{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:36:16Z","timestamp":1782484576130,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008394","name":"Fundaci\u00f3 Bosch i Gimpera","doi-asserted-by":"publisher","award":["300155"],"award-info":[{"award-number":["300155"]}],"id":[{"id":"10.13039\/501100008394","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.reprotox.2023.108469","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T18:53:03Z","timestamp":1693853583000},"page":"108469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Developmental neurotoxicity evaluation of three Chinese herbal medicines in zebrafish larvae by means of two behavioral assays: Touch-evoked response and light\/dark transition"],"prefix":"10.1016","volume":"121","author":[{"given":"Noelia G.","family":"Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Teixid\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rdis","family":"Klose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping Chung","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Ca\u00f1igueral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Fritsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Barenys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.reprotox.2023.108469_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22020715","article-title":"\u2018Epigallocatechin gallate ameliorates the effects of prenatal alcohol exposure in a fetal alcohol spectrum disorder-like mouse model\u2019","volume":"22","author":"Almeida-Toledano","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2023.108469_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/10408444.2014.981331","article-title":"\u2018Putative adverse outcome pathways relevant to neurotoxicity\u2019","author":"Bal-Price","year":"2015","journal-title":"Crit. Rev. Toxicol. Inf. Healthc."},{"issue":"2","key":"10.1016\/j.reprotox.2023.108469_bib3","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s00204-016-1709-8","article-title":"\u2018Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro\u2019","volume":"91","author":"Barenys","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108469_bib4","first-page":"196","article-title":"\u2018Is Intake of Flavonoid-Based Food Supplements During Pregnancy Safe for the Developing Child? A Literature Review\u2019","author":"Barenys","year":"2017","journal-title":"Curr. Drug Targets"},{"issue":"6","key":"10.1016\/j.reprotox.2023.108469_bib5","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s00204-015-1568-8","article-title":"\u2018Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events\u2019","volume":"90","author":"Baumann","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108469_bib6","first-page":"311","article-title":"\u2018Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals\u2019","author":"Blum","year":"2023","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.reprotox.2023.108469_bib7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0010-7824(94)00001-D","article-title":"\u2018Adverse effect of Tripterygium wilfordii extract on mouse embryonic development\u2019","volume":"51","author":"Chan","year":"1995","journal-title":"Contraception"},{"key":"10.1016\/j.reprotox.2023.108469_bib8","unstructured":"Chinese Pharmacopoeia Commission (2020) \u2018Chinese Pharmacopoeia Commission Pharmacopoeia of the People\u2019s Republic of China\u2019."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108469_bib9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4314\/ahs.v20i1.11","article-title":"\u2018A cross-sectional study to determine the use of alternative medicines during pregnancy in the district hospitals in manicaland, zimbabwe\u2019","volume":"20","author":"Dimene","year":"2020","journal-title":"Afr. Health Sci."},{"issue":"6","key":"10.1016\/j.reprotox.2023.108469_bib10","article-title":"\u2018Development of Integrated Approaches to Testing and Assessment (IATA) case studies on developmental neurotoxicity (DNT) risk assessment\u2019","volume":"19","author":"EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues)","year":"2021","journal-title":"EFSA J."},{"issue":"8","key":"10.1016\/j.reprotox.2023.108469_bib11","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1016\/j.sjbs.2021.04.084","article-title":"\u2018Effect of prenatal exposure of green tea extract on the developing central nervous system of rat fetuses; histological, immune-histochemical and ultrastructural studies\u2019","volume":"28","author":"El-Borm","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.reprotox.2023.108469_bib12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1471-0528.2002.t01-1-01009.x","article-title":"\u2018Herbal medicinal products during pregnancy: Are they safe","author":"Ernst","year":"2002","journal-title":"BJOG: Int. J. Obstet. Gynaecol."},{"issue":"4","key":"10.1016\/j.reprotox.2023.108469_bib13","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1067\/mob.2003.223","article-title":"\u2018Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population\u2019","volume":"188","author":"Glover","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108469_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5604\/01.3001.0012.7860","article-title":"\u2018Celastrol attenuates intrahepatic cholestasis of pregnancy by inhibiting matrix metalloproteinases-2 and 9\u2032","volume":"18","author":"Guo","year":"2019","journal-title":"Ann. Hepatol."