epidemiologic evaluation of measurement data in the presence of detection limits","volume":"112","author":"Lubin","year":"2004","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108396_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00001648-199901000-00008","article-title":"Causal diagrams for epidemiologic research","volume":"10","author":"Greenland","year":"1999","journal-title":"Epidemiology"},{"issue":"5","key":"10.1016\/j.reprotox.2023.108396_bib24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/01.ede.0000135174.63482.43","article-title":"A structural approach to selection bias","volume":"15","author":"Hern\u00e1n","year":"2004","journal-title":"Epidemiology"},{"key":"10.1016\/j.reprotox.2023.108396_bib25","article-title":"Selection bias in a male-offspring cohort investigating fecundity: is there reason for concern","author":"Gaml-S\u00f8rensen","year":"2022","journal-title":"Hum. Reprod."},{"issue":"9135","key":"10.1016\/j.reprotox.2023.108396_bib26","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0140-6736(97)10514-1","article-title":"Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners","volume":"352","author":"Bonde","year":"1998","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.reprotox.2023.108396_bib27","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1111\/acer.12395","article-title":"Effects of prenatal alcohol exposure on testosterone and pubertal development","volume":"38","author":"Carter","year":"2014","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"4","key":"10.1016\/j.reprotox.2023.108396_bib28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1530-0277.1985.tb05559.x","article-title":"Effects of in utero exposure to alcohol upon male rats","volume":"9","author":"Udani","year":"1985","journal-title":"Alcohol.: Clin. Exp. Res."},{"issue":"3","key":"10.1016\/j.reprotox.2023.108396_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0018-506X(79)90040-0","article-title":"Effects of perinatal alcohol on sexual differentiation and open-field behavior in rats","volume":"13","author":"Chen","year":"1979","journal-title":"Horm. Behav."},{"issue":"6","key":"10.1016\/j.reprotox.2023.108396_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-004467","article-title":"In utero exposure to alcohol and puberty in boys: a pregnancy cohort study","volume":"4","author":"H\u00e5konsen","year":"2014","journal-title":"BMJ Open"},{"key":"10.1016\/j.reprotox.2023.108396_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/531042","article-title":"Sperm DNA integrity assessment: a new tool in diagnosis and treatment of fertility","volume":"2012","author":"Bungum","year":"2012","journal-title":"Obstet. Gynecol. Int."},{"issue":"5","key":"10.1016\/j.reprotox.2023.108396_bib32","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.rbmo.2021.02.006","article-title":"Age-related changes in human conventional semen parameters and sperm chromatin structure assay-defined sperm DNA\/chromatin integrity","volume":"42","author":"Gao","year":"2021","journal-title":"Reprod. Biomed. Online"},{"issue":"7","key":"10.1016\/j.reprotox.2023.108396_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/and.14442","article-title":"High DNA stainability (HDS) should not be recommended as a marker for the detection of sperm DNA damage","volume":"54","author":"Lu","year":"2022","journal-title":"Andrologia"},{"issue":"12","key":"10.1016\/j.reprotox.2023.108396_bib34","first-page":"2713","article-title":"Testicular function in a birth cohort of young men","volume":"30","author":"Hart","year":"2015","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.reprotox.2023.108396_bib35","doi-asserted-by":"crossref","first-page":"638","DOI":"10.2164\/jandrol.107.002741","article-title":"Andrology lab corner*: one semen sample or 2? Insights from a study of fertile men","volume":"28","author":"Stokes-Riner","year":"2007","journal-title":"J. Androl."},{"issue":"7","key":"10.1016\/j.reprotox.2023.108396_bib36","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/aogs.12890","article-title":"Time trends in alcohol intake in early pregnancy and official recommendations in Denmark, 1998\u20132013","volume":"95","author":"Kesmodel","year":"2016","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"4","key":"10.1016\/j.reprotox.2023.108396_bib37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1530-0277.1988.tb00233.x","article-title":"Underreporting of alcohol use in pregnancy","volume":"12","author":"Ernhart","year":"1988","journal-title":"Alcohol.: Clin. Exp. Res."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823000709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823000709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:01:14Z","timestamp":1760191274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623823000709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":37,"alternative-id":["S0890623823000709"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108396","relation":{},"ISSN":["0890-6238"],"issn-type":[{"type":"print","value":"0890-6238"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal alcohol intake in early pregnancy and biomarkers of fecundity in adult sons: A cohort study","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108396"}}