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108469_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12302-020-00421-7","article-title":"\u2018Evaluation of the effects of acetylcholinesterase inhibitors in the zebrafish touch-evoked response: quantitative vs. qualitative assessment\u2019","volume":"32","author":"Guzman","year":"2020","journal-title":"Environ. Sci. Eur."},{"issue":"3","key":"10.1016\/j.reprotox.2023.108469_bib16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/140349489101900310","article-title":"\u2018A Survey on the use of Alternative Drugs During Pregnancy\u2019","volume":"19","author":"Hemminki","year":"1991","journal-title":"Scand. J. Soc. Med."},{"key":"10.1016\/j.reprotox.2023.108469_bib17","unstructured":"HMPC (2012) Community herbal monograph on Camellia sinensis (L.) Kuntze, non fermentatum folium. \u3008www.ema.europa.eu\u3009."},{"key":"10.1016\/j.reprotox.2023.108469_bib18","unstructured":"HMPC (2013) Assessment report on Camellia sinensis (L.) Kuntze, non fermentatum folium. \u3008www.ema.europa.eu\u3009."},{"key":"10.1016\/j.reprotox.2023.108469_bib19","doi-asserted-by":"crossref","unstructured":"Hollyer, T. et al. (2002) The use of CAM by women suffering from nausea and vomiting during pregnancy. \u3008http:\/\/www.biomedcentral.com\/1472\u20136882\/2\/5\u3009.","DOI":"10.1186\/1472-6882-2-5"},{"key":"10.1016\/j.reprotox.2023.108469_bib20","first-page":"794","article-title":"\u2018Traditional Chinese Medicine and Traditional Indonesian Medicine: A Comparative Review of Herbal Medicines Restricted in Pregnancy\u2019","author":"Jun","year":"2021","journal-title":"Chin. J. Integr. Med. Springe Sci. Bus. Media Dtschl. GmbH"},{"key":"10.1016\/j.reprotox.2023.108469_bib21","doi-asserted-by":"crossref","unstructured":"Kennedy, D.A. et al. (2013) Herbal medicine use in pregnancy: results of a multinational study. \u3008http:\/\/www.biomedcentral.com\/1472\u20136882\/13\/355\u3009.","DOI":"10.1186\/1472-6882-13-355"},{"key":"10.1016\/j.reprotox.2023.108469_bib22","first-page":"3","article-title":"\u2018Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro","volume":"1","author":"Klose","year":"2022","journal-title":"AOP Framew. Causal Connects Toxicol. Mech. information\u2019, Cell Biol. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108469_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113506","article-title":"\u2018Application of the adverse outcome pathway to identify molecular changes in prenatal brain programming induced by IUGR: Discoveries after EGCG exposure\u2019","volume":"170","author":"K\u00fchne","year":"2022","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.reprotox.2023.108469_bib24","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/mnfr.201300325","article-title":"\u2018Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans\u2019","volume":"58","author":"De la Torre","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.reprotox.2023.108469_bib25","doi-asserted-by":"crossref","unstructured":"Leuenroth, S.J. et al. (2007) Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease. \u3008www.pnas.org\/cgi\/content\/full\/\u3009.","DOI":"10.1073\/pnas.0700499104"},{"key":"10.1016\/j.reprotox.2023.108469_bib26","article-title":"\u2018Systematic review of Chinese Medicine for miscarriage during early pregnancy\u2019","author":"Li","year":"2014","journal-title":"Evid. -Based Complement. Altern. Med."},{"key":"10.1016\/j.reprotox.2023.108469_bib27","article-title":"\u2018A review on central nervous system effects of gastrodin\u2019","author":"Liu","year":"2018","journal-title":"Front. Pharmacol. Front. Media S. A"},{"issue":"11","key":"10.1016\/j.reprotox.2023.108469_bib28","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1111\/j.1530-0277.2010.01282.x","article-title":"\u2018The preventive effect of oral EGCG in a fetal alcohol spectrum disorder mouse model\u2019","volume":"34","author":"Long","year":"2010","journal-title":"Alcohol.: Clin. Exp. Res."},{"issue":"10","key":"10.1016\/j.reprotox.2023.108469_bib29","article-title":"\u2018Establishment of an a priori protocol for the implementation and interpretation of an in\u2010vitro testing battery for the assessment of developmental neurotoxicity\u2019","volume":"17","author":"Masjosthusmann","year":"2020","journal-title":"EFSA Support. Publ."},{"key":"10.1016\/j.reprotox.2023.108469_bib30","series-title":"Regulatory Toxicology and Pharmacology","article-title":"\u2018The Botanical Safety Consortium: A public-private partnership to enhance the botanical safety toolkit\u2019","author":"Mitchell","year":"2022"},{"key":"10.1016\/j.reprotox.2023.108469_bib31","unstructured":"Muriana, A. et al. (2021) An Inter-laboratory Case Study to Harmonize Zebrafish Light-Dark Transition Test to Predict Developmental Neurotoxicity (WC11)."},{"key":"10.1016\/j.reprotox.2023.108469_bib32","series-title":"Blood sampling: Mouse","article-title":"Approaches for sampling blood in the mouse, covering non-surgical, surgical and terminal techniques","author":"National Centre for the Replacement, R. and R. of A. in R","year":"2013"},{"issue":"11\u201312","key":"10.1016\/j.reprotox.2023.108469_bib33","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1111\/jocn.12323","article-title":"\u2018Incidence of pregnancy-related discomforts and management approaches to relieve them among pregnant women\u2019","volume":"23","author":"Nazik","year":"2014","journal-title":"J. Clin. Nurs."},{"issue":"6","key":"10.1016\/j.reprotox.2023.108469_bib34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/pds.945","article-title":"\u2018Use of herbal drugs in pregnancy: A survey among 400 Norwegian women\u2019","volume":"13","author":"Nordeng","year":"2004","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.reprotox.2023.108469_bib35","unstructured":"OECD (2022) \u2018Guidance evaluation of data developmental neurotoxicity in vitrotesting\u2019."},{"issue":"2","key":"10.1016\/j.reprotox.2023.108469_bib36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbr.2011.12.016","article-title":"Measuring thigmotaxis in larval zebrafish","volume":"228","author":"Schn\u00f6rr","year":"2012","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.reprotox.2023.108469_bib37","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.reprotox.2011.08.003","article-title":"\u2018Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds\u2019","volume":"33","author":"Selderslaghs","year":"2012","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108469_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/jcpt.12597","article-title":"\u2018Epigallocatechin gallate enhances treatment efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia: A double-blind, randomized and placebo-controlled clinical study\u2019","volume":"43","author":"Shi","year":"2018","journal-title":"J. Clin. Pharm. Ther."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108469_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-40328-9","article-title":"\u2018Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models\u2019","volume":"9","author":"Souchet","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108469_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000121224","article-title":"\u2018Meningoencephalocele Associated with Tripterygium wilfordii Treatment\u2019","volume":"27","author":"Takei","year":"1997","journal-title":"Pediatr. Neurosurg."},{"key":"10.1016\/j.reprotox.2023.108469_bib41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.midw.2015.11.010","article-title":"\u2018Consumption of Chinese herbal medicines during pregnancy and postpartum: A prospective cohort study in China\u2019","volume":"34","author":"Tang","year":"2016","journal-title":"Midwifery"},{"key":"10.1016\/j.reprotox.2023.108469_bib42","unstructured":"TCM Treatment (2011) TCM China: Introduction To Gastrodia Tuber (tian ma). \u3008https:\/\/www.tcmtreatment.com\/herbs\/0-tianma.htm\u3009 (Accessed: 29 March 2023)."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108469_bib43","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.tiv.2012.07.010","article-title":"\u2018Assessment of developmental delay in the zebrafish embryo teratogenicity assay\u2019","volume":"27","author":"Teixid\u00f3","year":"2013","journal-title":"Toxicol. Vitr."},{"issue":"8","key":"10.1016\/j.reprotox.2023.108469_bib44","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1017\/S146114571000060X","article-title":"\u2018Epigallocatechin-3-gallate ameliorates alcohol-induced cognitive dysfunctions and apoptotic neurodegeneration in the developing rat brain\u2019","volume":"13","author":"Tiwari","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108469_bib45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/01480545.2010.494664","article-title":"\u2018Toxic effects of celastrol on embryonic development of zebrafish (Danio rerio","volume":"34","author":"Wang","year":"2011","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108469_bib46","unstructured":"Work Plan TGP (2021) Work plan for the Test Guidelines Programme (TGP)."},{"key":"10.1016\/j.reprotox.2023.108469_bib47","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jep.2016.06.057","article-title":"\u2018The rhizome of Gastrodia elata Blume \u2013 An ethnopharmacological review\u2019","volume":"189","author":"Zhan","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.reprotox.2023.108469_bib48","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/jhn.12470","article-title":"\u2018Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial\u2019","volume":"30","author":"Zhang","year":"2017","journal-title":"J. Hum. Nutr. Diet."},{"key":"10.1016\/j.reprotox.2023.108469_bib49","article-title":"\u2018Evaluation of the effect of green tea and its constituents on embryo development in a zebrafish model\u2019","author":"Zhang","year":"2022","journal-title":"J. Appl. Toxicol. [Prepr. ]"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823001430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823001430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:00:57Z","timestamp":1760191257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623823001430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":49,"alternative-id":["S0890623823001430"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108469","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental neurotoxicity evaluation of three Chinese herbal medicines in zebrafish larvae by means of two behavioral assays: Touch-evoked response and light\/dark transition","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108469"}}